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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) PROSIDING SEMINAR KIMIA INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia PENDIPA Journal of Science Education JRB-Jurnal Riset Bisnis JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Kesehatan Jurnal Pendidikan dan Konseling Contagion: Scientific Periodical Journal of Public Health and Coastal Health Syntax Idea Jurnal Ners Jurnal Riset Kefarmasian Indonesia Jurnal Farmagazine Bioscientist : Jurnal Ilmiah Biologi Daengku: Journal of Humanities and Social Sciences Innovation Jurnal Info Sains : Informatika dan Sains Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Sciences of Pharmacy Jurnal Sosial dan Sains Sanskara Ekonomi dan Kewirausahaan Jurnal Farmasi Indonesia Parapemikir Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Natural Product for Degenerative Diseases
Shirly Kumala
Universitas Pancasila
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Antibacterial Activity of Kecombrang (Etlingera elatior) Stems Against Skin Infection-Causing Bacteria Adini, Syilvi; Kumala, Shirly; Setyahadi, Siswa
Sciences of Pharmacy Volume 4 Issue 3
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0403322

Abstract

Skin infections caused by Staphylococcus aureus, Staphylococcus epidermidis, and Propionibacterium acnes often exhibit resistance to conventional treatments. This issue has led to the exploration of medical plants, such as kecombrang stems (Etlingera elatior), which are known for their antibacterial properties. This study aimed to evaluate the antibacterial activity of kecombrang stem and to identify its active compounds. The methanolic extract of kecombrang stems was tested against the three bacteria using the disc diffusion method at concentrations of 80%, 40%, and 20%. The Minimum Inhibitory Concentration (MIC) was determined using the microdilution method and an ELISA reader. TLC-Bioautography was employed to identify the antibacterial compounds present in the extract. The methanol extract of kecombrang stems exhibited antibacterial activity against S. aureus, S. epidermidis, and P. acnes, with an inhibition zone diameter ranging from 9.23 ± 0.472 to 25.53 ± 0.378 mm. The MIC results showed that the minimum concentration of 78.12 ppm could inhibit the growth of S. aureus by 33.74%, S. epidermidis by 14.45%, and P. acnes by 3.5%. The results of TLC Bioautography analysis indicate that flavonoids exhibit antibacterial properties. The kecombrang stem has the potential to serve as an antibacterial agent against bacteria that cause skin infections.
Preparation, Evaluation, and In Vitro Antiacne Activity of Cymbopogon citratus DC and Cymbopogon nardus (L.) Rendle Essential Oil Microemulsion Datubara, Martaulina Elisabet; Kumala, Shirly; Rahmat, Deni
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 1 (2023): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i1.5463

Abstract

This study was conducted to formulate and evaluate a topical anti-acne microemulsion containing essential oils of Cymbopogon citratus DC and Cymbopogon nardus (L). Using the disc diffusion method, the antibacterial activity of the essential oils of C. citratus and C. nardus against Propionibacterium acne and Staphylococcus epidermidis was investigated. After identifying the active concentration, the formula for a topical microemulsion was devised and tested for physical and chemical parameters. The results revealed that the essential oils of C. citratus and C. nardus had antimicrobial activity against P. acnes and S. epidermidis. The results demonstrated that the obtained microemulsion meets the physical and chemical requirements and possesses antimicrobial activity. It can be concluded that the essential oils extracted from C. citratus and C. nardus have the potential for further development and commercial application in the treatment of acne.
Study of Potential Antiobesity Compounds from Amylchlorogenate Derivates on Leptin Hormone and their Toxicity using Molecular Docking Approach Faridah, Faridah; Shirly Kumala; Gumilar Adhi Nugroho; Partomuan Simanjuntak
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6070

Abstract

Chlorogenic acid, a type of phenolic acid, is a polar compound that has anti-obesity effects with unclear mechanisms. This study aims to obtain compounds that are active as antiobesity, their interaction with receptors and its toxicity. This research was carried out in several steps, internal validation of targets and methods using Yasara, docking of test compounds and positive control using PLANTs, interaction visualization using Pymol and toxicity testing using Protox-II. Validation results show four receptors and test method meet the requirements. Docking results of setmelanotide on receptor code 1PXH -113.81; 2QBP -109.163; 2QBR -110.113, 2; QBS -110.817 kcal/mol respectively. The docking results of the test compounds in 1PXH namely 7,4,5-Triamylchlorogenate (compound a) -114,333 kcal/mol. In 2QBP namely 7,3'-Diamylchlorogenate (110,152) (compound b), (compound a) (-109,818), 7,4,3',4'-Tetraamylchlorogenate (compound c) (-115,309), 7,5,3',4'-Tetraamylchlorogenate (compound d) (-112,85), 7,4,5,3',4'-Pentaamylchlorogenate (compound e) (-110,414) and 2',5'-Diamylchlorogenic acid (compound f) (-113, 565) kcal/mol. In 2QBR namely, (compound a) (-114,276), (compound e) (-111,059), and (compound f) (-110,398) kcal/mol. In 2QBS namely, (compound a) (-113.53), and (compound d) (-111,676) kcal / mol. The active site of amino acids that have affinity are, ARG45 and LYS120 in 1PXH; ASP48, SER118 and ARG47 in 2QBP; ASP48 and ARG24 in 2QBR; ASP48 and GLN262 in 2QBS code. Toxicity tests obtained oral LD50 of 5000 mg/kg BW (compounds a and f); 3800 mg/kg BW (compounds b, c, d and e). The potential compound that was active in all the test receptor codes was 7,4,5-Tripentylchlorogenate (compound a). All active test compounds were relatively safe.
Colocasia esculenta L. Extract Increase Growth and Motility of Rotenone Induced Zebrafish (Danio rerio) Larvae Stunting Model Furqon, Muhammad; Kumala, Shirly; Farida, Yunahara; Zaidan, Sarah; Sumiyati, Yati
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.10670

Abstract

This study aims to determine the effect of Colocasia esculenta L on the growth and motility of zebrafish (Danio rerio) larvae after induction of rotenone as a stunting model. The Zebrafish have divided 3 groups i.e Normal (embryonic medium without rotenone induction), Negative Control (embryonic medium with rotenone induction), and Treatment Groups (embryonic medium with rotenone induction and Colocasia esculenta extracts, dose 30-60-90 ppm). The stunting model is designed by induction of 12.5 ppb rotenone to Zebrafish larvae. The growth of the larvae was observed by using a microscope to measure the body and head length. Evaluation of motility was carried out by recording the movement of the fish for 1 minute, and the pace was analyzed by using Video Tracker. The evaluations were observed at 3, 6, 9 dpf (day post-fertilization). Colocasia Esculenta Extract (CEE) groups have higher body lengths compared to the Negative Control Group. The lengths were 125.4 µm for CEE30, 119.4 µm for CEE60, and 121.4 µm CEE90 while the length for the Negative Control Group was 118.3 µm at 9 dpf. However, there were no different values for the ratio of head length to body length of all groups. The ratio was 1:6 at 3 dpf, and 1:4 at 6 and 9 dpf. Moreover, the motility was higher in CEE groups compared to the Negative Control at 3, 6, 9 dpf. The body length and motility of Zebrafish larvae higher compare to the Negative Control Group showing the potential of Colocasia esculenta extract on growth and enhancement of motoric activity.
Dampak Konseling Apoteker, Ketersediaan Obat, Dan Kualitas Pelayanan Kefarmasian Terhadap Kepuasan Dan Loyalitas Pasien Dwi Aryanti, Anindita; Kumala, Shirly; Ramadaniati, Hesty Utami
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.17533

Abstract

The increase of hospitals in DKI Jakarta from 2018-2020 was followed by increased competition between hospitals, Kartini Hospital need to develop strategies to increase patient satisfaction and loyalty to compete with other hospitals. The purpose of this study to analys pharmacist counseling, availability of medication, and quality of pharmaceutical services to increase patient satisfaction and its impact on patient loyalty. The design in this reasearch was an analytic observational study with a cross-sectional. The sample of this study were patients who had received counseling services. Data analysis using questionary that had been tested for validity and reliability, as well as secondary data is measurement of Pharmacy Quality from Komite Mutu Rumah Sakit . Analysis methods with Structural Equation Modeling (SEM) using LISREL 8.8 software. The results of this study concluded that pharmacist counseling, availability of medication, and quality of pharmaceutical services could increase patient satisfaction of 47% (R2 = 0.4678). Pharmacist counseling, availability of medication, and quality of pharmaceutical services and patient satisfaction also have an impact on patient loyalty with a contribution of 52% (R2 = 0.5204).
The Effect Of Brand Image, Quality And Price Of Immunomodulator Products On Satisfaction And Its Impact On Consumer Loyalty In Jabodetabek: PENGARUH CITRA MEREK, KUALITAS DAN HARGA PRODUK IMUNOMODULATOR TERHADAP KEPUASAN DAN DAMPAKNYA PADA LOYALITAS KONSUMEN JABODETABEK Fauzi Setyo Fandheo; Shirly Kumala; Lies Putriana
Jurnal Riset Bisnis Vol. 8 No. 2 (2025): April
Publisher : Fakultas Ekonomi dan Bisnis Universitas Pancasila Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jrb.v8i2.7264

Abstract

When the immune system is not working properly, the body is susceptible to disease. There are some ways to boost the immune system; consuming herbs or supplements which functioned immunomodulators. Before buying a product, potential consumers usually considerate the brand, quality, and price of the product that will be purchased. Stimuno and Imboost are the top brands category of immune system vitamins on the Top Brand Index (TBI) from 2015 until 2021. This study to analyze the effect of brand image, quality, and price of immunomodulator products from the stimuno and imboost brands on satisfaction and their impact on customer loyalty. This research is explanatory research – quantitative data - probability sampling method - purposive sampling technique. The obtained data then tested for the validity, reliability, and suitability of each variable using SEM PLS (Structural Equation Model Partial Least Square) software. The results of the analysis show that brand image (3.797 and 0.000), quality (2.037 and 0.042), and product price (11.491 and 0.000) have a t-value > 1.96 and p-value <0.05 directly on customer satisfaction. Brand image (3.198 and 0.001), quality (1.967 and 0.049), and product price (3.912 and 0.000) indirectly through customer satisfaction have t- value > 1.96 and p-value < 0.05. Based on the results of the analysis, it can be concluded that brand image, product quality, and price directly have a positive and significant effect on customer satisfaction. Brand image, product quality, and price indirectly through customer satisfaction have a positive and significant effect on customer loyalty.
Co-Authors . Desi . Suhaimi . Syamsudin . Yuliani Abdul Aziz Setiawan Adini, Syilvi Ahmad Subhan Aji, Nur Anwar Wahyudi Anwar, Yelfi Ariyani Kiranasari Ariyani Kiranasari Armansyah, Septiyana Lia Atut Ruswita Aulena, Desi Nadya Ayuditiawati, Meita Bekti, Novi Dyah Purnama Bekti, Novi Dyah Purnama Datubara, Martaulina Elisabet Delina Hasan Deni Rahmat Dian Indriani Dian Ratih L. Didik Tulus Dimas Adrianto Dosi Ahmad Yani Dwi Aryanti, Anindita Dwi Fitriyani, Dwi Dwi Hapsari Juniarti Dwi Windi Sapitri Elvina Dhiaul Iftitah Erlita Agustina Esti Mumpuni Esti Mumpuni, Esti Fachry Abda El Rahman Farida, Yunahara Faridah Faridah Fauzi Setyo Fandheo Febbyasi Megawaty Gabriel Gabriel Gabriel, Gabriel Gandes Winarni Gumilar Adhi Nugroho Halim, Marta Hasan, Delina Herru Setiawan Hersunaryati, Yetti Heru Santosa Heru Santosa Hery Prambudi Hesty Utami Hesty Utami R Huda, Badrul I Ketut Suada Iha Haryani Hatta Indarwati Indarwati Kurota Aini Lea P. Retnoningsih Leonardus B.S. Kardono Lestari Rahayu Lies Putriana Mardiastuti, . Mardiastuti, . Marlin M. Raunsai Mochtar, Dede Mochtar, Dede Nancy Dewi Yuliana Nancy Raisa Nancy Raisa, Nancy Noor, Laili Savitri Nur Aji Nurmaini Nurmaini Partomuan Simanjuntak Partomuan Simanjuntak Pasanema, Dimas A. M. Pasanema, Dimas A. M. Pasaribu, Rita Kristina Pieter Hazmen Pratama, Anton Pratiwi Pujilestari Sudarmono Prih Sarnianto Priyo Wahyudi R, Hesty Utami Rachmani, Rum Rachmani, Rum RAHMAT, DENI Raihan, Dany Ramadaniati, Hesty Utami Restu Restiani Reubun, Yonathan Tri Atmodjo Reza Agung Sriwijaya Risma Marisi Tambunan, Risma Marisi Rita Kristina Pasaribu Robert Utji Rochimah Ros Sumarny RR. Ella Evrita Hestiandari Ruskar, Dandung Sarnianto, Prih Saru Noliqo Rangkuti Sembiring, Rinawati Sesilia A. Keban Sesilia Andriani Keban Setiadi, Feri Setiyarini, Setiyarini Shanny, Fransisca Shanny, Fransisca Simanjuntak, Partomuan Siswa Setyahadi Siswa Setyahadi Siti Jabal Mastura Sofyan Ramani Sri Widyastuti Stiani, Sofi Nurmay Sugiastuti, Fenty Suhaimi Suhaimi Suhaimi, . Syarifah Aini Teti Indrawati Umilawati Rawi Utami R, Hesty Violeta, Violeta Wahyudi Uun Widiyastuti, Asih Yati Sumiyati, Yati Yusransyah, Yusransyah Zaidan, Sarah