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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Jurnal Ners Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan Cermin Dunia Kedokteran

Daan Khambri

Fakultas Kedokteran, Universitas Andalas

Author-ID : 3367697

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Association of Early Drain Removal with Formation of Seroma in Breast Cancer Patients After Modified Radical Mastectomy Ramadanus; Daan Khambri; Wirsma Arif Harahap
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 7 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i7.544

Background: The installation of drainage after MRM surgery has been aimed at reducing seroma formation. However, when the drain should be removed has not been studied well. This study aims to determine the association of early drain removal with seroma formation. Methods: A nested cohort study was conducted on 40 breast cancer patients undergoing MRM surgery. Patients were divided into 2 groups; off-drain day I and day III post-surgery. Seroma formation was assessed 7 days after the patient was discharged. Results: Seroma formation seven days after discharge occurs in 25 of the total 40 patients (62.5%). There was no difference in seroma incidence between groups of patients on the off-drain day I and day III seven days after discharge (65% vs. 60%) (p 1,000) or the number of seromas (157.31 +120.00 ml vs. 149.58 + 110.00 ml) (p 0.437). Conclusion: Removing the drain faster does not reduce the incidence and number of seromas seven days after discharge.

KEJADIAN DEMAM NEUTROPENIA PADA PASIEN KANKER PAYUDARA YANG MENDAPAT KEMOTERAPI Rulli Firmansyah; Daan Khambri; Edison Edison; Zelly Dia Rofinda
Majalah Kedokteran Andalas Vol 38, No 1 (2015): Published in May 2015
Publisher : Faculty of Medicine, Universitas Andalas

AbstrakKemoterapi memiliki peranan penting dalam penatalaksanaan kanker payudara. Obat ini bekerjamembunuh sel-sel kanker, namun dapat juga menghancurkan sel-sel sehat termasuk sel darahsehingga dapat menyebabkan neutropenia. Penelitian ini bertujuan untuk mengetahui kejadiandemam neutropenia pada pasien kanker payudara yang mendapat kemoterapi. Jenis penelitianini adalah obsevasional dengan desain cross sectional study. Jumlah sampel sebanyak 98 orangpenderita kanker payudara yang menjalani kemoterapi di RSUP Dr. M Djamil Padang.Pemeriksaan yang dilakukan adalah differential count dan suhu tubuh oral, kemudian dilakukananalisis statistik dengan uji non parametrik. Kejadian demam neutropenia ditemukan pada 10pasien (10,2%), dimana didapatkan hubungan yang bermakna antara regimen kemoterapidengan kejadian demam neutropenia (p=0,028), dan tidak terdapat hubungan yang bermaknaantara kejadian demam neutropenia dengan umur pasien (p=0,683) serta setting kemoterapi(p=0,631). Hubungan antara kejadian demam neutropenia dengan siklus kemoterapi tidak dapatdianalisis secara statistik. Penelitian ini dapat disimpulkan bahwa regimen kemoterapi non FACmeningkatkan resiko kejadian demam neutropenia pada pasien kanker payudara yangdikemoterapi.AbstractChemotherapy has an important role in breast cancer management. Chemotherapy works bykilling cancer cells in the body. However, healthy cells including blood cells are also destroyedleading to a condition called neutropenia. This study aimed to determine the incidence ofneutropenia febrile in patients with breast cancer who received chemotherapy in thechemotherapy unit of Dr. M. Djamil Padang Hospital. This study was a cross-sectional study of98 samples. Leucosite differential count and oral body temperature were examined and wereanalyzed with non parametric test. Neutropenia febriles were found on 10 out of 98 patients(10.2%). There was a significant association found between chemotherapy regimen and theincidence of neutropenia febrile (p=0.028), however, there were no significant associationbetween the incidence of neutropenia febrile with patient’s age (p=0.683) and the setting ofchemotherapy (p=0.631). While the correlation between the incidence of neutropenia febrile andchemotherapy cycle can not be statistically analyzed. It is concluded that chemotherapy causesincidence of neutropenia febrile at 10.2% patient. Non FAC chemotherapy regimens increasesthe risk of neutropenia febrile in patients with breast cancer patient receiving chemotherapy.

PERAN TERAPI HORMONAL PADA KANKER PAYUDARA Daan Khambri
Majalah Kedokteran Andalas Vol 38 (2015): Supplement 1 | Published in September 2015
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (98.422 KB)

PERAN TERAPI HORMONAL PADA KANKER PAYUDARA

HUBUNGAN EKSPRESI Ki-67 DENGAN KARAKTERISTIK HISTOPATOLOGIK PADA KANKER PAYUDARA TRIPEL NEGATIF Aswiyanti Asri; Pamelia Mayorita; Daan Khambri
Majalah Kedokteran Andalas Vol 38, No 3 (2015): Published in December 2015
Publisher : Faculty of Medicine, Universitas Andalas

Kanker payudara triple negative mempunyai prognosis paling buruk. Ki-67, derajat diferensiasi dan invasi limfovaskular (LVI) adalah parameter prognostik patomolekuler, dimana Ki-67 juga dipakai sebagai prediktor respon terapi. Penelitian ini bertujuan untuk mengetahui hubungan derajat diferensiasi dan LVI dengan ekspresi Ki-67 pada kanker payudara tripel negatif. Sembilan belas kasus kanker payudara tripel negatif dikumpulkan dan direview ulang derajat diferensiasi dan LVI. Hasil pemeriksaan Ki-67 dikelompokkan dimana ≤10 % sampai 29 % ekspresi rendah-sedang; dan >30% ekspresi tinggi. Hubungan antara ekspresi Ki-67 dengan derajat diferensiasi dan invasi limfovaskular dianalisis menggunakan Chi Square. Dari 19 kasus kanker payudara tripel negatif, 52,6 % kasus mempunyai derajat diferensiasi tinggi dan sisanya derajat diferensiasi rendah. Invasi limfovaskular ditemukan positif pada 68,4% kasus. Ekspresi Ki-67 yang tinggi hanya ditemukan pada 1 kasus. Uji statistik antara ekspresi Ki-67 dengan derajat diferensiasi maupun dengan invasi limfovaskular tidak ditemukan hubungan yang bermakna. Tidak ditemukan korelasi antara ekspresi Ki-67 dengan derajat diferensiasi dan invasi limfovaskular pada kanker payudara tripel negatif.

Evaluasi Terapi Adjuvant Hormonal Dan Hubungannya Terhadap Outcome Klinis Pasien Kanker Payudara Stadium Dini Di Kota Padang wessi windrasari; Fatma Sri Wahyuni; Daan Khambri
Jurnal Sains Farmasi & Klinis Vol 5, No 3 (2018): J Sains Farm Klin 5(3), Desember 2018
Publisher : Fakultas Farmasi Universitas Andalas

Terapi adjuvant hormonal merupakan pilihan terapi yang efektif bagi pasien kanker payudara stadium dini dengan hormonal responsif dan Her-2 negatif. Outcome klinis dari terapi kanker payudara adalah Disease Free Survival (DFS), Overall Survival (OS). Penelitian ini bertujuan mengevaluasi terapi adjuvant hormonal dan pengaruhnya terhadap outcome klinis pasien. Penelitian ini merupakan penelitian deskriptif dengan desain cross sectional study menggunakan data retrospektif registrasi kanker payudara Persatuan Ahli Bedah Onkologi Indonesia (PERABOI) Kota Padang selama periode 2008-2017. Analisis data menggunakan Kaplan Meier Analysis dengan Log rank. Diperoleh sebanyak 58 orang pasien yang memenuhi kriteri inklusi, dengan rerata umur yaitu 49,41 ± 8,69 tahun, kejadian relaps 22,4% dan sebanyak 6,9% pasien mengalami kematian. Terapi terbanyak pada pasien premenopause adalah tamoxifen (58,3%), pada pasien pascamenopause adalah Aromatase Inhibitor (54,5%). Secara statistik pada pasien premenopause tidak ada pengaruh terapi adjuvant hormonal yang berbeda terhadap DFS (P log rank test 0,243 dan HR = 0.513) dan OS (P log rank test 0,545 dan HR = 0.314). Pada pasien pascamenopause tidak ada pengaruh terapi yang berbeda terhadap DFS (P log rank test 0,586 dan HR = 0,10) dan OS (P log rank test 0,594 dan HR = 0,12).

Karakteristik Penderita Kanker Payudara dengan Metastasis Jauh Tunggal di Kota Padang Tahun 2014-2018 Muhammad Reno Akhyar Marpaung; Daan Khambri; Asterina Asterina
Jurnal Ilmu Kesehatan Indonesia Vol 2 No 1 (2021): Maret 2021
Publisher : Fakultas Kedokteran, Universitas Andalas

Introduction: Breast cancer is the most common malignancy in women. Distant metastases are the main cause of death in breast cancer. Objective : To determine the characteristics of breast cancer sufferers with distant metastases. Method: This study is descriptive study with cross-sectional design. The sample of this study were all breast cancer patients with single distant metastases in RSI Ibnu Sina and RSK Ropanasuri Surgery Padang in 2014-2018 with a minimum sample is 97. The research instruments used were medical records and breast cancer registration sheets. Results: The results of this study found 136 cases of breast cancer with the most distant metastases to the lungs 42%, bones 33%, liver 12%, brain 8%, and other organs 5%. The mean age of patients was 47.5 years, with the most histopathological type, namely IDC 63.2%. Mostly education level was high 41.9%. Most examination of body mass index was overweight / obese 64.7%. According to menarche history was normal 79.4%. Based on the examination, the most tumor size that was T4 52.9% and the most nodule size was N1 50.7% with the most molecular subtypes was Luminal A as much as 34.6%. Conclusion: Most breast cancer with distant metastasis goes to lungs.

Risk Factor Analysis Of Fibroadenoma Mammae In Adolescent Girls In 2021 Afrinita Eka Fitri; Daan Khambri; Afriwardi
Science Midwifery Vol 10 No 2 (2022): April: Science Midwifery
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Breast tumor is one type of tumor found in the breast and most often attacks women. Based on a report from the New South Wales Breast Center Institute in the United States, Fibroadenoma mammae usually occurs in adolescent girls, namely at the age of 21-25 years. Less than 5% of Fibroadenoma mammae occurs at the age above 50 years and the prevalence is more than 29% of women affected by Fibroadenoma mammae in the world. The study was conducted in Padang from August - September 2021 with the design used was Case Control with a total sample of 94 respondents divided into two groups, namely 47 respondents in the case group experiencing Fibroadenoma mammae and 47 respondents in the control group not experiencing Fibroadenoma mammae. The data used were primary data and secondary data. Data were presented univariately and bivariately by using the chi-square test. The results showed that there was a significant relation between age at menarche with p value = 0.013 (p < 0.05) and OR = 4.336, family history p value = 0.036 (p < 0.05) and OR = 2.679 and lifestyle p = 0.007 (p < 0.05). 0.05) and OR = 3.531 with the incidence of Fibroadenoma mammae. The conclusion of this study is that there was a relation among age at menarche, family history, and lifestyle with the incidence of Fibroadenoma mammae. It is suggested that adolescents should pay more attention on their lifestyle, especially those related to the triggers of Fibroadenoma mammae..

Lepas Drain Dini Terhadap Kualitas Hidup Pasien Kanker Payudara Pasca Operasi Modified Radical Mastectomy (MRM) Ramadanus Ramadanus; Daan Khambri; Wirsma Arif Harahap
JURNAL KESEHATAN PERINTIS Vol 7 No 1 (2020): JUNI 2020 : Jurnal Kesehatan Perintis (Perintis's Health Journal)
Publisher : LPPM UNIVERSITAS PERINTIS INDONESIA

Pemasangan drain setelah operasi Modified Radical Mastectomy (MRM) bertujuan untuk mengurangi pembentukan seroma, namun di sisi lain dapat menyebabkan nyeri dan ketidaknyamanan serta mempengaruhi kualitas hidup pasien. Belum ada penelitian di Indonesia mengenai kapan sebaiknya drain dilepas dan bagaimana hubungannya dengan kualitas hidup pasien. Penelitian ini bertujuan mengetahui hubungan lepas drain dini dengan kualitas hidup pasien pasca operasi MRM; Penelitian ini merupakan penelitian nested cohort pada 40 pasien kanker payudara yang menjalani operasi MRM. Pasien dibagi atas 2 kelompok; lepas drain hari I dan hari III pasca operasi. Semua pasien dipulangkan pada hari III. Dilakukan penilaian kualitas hidup pasien 7 hari setelah pasien dipulangkan menggunakan Kuesioner EORTC QLQ-C30 meliputi skala gejala, skala fungsi dan skala kesehatan secara umum. Skor skala gejala kelompok pasien lepas drain hari I lebih rendah dan berbeda bermakna daripada hari III (7,75±3,19 vs 11,25±3,58) (p 0,002) namun tidak berbeda bermakna pada skala fungsional (86,50±3,03 vs 86,35±2,86) (p 0,869) dan kualitas hidup secara umum (72,92±10,06 vs 71,67±8,29) (p 0,671). Terdapat hubungan bermakna lepas drain dini dengan kualitas hidup pasien dalam skala gejala. Kualitas hidup pasien lepas drain hari I lebih baik daripada lepas drain hari III.

Metilasi Promoter Gen BRCA1 dan Pengaruhnya terhadap Karakteristik Kanker Payudara Premenopausal Sporadik Etnis Minang Wirsma Arif Harahap; Daan Khambri; Dessy Arisanty; Yanwirasti -; Sofia Mubarika
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i3.1031

Karsinoma payudara sporadik merupakan kanker yang paling sering pada wanita premenopause etnis Minang. Terdapat perbedaan faktor risiko dan karakteristik tumor jika dibandingkan dengan pasien Kaukasian. Diduga faktor metilasi pada promoter BRCA1 berperan dalam kejadian ini. Penelitian ini bertujuan untuk mendeskripsikan kejadian metilasi promoter gen BRCA1 pada pasien kanker payudara premenopause sporadik etnis Minang. Penelitian menggunakan metoda deskriptif analitik pemeriksaan metilasi dengan teknik Bisulfit PCR pada promoter gen BRCA1 pada 43 jaringan kanker payudara sporadik usia premenopause etnis Minang yang diobati di RS M Jamil Padang. Faktor prognosis yang diperiksa adalah stadium, gradasi tumor, indeks mitosis, dan pemeriksaan imunohistokimia (Er,Pr,HER2,Ki67). Didapatkan 35 pasien kanker payudara yang memenuhi syarat, dengan perincian: 17,2% stadium II, 71,4% stadium III, dan 11,4% stadium IV. Subtipe adalah Luminal A 16 orang (17,1%), Luminal B 9 orang (25,7 %), HER2 3 orang (8,6%) dan TNBC 17 orang (48,6%). Metilasi pada jaringan kanker didapatkan pada 21 pasien (60 %). Metilasi berhubungan dengan derajat proliferasi tinggi (Ki67 >14%), stadium lanjut, dan subtipe jenis TNBC. Kanker payudara dengan metilasi pada promoter gen BRCA1 memiliki prognosis lebih buruk. Perlu penelitian lebih lanjut untuk melihat dampak klinis obat anti-metilasi pada penderita KPD dengan metilasi pada promoter BRCA1. Sporadic breast carcinoma is the most common cancer among premenopausal Minang ethnic women. There are differences of risk factors and tumor characteristics compared with Caucasian patients. It was assumed that promoter methylation in BRCA1 plays a role in this differences. This descriptive analytic study aimed to describe the incidence of promoter methylation in the BRCA1 gene in sporadic premenopausal ethnic Minang breast cancer patients. This research used methylation with bisulfate PCR technique method in the BRCA1 promoter in 43 sporadic premenopausal ethnic Minang breast cancer patients at M Djamil Hospital Padang. Stage, tumor grading, mitotic index, and immunohistochemical examination (Er, Pr, HER2, Ki67) are examined prognostic factor. Among eligible 35 breast cancer patients, 17.2% are stage II, 71.4% are stage III and 11.4% are stage IV. Cancer subtypes were Luminal A in 16 patients (17.1%), Luminal B in 9 patients (25.7%), HER2 in 3 patients (8.6%), and TNBCin 17 patients (48.6%). Methylation in cancer tissue was found in 21 patients (60%). Methylation associated with a high degree of proliferation (Ki67>14%), advanced stage and type of TNBC subtypes. Breast cancer with promoter methylation in the BRCA1 gene have a worse prognosis. Further research is needed to study the clinical impact of antimethylation in breast cancer patients with BRCA1 promoter methylation.

Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza .; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris .
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.1645

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.

Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Erlina Rustam Ermawati Ermawati Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Fillia Putri Firdawati Firdawati Frengki Frengki Frengki Frengki, Frengki Hafiz, Muhammad Zaki Abdul Hafni Bachtiar Hanum, Fathiya Juwita Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda henny Mulyani Henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Made Satya Nugraha Gautama Maisa, Esthika Ariany Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Nindita, Priska Audina Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Nurhayati Nurhayati Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Putra, Fachri Putri, Biomechy Oktomalio Putriyuni, Anandia Raden Mohamad Herdian Bhakti Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rizanda Machmud Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rufi'i Rulli Firmansyah Rustam, Rony Safnita, Dewi Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Soehartati Gondhowiardjo Sofia Mubarika Sofia Mubarika Haryana Sonar Soni Panigoro Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suchitra, Avit Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal Tofrizal Tofrizal Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yusticia Katar Yusticia Katar, Yusticia

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