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All Journal Nurse Media Journal of Nursing Pharmaciana: Jurnal Kefarmasian Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Sains dan Teknologi Farmasi Biomedical Journal of Indonesia Jurnal Fitofarmaka Indonesia JSFK (Jurnal Sains Farmasi & Klinis) Jurnal Endurance: Kajian Ilmiah Problema Kesehatan JURNAL KESEHATAN PERINTIS Acta Biochimica Indonesiana Majalah Kedokteran Andalas Majalah Patologi Indonesia Jurnal Ilmiah Kebidanan Indonesia (Indonesian Midwifery Scientific Journal) Andalas obstetrics and gynecology journal Jurnal Ners Science Midwifery Bioscientia Medicina : Journal of Biomedicine and Translational Research Cermin Dunia Kedokteran Jurnal Ilmu Kesehatan Indonesia (JIKSI) Indonesian Journal of Cancer Jurnal Kedokteran Hewan Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Sains, Teknologi dan Kesehatan Media Penelitian dan Pengembangan Kesehatan Cermin Dunia Kedokteran
Daan Khambri
Fakultas Kedokteran, Universitas Andalas
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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SOX10 and The Tendency of Perineural Invasion in Salivary Gland Adenoid Cystic Carcinoma Safnita, Dewi; Hilbertina, Noza; Mulyani, Henny; Tofrizal; Khambri, Daan; Yetti, Husna
Majalah Patologi Indonesia Vol. 34 No. 3, September 2025
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v34i3.641

Abstract

Background Adenoid cystic carcinoma is a malignant salivary gland tumor with unique features, including slow growth, progressive, poor prognosis, recurrence propensity, and perineural invasion tendency. SOX10 is a transcription factor expressed in the majority of tumors. SOX10 overexpression was hypothesized to play an important role in tumor-stroma interactions, especially perineural invasion and histopathological patterns.   Method A cross-sectional study was performed using 30 blocks of formalin-fixed embedded specimens previously diagnosed as salivary gland adenoid cystic carcinomas. Perineural invasion and histopathological patterns were evaluated followed by immunohistochemical staining to evaluate SOX10 expression. The staining intensity and proportion of positively stained cells in both tumor and stroma cells were grouped into high and low expression levels. Chi-square tests were used for statistical analysis.   Result The cribriform pattern was the most common histopathological pattern in both high and low SOX10 expression. The majority of tumors with high SOX10 expression (66.67% in stroma cells and 73.33% in tumor cells) were found to have more perineural invasion.   Conclusion There was a tendency for perineural invasion in tumors with high SOX10 expression, although this was not statistically significant. There was no significant association between SOX10 expression and histopathological pattern.
Determinants of Physical and Mental Health-related Quality of Life among Patients with Breast Cancer During COVID-19 Pandemic Jamil, Mohd; Merdawati, Leni; Krisdianto, Boby Febri; Khambri, Daan; Harahap, Wirsma Arif; Arifin, Hidayat
Nurse Media Journal of Nursing Vol 13, No 3 (2023): (December 2023)
Publisher : Department of Nursing, Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/nmjn.v13i3.54738

Abstract

Background: The concern surrounding the physical and mental health-related quality of life (HRQoL) among patients with breast cancer emerged during COVID-19. However, there is a lack of sufficient studies that have specifically addressed this issue. It is crucial to emphasize the evaluation of this aspect as it significantly impacts the enhancement of future physical and mental HRQoL for these patients.Purpose: This study investigated the determinants of physical and mental HRQoL among patients with breast cancer during COVID-19.Methods: In a cross-sectional study conducted between September and October 2022, participation involved 260 patients diagnosed with breast cancer, selected through convenience sampling. Our observation focused on assessing the outcomes of physical and mental HRQoL using the Short Form (SF-12) questionnaire for data collection. Additionally, the data underwent analysis via binary logistic regression.Results: Respondents aged <50 years (p=0.010; aOR=2.08; 95% CI=1.18–3.67), unemployed (p=0.022; aOR=2.29; 95% CI=1.16–4.53), and had high depression (p=0.026; aOR=2.41; 95% CI=1.13–5.12) have a more likelihood to have low physical HRQoL. In addition, unemployed respondents (p=<0.001; aOR=4.15; 95% CI=2.14–8.04) and had high anxiety (p=0.004; aOR=2.71; 95% CI=1.38–5.33) have more likelihood to have low mental HRQoL.Conclusion: In this study, it was found that anxiety, depression, and unemployed respondents were associated with a higher likelihood of experiencing lower physical and mental HRQoL. Nurses and healthcare workers should prioritize addressing psychological issues such as anxiety and depression among breast cancer patients, emphasizing the necessity for interventions aimed at alleviating these concerns. 
Mutation of BRCA1/2 Gene in Premenopausal Triple-Negative Breast Cancer Patients in West Sumatera Harahap, Wirsma Arif; Khambri, Daan; Panigoro, Sonar Soni; Hafiz, Muhammad Zaki Abdul
Indonesian Journal of Cancer Vol 19, No 1 (2025): March
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v19i1.1255

Abstract

Background: The BRCA1/2 mutation rate was found to be higher in triple-negative breast cancer (TNBC) patients depending on young age, and the presence of a family history of breast cancer and ovarian cancer. Research on BRCA1/2 germline mutations that focused on premenopausal TNBC patients in Indonesia has never been carried out. The objective of this research is to determine the BRCA1/2 germline gene mutation status in premenopausal TNBC patients in West Sumatra.Methods: This is a descriptive study conducted at the Surgical Oncology Division of DR. M. Djamil Hospital, Padang from April to July 2023. This study included patients aged 50 years who were diagnosed with the TNBC subtype at Dr. M. Djamil Hospital, Padang from January 2016 to July 2023. Secondary data was collected through the patient’s medical records to observe the TNBC patient’s characteristics. A blood test of TNBC patients was carried out to determine germline mutation of BRCA1/2.Results: 22 patients with TNBC participated in the study. In this study, 4/22 (18.2%) had BRCA2 pathogenic mutations and no BRCA1 pathogenic mutation was found. All patients with BRCA2 pathogenic mutation have the same mutation characteristics, i.e exon 3, genetic variation (c.262_263delCT), amino acids (p.Leu88AlafsTer12), and type of mutation (Frameshift Deletion). Conclusions: TNBC patients in West Sumatra have BRCA2 pathogenic mutations with the same characteristics as the mutations
Hubungan Kanker Payudara Tripel Negatif dengan Kejadian Metastasis Aksila dan Metastasis Jauh di RSUP Dr. M. Djamil Padang Nindita, Priska Audina; Handayani, Tuti; Suchitra, Avit; Khambri, Daan; Mulyani, Henny; Rustam, Erlina
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 1 (2024): Maret 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i1.1137

Abstract

Latar Belakang: Lebih dari 90% kematian terkait kanker payudara disebabkan oleh tumor sekunder di organ yang jauh akibat metastasis. Kanker payudara tripel negatif atau triple negative breast cancer (TNBC) merupakan subtipe paling agresif diantara subtipe lainnya. Secara klinis TNBC memiliki ukuran tumor yang lebih besar, melibatkan kelenjar getah bening, dan memiliki derajat keganasan yang lebih buruk. Pasien TNBC lebih berisiko mengalami metastasis dan kematian dibandingkan dengan jenis subtipe lainnya sehingga prognosisnya juga lebih buruk. Objektif: Mengetahui hubungan kanker payudara tripel negatif dengan kejadian metastasis aksila dan metastasis jauh di RSUP Dr. M. Djamil Padang. Metode: Penelitian analitik observasional dengan desain penelitian cross-sectional bersifat retrospektif. Jumlah sampel penelitian sebanyak 11 pasien TNBC dan 99 pasien non-TNBC di RSUP Dr. M. Djamil Padang tahun 2016 – 2021. Digunakan analisis uji Chi Square. Hasil: Kejadian metastasis aksila pada pasien TNBC sebesar 45,5% dan kejadian metastasis jauh sebesar 90,9% dengan lokasi metastasis terbanyak pada organ paru. Tidak terdapat hubungan antara kanker payudara tripel negatif dengan kejadian metastasis aksila (p=0,071) dan terdapat hubungan bermakna antara kanker payudara tripel negatif dengan kejadian metastasis jauh (p=0,018). Kesimpulan: Penelitian ini dapat disimpulkan bahwa tidak terdapat hubungan antara kanker payudara tripel negatif dengan kejadian metastasis aksila dan terdapat hubungan antara kanker payudara tripel negatif dengan kejadian metastasis jauh. Kata kunci: kanker payudara, tripel negatif, metastasis
The Difference of Using Antibiotics Before and After Antimicrobial Resistance Control Program (PPRA) at RSUP Dr. M. Djamil Padang Ermawati, Ermawati; Khambri, Daan; Almasdy, Dedy
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 1 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.1.29-42.2021

Abstract

Antibiotics have been proven to be beneficial for human life since their discovery. This type of drug is the most widely used in infections caused by bacteria. the function is to inhibit growth or kill microorganisms. Therefore, more than 30-80% of patients in developed countries who are hospitalized receive antibiotics, either alone or in combination. Evaluating the implementation of PPRA at RSUP. Dr. M. Djamil by comparing the evaluation of antibiotic use before and after the application of PPRA in inpatients in the Obgyn.We conducted this research including a type of correlational analytical research with a retrospective approach. The research sample was taken by the Medical Record room of the RSUP. Dr. M. Djamil Padang. The research was carried out for 1 month, from May 1 to May 31, 2020. The population in this research was all inpatients of Obstetrics and Gynecology in Dr. M. Djamil Padang.There was an increase in the percentage of antibiotic use in 2019 in line with the higher percentage of surgery in 2019 compared to 2018. As regulated by the guidelines for the use of antibiotics in Dr. M. Djamil, for surgery, prophylactic antibiotics are given 30 minutes before the procedure to prevent infection due to the invasive action. The use of prophylactic antibiotics whether to continue is determined by the type of operation, the length of the operation, the amount of bleeding during the operation, the clinical patient, the laboratory value.There were no significant changes in the implementation of PPRA's work on the qualitative analysis of antibiotic use.Keywords: Antibiotics, PPRA, Evaluation
POTENTIAL ANTIVIRAL OF CATECHINS AND THEIR DERIVATIVES TO INHIBIT SARS-COV-2 RECEPTORS OF M pro PROTEIN AND SPIKE GLYCOPROTEIN IN COVID-19 THROUGH THE IN SILICO APPROACH Frengki, Frengki; Putra, Deddi Prima; Wahyuni, Fatma Sri; Khambri, Daan; Vanda, Henni; Sofia, Vivi
Jurnal Kedokteran Hewan Vol 14, No 3 (2020): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v14i3.16652

Abstract

Catechin and their derivatives have been studied to have antiviral potential against COVID-19 through in silico method pharmacokinetics screening and molecular docking. Pharmacokinetics and toxicity profiles were obtained through the ADMETSAR server and SwissADME server. Then proceed with the prediction of affinity through the method molecular docking using the software application MOE 2007.09. The testmaterial is in the form of a 3D catechin structure and its derivatives as well as several control ligands downloaded via Pubmed. While templatethe Receptor M pro protein and the Spike glycoprotein are downloaded from pdb.org (PDB ID: 6LU7 and 6LXT). The pharmacokinetic profile of catechins is relatively better than all control ligands with the lowest toxicity. Molecular docking results also show that catechins and theirderivatives have a stronger affinity than control ligands. This research proves that catechin has antiviral potential through inhibition of Mpro protein and Spike glycoprotein COVID-19 virus.
Stigma sebagai Beban Psikososial pada Pasien Kanker Payudara: Studi Deskriptif Fillia Putri; Esthika Ariany Maisa; Daan Khambri; Made Satya Nugraha Gautama; Leni Merdawati
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.52033

Abstract

Kanker payudara merupakan kanker dengan prevalensi tertinggi pada perempuan dan berdampak pada aspek psikososial. Selain beban fisik akibat pengobatan, pasien juga menghadapi stigma yang memengaruhi citra diri, hubungan sosial, dan pemulihan.Penelitian ini bertujuan untuk menggambarkan tingkat stigma yang dialami oleh pasien kanker payudara di RSUP Dr. M. Djamil Padang. Desain penelitian yang digunakan adalah deskriptif kuantitatif dengan teknik purposive sampling. Sebanyak 280 responden yang memenuhi kriteria inklusi berpartisipasi dalam penelitian ini, yaitu perempuan berusia ≥18 tahun yang telah didiagnosis kanker payudara dan sedang atau telah menjalani pengobatan. Instrumen yang digunakan adalah Breast Cancer Stigma Assessment Scale (BCSAS) yang terdiri atas 28 item dengan tujuh domain. Analisis data dilakukan secara deskriptif menggunakan SPSS versi 26. Hasil penelitian menunjukkan bahwa sebagian besar pasien mengalami tingkat stigma tinggi (39,6%), sedangkan 25,4% dengan tingkat sedang dan 35% pada tingkat rendah. Domain dengan skor tertinggi adalah dapat disembunyikan dan perubahan citra diri, sedangkan skor terendah terdapat pada gangguan keluarga dan asal penyakit. Hasil ini menunjukkan bahwa stigma masih menjadi beban psikososial signifikan bagi pasien kanker payudara. Oleh karena itu, diperlukan intervensi psikososial yang berkelanjutan, seperti pembentukan peer support group, untuk membantu pasien saling berbagi pengalaman, meningkatkan penerimaan diri, dan mengurangi dampak stigma terhadap kesejahteraan emosional.
Validity and reliability test of the knowledge level questionnaire of cancer patients undergoing radiotherapy Hanum, Fathiya Juwita; Machmud, Rizanda; Gondhowiardjo, Soehartati; Khambri, Daan; Harahap, Wirsma Arif; Elliyanti, Aisyah; Firdawati, Firdawati; Semiarty, Rima
Media Penelitian dan Pengembangan Kesehatan Vol. 36 No. 1 (2026): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v36i1.3604

Abstract

Background: Radiotherapy is one of the main modalities in cancer treatment. The success of this therapy is strongly influenced by the knowledge of patients about the disease and radiotherapy. The researcher developed a questionnaire to measure the level of knowledge among cancer patients undergoing radiotherapy. Objective: This study aimed to assess the validity and reliability of a knowledge-level questionnaire for cancer patients receiving radiotherapy at Dr. M. Djamil General Hospital, Padang. Methods: This research employed a quantitative approach with a cross-sectional design. A total of 30 cancer patients undergoing radiotherapy were included as respondents using a consecutive sampling technique. The questionnaire instrument was developed by the researcher and consisted of 25 items covering five domains of knowledge: cancer, radiotherapy, side effects, self-care, and nutrition. Results: Validity testing was conducted using Pearson’s correlation analysis, while reliability was assessed using Cronbach’s Alpha. Out of the 25 items, 19 were statistically valid (p<0.05), with correlation coefficients (r) ranging from moderate to strong (0.470–0.745). The Cronbach’s Alpha value for the valid items was 0.904, indicating excellent reliability. Conclusion: The developed questionnaire was proven to be both valid and reliable for measuring the knowledge level of cancer patients undergoing radiotherapy. This instrument has the potential to be used in clinical practice and research to support more targeted educational interventions.
Co-Authors ., Azamris ., Oktahermoniza Abdul Hafiz, Muhammad Zaki Afrinita Eka Fitri Afriwardi Afriwardi Agus Susanta Ahmad Fakhrozi Helmi Aisha Rahmatya Aisyah Elliyanti Anandia Putriyuni Anandia Putriyuni Anggraini, Dessy Ari Oktavenra Ari Yanto Wijaya Arifin, Hidayat Arni Amir Asterina Aswiyanti Asri Azamris Azamris Aziza, Zulva Berna Elya Bobby Indra Utama Citra Ayu Fitrisia Deddi Prima Deddi Prima Putra Dedi Prima Putra Defri Heryadi Dessy Arisanty Dia Rofinda, Zelly Dia Edison Edison Eka Putri Eka Putri Elfira Yusri Erlina Rustam Ermawati Ermawati Eti Yerizel Fadrian, Fadrian Fatma Sri Wahyuni Fillia Putri Firdawati Firdawati Frengki Frengki Frengki Frengki, Frengki Hafiz, Muhammad Zaki Abdul Hafni Bachtiar Hanum, Fathiya Juwita Hasmiwati Henni Vanda Henni Vanda Henni Vanda Henni Vanda Henny Mulyani henny Mulyani Henny Vanda Hera Novianti Heryadi, Defri Hidayat, Nur Latifah Alfaina Husna Yetti Intan, Shinta Ayu Isra Analdo Arza Jamil, Mohd Jamilah Abbas Krisdianto, Boby Febri Leni Merdawati M. Al Farisyi Made Satya Nugraha Gautama Maisa, Esthika Ariany Muhammad Reno Akhyar Marpaung Muhammad Zaki Abdul Hafiz Niki Astria Nina Kurniasih Nindita, Priska Audina Nirmala Sari Noni Zakiah Nora, Sondang Noza Hilbertina Noza Hilbertina, Noza Nurhayati Nurhayati Oktahermoniza Oktahermoniza . Oktavenra, Ari Pamelia Mayorita Putra, Fachri Putri, Biomechy Oktomalio Putriyuni, Anandia Raden Mohamad Herdian Bhakti Ramadanus Ramadanus Ramadanus Rifa, Farras Zahra Rima Semiarty Rini Purnama Sari Rizanda Machmud Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rony Rustam Rosfita Rasyid Rufi'i Rulli Firmansyah Rustam, Rony Safnita, Dewi Selfi Renita Rusdji Selfi Renita Rusjdi Septiyeni, Elsa Soehartati Gondhowiardjo Sofia Mubarika Sofia Mubarika Haryana Sonar Soni Panigoro Sondang Nora Sondang Nora Sondang Nora Harahap Sorayya A'dilah Putri Suchitra, Avit Suyuthie, Heldrian Dwinanda Syamel Muhammad Tofrizal Tofrizal Tofrizal Vashti Resti Putri Firdaus Veithzal Rivai Zainal Vivi Sofia wessi windrasari Wirsma Arif Harahap Wirsma Arif Harahap Yanwirasti - Yanwirasti - Yenita . Yenita Afriyeni Yopiq Triputra Yusticia Katar Yusticia Katar, Yusticia