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All Journal Journal of Food and Pharmaceutical Science JURNAL ILMIAH KESEHATAN KEPERAWATAN Disease Prevention and Public Health Journal Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Indonesian Journal of Pharmaceutical Science and Technology Pharmacon Majalah Obat Tradisional INDONESIAN JOURNAL OF PHARMACY JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Jurnal Surya Medika Majalah Farmaseutik Indonesian Journal of Chemistry PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Ilmu Kefarmasian Indonesia Jurnal Mandala Pharmacon Indonesia BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Jurnal Ilmiah Pharmacy PHARMACOLOGY, MEDICAL REPORTS, ORTHOPEDIC, AND ILLNESS DETAILS (COMORBID) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Farmasi Sains dan Praktis Prosiding University Research Colloquium Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Indonesian Journal of Pharmacology and Therapy
Laela Hayu Nurani
Universitas Ahmad Dahlan
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Journal : jurnal farmasi dan ilmu kefarmasian indonesia

 1 
Efek Kapsul Ekstrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) terhadap Kadar Bilirubin Sukarelawan Sehat Nur Azizah; Endang Darmawan; Laela Hayu Nurani
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 4 No. 1 (2017): Jurnal Farmasi dan Ilmu Kefarmasian Indonesia
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (248.832 KB) | DOI: 10.20473/jfiki.v4i12017.13-18

Abstract

Pendahuluan: Hibiscus sabdariffa adalah salah satu ramuan tradisional yang memiliki banyak manfaat termasuk efek imunostimulan, karena banyak mengandung antioksidan di dalamnya termasuk anthocyanin dan flavonoid. Berdasarkan aktivitasnya pada tes praklinis, H.sabdariffa telah memenuhi syarat untuk melanjutkan ke fase uji klinis. Tujuan: Penelitian ini bertujuan untuk mengetahui pengaruh kapsul ekstrak etanol kelopak bunga rosella (Hibiscus sabdariffa L.) pada kadar bilirubin  11 sukarelawan sehat  pria dan 10 sukarelawan sehat wanita. Metode: Penelitian ini menggunakan rancangan pre-post treatment. Sukarelawan sehat mengkonsumsi kapsul ekstrak etanol kelopak bunga rosella selama 30 hari dengan dosis 500 mg sekali sehari pada malam hari. Tes Bilirubin dilakukan pada hari ke-0; 31 dan 45, menggunakan metode Jendrassik dan Grof. Hasil dianalisis menggunakan SPSS dengan paired t-test dan uji Wilcoxon. Hasil: Perbandingan nilai rata-rata pada hari ke-0 dan 31, dengan hari ke-31 dan 45, dan perbandingan nilai rata-rata antara hari ke-0 dan ke-45 tidak menunjukkan perbedaan yang signifikan pada kadar bilirubin total dan direct (p > 0,05), sedangkan perbandingan nilai rata-rata untuk kadar bilirubin indirect hari ke-0 dan ke-45 menunjukkan adanya perbedaan yang signifikan (p = 0,05) akan tetapi kadar bilirubin indirect tersebut masih dalam rentang nilai normal. Kesimpulan: Kapsul ekstrak etanol kelopak bunga rosella tidak mempengaruhi kadar bilirubin total, direct dan indirect pada sukarelawan sehat.
Antihypertensive Activity of Black Garlic Extract in Rats and Its Phytochemical Analysis using GC-MS Estiningsih, Daru; Saiful Bachri, Moch; Hayu Nurani, Laela; Ma’ruf, Muhammad; Yuliani, Sapto; Sofia, Vivi; Prasasti, Dian
JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Vol. 12 No. 1 (2025): JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jfiki.v12i12025.67-74

Abstract

Background: Hypertension is defined as a medical condition where blood pressure rises above 140/90 mmHg. Black garlic is recognized as a natural remedy that may help lower high blood pressure, primarily due to its abundant antioxidant properties, which are believed to inhibit the function of the angiotensin-converting enzyme (ACE) that is essential for regulating blood pressure. Objective: This study aimed to identify the chemical composition of black garlic using GC-MS and assess its antihypertensive effects in rat models. Methods: This study characterized the chemical composition of black garlic using GC-MS (Agilent 7890A) and evaluated its antihypertensive effects in rats. Hypertension was induced by oral administration of NaCl at a dose of 3.75 g/20 g body weight (BW) from day 0 to day 14. Blood pressure measurements were taken on days 0, 14, and 21. Black garlic extract was administered at three dose levels 4.2 mg/20 g BW, 8.4 mg/20 g BW, and 12.4 mg/20 g BW to evaluate dose dependent antihypertensive responses. Statistical analysis included the Kolmogorov-Smirnov test for normality, homogeneity testing, One-Way ANOVA Results: The GC-MS analysis identified 9-octadecenoic acid as the dominant compound in black garlic, accounting for 34.53% of its total composition. The antihypertensive activity test showed that administering black garlic at a dose of 12.4 mg/20 g BW significantly lowered systolic, diastolic, and mean arterial blood pressure while enhancing nitric oxide levels in hypertensive rats. Conclusion: Black garlic has the potential as an effective herbal treatment to lower blood pressure.
Co-Authors Abdul Rohman Abdul Rohman Abdul Rohman Abdul Rohman Achmad Mursyidi Achmad Mursyidi Afiana Rohmani Agitohutomo, Muhammad Ainiyah, Nadia Putri Aisyah, Vani Aisyah, Vani Akrom Akrom, Akrom Aldri Frinaldi ANDI WIJAYA Anggita Rosiana Putri Anjar Windarsih Annisa Fatmawati Any Guntarti Any Guntarti Any Guntarti Any Guntarti Any Guntarti Arif Santoso Aris Asahi Aristiani, Windi Aristiani, Windy Astuti, Ratih Arum Azzahra, Fara Bachri, Mochammad Saiful Citra Ariani Edityaningrum, Citra Citra Dhea Cantika Danang Prasetyaning Amukti Daru Estiningsih Daud, Intan Devi Kumala Dewi Dewi Andini Kunti Mulangsri, Dewi Andini Kunti Dewi, Devi Kemala Dian Prasasti Djannah, Sitti Nur Djannah, Sitti Nur Dwi Utami Edityaningrum, Citra Ariyani Efiana, Nuri Ari Eka Kumalasari Eka Kumalasari Eka Kumalasari Eka Sakti Wahyuningtyas Eka Wahyuning Tyas Elya Zulfa, Elya Endang Darmawan Eti Nurwening Sholikhah Eti Nurwening Sholikhah Fara Azzahra Fara Azzahra Fauziyya, Riri Feri Anggita Hastanto Feri Anggita Hastanto Fikri Achmad Arif Fitriyati, Laeli Galih Dwi Mulyati Gela Setya Ayu Putri Hari Susanti Heni Lutfiyati, Heni Heni Setyowati Esti Rahayu Hidayati, Sholihatil Husnun Khairunnisa Pratiwi Ibnu Gholib Gandjar Ibnu Gholib Gandjar Ibnu Gholib Gandjar Ichsan Luqmana Indra Putra, Ichsan Luqmana Indra Ichwan Ridwan Rais Iin Narwanti Iin Narwanti Iis Wahyuningsih Intan Rahayu Irfan, Nawwar Irnawati Irnawati Isabella Meliawati Sikumbang Isabella Meliawati Sikumbang Jumina Jumina Jumina Jumina Kartikadewi, Arum Khairurrizki, Amanda Khayatulisma, Dika Kurnianto, Erwan Lalu Muhammad Irham Mahardika Agus Wijayanti Ma’ruf, Muhammad Meta Safitri Milanie, Rida Dwi Miratun Syarifah Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Fikri Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mustofa Mustofa Nanik Sulistyani Nasruddin Nasruddin Nasruddin Nasruddin Nasruddin, N Nina Salamah Nining Sugihartini Nining Sugihartini Nugrahini, Febrina Nur Azizah Nur Ismiyati Nurkhasa Nurkhasa, Nurkhasa Nurkhasanah Nurkhasanah Mahfudh Nurkhasanah Nurkhasanah Putri Kurniasiwi Putri Lestari Rahma Dona Ramadhan, Muhammad Marwan Rini Sulistyawati Rizki Amelia Rohman, Abdul Salsabila, Nia Sapto Yuliani SATRIYAS ILYAS Sikumbang, Isabella Meliawati Sitarina Widyarini Sitarina Widyarini Siti Fatmawati Fatimah, Siti Fatmawati Siti Rofida Siti Salma Yusuf Siti Setianingsih Sitti Nur Djannah Sudjadi . Sugiyanto - Sulistyorini, Dwi Agustin Suwidjiyo Pramono Syarif, Yaumi Musfirah Titiek Suhardi Haripurnomo Kushadiwijaya Hidayati Tri Ani Marwati Tri Yanuarto Tria Zakinah Utari, Dina Vani Aisyah Vivi Sofia Wahyu Widyaningsih Wahyuningtyas, Nurma Widea Rossi Desvita Widyarini, Sitarina Wihasty Nur Istyqomah Wiwara Awisarita Yaumi Musfirah Syarif Yeni Dianita Yeni Yeni, Yeni Dianita Yeni, Yeni Dianita Yoga Yuniadi Yusuf, Siti Salma Zainab Zainab Zainab Zainab