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All Journal HAYATI Journal of Biosciences VALENSI Jurnal Natur Indonesia Jurnal Pendidikan Khusus AL KAUNIYAH Jurnal Penelitian Hasil Hutan PREDIKSI Indonesian Journal of Cancer Chemoprevention Quagga Jurnal Riset Kimia Biology, Medicine, & Natural Product Chemistry EduChemia: Jurnal Kimia dan Pendidikan Indonesian Journal of Cancer Padjadjaran Journal of Dentistry Jurnal Ilmiah Universitas Batanghari Jambi Chimica et Natura Acta ALCHEMY Jurnal Penelitian Kimia Indonesian Journal of Chemistry Akta Kimia Indonesia Jambura Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Jurnal Ilmu Manajemen Jurnal Penelitian Hasil Hutan Jurnal Ilmiah Ekonomika Jurnal Manajemen Journal of Education Research Ekalaya: Jurnal Pengabdian Kepada Masyarakat Indonesia Sains Medisina Jurnal Pengabdian Masyarakat dan Riset Pendidikan Da'watuna: Journal of Communication and Islamic Broadcasting Jurnal Ekonomi, Manajemen, Akuntansi Journal of Experimental and Applied Physics Jurnal Penelitian Hasil Hutan

Tati Herlina

Departemen Kimia Fakultas Matematika Dan Ilmu Pengetahuan Alam Universitas Padjadjaran

Author-ID : 280308

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Public Health Social Sciences Other

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Kemampuan Kepala Sekolah dalam Membina Hubungan dengan Guru Untuk Meningkatkan Mutu Pendidikan Herlina, Tati; Ahmad, Syarwani; Wahidy, Achmad
Journal of Education Research Vol. 1 No. 3 (2020): December 2020
Publisher : Perkumpulan Pengelola Jurnal PAUD Indonesia

Penelitian ini bertujuan untuk menganalisis kemampuan Kepala Sekolah dalam membina hubungan dengan guru untuk meningkatkan mutu pendidikan di SMP Negeri 1 Prabumulih. Metode penelitian yang digunakan adalah metode penelitian kualitatif. Sumber data dalam penelitian ini Kepala Sekolah dan 15 orang guru yang mewakili masing-masing kelas. Teknik pengumpulan data adalah wawancara, observasi dan dokumentasi. Data yang telah terkumpul dianalisis dengan tahapan reduksi data, penyajian data dan pengambilan kesimpulan dan verifikasi data. Berdasarkan hasil penelitian, dapat disimpulkan bahwa: 1) ditinjau dari keterampilan teknis Kepala Sekolah mampu mengelola sekolah dan menetapkan arah sekolah sebagai lembaga pendidikan dengan cara merumuskan visi, misi dan tujuan pencapaian yang telah direncanakan; 2) ditinjau dari keterampilan hubungan manusia Kepala Sekolah mampu memberikan pandangan strategi bagi guru dalam melaksanakan tugas, dan 3) ditinjau dari keterampilan konseptual Kepala Sekolah mampu dan berperan serta dalam kegiatan-kegiatan di sekolah.

Cytotoxic Activity of Alpinumisoflavone from Erythrina poeppigiana (Leguminosae) Against Colon Cancer (WiDr), Cervical Cancer (Hela), and Hepatoma Cancer (HepG2) Cells Tati Herlina; Nayla Haraswati; Riza Apriani; Vicki Nishinarizki; Shabarni Gaffar; Unang Supratman
HAYATI Journal of Biosciences Vol. 26 No. 2 (2019): April 2019
Publisher : Bogor Agricultural University, Indonesia

Cancer is the second cause of death after cardiovascular diseases in the world. Anticancer prevention used can cause undesirable things. Flavonoids are secondary metabolites derived from natural products that are useful for anticancer treatment. This study was performed to observe the cytotoxic activity of alpinumisoﬂavone from Erythrina poeppigiana, toward cervical cancer (Hela), colon cancer (WiDr), and hepatoma cancer (HepG2) cells. The cytotoxic activity of alpinumisoﬂavone was tested using (3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyltetrazolium bromide) assay. The percentage of cell mortality was calculated and the IC50 was calculated using probit analysis. The result shown that alpinumisoﬂavone has antiproliferative eﬀect to colon cancer (WiDr), cervical cancer (Hela), and hepatoma cancer (HepG2) cells with the value of IC50 are 5.63, 7.18, and 18.08 µg/ml, respectively. Based on the value of IC50 alpinumisoﬂavone is very cytotoxic to colon cancer WiDr cell.

Flavanoids fromthe Stembark of Chisocheton pentandrus(Meliaceae) Supriatno Supriatno; Ace Tatang Hidayat; Kindi Farabi; Fajar Fauzi Abdullah; Nurlelasari Nurlelasari; Tati Herlina; Unang Supratman; Khadijah Awang
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 3, No. 2, November 2017
Publisher : Syarif Hidayatullah State Islamic University

Two flavanoid compounds, catechin (1) and epicatechin (2), have been isolated from the stembark of Chisocheton pentandrus. The chemical structure of compounds1and2were identified byspectroscopic data including, UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY) and MS and by comparing with previously reported spectral data. Compounds 1 and 2, were isolated in this plant for first time and showed no cytotoxic activity against MCF-7 breast cancer cells.

A New Antiplasmodial Compound from the Papuan Marine Sponge Xestospongia sp. Murtihapsari Murtihapsari; Amir M Suruwaky; Kadarusman Kadarusman; Dikdik Kurnia; Tati Herlina; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 1, Mei 2018
Publisher : Syarif Hidayatullah State Islamic University

A new antiplasmodial compound, 2-(3H-diazirine-3-yl)benzaldehyde (1), has been isolated from the Papuan marine sponge Xestospongia sp. The structure elucidation of compound 1 was determined by spectroscopic evidences including UV, IR, MS, 1D and 2D-NMR analysis. Compound 1 showed moderate antiplasmodial activity against Plasmodium falciparum with IC50 value of 1.08 x 10-6 mM. DOI:http://dx.doi.org/10.15408/jkv.v4i1.6735

Isolasi Senyawa Triterpenoid dari Ekstrak Etil Asetat Pirdot (Saurauia vulcani. Kurth) Boima Ramses Situmeang; Achmad Rante Suparman; Murtihapsari kadarusman; Apriani sulu parumbak; Tati Herlina
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 4, No. 2, November 2018
Publisher : Syarif Hidayatullah State Islamic University

Pirdot plant(Saurauia vulcani. Kurth)is a plant that grows naturally in a tropical climate. During this decoction pirdot leaves plants are used by the people to treat diabetes disease. The purpose of this study was to isolate triterpenoid compound from ethyl acetate extract of pirdot leaves. The sample extraction was performed by total of maceration method using ethyl acetate as a solvent. The separation and purification of the compound was carried out by column chromatography method followed by stain pattern analysis with thin layer chromatography (TLC). Structure characterization of pure compound was determined using UV, IR, 1H-NMR, 13C-NMR, DEPT 135º, HMQC, HMBC, 1H-1H COSY and MS spectroscopies including compared with various literatures. Based on the analysis result, the pure isolate obtained was identified as a pentacyclic triterpenoid compound, 3-hydroxy acid, 12(13)-en,28-oleanolate acid with the molecular formula C30H48O3. The triterpenoid compound of pentacyclic oleanolic acid is the first reported from the pirdot plant (Saurauia vulcani. Kurth).

Ethyl Acetate Fraction of Moringa oleifera Leaves Induces Cell Cycle Arrest on T47D Breast Cancer Cell via G0/G1 through Cyclin D1 Expression Riza Apriani; Tati Herlina; Shabarni Gaffar
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 1, May 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i1.15431

Cancer is a disease that is the leading cause of death worlwide. Exploration of a natural product containing anticancer agent provides a promising line for research on cancer. One of plant that used in traditional medicine for the cancer treatment is Moringa oleifera. The previous study has reported that the n-hexane fraction of M. oleifera leaves induce apoptosis and cell cycle arrest in T47D cells. Based on the preliminary result, ethyl acetate fraction of M. oleifera (EMO) leaves showed medium cytotoxic activity on T47D cells with IC50 values of 243.58 μg/mL and induced apoptosis cell death. This study was carried out to investigate the anticancer activity mechanism on the cellular and molecular basis of EMO against T47D breast cancer cell line by observing cell cycle progression and Cyclin D1 expression level. Analysis of the cell cycle was performed using flow cytometry and cyclin D1 expression was analyzed using the immunocytochemistry method. The result shows that EMO induced cell cycle arrest in G0/G1 phases. Immunocytochemistry assay showed that the EMO decreased expression of cyclin D1. This result indicates that EMO has a potential compound to be explored as chemo preventive agent for breast cancer.

Senyawa Fenolik dari Daun Tanaman Kalanchoe prolifera (Crassulaceae) Yenny Febriani Yun; Lilis Siti Aisyah; Tri Reksa Saputra; Arif Rahman Hakim; Sari Purbaya; Tati Herlina; Euis Julaeha; Achmad Zainuddin; Unang Supratman
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 3, No. 1, Mei 2017
Publisher : Syarif Hidayatullah State Islamic University

Phenolic compounds such as kaempferol (1), quercetin (2), and methyl caffeate (3) have been isolated from the ethyl acetate extract of Kalanchoe prolifera (Crassulaceae). The chemical structure of isolated compounds 1-3 were elucidated on the basis of spectroscopic evidence (UV, IR, NMR) and comparison with those compound previouly reported.DOI: http://dx.doi.org/10.15408/jkv.v0i0.5037

Poriferasta-5,22E,25-trien-3β-ol,22-dehidrokolesterol dari daun Kalanchoe serrata (Crassulaceae) Fajar Fauzi Abdullah; Satwika Nandiwardhana; Arif Rahman Hakim; Tati Herlina; Unang Supratman
Jurnal Kimia Valensi Jurnal Valensi Volume 3, No.1, Mei 2013
Publisher : Syarif Hidayatullah State Islamic University

Dalam penelitian berkelanjutan untuk pencarian senyawa metabolit sekunder baru dari tumbuhan Kalanchoe Indonesia, telah dilakukan kajian fitokimia terhadap Kalanchoe serrata. Daun segar K. serrata sebanyak 14,8 kg diekstraksi dengan metanol pada temperatur kamar. Ekstrak metanol (292 g) dipartisi berturut-turut dengan n-heksana dan metilenklorida. Ekstrak metilenklorida (0,80 g) selanjutnya dipisahkan pada kromatografi cair vakum pada silika gel G60 dengan eluen kloroform-aseton yang meningkat kepolarannya sehingga dihasilkan 10 fraksi yang dikelompokan berdasarkan analisis KLT. Padatan yang diperoleh pada fraksi yang terelusi dengan 20% aseton selanjutnya dipisahkan pada kromatografi kolom pada silika gel (230-400 mesh) dengan eluen kloroform dan dimurnikan lebih lanjut dengan kristalisasi pada aseton sehingga dihasilkan isolat berbentuk kristal jarum tak-berwarna sebanyak 23 mg. Isolat menunjukkan titik leleh 115-118oC dan memberikan warna hijau-kebiruan pada uji Liebermann-Burchard menunjukkan adanya kerangka steroid. Hasil analisis spektroskopi yang meliputi UV, IR, 1D-NMR dan 2D-NMR menunjukan bahwa isolat merupakan turunan sterol dan diidentifikasi sebagai poriferasta-5,22E,25-trien-3β-ol,22-dehidrokolesterol.

Depsidon Dari Buah Tumbuhan Asam Kandis (Garcinia cowa) Darwati Darwati; Nurlelasari Nurlelasari; Tati Herlina; Tri Mayanti
Chimica et Natura Acta Vol 6, No 1 (2018)
Publisher : Departemen Kimia

Suatu senyawa kelompok depsidon (1) telah berhasil diisolasi dan dielusidasi struktur kimia dari ekstrak etil asetat Garcinia cowa.Roxb. asal Indonesia. Isolasi dan pemurnian dilakukan dengan teknik kromatografi vakum cair dan kromatografi kolom gravitasi, menggunakan adsorben silika gel, dengan sistem elusi bergradien: n-heksan, CH2Cl2, EtOAc, dan MeOH. Penentuan struktur molekul ditetapkan dengan metode spektroskopi meliputi spektroskopi UV, IR, NMR 1 D dan 2 D. Senyawa hasil isolasi ditetapkan sebagai 1,3-dihidroksi-7-metoksi 2,8-(3-metilbutenil) depsidon (1). Senyawa ini untuk pertama kalinya dilaporkan sebagai komponen kimia dari buah G. cowa.

ISOLASI DAN MOLECULAR DOCKING SENYAWA 6,7-DIHIDRO-17-HIDROKSIERISOTRIN DARI DAUN DADAP BELENDUNG (Erythrina poeppigiana) TERHADAP AKTIVITAS SITOTOKSIK ANTIKANKER PAYUDARA MCF-7 Richa Mardianingrum; Tati Herlina; Unang Supratman
Chimica et Natura Acta Vol 3, No 3 (2015)
Publisher : Departemen Kimia

Erythrina (Leguminose) memiliki jumlah alkaloid paling banyak jika dibandingkan dengan senyawa metabolit sekunder lainnya, sehingga tumbuhan Erythrina dikenal dengan sebutan alkaloid eritrina. Erythrina yang paling banyak tumbuh di Indonesia adalah E. poeppigiana. Tujuan penelitian ini adalah untuk mengungkapkan senyawa aktif antikanker payudara MCF-7 secara in silico yang terdapat di dalam daun E. poeppigiana. Alkaloid dipisahkan dan dimurnikan melalui tahapan ekstraksi, fraksinasi, pemisahanan dan pemurnian yang dipandu dengan uji Dragendorff, senyawa alkaloid yang diperoleh diuji antikanker secara in silico terhadap reseptor EGFR2 yang bekerja pada sel kanker payudara MCF-7 menggunakan program ArgusLab dengan pembanding canertinib dan parameter yang diukur adalah energi bebas Gibbs ikatan (ΔG) dan konstanta inhibisi (Ki). Hasil dari penelitian ini diperoleh senyawa alkaloid golongan isokuinolin yakni 6,7-dihidro-17-hidroksierisotrin. Senyawa 6,7-dihidro-17-hidroksierisotrin diprediksi mempunyai aktivitas sitotoksik terhadap sel kanker payudara MCF-7 dengan nilai ΔG (Kcal/mol) dan Ki (nM) masing-masing sebesar -8,11457 dan 1,12.10-6. Sehingga dapat disimpulkan bahwa tumbuhan E. poeppigiana mempunyai potensi sebagai bahan dasar obat herbal antikanker payudara.

Co-Authors Ace Tatang Hidayat Achmad Rante Suparman, Achmad Rante Achmad Wahidy, Achmad Achmad Zainuddin Achmad Zainuddin Ade Akbar Abdilla Ade Kania Ningsih, Ade Kania Aditya Seiza Wibisono Adrian Nova, Gitta Destalya Ahmad Syahlani, Ahmad Ajeng Diantini, Ajeng Albayyinah, Dyandra Hera Alya Tsamrotul Amalia, Riezki Amir M. Suruwaky Anas Subarnas Aneu Wahyuni Anisa, Mutiara Apriani Sulu Parubak Apriani Sulu Parubak Apriani sulu parumbak Arif Rahman Hakim Arif Rahman Hakim Arif Rahman Hakim Azmi, Mohamad Nurul Binasthika, Tata Boima Ramses Situmeang Dadan Sumiarsa Dahlia Dahlia Darwati Darwati Darwati Darwati Darwati Darwati Darwati, Darwati Deden Deni Destiana . Dikdik Kurnia Elizabeth Fitriana Sari Ersanda Hafiz Euis Julaeha Euis Julaeha Faizal Hermanto Fajar Fauzi Abdullah Fajar Fauzi Abdullah Fitri Anita, Fitri Gabriella Constantia Gultom, Angga Wibowo Hafiz, Ersanda Hamdi Hamdi HANA RATNAWATI Harizon Harizon Hesti Lina Wiraswati Hideo Hayashi Hideo Hayashi I Dewa Gde Sathya Deva Ida Indrawati Ida Nur Farida Indri Indriyani Indriyani, Indri Jihan Kadarusman Kansy Haikal Khadijah Awang Khairunnisa, Shofiyah Kindi Farabi Latifah Latifah Letmi Dwiridal Lilis Siti Aisyah Lilis Siti Aisyah Lilis Siti Aisyah, Lilis Siti Ma'ruf, Ilma Fauziah Madihah Madihah Maesaroh Maesaroh Mohamad Nurzaman Muhammad Hanafi Muhammad Yudha Nugraha Murtihapsari . Nani Suryani Natalia, Titi Syahnaz Nayla Haraswati Niken Ayu Noor Rain Abdullah Noviansyah Noviansyah, Noviansyah Nurlelasari Nurlelasari Permadi, Nandang Putriani, Dyah Ayu Rabiulkhri, Mailani Radite Yogaswara Rahmawati Rahmawati RANI ANWAR, RANI Rian Prayudi Saputra Richa Mardianingrum Rima Melati Riza Apriani Riza Apriani Riza Apriani Riza Yulisar Rosmala Dewi Sari Purbaya Sari, Palupi Indah Satwika Nandiwardhana Shabarni Gaffar Shindi Zahra Shiono, Yoshihito Silfina Agustin Sinaga, Siska Elisahbet Supriatno Supriatno Supriyatna Sutardjo Supriyatna Sutardjo Suseno Amien Syafriani Syafriani, Syafriani Syafruddin Syafruddin Syarwani Ahmad Tambunan, Ghina Uli Felicia Tarso Rudiana, Tarso Tjomiadi, Cynthia Eka Fayuning Tri Mayanti Tri Rahayu Hidayat Tri Reksa Saputra Tri Reksa Saputra, Tri Reksa Tusri, Yudi Unang Supratman Vicki Nishinarizki Wahyu Widowati Wahyuni, Aneu Wibisono, Aditya Seiza Widayat, Agung Wiranawata, Hilmi Witriany Rayapratiwi Wulanda, Nourma Yasmiwar Susilawati Yenny Febriani Yun Yenny Febriani Yun, Yenny Febriani Yulisar, Riza Yunita Sari Zalinar Udin

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