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All Journal HAYATI Journal of Biosciences Jurnal Ilmu Dasar Jurnal Penelitian Sains (JPS) Jurnal Natur Indonesia Alchemy Jurnal Penelitian Kimia Majalah Obat Tradisional CHEMPUBLISH JOURNAL JIMKesmas (Jurnal Ilmiah Mahasiswa Kesehatan Masyarakat) Jurnal Penelitian Sains (JPS) IJFAC (Indonesian Journal of Fundamental and Applied Chemistry) Jurnal Penelitian Sains ALCHEMY Jurnal Penelitian Kimia AcTion: Aceh Nutrition Journal Indonesian Journal of Chemistry Preventif Journal Martabe : Jurnal Pengabdian Kepada Masyarakat JSFK (Jurnal Sains Farmasi & Klinis) JURNAL PENDIDIKAN TAMBUSAI Sainmatika: Jurnal Ilmiah Matematika dan Ilmu Pengetahuan Alam Jurnal Pengabdian Magister Pendidikan IPA YUME : Journal of Management JPBIO (Jurnal Pendidikan Biologi) Molekul: Jurnal Ilmiah Kimia Jurnal Abdi Insani PUBLIKASI PENELITIAN TERAPAN DAN KEBIJAKAN JPK: Jurnal Proteksi Kesehatan Jurnal Abdidas Miracle Journal Of Public Health (MJPH) Education Enthusiast : Jurnal Pendidikan dan Keguruan Jurnal Abdi Masyarakat Indonesia Jurnal Altifani Penelitian dan Pengabdian kepada Masyarakat JKP (Jurnal Kajian Pemerintah: Journal of Government Social and Politics) Makara Journal of Science Jurnal Pepadu Innovative: Journal Of Social Science Research Journal of Local Therapy Journal of Security, Computer, Information, Embedded, Network and Intelligence System Indonesian Technology and Education Journal Jurnal Kefarmasian Indonesia PITIMAS: Journal of Community Engagement in Health
Muharni Muharni
Department Of Chemistry, Faculty Of Mathematics And Natural Sciences , Sriwijaya University, Jl. Raya Palembang Prabumulih Km 32, Indralaya, Ogan Ilir, South Sumatera 30662
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Journal : CHEMPUBLISH JOURNAL

 1 
Analgesic Effect of Ethanol Extract of Dillenia ochreata (Miq.) Teijsm. & Binn. Ex Martelli in Wistar Rats Yohandini, Heni; Ghaniya, Fahdelaa; Muharni, Muharni; Fitrya, Fitrya
Chempublish Journal Vol. 9 No. 1 (2025): Chempublish Journal
Publisher : Department of Chemistry, Faculty of Science and Technology Universitas Jambi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22437/chp.v9i1.43080

Abstract

Dillenia ochreata is a traditional medicine used to treat wounds and scabies. In wound healing, one of the treatments is to reduce pain (analgesic). Some compounds of triterpenoid groups have been known to be active as analgesic compounds. The leaf of D. ochrea was reported to contain secondary metabolites triterpenoid centulic acid and 3β-glucopyranosyl-lup-20(29)-en-28 oat. This study aimed to evaluate the analgesic activity and standardization of the ethanol extract of D. ochreata leaf and determine the mechanism of action. Analgesic activity was determined by a hot plate method and formalin test, and the mechanism of action was through muscarinic, dopamine, and opiate receptors, standardization of extract using the method issued by the Indonesian Ministry of Health.  The ethanol extract of D. ochreata leaf at a 400 mg/kg bw dose has higher analgesic activity (24.85%) than the positive control (18.32%).  Statistical analysis showed a significant difference in analgesic activity percentage between the positive group and those with a 400 mg/kg bw group dose. The 400 mg/kg bw dose also showed a significant difference (p<0.05) between neurogenic pain (46.92%) and inflammation (61.19%) in the formalin test caused by opioid receptors. The evaluation of the analgesic mechanism showed the ethanol extract of D. ochreata leaf works through opioid receptors. The extract meets the requirements of the standard parameters.  The leaf extract of D. ochreata can be developed as an anti-analgesic from natural medicine.
Co-Authors . ELFITA . MUNAWAR Abd. Rasyid Syamsuri Abdullah Abdullah Ade Oktasari Adriansyah, Fikri Afnidar Agusreni Agus Purwoko Aminah Aminah Aminu, Nurmin Aminudin Bama, Akhmad Amsina, Nuryani Anak Agung Istri Sri Wiadnyani Ananda, Dea Ani Sarah Arianti, Novi Sagita Arif Fadhilah, Arif At panagan At panagan Awaliah, Widiarti Azriani, Yuni Bahri, Usman Bana, Akhmad Aminuddin Budiono Budiono Candra Candra, Putra Setia Aji Carissa, Restri Diah Cenora, Cindy Dachariyanus Dachariyanus Dachrianus Dachrianus Dachriyanus Dasril Basir Deswari, Sri Devi Savitri Effendy, Devi Savitri Dewi Fatmarani Surianto Dewi Rahayu Dian Rianita Didi Pratama Dwi Anjar Susanti Elfita Elfita . Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elfita Elisa Nurnawati Eliza Eliza Eliza Eliza Emil Pertiwi Erni Erni Fajri, Riyadhul Fajri, Ryadhul Feriska Feriska Ferlinahayati Ferlinahayati Fitri Fitri Fitrya . Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Fitrya Gemini, Pra Ghaniya, Fahdelaa Gusti Pratiwi Hadir Kaban, Hadir Harmida Harmida Harmida Harvianti, Yuniar Hary Widjajanti Hasanah, Khairatul Heni Yohandini Husein Hernadi Bahti Huzaifah, Huzaifah I Gusti Bagus Wiksuana Indah, Tri Irwan Irwan Jorena Jorena, Jorena Julinar Julinar Julinar Julinar Julinar Jurnal Pepadu Juswardi Juswardi, Juswardi Khakim, Mokhamad Yusup Nur Laila Hanum Lenny Anwar Lily Restusari Listina, Yuli Luqiana, Nur Mardiyanto Mardiyanto Maretha Kobaywan Maretha Kobaywan Maria, Tri Anna Marini . Maryadi Maryadi Maryadi Maryadi MASTUR ADHY SUDRAJAT Masyita Masyita Miksusanti Miksusanti Milanti Okta Ruliza Milanti oktaruliza Milanti oktaruliza, Milanti Mokhamad Yusup Nur Khakim Munajat, Muhammad Fahrizal Munawar . Munawar Munawar Munawar Munawar Munira, Widia Musifa, Eva Nina Tanzerina Nita Aminasih Novilla Rezka Sjahjadi Oktafiani, Tiara oktaviani, muthia Poedji Loekitowati Hariani Rahmadania Rahmadania Rahmawati, Rahmawati Rahmi, Nelvin Ramadhan Tosepu Rifdah Nabila Riska Adillah Rivai, M Yunus Rizki . Rizqaini, Alfitratul Sabandia, La Salni Sarmayanta Sembiring Selviani, Ananda Seni Metasari Siregar, Wardah Khoiriah Sofa Farida Sofa Farida Sri Hidayati Sri Mulyani Suhadi Suhadi Suheyanto Suheryanto Sulaiman Zuhdi Sumarti Sumarti Supriyatna Supriyatna Supriyatna Supriyatna Surianto, Dewi Fatmawati Suryana, Nina Susanty, Sri Syafrina Lamin, Syafrina Syamsiah Wahyuni, Yayu Yadi Oktariansyah Yolahumaroh, Yolahumaroh Yuanita Windusari Yuliana Arsil Yusmarita, Yusmarita Yusnita, Rini Yusup Nur Khakim, Mokhamad Zainuddin, Asnia Zara Yunizar Zefron, Zefron