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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Cermin Dunia Kedokteran

Daan Khambri

Fakultas Kedokteran, Universitas Andalas

Author-ID : 3367697

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Hubungan Grading Histopatologi dan Infiltrasi Limfovaskular dengan Subtipe Molekuler pada Kanker Payudara Invasif di Bagian Bedah RSUP. Dr. M. Djamil Padang Vashti Resti Putri Firdaus; Aswiyanti Asri; Daan Khambri; Wirsma Arif Harahap
Jurnal Kesehatan Andalas Vol 5, No 1 (2016)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v5i1.463

AbstrakGejala kanker payudara sering tidak disadari atau dirasakan dengan jelas oleh penderita, sehingga banyak penderita yang datang dalam keadaan stadium lanjut. Banyak faktor yang mempengaruhi prognosis dari kanker payudara, antara lain grading histopatologi, reseptor estrogen dan progesteron, HER2, serta infiltrasi limfovaskular. Tujuan penelitian ini adalah menentukan hubungan antara grading histopatologi dan infiltrasi limfovaskular terhadap subtipe molekuler pada kanker payudara invasif. Distribusi frekuensi dari grading histopatologi, infiltrasi limfovaskular, dan subtipe molekuler pada kanker payudara invasif di bagian bedah RSUP.Dr. M. Djamil Padang selama periode 1 Januari 2010 – 31 Desember 2013. Metode penelitian ini adalah observational analitik, dengan pendekatan cross sectional. Dalam penelitian ini didapatkan 424 kasus kanker payudara invasif, dengan 66 kasus yang dapat dianalisis. Analisis data yang digunakan univariat dan bivariat dengan menggunakan uji chi-square dengan derajat kemaknaan p<0,05. Ada hubungan yang bermakna antara grading histopatologi dengan subtipe molekuler (p=0,032). Hubungan infiltrasi limfovaskular dengan subtipe molekuler pada kanker payudara invasif didapatkan bermakna (p=0,000).Kata kunci: grading histopatologi, infiltrasi limfovaskular, subtipe molekuler, kanker payudara invasif AbstractBreast cancer symptoms are often not recognized or clearly perceived by the patient, so it makes most of patients come to doctor in late stage. There are many prognosis factors in breast cancer, such as hystopathology grading, estrogen and progesteron receptors, HER2, and lymphovascular infiltration.The objective of this study was to determine the association between hystopathology grading and lymphovascular infiltration with molecular subtype in invasive breast cancer. Determine the distribution and frequency of hystopatology grading, lymphovascular infiltration, and molecular subtype in invasive breast cancer at surgery department Dr. M. Djamil Hospital Padang period January 1, 2010 – December 31, 2013. The method of this research is analitic observational with cross sectional study. In this research obtained 424 cases of invasive breast cancer, with only 66 cases that could be analyzed. The analysis system that used is univariat and bivariat with chi-square (p<0,05). There is significant correlation between hystopathology grading with molecular subtype (p=0,032). There is significant correlation between lymphovascular infiltration with molecular subtype (p=0,000).Keywords: histopathology grading, lymphovascular infiltration, molecularsubtypes, invasive breast cancer

Hubungan Daerah Tempat Tinggal dengan Gambaran Histopatologi Karsinoma Tiroid pada Masyarakat Sumatera Barat Eka Putri; Daan Khambri; Selfi Renita Rusjdi
Jurnal Kesehatan Andalas Vol 6, No 1 (2017)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v6i1.665

Karsinoma tiroid dapat dibagi berdasarkan gambaran histopatologi menjadi tipe papiler, folikuler, meduler dan anaplastik. Salah satu faktor yang mempengaruhi gambaran histopatologi karsinoma tiroid adalah keadaan geografis, dimana karsinoma tipe folikuler dan anaplastik akan lebih sering ditemukan pada daerah beresiko defisiensi yodium dibandingkan daerah tidak beresiko defisiensi yodium. Tujuan penelitian ini adalah menentukan hubungan antara daerah tempat tinggal dan gambaran histopatologi karsinoma tiroid. Penelitian ini menggunakan desain analitik observasional dengan mengumpulkan data sekunder di Laboratorium Patologi Anatomi FK Unand dan rekam medik RSUP M. Djamil periode Januari 2010 sampai Desember 2011. Hasil penelitian ini ditemukan 102 kasus karsinoma tiroid, dimana 32 kasus bertempat tinggal di daerah beresiko defisiensi yodium dan 70 kasus bertempat tinggal di daerah tidak beresiko defisiensi yodium. Pada daerah beresiko defisiensi yodium, 34,4% merupakan karsinoma folikuler dan anaplastik, dan 65,5% merupakan karsinoma selain folikuler dan anaplastik. Pada daerah tidak beresiko defisiensi yodium, 22,9% merupakan karsinoma folikuler dan anaplastik, dan 77,1% merupakan karsinoma selain folikuler dan anaplastik. Analisis statistik hubungan antara daerah beresiko defisiensi yodium dan kejadian karsinoma folikuler dan anaplastik berdasarkan uji chi-square didapatkan nilai p =0,33. Simpulan penelitian ini ialah tidak terdapat hubungan bermakna antara daerah tempat tinggal dengan gambaran histopatologi karsinoma tiroid pada masyarakat Sumatera Barat pada periode Januari 2010 sampai Desember 2011.

Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatologi Kanker Hubungan Usia dengan Gambaran Klinikopatolo Aisha Rahmatya; Daan Khambri; Henny Mulyani
Jurnal Kesehatan Andalas Vol 4, No 2 (2015)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v4i2.277

AbstrakKanker payudara merupakan kanker yang paling sering mengenai perempuan dan menjadi penyebab kematian terbanyak akibat kanker pada perempuan. Angka kejadian kanker payudara bervariasi secara global dimana terjadi peningkatan insiden di negara berkembang tetapi cenderung menurun di negara maju. Gambaran klinikopatologi kanker payudara dapat bervariasi sesuai kelompok usia dan memiliki peran penting dalam faktor prognostik penyakit. Tujuan penelitian ini adalah untuk mengetahui hubungan usia dengan gambaran klinikopatologi kanker payudara. Gambaran klinikopatologi meliputi stadium klinis, subtipe histologi, dan gradasi histologi. Penelitian ini adalah penelitian analitik menggunakan metode cross sectional dengan teknik total sampling. Sampel penelitian yaitu data pasien kanker payudara primer di bagian bedah RSUP Dr. M. Djamil Padang periode Januari 2012 – Desember 2012. Dari 112 penderita kanker payudara primer hanya 46 yang memenuhi kriteria. Sampel penelitian dianalisis dengan uji chi square (p ≤ 0,05). Hasil penelitian ditemukan bahwa sebagian besar penderita berusia ≥ 40 tahun (78,3%) dan <50 tahun (67,4%), datang pada stadium lanjut (69,6%) dengan tipe invasive ductal carcinoma (87%) dan bergradasi rendah (78,3%). Analisis bivariat menunjukkan bahwa tidak terdapat hubungan yang bermakna antara usia dengan gambaran klinikopatologi kanker payudara.Kata kunci: kanker payudara, gambaran klinikopatologi, stadium klinis, subtipe histologi, gradasi histologi AbstractBreast cancer is now become the most common cancer diagnosed in women and the leading cause of deaths from cancer among women. The incidences of the disease vary globally, it has been reported to be increasing in developing countries while slightly down in developed countries. The clinicopathologic features of breast cancer may vary from each age groups and it has an important role as a prognostic factors. The objective of this study was to determine the relationship between age of the breast cancer patients and their clinicopathologic features. The clinicopathologic features i.e. staging, histologic subtypes, and histologic grades. This was an analythical study by using cross sectional method with total sampling technique. Samples were patients with primary breast cancer in Dr. M. Djamil General Hospital period January 2012 – December 2012. From 112 patients with primary breast cancer there were only 46 who fulfilled the criteria. The samples were analyzed by chi square test (p ≤ 0.05). The result of this study has revealed that most of the patients ≥ 40 years of age (78.3%) and < 50 years of age (67.4%), diagnosed in late stage (69.6%) with invasive ductal carcinoma (87%) and low histologic grade (78.3%). Bivariat analyze found that there is no significant relation between age and clinicopathologic features of breast cancer.Keywords: breast cancer, clinicopathologic features, staging, histologic subtypes, histologic grades

Faktor Yang Mempengaruhi Kepatuhan Berobat Pasien Yang Diterapi Dengan Tamoxifen Setelah Operasi Kanker Payudara Arif Budiman; Daan Khambri; Hafni Bachtiar
Jurnal Kesehatan Andalas Vol 2, No 1 (2013)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v2i1.60

Abstrak Banyak faktor yang mempengaruhi kepatuhan berobat pasien yang diterapi dengan tamoxifen setelah operasi kanker payudara. Pada penelitian ini bertujuan untuk mengetahui faktor apa saja yang dapat mempengaruhi kepatuhan berobat pasien di RS. Dr. M Djamil, Padang. Sehingga dapat menjadi masukan dan perbaikan untuk meningkatkan kepatuhan berobat pasien. Metode yang digunakan adalah wawancara langsung, penderita mengisi daftar pertanyaan (kuesioner) dan skala likert pelayanan tenaga medis. Periode penelitian dilakukan selama 3 bulan. Analisis univariat, bivariat dan multivariat dilakukan dengan memakai SPSS versi 18.00. Dari 61 pasien didapatkan 9 pasien tidak patuh terapi tamoxifen, hasil penelitian bivariat didapatkan hubungan yang bermakna antara kepatuhan dengan umur, tingkat pendidikan, pendapatan keluarga, ketersediaan asuransi kesehatan dan pelayanan tenaga medis (p<0,05) sedangkan efek samping tidak berhubungan dengan kepatuhan (p>0,05). Analisis multivariat didapatkan faktor yang paling berpengaruh adalah pelayanan tenaga medis dengan p= 0,06. Dapat disimpulkan bahwa pelayanan medis merupakan faktor yang paling berpengaruh terhadap kepatuhan berobat pasien yang diterapi tamoxifen setelah operasi kanker payudara, faktor lain yang berpengaruh adalah umur, tingkat pendidikan, pendapatan keluarga dan ketersediaan asuransi kesehatan. Hasil penelitian ini dapat menjadi masukan pada tenaga medis sehingga dapat meningkatkan kepatuhan berobat pasien. Kata kunci: Kepatuhan, tamoxifen, kanker payudara.AbstractMany factors affect compliance of treatment in patients treated with tamoxifenAfter breast cancer surgery. This study aims to determine the factors that may affect treatment compliance of patients in the hospital. Dr.M.Djamil, Padang. So it can be sugestion and improvement to enhance patients treatment compliance.Methods. The method is a direct interview, patients filled out a questionnaire (questionnaire) and Likert scale medical services. Period of research carried out for 3 months. Analysis univariat, bivariat and multivariat performed by using SPSS version 18.00.Results. Of the 61 patients we found 9 patients not adherent tamoxifen therapy, the results bivariant a significant association between adherence to the age, level of education, familyIncome, availability of health insurance and medical care (p<0.05). Multivariate analysis found that the most influential factor is the care of medical personnel with p=0.06. Discussion. It can be concluded that the medical services are the most influential factor on treatment compliance of patients receiving tamoxifen after breast cancer surgery, other factors are age, education level, family income and the availability of health insurance. The results of this study can be suggestion on the medical staff so as to improve treatment compliance of patients.Keywords:Compliance, tamoxifen, breast cancer.

Analisis Faktor-faktor yang Berhubungan dengan Kejadian Lesi Pra Kanker Serviks pada Wanita Pasangan Usia Subur di Wilayah Kerja Puskesmas Muara Bungo 1 Citra Ayu Fitrisia; Daan Khambri; Bobby Indra Utama; Syamel Muhammad
Jurnal Kesehatan Andalas Vol 8, No 4 (2019): Online December 2019
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v8i4.1147

Lesi pra kanker serviks adalah awal perubahan menuju kanker serviks. Program pengendalian kanker serviks melalui pemeriksaan Visual Inspection with Acetic Acid (VIA) di tingkat Puskesmas dapat menurunkan insiden kanker serviks hingga 83,6%. Kanker serviks ini berkaitan dengan banyak faktor risiko.Tujuan: Menganalisis hubungan antara faktor risiko dengan kejadian lesi pra kanker serviks. Metode: Cross sectional yang dilakukan di wilayah kerja Puskesmas Muara Bungo 1 dari bulan Februari sampai Mei 2019 terhadap 362 responden. Pengambilan sampel menggunakan metode multistage random sampling. Pengambilan data menggunakan kuisioner dan observasi. Data dianalisis menggunakan uji Chi-square. Hasil: Terdapat hubungan signifikan (p<0,05) antara kejadian lesi prakanker serviks dengan usia >35 tahun, usia pertama kali berhubungan seksual <20tahun, jumlah paritas ≥4kali, menggunakan pembersih vagina dan lama penggunaan kontrasepsi hormonal ≥5 tahun. Jumlah pasangan seksual, paparan asap rokok dan riwayat keluarga kanker serviks, tidak memiliki hubungan yang signifikan dengan kejadian lesi pra kanker serviks (p≥0,05). Faktor risiko yang paling dominan adalah usia pertama kali berhubungan seksual <20 tahun (p=0,008; OR: 6,092). Simpulan: Faktor risiko usia, usia pertama kali berhubungan seksual, jumlah paritas, menggunakan pembersih vagina dan lama menggunakan kontrasepsi hormonal berhubungan dengan kejadian lesi prakanker serviks.

Hubungan Daerah Tempat Tinggal dengan Gambaran Histopatologi Karsinoma Tiroid pada Masyarakat Sumatera Barat Eka Putri; Daan Khambri; Selfi Renita Rusdji
Jurnal Kesehatan Andalas Vol 3, No 2 (2014)
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v3i2.65

AbstrakKarsinoma tiroid merupakan keganasan kelenjar endokrin yang paling sering ditemukan dan insidennya meningkat setiap tahun. Berdasarkan gambaran histopatologinya, karsinoma tiroid dibagi menjadi tipe papiler, folikuler, meduler, dan anaplastik. Salah satu faktor yang mempengaruhi gambaran histopatologi karsinoma tiroid adalah keadaan geografis, dimana karsinoma tipe folikuler dan anaplastik akan lebih sering ditemukan pada daerah beresiko defisiensi yodium dibandingkan daerah tidak beresiko defisiensi yodium. Tujuan dari penelitian ini adalah untuk mengetahui hubungan daerah tempat tinggal dengan gambaran histopatologi karsinoma tiroid. Penelitian ini menggunakan desain analitik observasional dengan mengumpulkan data sekunder di Laboratorium Patologi Anatomi FK Unand dan rekam medik RSUP M. Djamil periode Januari 2010 – Desember 2011 Dari penelitian ini ditemukan 102 kasus karsinoma tiroid, dimana 32 kasus bertempat tinggal di daerah beresiko defisiensi yodium dan 70 kasus bertempat tinggal di daerah tidak beresiko defisiensi yodium. Pada daerah beresiko defisiensi yodium, 34,4% merupakan karsinoma folikuler dan anaplastik, dan 65,5% merupakan karsinoma selain folikuler dan anaplastik. Pada daerah tidak beresiko defisiensi yodium, 22,9% merupakan karsinoma folikuler dan anaplastik, dan 77,1% merupakan karsinoma selain folikuler dan anaplastik. Dari analisis statistik hubungan daerah beresiko defisiensi yodium dengan kejadian karsinoma folikuler dan anaplastik berdasarkan uji chi-square didapatkan nilai p =0,33. Tidak terdapat hubungan bermakna antara daerah tempat tinggal dengan gambaran histopatologi karsinoma tiroid pada masyarakat Sumatera Barat pada periode Januari 2010 – Desember 2011. Kata kunci: Gambaran histopatologi karsinoma tiroid, daerah tempat tinggalKata kunci: Gambaran histopatologi karsinoma tiroid, daerah tempat tinggalAbstractThyroid carcinoma is the most common endocrine tumor and is increasing in incidence every year. Based on histopathological types, thyroid carcinomas are divided into papillary carcinoma, follicular carcinoma, medullary carcinoma, and anaplastic carcinomas. Factors that can influence the histopathological type of thyroid carcinomas is geographical factor, which follicular and anaplastic type of thyroid carcinomas more frequently found in areas at risk of iodine deficiency than the area not at risk of iodine deficiency.The purpose of this study was to determine the relationship of residential areas with histopathologic types of thyroid carcinoma. This analytic research with observational design obtaining secondary data from Pathology Anatomy Laboratory of Medical Faculty of Andalas University and medical record of M. Djamil Hospital in a period of January 2010 – December 2011. From this reseach, found 102 cases of thyroid carcinoma, of which 32 cases residing in areas at risk of iodine deficiency and 70 cases residing in the area are not at risk of iodine deficiency. In areas at risk of iodine deficiency, 34.4% are follicular and anaplastic carcinomas, and 65.5% are papillary carcinomas. In areas not at risk of iodine deficiency, 22.9% are follicular and anaplastic carcinomas, and 77.1% are papillary carcinomas. Statistical analysis of the relationship of the area at risk of iodine deficiency with follicular and anaplastic carcinoma incidence by chi-square test p value = 0.32.There is no significant correlation between residential areas and histopathological types of thyroid carcinoma of West Sumatera society.Keywords:Histopathological types of thyroid carcinoma, residential areas

In silico analysis of wild-type and mutant KRAS Frengki Frengki; Dedi Prima Putra; Fatma Sriwahyuni; Daan Khambri; Henni Vanda
Pharmaciana Vol 9, No 1 (2019): Pharmaciana
Publisher : Universitas Ahmad Dahlan

The mutations of the KRAS gene at codons 12, 13, and 61 have been widely reported with different prognosis. In silico is one approach to explain the characteristics of the mutant genes. This study aimed to reveal the potential energy and fluctuations of the binding site and active site of wild-type KRAS (KRAS Wt) and mutant KRAS (KRAS Mt) at codons 12, 13, and 61. The samples used in this study were the sequences of KRAS Wt and KRAS Mt genes, which were subjected to in-silico analysis that included molecular homology, docking, and dynamics using MOE, PyMOL, and online CABS servers. The results showed that fluctuations in the binding site of all KRAS Mt were lower than that of KRAS Wt. On the contrary, the active site (switch I and switch II) of KRAS Mt fluctuated more widely than KRAS Wt. The potential energy of KRAS Mt before forming a complex with GTP was higher (p<0.01) than KRAS Wt. After this formation, it remained higher at codons 12 and 61 but lower at codons 11 and 13 (p <0.001). Mt G12A did not show any changes. The higher fluctuations in the switch I and switch II regions and the post energy of KRAS-GTP complexes may explain why types of cancers with mutations at codons 11 and 13 have a better prognosis than those with mutations at codons 12 and 61.

Prediction of diacerein inhibition activity against interleukin-1 receptors through docking method and tracing of pharmacokinetic profiles and their toxicity Frengki Frengki; Vivi Sofia; Deddi Prima Putra; Fatma Sri Wahyuni; Daan Khambri; Henni Vanda
Pharmaciana Vol 10, No 3 (2020): Pharmaciana
Publisher : Universitas Ahmad Dahlan

IL-1 is one of the cytokines involved in joint diseases such as osteoarthritis. IL-1 plays a role in maintaining the balance of proteolytic proteins:MMPs and TIMPs inhibitors. Increased expression and uncontrolled IL-1 activity tend to increase the role of MMPs in degrading proteoglycans and joint tissue collagen. This study aims to reveal the interaction model of one of the osteoarthritis drugs, namely diacerein. A drug belongs to a group of disease-modifying osteoarthritis drugs (DMOADs) to suppressthe development of the disease rate, improving the structure and function of the cartilage and surrounding tissue. "In silico" digital test uses the technique of "molecular docking: used as a method of the approach using the MOE 2007.09 software application. The test material was in the form of a diacerein 3D structure and five control ligands, while the IL-1Î² / IL-1RI receptor template was downloaded from pdb.org (PDB ID: 1ITB). The ligand pharmacokinetic profile will also be displayed obtained through the ADMETSAR server. The docking results showed diacerein had the lowest docking score of -12.3285 kcal/mol with the strongest affinity, the best pharmacokinetic profile but more toxic. This study proves that the mechanism of diacerein inhibition of IL-1Î² / IL-1RI receptors is similar to dexamethasone, prednisolone,and minocycline.

Role of malondialdehyde (MDA) in patients with breast cancer diseases Eti Yerizel; Niki Astria; Daan Khambri
Acta Biochimica Indonesiana Vol. 2 No. 2 (2019): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.v2i2.41

Background: Breast cancer is one of the most common cancers as well as one of the leading causes of cancer mortality in women worldwide. Cancer risk potentially continues to increase because of the many sources of exposure to carcinogenic chemical compounds. Carcinogenic compounds can contribute to free radical formation which might further interact and damage biomolecules such as lipids. Lipid peroxidation will increase malondialdehyde (MDA) levels, triggering gene mutations that leads to cancer. Objective: The purpose of this research was to measure and compare MDA levels between breast cancer patients and control. Methods: This research was observational research using a cross-sectional comparative design of 30 breast cancer patients and 30 healthy controls. The place of this research is in Ropanasuri specialized surgery hospital and biochemical laboratory, Faculty of Medicine, Andalas University, Padang. This research was conducted from August to September 2019. The MDA was measured using a spectrophotometer and an independent T-test was done. Results: The result of this research showed the mean MDA level of breast cancer patients was 3.98 ± 0.35 nmol/ml, higher than controls was 3.04 ± 0.36 nmol/ml with p-value = 0.001. Conclusion: There were significant differences in MDA levels among breast cancer patients and control in Ropanasuri specialized surgery hospital, Padang.

The Relationship of Breast Cancer Subtypes with the Event of Metastasis in Dr. M. Djamil Hospital Padang Ahmad Fakhrozi Helmi; Daan Khambri; Rony Rustam
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 4 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i4.410

Background: One of the high mortality rates from breast cancer is related to the incidence of metastases. It is known that >90% of deaths in breast cancer are related to the incidence of metastases and the complications that follow. Breast cancer is divided into several subtypes based on the expression of receptor genes in breast cancer tissue, namely Luminal A, Luminal B, HER 2 and Triple Negative Breast Cancer (TNBC). This study aims to determine the relationship between breast cancer subtypes and the incidence of metastases in Dr. M. Djamil Padang. Methods: This study used a retrospective case-control study to breast cancer patients with metastatic at Dr M Djamil Hospital, Padang from 2016-2021. The research subjects were 260 breast cancer patients who met the inclusion criteria. The study subjects were divided into 130 patients as the case group with metastases and 130 patients as the control group with no metastases. To determine the relationship between breast cancer subtypes and the incidence of metastases, the chi-square test was used. If the p value <0.05, it can be concluded that it is significant. Furthermore, analysis is continued to obtain an odds ratio (OR) in identifying risk opportunities with Cochran's and Mantle-Haenszel statistics common odds ratio estimate. The data were analysed using the Statistical Package for Social Sciences (SPSS) program. Result: Characteristics of the subjects in this study can be seen that there is a relationship between hormonal contraception, T and N status with the incidence of metastasis (p <0.05). Patients with metastases were more common with breast cancer subtypes luminal B (61.5%), HER2+ (21.5%), TNBC (14.6%) and luminal A (2.3%). The most common locations for breast cancer metastases were lung (48.5%), bone (26.2%), liver (19.2%), brain (5.4%) and other places (0.8%). There was a relationship between breast cancer subtypes and the incidence of metastasis (p<0.038). The highest risk of metastases was in patients with TNBC subtype with OR = 7.74 (95% CI 1.72-34.79). There was no relationship between breast cancer subtypes with metastatic location (p>0.05) and breast cancer subtypes TNBC had a risk (OR) of 9.60 (95% CI 1.96-47.14) times increasing the risk of metastases in brain. Conclusion: It can be concluded that there was a relationship between breast cancer subtypes and the incidence of metastasis

Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Ermawati Ermawati Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Frengki Frengki Hafni Bachtiar Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henny Mulyani henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Nurhayati Nurhayati Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Putra, Fachri Putri, Biomechy Oktomalio Putriyuni, Anandia Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rulli Firmansyah Rustam, Rony Safnita, Dewi Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Sofia Mubarika Sofia Mubarika Haryana Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal tofrizal - tofrizal Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yulia Kurniawati Yusticia Katar Yusticia Katar, Yusticia

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