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All Journal Jurnal Fitopatologi Indonesia VALENSI Jurnal Kimia (Journal of Chemistry) Agrikultura Biotika: Jurnal Ilmiah Biologi Journal of Marine Research Cropsaver : Journal of Plant Protection Padjadjaran Journal of Dentistry Chimica et Natura Acta Indonesian Journal of Chemistry Molekul: Jurnal Ilmiah Kimia Makara Journal of Science Molekul: Jurnal Ilmiah Kimia Media Penelitian dan Pengembangan Kesehatan Jurnal Penelitian Hasil Hutan
Tri Mayanti
Jurusan Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health

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Journal : Makara Journal of Science

 1 
Antioxidant Constituents from the Bark of Aglaia eximia (Meliaceae) Sianturi, Julinton; Farabi, Kindi; Mayanti, Tri; Harneti, Desi; Darwati,; Supratman, Unang; Awang, Khalijah; Hayashi, Hideo
Makara Journal of Science Vol. 20, No. 1
Publisher : UI Scholars Hub

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The genus Aglaia is a a rich source of different compounds with interesting biological activities. A part of our continuing search for novel biologically active compounds from Indonesia Aglaia plants, the ethyl acetate extract of bark of Aglaia eximia showed significant antioxidant activity. Four antioxidant compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), kaempferol-3-O-β-D-glucoside (3) and kaempferol-3-O-β-D-glucosyl-(1→4)-α-L-rhamnoside (4) were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1-4 were identified on the basis of spectroscopic datas including UV, IR, NMR and MS along with by comparison with those spectra datas previously reported. All compounds showed DPPH radical-scavenging activity with IC50 values of 1.18, 6.34, 8.17, 10.63 mg/mL, respectively.
Flavonoid Compounds from the Bark of Aglaia eximia (Meliaceae) Sianturi, Julinton; Purnamasari, Mayshah; Mayanti, Tri; Harneti, Desi; Supratman, Unang; Awang, Khalijah; Hayashi, Hideo
Makara Journal of Science Vol. 19, No. 1
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Three flavonoid compounds, kaempferol (1), kaempferol-3-O-α-L-rhamnoside (2), and kaempferol-3-O-β-D-glucosyl-α-L-rhamnoside (3), were isolated from the bark of Aglaia eximia (Meliaceae). The chemical structures of compounds 1–3 were identified with spectroscopic data, including UV, IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H-COSY NMR), and MS, as well as a compared with previously reported spectra data. All compounds were evaluated for their cytotoxic effects against P-388 murine leukemia cells. Compounds 1–3 showed cytotoxicity against P-388 murine leukemia cells with IC50 values of 1.22, 42.92, and >100 mg/mL, respectively
Cytotoxic Triterpenoid from the Stembark of Chisocheton celebicus (Meliaceae) Katja, Dewa Gede; Farabi, Kindi; Harneti, Desi; Mayanti, Tri; Supratman, Unang
Makara Journal of Science Vol. 21, No. 1
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Plants belonging to the Chisocheton genus are a rich source of tetracylic triterpenoids with diverse biological activities. Two triterpenoid compounds,dammar-20,24-dien-3-one (1) and 3β-hydroxy-tirucall-7-en (2) were isolated from the stembark of Chisocheton celebicus. The chemical structures of compounds 1 and 2 were identified by spectroscopic data, including IR, NMR (1H, 13C, DEPT 135°, HMQC, HMBC, 1H-1H COSY), and MS, and they were compared with previously reported spectral data. Compounds 1 and 2 were evaluated for their cytotoxic effects against P-388 murineleukemia cells. The compounds showed cytotoxicity against P-388 murine leukemia cells, with IC50 values of 30.2 and 4.3 μg/mL, respectively.
Limonoids Isolated from Chisocheton pentandrus (Meliaceae) Stembarks and its Cytotoxicity Towards MCF-7 Breast Cancer Cell Line Runadi, Dudi; Anjari, Intan Hawina; Purnama, Purnama; Nurlelasari, Nurlelasari; Harneti, Desi; Mayanti, Tri; Harizon, Harizon; Hidayat, Ace Tatang; Salam, Supriatno; Azmi, Mohamad Nurul; Supratman, Unang
Makara Journal of Science Vol. 28, No. 2
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Chisocheton is a large source of limonoids with various pharmacological effects, such as antiviral, antibacterial, antimalarial, antifungal, and cytotoxic activities. This study aimed to isolate, elucidate, and evaluate the cytotoxicity of limonoids from C. pentandrus stembarks. Isolation was carried out using various separation methods including extraction and column chromatography. Spectral data were analyzed by FT-IR, UV, DEPT 135°, 1H, 13C-NMR, and HRTOF-MS and compared with those previously reported to determine the chemical structure.The obtained limonoids were lasiocarpine (1), lasiocarpine B (2), pentandricine (3), and 16β-hydroxydysobinin (4); all of which were successfully isolated from C. pentandrus for the first time. The cytotoxic activity of these limonoids were also evaluated against Michigan Cancer Foundation-7 (MCF-7) breast cancer cells using PrestoBlue method. Lasiocarpine A revealed the strongest cytotoxicity with an IC50 of 42.62 µM in moderate level.
Co-Authors Abdillah, Lutfi Ace Tatang Hidayat Agus Susanto Ajeng Diantini, Ajeng Andre A. Sonda Anindyta, Annisa Anjari, Intan Hawina Aoliya, Salwa Rohmatul Azmi, Mohamad Nurul Azzahra, Fathia Darwati Darwati Darwati Darwati, Deden Indra Dinata, Deden Indra Desi Harneti Putri Huspa Dewa Gede Katja Dikdik Kurnia DUDI RUNADI Elizabeth Fitriana Sari Endah Yulia Euis Julaeha Fajar Fauzi Abdullah Farabi, Kindi Ferry Ferdiansyah Sofian, Ferry Ferdiansyah Gunawan, Latifah Harizon Harizon Hideo Hayashi Hilmayanti, Erina Indriyani, Indri Isramiharti Isramiharti Jamaludin Al-Anshori Kautsari, Arsi Khalijah Awang Kindi Farabi Kindi Farabi Kindi Farabi Kusumiyati Madihah Madihah Maira, Faizah Mayshah Purnamasari Mohamad Nurzaman Muchlis, Handi Nugraha Muhammad Andry Muhammad Hanafi Mustaqim, Iqbal Wahyu Mustofa, Hidayat Nurul Nafiah, Mohamad Azlan Naini, Al Arofatus Noor Istifadah Nurcahyanti, Ois Nurjihan, Khansa Nurlelasari Nurlelasari Nurlelasari Purnama Purnama Qomarilla, Nurul Rani Maharani Reina Yulianti Reina Yulianti Yulianti Rida Evalina Tarigan Rika Meliansyah Romundza, Febbry Ronny Lesmana Rurini Retnowati Salam, Supriatno Sandra Amalia Riyadi Setiani, Cahya Shiono, Yoshihito Sianturi, Julinton Siska Elisahbet Sinaga Sofa Fajriah Sri Hartati Sri Rejeki Rahayuningsih Surbakti, Chemayanti Tati Herlina Tenny Putri Wikayani, Tenny Putri Unang Supratman Wahyuni, Aneu Wawan Hermawan Wibisono, Aditya Seiza Yoshihito Shiono Yulisar, Riza Zahidah Nurulhaq