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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Microbiology Indonesia Indonesian Journal of Cancer Chemoprevention agriTECH Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Majalah Obat Tradisional PROSIDING SEMINAR KIMIA INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Jurnal Fitofarmaka Indonesia Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia Journal of Economic, Bussines and Accounting (COSTING) PENDIPA Journal of Science Education JRB-Jurnal Riset Bisnis PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Kesehatan Poltekita : Jurnal Ilmu Kesehatan Jurnal Pendidikan dan Konseling Contagion: Scientific Periodical Journal of Public Health and Coastal Health Syntax Idea Jurnal Ners Jurnal Riset Kefarmasian Indonesia Enrichment : Journal of Management Lumbung Farmasi : Jurnal Ilmu Kefarmasian Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Farmagazine Bioscientist : Jurnal Ilmiah Biologi Jurnal Pengabdian Masyarakat Indonesia Daengku: Journal of Humanities and Social Sciences Innovation Jurnal Info Sains : Informatika dan Sains Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Sciences of Pharmacy Jurnal Sosial dan Sains Sanskara Ekonomi dan Kewirausahaan West Science Business and Management Jurnal Farmasi Indonesia Parapemikir Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Journal of Natural Product for Degenerative Diseases
Shirly Kumala
Univeristas Pancasila
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Faktor-Faktor yang Berhubungan dengan Kejadian Infeksi Saluran Pernafasan Akut (ISPA) pada Balita Di Daerah Pesisir Kota Sibolga Tahun 2020 Pasaribu, Rita Kristina; Santosa, Heru; Kumala, Shirly; Nurmaini, Nurmaini; Hasan, Delina
Syntax Idea Vol 3 No 6 (2021): Syntax Idea
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36418/syntax-idea.v3i6.1232

Abstract

ISPA (Acute Respiratory Tract Infection) is a transmitted respiratory tract disease caused by environmental and human factors. Balita (below five year-old children) is very vulnerable to it. It was caused by virus or bacteria. The symptoms are high fever, followed by pain in throat, difficult to swallow, flu, and coughing with or without phlegm transmitted through patients' droplet (Riskesdas,2018). Revealed that, nationally, the prevalence of ISPA in balita was 12.8%, 8. 7% in North Sumatera, and 57% in Sibolga. The objective of the research was to analyze some factors which were correlated with the incidence of ISPA in balita at the coastal area of Sibolga . The data were gathered by using questionnaires. The research used cross sectional design. The samples were 265 (Isaac and Michael tables). The data were analyzed by using univariate analysis, bivariate analysis, and multivariate analysis with multiple logistic regression tests. From the samples, it was found that 144 of them (54.3%) were affected by ISPA and 121 of them (45. 7%) were not. The result of univariate analysis showed that 141 respondents (53.2%) had good requirement for their floors, 146 of them (55.1%) for walls, 70 of them (26.4%) for air ventilation, 257 of them (97%) for room temperature, 225 of them (84.9%) for lighting, 233 of them (87.9%) for moisture, 181 of them (68. 3%) for population density. From the factor of children, it was found that there were 131 boys (49.4%), 188 of the balita (70.9%) were 6- 35 months old, 217 of them (81.9%) were not BBLR, 206 of them (77.7%) had bad nutrition, 160 of them (60.4%) got vitamin A, 139 of them (52.5%) got immunization completion, 177 of them (66.8%) were breastfed with ASI (breast milk), 202 of them (76. 2%) smoked, 40 of them (15.1 %) used wood as fuel, and 27 of them (10.2%) used mosquito coils The result of bivariate analysis showed that 8 (eight) independent variables which were correlated were smoking (p-value=0. 003), using mosquito coils (p-value=0.026), floors (p-value=0.033), walls (p-value=0.002), population density (p-value=0.001), nutritional status (pvalue=0.001), air ventilation (p-value=0.012), Vitamin A(p-value=0.024), and complete immunization (p-value=0.035). The result of multivariate analysis showed that the variables of smoking, condition of house walls, nutritional status, and immunization completion caused the incidence of ISPA in balita at the coastal area of Sibolga (75.8%). It is recommended that prevent ISPA by increasing nutritional status, ASI, visiting posyandu, and no smoking inside their houses.
n-Butanolic fraction of endofitic fungi of Buah Makasar increases apoptotic effect of doxorubicin on MCF-7 cells Meiyanto, Edy; Kumala, Shirly; Septisetyani, Endah Puji
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (664.738 KB) | DOI: 10.14499/indonesianjpharm0iss0pp42-47

Abstract

Makassar fruit, Brucea javanica (L.) Merr., showed chemopreventive activity. Secondary metabolites come from B. javanica fruit, brucatol and bruceantine, induced cell differentiation and apoptosis on Leukemia cell, while quassinoid and its derivates acted as antitumor promoter. Butanolic fraction of supernatan of endofitic fungi 1.2.11 isolate fermentation which isolated from B. javanica fruit showed cytotoxicity toward several cancer cells. This fraction has been predicted contain secondary metabolites from B. javanica and has been identified as Bruceosin and Canthin-6-one derivates. Butanolic fraction (FB) of supernatan from endofitic fungi 1.3.11 isolate fermentation is predicted for having similiar cytotoxycity as active as 1.2.11 isolate. This research is aimed to explore cytotoxycity potention dan doxorubicin on MCF-7 breast cancer cell.Synergism of BF-doxorubicin combination detect from cell viability inhibition and apoptosis induction on MCF-7, a breast cancer cell lines which shows resistancy toward doxorubicin. Cell viability on single treatment of FB and doxorubicin and its combination were carried out by MTT assay to determine IC50 and combination index (CI). Apoptosis induction of FB, doxorubicin and its combination were carried out by ethidium bromideacridine orange DNA staining.n- Butanolic fraction and doxorubicin showed cell viability inhibition on MCF-7 cell with IC50 48 μg/mL and 148 nM, respectively. Both of FB and doxorubicin showed apoptosis induction on IC50. Combination of FBdoxorubicin showed synergism and increased apoptosis induction on MCF-7 cell.Key words: Brucea javanica, endofitic fungi, MCF-7 cell, synergism, doxorubicin.
n-Butanolic fraction of endofitic fungi of Buah Makasar increases apoptotic effect of doxorubicin on MCF-7 cells Kumala, Shirly
Indonesian Journal of Pharmacy Vol 20 No 1, 2009
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjpharm0iss0pp42-47

Abstract

Makassar fruit, Brucea javanica (L.) Merr., showed chemopreventive activity. Secondary metabolites come from B. javanica fruit, brucatol and bruceantine, induced cell differentiation and apoptosis on Leukemia cell, while quassinoid and its derivates acted as antitumor promoter. Butanolic fraction of supernatan of endofitic fungi 1.2.11 isolate fermentation which isolated from B. javanica fruit showed cytotoxycity toward several cancer cells. This fraction has been predicted contain secondary metabolites from B. javanica and has been identified as Bruceosin and Canthin-6-one derivates. Butanolic fraction (FB) of supernatan from endofitic fungi 1.3.11 isolate fermentation is predicted for having similiar cytotoxycity as active as 1.2.11 isolate. This research is aimed to explore cytotoxycity potention and apoptosis induction of BF from 1.3.11 isolate and combination effect of BFdoxorubicinon MCF-7 breast cancer cell.Synergism of BF-doxorubicin combination detect from cell viability inhibition and apoptosis induction on MCF-7, a breast cancer cell lines which shows resistancy toward doxorubicin. Cell viability on single treatment of FB and doxorubicin and its combination were carried out by MTT assay to determine IC50 and combination index (CI). Apoptosis induction of FB, doxorubicin and its combination were carried out by ethidium bromideacridine orange DNA staining.n- Butanolic fraction and doxorubicin showed cell viability inhibition on MCF-7 cell with IC50 48 μg/mL dan 148 nM, respectively. Both of FB and doxorubicin showed apoptosis induction on IC50. Combination of FBdoxorubicin showed synergism and increased apoptosis induction on MCF-7cell.Key words: Brucea javanica, endofitic fungi, MCF-7 cell, synergism, doxorubicin.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI OUTCOME TERAPI PASIEN PNEUMONIA DI RUMAH SAKIT UMUM PUSAT FATMAWATI JAKARTA Setiadi, Feri; Kumala, Shirly; Utami R, Hesty; Subhan, Ahmad
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 5 No. 3 (2019)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (364.673 KB) | DOI: 10.22487/htj.v5i3.127

Abstract

Berdasarkan data Riset Kesehatan Dasar (Riskesdas)2018 prevalensi pneumonia di jakarta 2.3 %. Pneumoni mempunyai case fatality rate (CFR) yang tinggi yaitu 7.6% sehingga beresiko mempunyai outcome terapi yang tidak baik. Oleh karena itu penelitian ini bertujuan menganalisis faktor-faktor yang mempengaruhi outcome terapi pasien pneumonia di RSUP Fatmawati. Penelitian ini dilakukan secara retrospektif dengan metode cross sectional pada pasien pneumonia (hospital acquired pneumonia/HAP dan community-acquired pneumonia/CAP) yang memenuhi kriteria inklusi selama periode januari-september 2018. Penelitian ini dilakukan dengan pengkajian data rekam medis pasien. Ada dua jenis outcome terapi yang digunakan yaitu pasien pulang/sembuh dan pasien meninggal. Analisis faktor yang mempengaruhi outcome dilakukan dengan uji chi square menggunakan SPSS. Selama penelitian didapatkan 40 pasien memenuhi kriteria inklusi terdiri dari 22 HAP dan 18 CAP. Hasil umur pasien (65.0%) berada pada kelompok usia 17-65 tahun. Lebih banyak pasien laki-laki (57.5%) dibandingkan pasien perempuan (42.5%). Sebagian besar pasien (37.5%) di rawat selama 8-14 hari. Penggunaan antibiotik (35.0%) terbanyak digunakan antibiotik ceftriaxone golongan sefalosporin. Proporsi pasien dengan outcome sembuh/pulang sebanyak (52.5%) dan pasien meninggal ( 47.5%). Hasil analisis statistik menunjukkan faktor yang signifikan mempengaruhi outcome adalah penyakit penyerta (P=0.022) Adapun faktor yang tidak ada hubungan bermakna terhadap outcome pasien pneumonia yaitu: usia pasien, lama perawatan dan kerasionalan antibiotik.
Pengaruh Edukasi Farmasis terhadap Outcome Terapi Pasien TB Paru Fase Intensif di RSUP Persahabatan Periode Maret-Juli 2015 Reza Agung Sriwijaya; Shirly Kumala; Sesilia A. Keban
Jurnal Penelitian Sains Vol 20, No 3 (2018)
Publisher : Faculty of Mathtmatics and Natural Sciences

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (291.976 KB) | DOI: 10.56064/jps.v20i3.514

Abstract

The background knowledge of this research is based on the amount of patients’ pulmonary tubercu-losis who get failed doing their therapy and recur in having it after doing the treatment at RSUP Persahaba-tan.The objective of this research is to decrease the amount of patients get failed doing the therapy and recur at RSUP Persahabatan. The method of the research is Quasi-experimental with Nonrandomized Control Group Pretest-Postest Design. Furthermore, the technical sampling used is voluntaryby two apparent groups, 54 pa-tients as control group and 54 patients as experiment group.The instrument of this research are pre-test,posttest and Likert Questionair Model which is used to measure the knowledge and compliance toward the outcome of the therapy before and after it meets a good validity and reability test with standard α = 0,05. The conclusion is education pharmacy can increase knowledge and compliance with TB patients so that the outcomes of therapy against Pulmonary TB patients at RSUP Persahabatan is improved.
Faktor-Faktor yang Berhubungan dengan Kejadian Infeksi Saluran Pernafasan Akut (ISPA) pada Balita Di Daerah Pesisir Kota Sibolga Tahun 2020 Rita Kristina Pasaribu; Heru Santosa; Shirly Kumala; Nurmaini Nurmaini; Delina Hasan
Syntax Idea Vol 3 No 6 (2021): Syntax Idea
Publisher : Ridwan Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46799/syntax-idea.v3i6.1232

Abstract

ISPA (Acute Respiratory Tract Infection) is a transmitted respiratory tract disease caused by environmental and human factors. Balita (below five year-old children) is very vulnerable to it. It was caused by virus or bacteria. The symptoms are high fever, followed by pain in throat, difficult to swallow, flu, and coughing with or without phlegm transmitted through patients' droplet (Riskesdas,2018). Revealed that, nationally, the prevalence of ISPA in balita was 12.8%, 8. 7% in North Sumatera, and 57% in Sibolga. The objective of the research was to analyze some factors which were correlated with the incidence of ISPA in balita at the coastal area of Sibolga . The data were gathered by using questionnaires. The research used cross sectional design. The samples were 265 (Isaac and Michael tables). The data were analyzed by using univariate analysis, bivariate analysis, and multivariate analysis with multiple logistic regression tests. From the samples, it was found that 144 of them (54.3%) were affected by ISPA and 121 of them (45. 7%) were not. The result of univariate analysis showed that 141 respondents (53.2%) had good requirement for their floors, 146 of them (55.1%) for walls, 70 of them (26.4%) for air ventilation, 257 of them (97%) for room temperature, 225 of them (84.9%) for lighting, 233 of them (87.9%) for moisture, 181 of them (68. 3%) for population density. From the factor of children, it was found that there were 131 boys (49.4%), 188 of the balita (70.9%) were 6- 35 months old, 217 of them (81.9%) were not BBLR, 206 of them (77.7%) had bad nutrition, 160 of them (60.4%) got vitamin A, 139 of them (52.5%) got immunization completion, 177 of them (66.8%) were breastfed with ASI (breast milk), 202 of them (76. 2%) smoked, 40 of them (15.1 %) used wood as fuel, and 27 of them (10.2%) used mosquito coils The result of bivariate analysis showed that 8 (eight) independent variables which were correlated were smoking (p-value=0. 003), using mosquito coils (p-value=0.026), floors (p-value=0.033), walls (p-value=0.002), population density (p-value=0.001), nutritional status (pvalue=0.001), air ventilation (p-value=0.012), Vitamin A(p-value=0.024), and complete immunization (p-value=0.035). The result of multivariate analysis showed that the variables of smoking, condition of house walls, nutritional status, and immunization completion caused the incidence of ISPA in balita at the coastal area of Sibolga (75.8%). It is recommended that prevent ISPA by increasing nutritional status, ASI, visiting posyandu, and no smoking inside their houses.
Aktivitas Antibakteri Rebusan Secang (Caesalpinia sappan L.) terhadap Salmonella thypii Secara In Vivo Shirly Kumala; Devana Devana; Didik Tulus
agriTECH Vol 33, No 1 (2013)
Publisher : Faculty of Agricultural Technology, Universitas Gadjah Mada, Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (807.458 KB) | DOI: 10.22146/agritech.9566

Abstract

One of the plant that has been used emperically for treatment was Caesalpinia sappan L“secang”. The bark of this plant contains metabolites with strong and effective antibaterial activity, namely tannin and brasilin. Two methods, namely A and B, were employed to perform the in vivo antibacterial study of this plant. In every method, there were six groups (K1-K6) which each of the group consisted of five mice. K1-K3 were the control groups consisting of control using healthy mice (K1), positive control in the presence of chloramphenicol (K2) and negative control (K3).  The test groups were K4-K6, mice in these group were treated with different concentrations of “secang” water extract at 15%, 30% and 75%, respectively.  The Salmonella thypii bacterial suspension was injected to the mice via intraperitonium adminsitration. In A method, treatment was given 2 hours after infecting the mice with the bacterial suspension, while in the B method, the treatment was given to the mice after 24 hours of bacterial infection. After 3 days of treatment, the intraperitonium fluid of the mice was taken under anaesthetic condition followed by qualitative and quantitative analysis of the biological sample obtained. Quantitative analysis via A method demonstrated that a decreased of 16.54%, 25.29 % and 25.12% in bacterial colony number was observed in the samples collected from K4, K5 and K6 respectively when compared to the respective controls.  B method showed smalled decreased (3.37 %,  9.83 % and 20.48 %) in the colony number counted. The qualitative analysis demonstrated that the isolated bacterial strain was Salmonella typhi. In conclusion, boiled water extract of secang could act as effective antibacterial agent because it inhibit the growth of Salmonella thypii under in vivo study conditions.ABSTRAK Salah satu tanaman yang secara empiris banyak digunakan untuk pengobatan adalah Caesalpinia sappan L. (Secang). Batang dari tanaman secang mengandung tanin dan brasilin, yang berkhasiat sebagai antibakteri. Uji antibakteri rebusan secang dilakukan secara in vivo menggunakan 2 metode yaitu metode A dan metode B. Setiap metode terdiri dari 6 kelompok dan setiap kelompok terdiri dari 5 ekor mencit (mus musculus) putih jantan galur DDY. Masing-masing kelompok terdiri dari kontrol normal (K1), kontrol positif kloramfenikol (K2), kontrol negatif (K3) dan kelompok yang diberi rebusan secang konsentrasi 15 % (K4), 30 % (K5) dan 75 % (K6). Suspensi bakteri Salmonella thypii diinfeksikan ke mencit secara intraperitonium. Pada metode A, pengobatan diberikan 2 jam setelah mencit diinfeksi bakteri, sedangkan pada metode B, pengobatan diberikan 24 jam setelah mencit diinfeksi bakteri. Setelah tiga hari pengobatan, mencit dianestesi dan cairan intraperitonium mencit diambil untuk dilakukan uji kuantitatif dan uji kualitatif. Hasil uji kuantitatif metode A menunjukkan terjadi penurunan jumlah koloni bakteri dalam cairan intraperitonium mencit pada kelompok 4 (K4), 5 (K5) dan 6 (K6) terhadap kontrol negatif (K3) sebesar 16,54 %; 25,29 % dan 25,12 %; sedangkan pada metode B sebesar 3,37 %; 9,83 % dan 20,48 %. Hasil uji kualitatif pada metode A dan metode B menunjukkan bakteri yang terisolasi dari cairan intraperitonium mencit adalah Salmonella thypii. Hasil penelitian menunjukkan rebusan secang dapat menghambat pertumbuhan Salmonella thypii secara in vivo.
Prediction of Geraniol Bond Mode in Aspergillus niger Linalool Dehydratase – Isomerase Yelfi Anwar; Andrianopsyah Mas Jaya Putra; Elvina Dhiaul Iftitah; Partomuan Simanjuntak; Shirly Kumala
Majalah Obat Tradisional Vol 24, No 2 (2019)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (629.33 KB) | DOI: 10.22146/mot.45599

Abstract

Geraniol is a very valuable aroma chemical and has commonly been used in fragrances and aroma compound. Geraniol biotransformation by Aspergillus niger has been studied. The main bioconversion products obtained from geraniol and liquid culture of A. niger are linalool and alpha-terpineol. Linalool plays a major role in anti-inflammatory, antibacterial and antioxidant activities. This study aims to know the interaction of geraniol in Aspergillus niger enzyme with docking molecular. Comparative modeling of Aspergillus niger enzyme was conducted by means of one of the crystal structure of Linalool Dehydratase – Idomerase (LDI) as a template. The best model of this comparative modeling was then used in docking molecular to investigate geraniol binding mode inactive site enzyme of Aspergillus niger. Inactive site enzyme of Aspergillus niger, geraniol is located with hydrophobic and hydrogen bonds: Amino acid – the amino acids are Asn 105, Arg 96, Lys 112 inactive site - OH with hydrogen bond, Arg 97 inactive site – CH3 with hydrophobic bond and Leu54 inactive site – CH3 with the hydrophobic bond. The distances among pharmacophore respectively are 3,603 A, 6,768 A, and 7,345A. It has higher score (ΔGbind: -3.4 kcal/mol) compared to linalool (ΔGbind: -3.6 kcal/mol). Virtual tethering of linalool with LDI Aspergillus niger enzyme in amino acid Leu120 and Glu118 had been done. The pharmacophore is - OH and methyl C8 group. The distances among pharmacophore respectively are 5,835 Å, 2,52 Å, and 5,32 Å. Virtual tethering of LDI Aspergillus niger enzyme with geraniol has a higher score (ΔGbind: -3.4 kcal/mol) compared to linalool (ΔGbind: -3.6 kcal/mol). It shows that interaction between linalool and LDI Aspergillus niger enzyme is easier to occur than the interaction between geraniol and LDI Aspergillus niger enzyme, geraniol reaction to linalool that occurs is rearrangement reaction.
Isolation and Screening of Endophytic Microbes from Morinda citrifolia and their Ability to Produce Anti-Microbial Substances SHIRLY KUMALA; ENDRO BUDI SISWANTO
Microbiology Indonesia Vol. 1 No. 3 (2007): December 2007
Publisher : Indonesian Society for microbiology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (69.23 KB) | DOI: 10.5454/mi.1.3.9

Abstract

Assaying for, and isolation and screening of endophytic microbes from the Morinda citrifolia plant and their ability to produce anti-microbial substances was carried out. Endophytic microbes are microorganisms that live asymptomatically within the living tissue of host plants. Microorganisms such as bacteria, fungi, and yeast can be associated with the host and produce secondary metabolites. These secondary metabolites may be enzymes and other bioactive substances with medicinal activity such as anti-arthritic, anti-cancer, and anti-microbial compounds. The aims of these experiments was to investigate the ability of endophytic microbes isolated from M. citrifolia to produce secondary metabolites which can act as anti-microbial agents. A direct seed inoculating technique was used by planting the plant sample onto the surface of Nutrient Agar and Potato-Dextrose Agar. Assessment of their ability to produce anti-microbial substances was conducted by growing the endophyte isolates in Muller Hinton Broth for bacterial isolates, and in Potato-Dextrose Yeast Broth for fungal isolates. The agar diffusion method using paper disk was applied to assay the anti-microbial activity of each substance. The results of the endophyte isolation in these experiments gave five bacterial isolates and eleven fungal isolates. All of the bacterial isolates showed a broad antimicrobial spectrum while ten of the fungal isolate demonstrated broad anti-microbial activity and four out of the ten fungal isolates had activity towards Candida albicans.
FORMULASI GEL KOMBINASI EKSTRAK KERING LIDAH BUAYA (Aloe vera. (L) brum. f.) DAN EKSTRAK KENTAL DAUN SIRIH MERAH (Piper crocatum ruiz & pav) UNTUK ANTIBAKTERI PENYEBAB JERAWAT . Suhaimi; Teti Indrawati; Shirly Kumala
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 3 No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (742.397 KB) | DOI: 10.37874/ms.v3i2.67

Abstract

Ekstrak kering lidah buaya dan ekstrak kental daun sirih merah mengandung senyawa alkaloid, flavonoid, tanin, saponin dan fenol yang mempunyai aktivitas sebagai antibakteri penyebab jerawat. Penelitian ini bertujuan untuk memformulasi sediaan gel antibakteri penyebab jerawat kombinasi ekstrak lidah buaya dan ekstrak kental daun sirih merah yang stabil secara fisik, kimia dan mikrobiologi serta memiliki efektivitasnya. Formulasi gel kombinasi esktrak kering lidah buaya dan ekstrak kental dan sirih merah sebanyak 4 formula menggunakan gelling agent, carbophol serta bahan tambahan lainnya. Sediaan yang dihasilkan dievaluasi dan diuji aktivitasnya. Evaluasi sediaan meliputi pemeriksaan organoleptis, homogenitas, uji kemampuan menyebar, viskositas, sifar alir, pH dan uji mikrobiologi. Uji aktivitas meliputi pertumbuhan terhadap bakteri Propionibacterium acnes dan Staphylococcus aureus. Hasil evaluasi didapatkan formula terbaik yaitu formula 1 yang mengandung 1,56 % kombinasi ekstrak kering lidah buaya dan ekstrak kental daun sirih merah kemudian di uji stabilitas pada suhu kamar (25-30oC) dan suhu 60oC selama 3 minggu. Hasil uji stabilitas menunjukan tidak ada perbedaan yang signifikan selama penyimpanan.
Co-Authors . Desi . Suhaimi . Syamsudin . Yuliani Abdul Aziz Setiawan Adefira Elisyia Juniharti Adini, Syilvi Afrini Saraswati Agan Syahrial Agung Dewantoro Ahmad Subhan Aji, Nur AMEILIA AMEILIA Anarisa Budiati Andri Prasetiyo Andria Agusta Andrianopsyah Mas Jaya Putra Anggelina Aprilia Pangalila Anggi Isnaasar Anny Victor Purba Anwar Wahyudi Anwar Wahyudi Anwar, Yelfi Ariyani Kiranasari Ariyani Kiranasari Armansyah, Septiyana Lia Asnah Tarigan Atut Ruswita Atut Ruswita Handayani Aulena, Desi Nadya Aulia Tisna Dewi Ayuditiawati, Meita Bekti, Novi Dyah Purnama Bekti, Novi Dyah Purnama Carrista Carrista Dandung Ruskar Datubara, Martaulina Elisabet Delina Hasan Deni Rahmat Desi Nadya Aulena Devana Devana Dewi Laxmi Diah Dethriani Dian Indriani Dian Ratih L. Dian Ratih Laksmitawati Didik Tulus Didik Tulus Dimas Adrianto Dimas Adrianto Dosi Ahmad Yani Dwi Aryanti, Anindita Dwi Fitriyani, Dwi Dwi Hapsari Juniarti Dwi Windi Sapitri Dwi Windi Sapitri EDY MEIYANTO Elvina Dhiaul Iftitah Elvina Dhiaul Iftitah ENDRO BUDI SISWANTO Erlita Agustina Erlita Erlita Esti Mumpuni Esti Mumpuni Esti, Esti Fachry Abda El Rahman Farida, Yunahara Faridah Faridah Fauzi Setyo Fandheo Fauzia Noprima Okta Febbyasi Megawaty Gabriel Gabriel Gabriel, Gabriel Gandes Winarni Gumilar Adhi Nugroho Halim, Marta Hasan, Delina Herru Setiawan Hersunaryati, Yetti Heru Santosa Heru Santosa Hery Prambudi Hesty Utami Hesty Utami Hesty Utami R Huda, Badrul I Ketut Suada I. G.A. Ayu Wiratih Iha Haryani Hatta Iha Haryani Hatta Indah Masri Indarwati Indarwati Khairunnisa Tamimi Kurota Aini Laili Savitri Noor Lea P. Retnoningsih Leonardus B.S. Kardono Lestari Rahayu Lies Putriana Lilik Sulastri Mardiastuti, . Mardiastuti, . Marlin M. Raunsai Meiyanto, Edy Meva Sari Chandra Miftahurrohmah, Nur Mochtar, Dede Mochtar, Dede Mulatsari, Esti Muthi Ikawati Nancy Dewi Yuliana Nancy Dewi Yuliana Nancy Raisa Nancy Raisa, Nancy Noor, Laili Savitri Noviyantih, Noviyantih Nur Aji NUR ANNISA FITRI Nurmaini Nurmaini Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Partomuan Simanjuntak Pasanema, Dimas A. M. Pasanema, Dimas A. M. Pasaribu, Rita Kristina Peny Budiarti Pieter Hazmen Pratama, Anton Pratiwi Pujilestari Sudarmono Prih Sarnianto Prih Sarnianto Priyo Wahyudi Qodriah, Rahmatul R, Hesty Utami Rachmani, Rum Rachmani, Rum RAHMAT, DENI Raihan, Dany Ramadaniati, Hesty Utami Raymond R. Tjandrawinata Reise Manninda Restu Restiani Reubun, Yonathan Tri Atmodjo Reza Agung Sriwijaya RIRIS ISTIGHFARI JENIE Risma Marisi Tambunan, Risma Marisi Rita Kristina Pasaribu Robert Utji Rochimah Ros Sumarny RR. Ella Evrita Hestiandari Ruskar, Dandung S.Farm., M.Farm., Apt, Sondang Khairani Sarah Zaidan Sarnianto, Prih Saru Noliqo Rangkuti Sembiring, Rinawati Septisetyani, Endah Puji Sesilia A. Keban Sesilia Andriani Keban Sesilia Andriani Keban Setiadi, Feri Setiawan, Abdul Aziz Setiyarini, Setiyarini Shanny, Fransisca Shanny, Fransisca Simanjuntak, Partomuan Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siswa Setyahadi Siti Jabal Mastura Sofyan Ramani Sri Widyastuti Stiani, Sofi Nurmay Sugiastuti, Fenty Suhaimi Suhaimi Suhaimi, . Syamsudin Syamsudin Syarifah Aini Syarmalina Syarmalina Teti Indrawati Teti Indrawati Umilawati Rawi Utami R, Hesty Violeta, Violeta Vyacheslav Dushenkov Wahyudi Uun Wibowo Mangunwardoyo Wida Feriningsih Widiyastuti, Asih Yati Sumiyati, Yati Yetti Hersunaryati Yonathan Atmodjo Reubun Yun Astuti Nugroho Yuniarto, Ari Yusransyah, Yusransyah