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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Indonesian Journal of Cancer Chemoprevention Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) PROSIDING SEMINAR KIMIA INDONESIAN JOURNAL OF PHARMACY Jurnal Penelitian Sains Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Syntax Literate: Jurnal Ilmiah Indonesia Journal of Economic, Bussines and Accounting (COSTING) PENDIPA Journal of Science Education JRB-Jurnal Riset Bisnis JFIOnline Jurnal Ilmu Kefarmasian Indonesia Jurnal Kesehatan Jurnal Pendidikan dan Konseling Contagion: Scientific Periodical Journal of Public Health and Coastal Health Syntax Idea Jurnal Ners Jurnal Riset Kefarmasian Indonesia Jurnal Farmagazine Bioscientist : Jurnal Ilmiah Biologi Daengku: Journal of Humanities and Social Sciences Innovation Jurnal Info Sains : Informatika dan Sains Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Medical Sains : Jurnal Ilmiah Kefarmasian Pharmaceutical Sciences and Research (PSR) Makara Journal of Science Sciences of Pharmacy Jurnal Sosial dan Sains Sanskara Ekonomi dan Kewirausahaan Jurnal Farmasi Indonesia Parapemikir Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Natural Product for Degenerative Diseases
Shirly Kumala
Universitas Pancasila
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Astronomy Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Study of Potential Antiobesity Compounds from Amylchlorogenate Derivates on Leptin Hormone and their Toxicity using Molecular Docking Approach Faridah, Faridah; Shirly Kumala; Gumilar Adhi Nugroho; Partomuan Simanjuntak
Journal of Natural Product for Degenerative Diseases Vol. 1 No. 2 (2024): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v1i2.6070

Abstract

Chlorogenic acid, a type of phenolic acid, is a polar compound that has anti-obesity effects with unclear mechanisms. This study aims to obtain compounds that are active as antiobesity, their interaction with receptors and its toxicity. This research was carried out in several steps, internal validation of targets and methods using Yasara, docking of test compounds and positive control using PLANTs, interaction visualization using Pymol and toxicity testing using Protox-II. Validation results show four receptors and test method meet the requirements. Docking results of setmelanotide on receptor code 1PXH -113.81; 2QBP -109.163; 2QBR -110.113, 2; QBS -110.817 kcal/mol respectively. The docking results of the test compounds in 1PXH namely 7,4,5-Triamylchlorogenate (compound a) -114,333 kcal/mol. In 2QBP namely 7,3'-Diamylchlorogenate (110,152) (compound b), (compound a) (-109,818), 7,4,3',4'-Tetraamylchlorogenate (compound c) (-115,309), 7,5,3',4'-Tetraamylchlorogenate (compound d) (-112,85), 7,4,5,3',4'-Pentaamylchlorogenate (compound e) (-110,414) and 2',5'-Diamylchlorogenic acid (compound f) (-113, 565) kcal/mol. In 2QBR namely, (compound a) (-114,276), (compound e) (-111,059), and (compound f) (-110,398) kcal/mol. In 2QBS namely, (compound a) (-113.53), and (compound d) (-111,676) kcal / mol. The active site of amino acids that have affinity are, ARG45 and LYS120 in 1PXH; ASP48, SER118 and ARG47 in 2QBP; ASP48 and ARG24 in 2QBR; ASP48 and GLN262 in 2QBS code. Toxicity tests obtained oral LD50 of 5000 mg/kg BW (compounds a and f); 3800 mg/kg BW (compounds b, c, d and e). The potential compound that was active in all the test receptor codes was 7,4,5-Tripentylchlorogenate (compound a). All active test compounds were relatively safe.
Colocasia esculenta L. Extract Increase Growth and Motility of Rotenone Induced Zebrafish (Danio rerio) Larvae Stunting Model Furqon, Muhammad; Kumala, Shirly; Farida, Yunahara; Zaidan, Sarah; Sumiyati, Yati
Bioscientist : Jurnal Ilmiah Biologi Vol. 12 No. 1 (2024): June
Publisher : Department of Biology Education, FSTT, Mandalika University of Education, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/bioscientist.v12i1.10670

Abstract

This study aims to determine the effect of Colocasia esculenta L on the growth and motility of zebrafish (Danio rerio) larvae after induction of rotenone as a stunting model. The Zebrafish have divided 3 groups i.e Normal (embryonic medium without rotenone induction), Negative Control (embryonic medium with rotenone induction), and Treatment Groups (embryonic medium with rotenone induction and Colocasia esculenta extracts, dose 30-60-90 ppm). The stunting model is designed by induction of 12.5 ppb rotenone to Zebrafish larvae. The growth of the larvae was observed by using a microscope to measure the body and head length. Evaluation of motility was carried out by recording the movement of the fish for 1 minute, and the pace was analyzed by using Video Tracker. The evaluations were observed at 3, 6, 9 dpf (day post-fertilization). Colocasia Esculenta Extract (CEE) groups have higher body lengths compared to the Negative Control Group. The lengths were 125.4 µm for CEE30, 119.4 µm for CEE60, and 121.4 µm CEE90 while the length for the Negative Control Group was 118.3 µm at 9 dpf. However, there were no different values for the ratio of head length to body length of all groups. The ratio was 1:6 at 3 dpf, and 1:4 at 6 and 9 dpf. Moreover, the motility was higher in CEE groups compared to the Negative Control at 3, 6, 9 dpf. The body length and motility of Zebrafish larvae higher compare to the Negative Control Group showing the potential of Colocasia esculenta extract on growth and enhancement of motoric activity.
Dampak Konseling Apoteker, Ketersediaan Obat, Dan Kualitas Pelayanan Kefarmasian Terhadap Kepuasan Dan Loyalitas Pasien Dwi Aryanti, Anindita; Kumala, Shirly; Ramadaniati, Hesty Utami
Jurnal Ners Vol. 8 No. 1 (2024): APRIL 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v8i1.17533

Abstract

The increase of hospitals in DKI Jakarta from 2018-2020 was followed by increased competition between hospitals, Kartini Hospital need to develop strategies to increase patient satisfaction and loyalty to compete with other hospitals. The purpose of this study to analys pharmacist counseling, availability of medication, and quality of pharmaceutical services to increase patient satisfaction and its impact on patient loyalty. The design in this reasearch was an analytic observational study with a cross-sectional. The sample of this study were patients who had received counseling services. Data analysis using questionary that had been tested for validity and reliability, as well as secondary data is measurement of Pharmacy Quality from Komite Mutu Rumah Sakit . Analysis methods with Structural Equation Modeling (SEM) using LISREL 8.8 software. The results of this study concluded that pharmacist counseling, availability of medication, and quality of pharmaceutical services could increase patient satisfaction of 47% (R2 = 0.4678). Pharmacist counseling, availability of medication, and quality of pharmaceutical services and patient satisfaction also have an impact on patient loyalty with a contribution of 52% (R2 = 0.5204).
The Effect Of Brand Image, Quality And Price Of Immunomodulator Products On Satisfaction And Its Impact On Consumer Loyalty In Jabodetabek: PENGARUH CITRA MEREK, KUALITAS DAN HARGA PRODUK IMUNOMODULATOR TERHADAP KEPUASAN DAN DAMPAKNYA PADA LOYALITAS KONSUMEN JABODETABEK Fauzi Setyo Fandheo; Shirly Kumala; Lies Putriana
Jurnal Riset Bisnis Vol. 8 No. 2 (2025): April
Publisher : Fakultas Ekonomi dan Bisnis Universitas Pancasila Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jrb.v8i2.7264

Abstract

When the immune system is not working properly, the body is susceptible to disease. There are some ways to boost the immune system; consuming herbs or supplements which functioned immunomodulators. Before buying a product, potential consumers usually considerate the brand, quality, and price of the product that will be purchased. Stimuno and Imboost are the top brands category of immune system vitamins on the Top Brand Index (TBI) from 2015 until 2021. This study to analyze the effect of brand image, quality, and price of immunomodulator products from the stimuno and imboost brands on satisfaction and their impact on customer loyalty. This research is explanatory research – quantitative data - probability sampling method - purposive sampling technique. The obtained data then tested for the validity, reliability, and suitability of each variable using SEM PLS (Structural Equation Model Partial Least Square) software. The results of the analysis show that brand image (3.797 and 0.000), quality (2.037 and 0.042), and product price (11.491 and 0.000) have a t-value > 1.96 and p-value <0.05 directly on customer satisfaction. Brand image (3.198 and 0.001), quality (1.967 and 0.049), and product price (3.912 and 0.000) indirectly through customer satisfaction have t- value > 1.96 and p-value < 0.05. Based on the results of the analysis, it can be concluded that brand image, product quality, and price directly have a positive and significant effect on customer satisfaction. Brand image, product quality, and price indirectly through customer satisfaction have a positive and significant effect on customer loyalty.
PENGARUH EDUKASI FARMASIS TERHADAP MOTIVASI DAN KEPATUHAN PENGGUNA PROGRAM TERAPI RUMATAN METADON DI PUSKESMAS TAMBORA PADA BULAN FEBRUARI - APRIL 2015 Halim, Marta; Kumala, Shirly; Hersunaryati, Yetti
Jurnal Riset Kefarmasian Indonesia Vol. 1 No. 1 (2019): Jurnal Riset Kefarmasian Indonesia
Publisher : APDFI (Asosiasi Pendidikan Diploma Farmasi Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33759/jrki.v1i1.8

Abstract

This study was triggered by the large number of users of Methadone Maintenance Therapy Program (MMTP) who Dropped Out due to lack of motivation and compliance. The purpose of this study was to increase the motivation and compliance of the Tambora Community Health Center MMTP users. The study design used the quasi-experimental method with the pretest-the posttest the group was not comparable. Voluntary research samples amounted to 100 with a distribution of @ 50 for the control group (KK) and @ 50 for the treatment group (KE). Based on the results of data analysis, the following results were obtained: (1) There was an increase in the motivation and compliance variables for the group given education with lectures and leaflets. (3) Pharmacist education (variable knowledge, attitudes and actions) simultaneously can increased the motivation of users with a score of 15.4% (p value 0.00 <0.05) in MMTP at the Tambora Community Health Center. (3) Pharmacist education (variable knowledge, attitudes and actions) simultaneously increases the compliance of service users in MMTP Tambora Community Health Center with a score of 12.7% (p value 0.00 <0.05). The Conclusion pharmacist education can increase motivation and compliance to users of Tambora Community Health Center MMTP services.
PENGARUH ELECTRONIC WORD OF MOUTH (eWOM) TERHADAP BRAND CREDIBILITY DAN BRAND ATTITUDE SERTA DAMPAKNYA TERHADAP REPURCHASE INTENTION PRODUK SANMOL SIRUP (Studi Kasus di Wilayah DKI Jakarta) Tamimi, Khairunnisa; Kumala, Shirly; Putriana, Lies
Journal of Economic, Bussines and Accounting (COSTING) Vol. 9 No. 1 (2026): COSTING : Journal of Economic, Bussines and Accounting
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/wmsf5383

Abstract

Salah satu produk yang terkena dampak issue cemaran EG/DEG yaitu Sanmol Sirup, peraih Top Brand Award pada 2018-2022 dengan nilai TBI 23,80%. Tujuan penelitian ini adalah untuk mengetahui pengaruh eWOM terhadap Brand Credibility dan Brand Attitude serta dampaknya terhadap Repurchase Intention Produk Sanmol Sirup. Jenis penelitian ini adalah penelitian asosiatif kuantitatif dengan desain cross-sectional. Kuesioner online disebar melalui media sosial pada Juni 2023. Sampel dipilih menggunakan teknik Convenience Sampling dengan jumlah sampel sebanyak 385 responden yang berusia ≥ 18 tahun, berdomisili di DKI Jakarta, telah membeli Sanmol Sirup minimal satu kali dalam 6 bulan terakhir dan mengetahui adanya issue cemaran EG/DEG. Analisis data dilakukan dengan metode SEM-AMOS. Hasil penelitian menunjukkan dari 11 kriteria pengukuran GOF, terlihat bahwa 2 kriteria yang menunjukkan hasil baik yaitu CMIN/DF, RMSEA, 7 kriteria cukup baik yaitu GFI, AGFI, CFI, TLI, NFI, IFI, PNFI dan 2 kriteria kurang baik yaitu P-Value dan PGFI. Hasil uji t menunjukkan terdapat pengaruh signifikan pada hubungan eWOM terhadap Brand Credibility, eWOM terhadap Brand Attitude, dan Brand Attitude terhadap Repurchase Intention dengan nilai C.R≥1,96 yaitu 9,987; -3,708; 9,004 dan P≤0,05 yaitu 0,904; -0,205; 0,000. Dan ditemukan tidak adanya pengaruh signifikan pada hubungan eWOM terhadap Repurchase Intention dan Brand Credibility terhadap Repurchase Intention dengan nilai C.R≤1,96 yaitu 1,686; -1,840 dan P≥0,05 yaitu 0,092; -0,066. Hasil penelitian ini dapat digunakan sebagai strategi perusahaan dimana eWOM berperan penting dalam membangun Brand Credibility dan Brand Attitude. Selain itu Brand Attitude berdampak pada Repurchase Intention produk.
Identification of Xanthine Oxidase Inhibitors in Single-Clove Black Garlic using Metabolomics and Molecular Docking Approaches Setiawan, Abdul Aziz; Kumala, Shirly; Laksmitawati, Dian Ratih; Yuniarto, Ari; Yuliana, Nancy Dewi
Makara Journal of Science Vol. 30, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Black garlic is produced through controlled fermentation under specific temperature and humidity conditions, during which the Maillard reaction enhances its sensory properties and bioactivity. The anti-hyperuricemic potential of single-clove black garlic (SBG) remains unexplored. This study combined Ultra High-Performance Liquid Chromatography–High Resolution Mass Spectrometry-based metabolomics and an in-silico approach to identify the potential xanthine oxidase inhibitors (XOI) in SBG. Methanolic extracts (10 ppm) exhibited xanthine oxidase inhibition ranging from 50.09% to 68.01%, which is comparable to allopurinol (78.74%) at the same concentration. Metabolomic profiling tentatively identified 45 compounds, and orthogonal partial least squares analysis revealed seven metabolites as strongly correlated with XOI activity, namely α-(1-deoxy-D-fructose-1-yl)-L-arginine, alliin, 2-amino-2-deoxy-D-glucose, S-allyl-L-cysteine, quercetin, and m-coumaric acid. Molecular docking showed that these compounds exhibited binding energies comparable to allopurinol, thus indicating favorable interactions within the xanthine oxidase active site. Molecular dynamics simulations confirmed the stability of ligand–enzyme complexes, with consistent hydrogen bond interactions, which support their stable binding conformations. ADMET analysis revealed that most compounds demonstrated acceptable pharmacokinetic profiles, high intestinal absorption, low blood–brain barrier permeability, and non-hepatotoxic and non-mutagenic properties. The integration of metabolomics, molecular docking, molecular dynamics, and ADMET prediction supports the potential of SBG-derived compounds as safe and effective XOIs, thereby highlighting SBG as a promising functional food candidate for the management of hyperuricemia
Co-Authors . Desi . Suhaimi . Syamsudin . Yuliani Abdul Aziz Setiawan Adini, Syilvi Ahmad Subhan Aji, Nur Anwar Wahyudi Anwar, Yelfi Ariyani Kiranasari Ariyani Kiranasari Armansyah, Septiyana Lia Atut Ruswita Aulena, Desi Nadya Ayuditiawati, Meita Bekti, Novi Dyah Purnama Bekti, Novi Dyah Purnama Datubara, Martaulina Elisabet Delina Hasan Deni Rahmat Dian Indriani Dian Ratih L. Dian Ratih Laksmitawati Didik Tulus Dimas Adrianto Dosi Ahmad Yani Dwi Aryanti, Anindita Dwi Fitriyani, Dwi Dwi Hapsari Juniarti Dwi Windi Sapitri Elvina Dhiaul Iftitah Erlita Agustina Esti Mumpuni Esti Mumpuni, Esti Fachry Abda El Rahman Farida, Yunahara Faridah Faridah Fauzi Setyo Fandheo Febbyasi Megawaty Gabriel Gabriel Gabriel, Gabriel Gandes Winarni Gumilar Adhi Nugroho Halim, Marta Hasan, Delina Herru Setiawan Hersunaryati, Yetti Heru Santosa Heru Santosa Hery Prambudi Hesty Utami Hesty Utami R Huda, Badrul I Ketut Suada Iha Haryani Hatta Indarwati Indarwati Kurota Aini Lea P. Retnoningsih Leonardus B.S. Kardono Lestari Rahayu Lies Putriana Mardiastuti, . Mardiastuti, . Marlin M. Raunsai Mochtar, Dede Mochtar, Dede Nancy Dewi Yuliana Nancy Raisa Nancy Raisa, Nancy Noor, Laili Savitri Nur Aji Nurmaini Nurmaini Partomuan Simanjuntak Partomuan Simanjuntak Pasanema, Dimas A. M. Pasanema, Dimas A. M. Pasaribu, Rita Kristina Pieter Hazmen Pratama, Anton Pratiwi Pujilestari Sudarmono Prih Sarnianto Priyo Wahyudi R, Hesty Utami Rachmani, Rum Rachmani, Rum RAHMAT, DENI Raihan, Dany Ramadaniati, Hesty Utami Restu Restiani Reubun, Yonathan Tri Atmodjo Reza Agung Sriwijaya Risma Marisi Tambunan, Risma Marisi Rita Kristina Pasaribu Robert Utji Rochimah Ros Sumarny RR. Ella Evrita Hestiandari Ruskar, Dandung Sarnianto, Prih Saru Noliqo Rangkuti Sembiring, Rinawati Sesilia A. Keban Sesilia Andriani Keban Setiadi, Feri Setiawan, Abdul Aziz Setiyarini, Setiyarini Shanny, Fransisca Shanny, Fransisca Simanjuntak, Partomuan Siswa Setyahadi Siswa Setyahadi Siti Jabal Mastura Sofyan Ramani Sri Widyastuti Stiani, Sofi Nurmay Sugiastuti, Fenty Suhaimi Suhaimi Suhaimi, . Syarifah Aini Tamimi, Khairunnisa Teti Indrawati Umilawati Rawi Utami R, Hesty Violeta, Violeta Wahyudi Uun Widiyastuti, Asih Yati Sumiyati, Yati Yuniarto, Ari Yusransyah, Yusransyah Zaidan, Sarah