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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Jurnal Ners Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Cermin Dunia Kedokteran
Daan Khambri
Fakultas Kedokteran, Universitas Andalas
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.189

Abstract

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki Frengki; Deddi Prima Putra; Fatma Sri Wahyuni; Daan Khambri; Henni Vanda; Vivi Sofia
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (855.035 KB) | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method “pharmacokinetics screening and molecular docking”. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Diseksi Kelenjar Inguinal pada Keganasan: Kasus Serial Ari Oktavenra; Daan Khambri; Yopiq Triputra
Cermin Dunia Kedokteran Vol 50 No 8 (2023): Dermatiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i8.1002

Abstract

Latar Belakang: Keganasan pada ekstremitas bawah, kulit penis, vulva/vagina, dan anus berisiko mengalami metastasis KGB inguinal. Diseksi KGB inguinal dapat memberikan hasil disease-free and overall survival yang baik. Tujuan: Melihat hasil pasca-operasi diseksi KGB inguinal pada kasus serial. Cara: Diseksi KGB inguinal dilakukan pada kasus melanoma maligna TxN2bM0, melanoma maligna TxN1M0, dan cutaneous apocrine carcinoma et phenoscrotal T3N1M0. Diskusi: Diseksi KGB inguinal pada kasus keganasan bermetastasis dari ekstremitas bawah, kulit penis, vulva/vagina, dan anus, memberikan hasil disease-free and overall survival yang baik, namun dengan komplikasi pasca-operasi berkurangnya kualitas hidup.   Introduction: Malignancy in lower extremities, penis skin, vulva/vagina, and anus may spread to inguinal lymph node. Inguinal lymph node dissection can provide good disease-free and overall survival results. Objective: To review postoperative results of inguinal lymph node dissection (ILND) in case series. Method: Inguinal lymph node dissection was done in cases of malignant melanoma TxN2bM0, malignant melanoma TxN1M0, and cutaneous apocrine carcinoma er phenoscrotal T3N1M0. Discussion: ILND can improve disease-free and overall survival results in malignancies cases from lower extremities, skin of the penis, vulva/vagina, and anus with metastases, albeit with postoperative complications that can decrease the quality of life.
Hubungan Ekspresi Sodium Iodide Symporter dengan Varian Histopatologi dan Stadium Papillary Thyroid Carcinoma Rini Purnama Sari; yenita - yenita; Noza - Hilbertina; tofrizal - tofrizal; Daan - Khambri; Husna - Yetti
Majalah Kedokteran Andalas Vol 46, No 8 (2024): Online Januari 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i8.p1280-1288.2024

Abstract

Abstrak                                                               Tujuan:  Mengetahui hubungan ekspresi sodium iodide symporter dengan varian histopatologi dan stadium papillary thyroid carcinoma. Metode: Penelitian ini merupakan penelitian observasional dengan pendekatan cross sectional. Sampel penelitian ini adalah kasus papillary thyroid carcinoma dari laboratorium Patologi Anatomi RSUP Dr. M. Djamil Padang periode Januari 2022-Desember 2022 sebanyak 37 kasus. Varian histopatologi papillary thyroid carcinoma dinilai berdasarkan WHO 2017 dan stadium klinis dinilai berdasarkan TNM American Joint Committee on Cancer edisi ke VIII. Ekspresi NIS dinilai melalui pulasan imunohistokimia. Analisis bivariat dilakukan dengan uji Chi-square dengan hasil uji statistik dianggap bermakna jika p < 0,05. Hasil: Penelitian ini menunjukkan ekspresi NIS positif sebesar 13,5%. Analisis statistik menunjukkan adanya hubungan yang bermakna antara ekspresi NIS dengan varian histopatologi papillary thyroid carcinoma (p=0,03). Varian histopatologi tertentu menunjukkan tingkat ekspresi NIS yang lebih tinggi dibandingkan dengan varian lainnya. Namun, penelitian ini tidak menemukan hubungan antara ekspresi NIS dengan stadium papillary thyroid carcinoma (p =0,61). Kesimpulan: Terdapat hubungan antara ekspresi NIS dengan varian histopatologi. Ekspresi NIS tidak berhubungan dengan stadium papillary thyroid carcinoma.Kata kunci: sodium iodide symporter; papillary thyroid carcinoma; varian histopatologi; stadium
The Relationship between Degree of Differentiation with the Incidence of Lymphovascular Infiltration Triple Negative Breast Cancer in West Sumatera Hidayat, Nur Latifah Alfaina; Yenita, Yenita; Khambri, Daan
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.1010

Abstract

Background: The degree of differentiation and the incidence of lymphovascular infiltration in Triple Negative Breast Cancer (TNBC) are several determinants of the prognosis and survival of sufferers. This disease has a more aggressive clinical course than other breast cancer phenotypes. Targeted therapy has not been able to improve survival in TNBC patients. This study aims to analyze the relationship between the degree of differentiation and lymphovascular infiltration in Triple Negative Breast Cancer in West Sumatra. Methods: This is an observational analytic study with a cross-sectional approach. The number of study samples was 44 TNBC patients at the Ropanasuri Special Surgery Hospital, Ibnu Sina Islamic Hospital, and RSUP Dr. M. Djamil, Padang, in 2016–2021. The data studied were the degree of differentiation and lymphovascular infiltration from the results of anatomical pathology examination which were analyzed using the Chi Square test. Results: The most histopathological types in TNBC were Invasive Carcinoma Mammae of No Special Type (79,5%) with the most age range of patients over 60 years (43,2%). The majority of the degrees of differentiation found were grade II (75%), lymphovascular infiltration negative category (65,9%), and there was a significant relationship (p 0,001) between the degree of differentiation and lymphovascular infiltration in TNBC Conclusions: There was a relationship between the degree of differentiation and lymphovascular infiltration in TNBC, namely the higher the histopathological grade of cancer cells, the higher the probability of experiencing lymphovascular infiltration.
Perbedaan Kadar Hormon Estradiol Berdasarkan Riwayat Penggunaan Kontrasepsi Oral Pada Wanita Kanker Payudara dan Tidak Kanker Payudara Sari, Nirmala; Khambri, Daan
Jurnal Ilmiah Kebidanan Indonesia Vol 13 No 03 (2023): Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Uni
Publisher : Q PRESS

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33221/jiki.v13i03.2083

Abstract

Secara nasional kejadian kanker payudara menduduki urutan pertama dalam 10 tahun terakhir sampai tahun 2016. Kadar estradiol yang tinggi dan paparan estrogen dalam waktu lama memiliki peran yang cukup tinggi, salah satunya penggunaan kontrasepsi oral. Tujuan dari penelitian ini adalah mengetahui perbedaan kadar hormone estradiol berdasarkan riwayat penggunaan kontrasepsi oral pada wanita kanker payudara dan tidak kanker payudara. Penelitian ini menggunakan metode case control dengan jumlah populasi 36 wanita postmenopause kanker payudara dan 36 wanita postmenopause tidak kanker payudara. Hasil penelitian didapatkan tidak terdapat hubungan signifikan antara riwayat penggunaan kontrasepsi oral dengan kadar hormone estradiol pada kelompok kanker payudara dan tidak kanker payudara. Penggunaan kontrasepsi oral sebaiknya dibawah pengawasan tenaga kesehatan, untuk meminimalisir risiko kanker payudara. Konseling pra pemilihan alat kontrasepsi harus dilakukan oleh tenaga kesehatan, sesuai dengan rencana strategis BKKBN dalam “Strategis Pelaksanaan Program Keluarga Berencana Berbasis Hak untuk Percepatan Akses terhadap Pelayanan Keluarga Berencana dan Kesehatan Reproduksi yang Terintegrasi dalam Mencapai Tujuan Pembangunan Indonesia” yang salah satunya tentang tersedianya sistem penyediaan pelayanan KB yang merata dan berkualitas di sektor pemerintah dan swasta untuk menjamin agar setiap warga negara dapat memenuhi tujuan reproduksinya.
KEPATUHAN MEMINUM OBAT ADJUVAN HORMONAL PADA PASIEN KANKER PAYUDARA DI RSUP DR. M. DJAMIL PADANG PADA MASA PANDEMI COVID-19 Ari Yanto Wijaya; Daan Khambri; Yusticia Katar; Wirsma Arif Harahap; Biomechy Oktomalio Putri; Elfira Yusri
Medic Nutricia : Jurnal Ilmu Kesehatan Vol. 9 No. 1 (2024): Medic Nutricia : Jurnal Ilmu Kesehatan
Publisher : Cahaya Ilmu Bangsa Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5455/nutricia.v9i1.6631

Abstract

Latar Belakang: Beberapa studi telah menunjukkan bahwa kepatuhan menjalani terapi adjuvan hormonal oral mampu meningkatkan survival rate pada pasien kanker payudara dengan ER+ atau PR+. Munculnya pandemi COVID-19 di awal tahun 2020 dapat mempengaruhi kepatuhan pasien karena masyarakat tidak bisa beraktivitas seperti biasanya. Objektif: Tujuan penelitian adalah mengetahui kepatuhan meminum obat adjuvan hormonal pada pasien kanker payudara di RSUP Dr. M. Djamil Padang pada masa pandemi COVID-19.Metode: Penelitian merupakan studi observasional dengan desain penelitian potong-lintang (cross sectional). Studi penelitian ini diikuti oleh 75 responden. Kepatuhan dinilai menggunakan Medication Posession Rate (MPR) dan kuesioner MMAS-8 yang telah dimodifikasi. Profil sosiodemografi dan klinis responden diperoleh melalui wawancara di Poliklinik Bedah, Sub Divisi Bedah Onkologi menggunakan kuesioner terstruktur dan pengamatan rekam medis responden.Hasil: Kepatuhan pasien adalah sebesar 93.3% (70 dari 75 pasien). Hasil analisis bivariat menunjukkan faktor ekonomi memiliki hubungan signifikan dengan kepatuhan terapi. Kesimpulan: Kepatuhan meminum obat yang tinggi pada pasien kanker payudara di RSUP Dr. M. Djamil Padang dan direkomendasikan untuk memberikan perhatian lebih terhadap pasien berpendapatan rendah
Reproductive function after radioactive iodine treatment for differentiated thyroid carcinoma patients: a systematic review Elliyanti, Aisyah; Aziza, Zulva; Kurniawati, Yulia; Khambri, Daan; Amir, Arni; Katar, Yusticia
Medical Journal of Indonesia Vol. 34 No. 1 (2025): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257458

Abstract

BACKGROUND Thyroid cancer is one of the most prevalent cancers in the endocrine system, with a rapidly rising incidence over the past 3 decades. Treatment for patients with differentiated thyroid cancer (DTC) typically includes surgery, radioactive iodine (I-131) therapy, and levothyroxine (L-T4) suppressive therapy. This study aimed to explore the potential side effects of I-131 therapy on reproductive function in men and women with DTC. METHODS A literature search was performed using 4 databases (PubMed, ScienceDirect, BioMed Central, and Google Scholar), limited to English publications since 2013. Clinical trials and observational studies that evaluated I-131 in DTC, focused on reproductive-age patients, and included pre-therapy or during-therapy examinations, administered doses, and treatment frequencies of I-131 were selected. The Joanna Briggs Institute Critical Appraisal Checklist is used as a comprehensive evaluation tool, and the literature quality was categorized as high, moderate, and low. RESULTS The final 17 articles examined the effect of I-131, with 13 focusing on women's reproductive function and 4 on men's. Women who received I-131 therapy can lower anti-Mullerian hormone levels and disrupt menstrual cycles within the first year, and it does not affect subsequent pregnancies. For men, the therapy led to elevated levels of follicle-stimulating hormone and luteinizing hormone, along with changes in sperm quantity, morphology, and motility, which tend to normalize within a year post-therapy. CONCLUSIONS The reproductive side effects associated with I-131 therapy are generally transient, with most individuals experiencing a return to normal within 1 year following treatment.
Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris
Cermin Dunia Kedokteran Vol 49 No 1 (2022): Bedah
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.189

Abstract

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.
Diseksi Kelenjar Inguinal pada Keganasan: Kasus Serial Ari Oktavenra; Daan Khambri; Yopiq Triputra
Cermin Dunia Kedokteran Vol 50 No 8 (2023): Dermatiologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v50i8.1002

Abstract

Latar Belakang: Keganasan pada ekstremitas bawah, kulit penis, vulva/vagina, dan anus berisiko mengalami metastasis KGB inguinal. Diseksi KGB inguinal dapat memberikan hasil disease-free and overall survival yang baik. Tujuan: Melihat hasil pasca-operasi diseksi KGB inguinal pada kasus serial. Cara: Diseksi KGB inguinal dilakukan pada kasus melanoma maligna TxN2bM0, melanoma maligna TxN1M0, dan cutaneous apocrine carcinoma et phenoscrotal T3N1M0. Diskusi: Diseksi KGB inguinal pada kasus keganasan bermetastasis dari ekstremitas bawah, kulit penis, vulva/vagina, dan anus, memberikan hasil disease-free and overall survival yang baik, namun dengan komplikasi pasca-operasi berkurangnya kualitas hidup.   Introduction: Malignancy in lower extremities, penis skin, vulva/vagina, and anus may spread to inguinal lymph node. Inguinal lymph node dissection can provide good disease-free and overall survival results. Objective: To review postoperative results of inguinal lymph node dissection (ILND) in case series. Method: Inguinal lymph node dissection was done in cases of malignant melanoma TxN2bM0, malignant melanoma TxN1M0, and cutaneous apocrine carcinoma er phenoscrotal T3N1M0. Discussion: ILND can improve disease-free and overall survival results in malignancies cases from lower extremities, skin of the penis, vulva/vagina, and anus with metastases, albeit with postoperative complications that can decrease the quality of life.
Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Erlina Rustam Ermawati Ermawati Ermawati Ermawati Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Frengki Frengki Frengki Frengki, Frengki Gautama, Made Satya Nugraha Hafiz, Muhammad Zaki Abdul Hafni Bachtiar Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Mulyani henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Maisa, Esthika Ariany Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Nindita, Priska Audina Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Nurhayati Nurhayati Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Prima Astuti Handayani Putra, Fachri Putri, Biomechy Oktomalio Putri, Fillia Putriyuni, Anandia Raden Mohamad Herdian Bhakti Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rulli Firmansyah Rustam, Rony Safnita, Dewi Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Sofia Mubarika Sofia Mubarika Haryana Sonar Soni Panigoro Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suchitra, Avit Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal tofrizal - tofrizal Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia Vivi Sofia Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yusticia Katar Yusticia Katar, Yusticia