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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Cermin Dunia Kedokteran

Daan Khambri

Fakultas Kedokteran, Universitas Andalas

Author-ID : 3367697

Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Metilasi Promoter Gen BRCA1 dan Pengaruhnya terhadap Karakteristik Kanker Payudara Premenopausal Sporadik Etnis Minang Wirsma Arif Harahap; Daan Khambri; Dessy Arisanty; Yanwirasti -; Sofia Mubarika
Cermin Dunia Kedokteran Vol 42, No 3 (2015): Nyeri
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v42i3.1031

Karsinoma payudara sporadik merupakan kanker yang paling sering pada wanita premenopause etnis Minang. Terdapat perbedaan faktor risiko dan karakteristik tumor jika dibandingkan dengan pasien Kaukasian. Diduga faktor metilasi pada promoter BRCA1 berperan dalam kejadian ini. Penelitian ini bertujuan untuk mendeskripsikan kejadian metilasi promoter gen BRCA1 pada pasien kanker payudara premenopause sporadik etnis Minang. Penelitian menggunakan metoda deskriptif analitik pemeriksaan metilasi dengan teknik Bisulfit PCR pada promoter gen BRCA1 pada 43 jaringan kanker payudara sporadik usia premenopause etnis Minang yang diobati di RS M Jamil Padang. Faktor prognosis yang diperiksa adalah stadium, gradasi tumor, indeks mitosis, dan pemeriksaan imunohistokimia (Er,Pr,HER2,Ki67). Didapatkan 35 pasien kanker payudara yang memenuhi syarat, dengan perincian: 17,2% stadium II, 71,4% stadium III, dan 11,4% stadium IV. Subtipe adalah Luminal A 16 orang (17,1%), Luminal B 9 orang (25,7 %), HER2 3 orang (8,6%) dan TNBC 17 orang (48,6%). Metilasi pada jaringan kanker didapatkan pada 21 pasien (60 %). Metilasi berhubungan dengan derajat proliferasi tinggi (Ki67 >14%), stadium lanjut, dan subtipe jenis TNBC. Kanker payudara dengan metilasi pada promoter gen BRCA1 memiliki prognosis lebih buruk. Perlu penelitian lebih lanjut untuk melihat dampak klinis obat anti-metilasi pada penderita KPD dengan metilasi pada promoter BRCA1. Sporadic breast carcinoma is the most common cancer among premenopausal Minang ethnic women. There are differences of risk factors and tumor characteristics compared with Caucasian patients. It was assumed that promoter methylation in BRCA1 plays a role in this differences. This descriptive analytic study aimed to describe the incidence of promoter methylation in the BRCA1 gene in sporadic premenopausal ethnic Minang breast cancer patients. This research used methylation with bisulfate PCR technique method in the BRCA1 promoter in 43 sporadic premenopausal ethnic Minang breast cancer patients at M Djamil Hospital Padang. Stage, tumor grading, mitotic index, and immunohistochemical examination (Er, Pr, HER2, Ki67) are examined prognostic factor. Among eligible 35 breast cancer patients, 17.2% are stage II, 71.4% are stage III and 11.4% are stage IV. Cancer subtypes were Luminal A in 16 patients (17.1%), Luminal B in 9 patients (25.7%), HER2 in 3 patients (8.6%), and TNBCin 17 patients (48.6%). Methylation in cancer tissue was found in 21 patients (60%). Methylation associated with a high degree of proliferation (Ki67>14%), advanced stage and type of TNBC subtypes. Breast cancer with promoter methylation in the BRCA1 gene have a worse prognosis. Further research is needed to study the clinical impact of antimethylation in breast cancer patients with BRCA1 promoter methylation.

Rekonstruksi Pectoralis Major Myocutaneuos Flap untuk Defek Operasi Kanker Tiroid Oktahermoniza .; Heldrian Dwinanda Suyuthie; Ari Oktavenra; Sondang Nora; Daan Khambri; Wirsma Arif Harahap; Rony Rustam; Azamris .
Cermin Dunia Kedokteran Vol 49, No 1 (2022): Bedah
Publisher : PT. Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v49i1.1645

Latar Belakang: Pembedahan kanker daerah kepala dan leher umumnya menimbulkan defek luas dan biasanya memerlukan flap. Meskipun free flap saat ini merupakan gold standard untuk rekonstruksi daerah kepala leher, pectoralis major myocutaneous flap (PMMC) masih digunakan. Kasus: Perempuan usia 47 tahun, dengan kanker tiroid papiler T4aN0M0 dengan ulserasi di kulit leher, menjalani tiroidektomi total dan defek operasi direkonstruksi dengan pectoralis major myocutaneous flap. Hasil rekonstruksi dapat diterima secara fungsional dan estetik. Tidak ada komplikasi hematom ataupun abses post operasi. Simpulan: Pectoralis major myocutaneous flap masih merupakan salah satu metode utama untuk rekonstruksi operasi kepala leher dan dapat diterima secara fungsional dan estetik jika free flap tidak dapat dilakukan. Background: Surgery for head and neck cancer generally leaves a wide defect that usually needed a flap. Although free flap is currently the gold standard for reconstruction of the head and neck, the pectoralis major myocutaneous flap is still popularly used. Case: A 47-year old female with thyroid carcinoma, underwent total thyroidectomy and the surgical defect was reconstructed with pectoralis major myocutaneous flap. The results were viable, functional, and aesthetically acceptable. No postoperative complications such as hematoma or abscess observed. Conclusion: Pectoralis major myocutaneous flap was still one of the main methods for head and neck reconstruction surgery.

Small Cell Neuroendocrine Carcinoma in Head and Neck Sondang Nora Harahap; Daan Khambri
Indonesian Journal of Cancer Vol 15, No 4 (2021): December
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Poorly differentiated neuroendocrine carcinomas (NECs) originating from the eye are rare and very highly malignant diseases with a poor prognosis. Small cell NEC of the head and neck is a rare disease and highly aggressive. Early recognition and treatment are crucial for reducing morbidity and mortality. Case Presentation: A 19-year-old male visited our oncology surgery outpatient department due to the progressive neck mass enlargement originating from the eye. The patient was previously diagnosed with invasive choroid malignant melanoma of the left eye which had metastasized to the lymph nodes of the left neck. He underwent a surgical removal/exenteration of the left eye. The result showed that the patient’s survival with poorly differentiated tumors was about 14% while patients with well-differentiated NEC had a survival rate of 34%. It also indicates that the prognosis of these tumors is very poor with a total of over 90% of patients having distant metastatic disease. Histopathological examination showed the tumor tissue and its immunohistochemistry with positive streaks of CD56, NSE, Synaptophysin, and Ki67 suggested small cell NEC.Conclusions: it is crucial to establish an early diagnosis of these tumors to reduce morbidity and mortality. No optimal treatment for such disease has yet been established.

Trichilemmal Carcinoma on the Head (Surgical Challenge to Achieve Free Margin): A Case Report Daan Khambri
Indonesian Journal of Cancer Vol 16, No 1 (2022): March
Publisher : National Cancer Center - Dharmais Cancer Hospital

Introduction: Trichilemmal carcinoma is a rare tumor derived from the outer hair sheath. It usually appears on the face, ears, neck, scalp, and sun-exposed areas. It generally occurs in patients older than 50 years old, and there is no sex predilection to this disease.Case Presentation: A 60-year-old woman came with a complaint of a lump in the head that often bled. The size of the lump was approximately like a bean seed and broke when she combed her hair. The lump was getting bigger within a year and easier to bleed. She often felt pain. Based on the history of surgery 2 months ago, the examination implies that the patient had trichilemmal carcinoma.Conclusions: Trichilemmal carcinoma generally occurs in the elderly category. Although trichilemmal carcinoma has a benign clinical course and local recurrence cases are uncommon, sufficient free margin and immediate reconstruction are challenging if the predilection is in the head and neck. Surgical excision is the recommended treatment for this disease

Factors Related to Patient Satisfaction Level of Thyroid Tumor on PostOperative Thyroidectomy Scar Based on Patient Scar Assessment Scale (PSAS) in General Hospital Dr. M. Djamil Padang Defri Heryadi; Daan Khambri; Rony Rustam
Biomedical Journal of Indonesia Vol. 7 No. 1 (2021): Vol 7, No 1, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i1.277

Introduction : Dr. M. Djamil Padang General Hospital (RSUP) still applies conventional methods as thyroidectomy treatment. Satisfaction and comfort to the scar is one of the issues because conventional thyroidectomy surgery scars are located in the neck area that will affect the confidence of patients, especially women. Method: This research was a quantitative research using cross sectional study design. The research was conducted at The Oncology Surgery Polyclinic of RSUP Dr.M. Djamil Padang with a sample of 50 respondents. Result: More than half of thyroid tumor patients found were women (56%), most patients had total thyroidectomy surgery (70%) with malignan tumor type (72%), and the most tumor size in the T4 group (52%). The average age of patients during surgery was 54.26 years. The average patient satisfaction score for post-thyroidectomy scars was 14.72 with a total score of 16, the lowest score was 6 and the highest score was 22. Significant relationships were found in variable tumor size (p= 0.000), type of surgery (p= 0.005), tumor type (p=0.004) and gender (p = 0.028), while there was no statistically significant relationship between age and patient satisfaction with postthyroidectomy scars (p=0,176). Conclusion: There were significant relationships between gender, type of surgery, type of tumor, tumor size to patient satisfaction with post-thyroidectomy scars, while age has no signifacnt relationship to patient satisfaction with post-thyroidectomy scars. A small number of PSAS score showed that the average patient was satisfied with post-thyroidectomy scar.

Glandula Tiroid Problem: Literature Review Muhammad Zaki Abdul Hafiz; Daan Khambri
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.295

Thyroid cancer is the most common endocrine system neoplas m . Based on the "Pathologycal Based Registration" in Indonesia, thyroi d cancer is a cancer with the highest incidence in the ninth rank. According to statistics from the National Cancer Institute (NCI), the incidence of thyroid cancer in men is about 2.5 per 100.000 population and women around 6.7 per 100.000 populati on. Thyroi d cancer can affect all age groups and the frequency increases afte r the age of 50 years. Only about 5% can affect the age of 15-20 years. NCI also states that this thyroid cancer can affect 16.000 people pe r year. Diagnosis is important to improve the quality of life for sufferers. Clinical diagnosis is the basis for determining furthe r management, so that knowledge and skills are needed in determining the diagnosis. The first treatment for a cancer is the best chance for the patient to achieve optimal cure rates, as is the case for thyroid cancer.

Giant Lipoma of The Breast: Special Clinical Finding Muhammad Zaki Abdul Hafiz; Daan Khambri; Anandia Putriyuni
Biomedical Journal of Indonesia Vol. 7 No. 2 (2021): Vol 7, No 2, 2021
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bji.v7i2.296

Lipomas are the most common benign tumors of mesenchymal origin. Lipoma of breast is somewhat difficult to diagnose clinically because of fatty consistency of breast. Giant lipoma is the mass of lipoma that exceeds at least 10 cm in one dimension or weighs a minimum of 1000 gr.Only very few case reports giant lipoma of the breast available in literature because rarity in size and location. Due to the fatty composition of the breast, difficulties in diagnosis, threatment, and reconstruction are often encountered.Presently, we have reported a case of this rare entity in 49 years old female with giant tumor of the left breast that most of its mass, causing breast asymmetry and feel heavy. The operative finding: looks like lipoma between pectoralis major muscle and pectoralis minor muscle with a diameter of 31 cm and weighs 3.1 kg. After excision the tumor we need to mammoplasty.Pathology anatomy examination showed a lipoma.

Relationship between Molecular Subtype, Degree of Differentiation, and Lymph Node Metastasis with Survival of Breast Cancer Patients at Dr. M. Djamil General Hospital, Padang, Indonesia Isra Analdo Arza; Daan Khambri; Rony Rustam; Hera Novianti; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 6 No. 16 (2022): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.696

Background: Breast cancer has the highest incidence of all cancers in women worldwide. A molecular subtype of breast cancer, degree of differentiation, and lymph node metastasis are prognostic and predictive factors of breast cancer. This study aims to explore the relationship between molecular subtype, degree of differentiation, and lymph node metastasis with overall survival and disease-free survival of breast cancer patients at Dr. M. Djamil General Hospital Padang. Methods: This study was an analytic observational study with a retrospective cohort approach using secondary data from 68 subjects. The test variables in this study were the molecular subtype of breast cancer, the degree of differentiation, and lymph node metastasis which were obtained from secondary data and medical records. Another test variable is patient survival, namely overall survival (OS) and disease-free survival (DFS). Data analysis with the help of SPSS software in univariate, bivariate, and multivariate. Results: Patients with lymph node metastases were 7.94 times more likely to experience an event (death) (HR=7.94 95% CI: 0.91–78.2). Patients with lymph node metastases were 10.2 times more likely to experience an event (recurrence) (HR=10.2 95% CI: 1.03–101.1). Conclusion: Lymph node metastases are the factors most related to survival (overall survival and disease-free survival) of breast cancer patients at Dr. M. Djamil General Hospital, Padang, Indonesia.

Karakteristik Klinikopatologi Karsinoma Payudara Invasif di RSUP Dr. M. Djamil Padang Periode 2018-2019 Sorayya A'dilah Putri; Aswiyanti Asri; Aisyah Elliyanti; Daan Khambri
Jurnal Ilmu Kesehatan Indonesia Vol 3 No 1 (2022): Maret 2022
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v3i1.664

Latar Belakang: Kanker payudara menempati urutan kedua di dunia dan menjadi penyebab kematian dari seluruh kasus kanker. Diagnosis berdasarkan karakteristik klinikopatologi karsinoma payudara invasif penting dalam menentukan tatalaksana dan prognosis kanker payudara. Objektif: Penelitian ini bertujuan untuk mengetahui gambaran karakteristik klinikopatologi karsinoma payudara invasif di RSUP Dr. M. Djamil Padang periode 2018-2019. Metode: Penelitian ini adalah penelitian deskriptif retrospektif dengan desain cross-sectional. Penelitian dilaksanakan pada Juni – Juli 2021. Sampel penelitian sebanyak 151 pasien. Data pasien didapatkan dari rekam medis, bagian bedah onkologi, dan bagian Patologi Anatomi di RSUP Dr. M. Djamil Padang. Hasil: Penderita karsinoma payudara invasif terbanyak pada usia >50 tahun (47%), Indeks Massa Tubuh (IMT) terbanyak adalah normal (47,7%). Subtipe histopatologi terbanyak adalah infiltrating duct carcinoma not otherwise specified (NOS) (75,5%) dengan stadium klinis IV (42,2%), tingkat grading pada grade II (71,5%), dan lokasi tumor pada kuadran lateral atas (30,8%). Karakteristik hormonal usia menarche ≥12 tahun (67,5%), usia menopause ≥40 tahun (34,4,%), multipara (61,6%), riwayat Hormonal Replacement Therapy (HRT) (1,3%), riwayat kontrasepsi suntik (19,9%). Karakterisitik non-hormonal didapatkan riwayat penyakit keluarga (16,6%), merokok (41,7%), tidak ada yang mengonsumsi alkohol, diet tinggi lemak (35,1%), dan riwayat radiasi (8,6%). Kesimpulan: Karakteristik klinikopatologi karsinoma payudara invasif paling banyak ditemukan pada usia lebih dari 50 tahun, IMT normal, subtipe infiltrating duct carcinoma NOS, stadium IV, grade II, lokasi tumor di kuadran lateral atas, usia menarche ≥12 tahun, usia menopause ≥40 tahun, multipara, dan riwayat kontrasepsi suntik.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v6i16.696

Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Ermawati Ermawati Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Frengki Frengki Hafni Bachtiar Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henny Mulyani henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Nurhayati Nurhayati Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Putra, Fachri Putri, Biomechy Oktomalio Putriyuni, Anandia Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rulli Firmansyah Rustam, Rony Safnita, Dewi Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Sofia Mubarika Sofia Mubarika Haryana Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal tofrizal - tofrizal Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yulia Kurniawati Yusticia Katar Yusticia Katar, Yusticia

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