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All Journal Jurnal Kedokteran Brawijaya MANDALA of Health Journal of Biomedicine and Translational Research Jurnal NERS MEDISAINS Majalah Kedokteran Universa Medicina Jurnal Pengabdian Pada Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Scripta Biologica Jurnal Informatika dan Rekayasa Elektronik Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Of Bionursing Jurnal Comprehensive Health Care BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Indonesian Journal of Global Health research Insights in Public Health Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Mandala of Health : A Scientific Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Jurnal Ekonomi, Bisnis, dan Akuntansi Medical and Health Journal Indonesian Journal of Dentistry Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia Linggamas: Jurnal Pengabdian Masyarakat

Lantip Rujito

Departemen Genetika Dan Biologi Molekuler, Fakultas Kedokteran Universitas Jenderal Soedirman

Author-ID : 365313

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Aminolevulinate dehydrogenase polymorphisms did not modified lead serum and memory relationship Lantip Rujito; Arini Dewi Setyowati; Saien Saien
Universa Medicina Vol. 31 No. 3 (2012)
Publisher : Faculty of Medicine, Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/UnivMed.2012.v31.184-191

BACKGROUND Lead accumulation in the blood widely known affecting the formation of heme and oxygen transport processes in vital organs, Leading to organ failure including the brain synapses. Lead affinity has been recognized influenced by constitutional genotype of aminolevulinate dehydrogenase (ALAD), which encodes for heme synthesis. This research aimed to determine the relationship between plumbum (Pb) and short term memory on each ALAD gene genotyping (ALAD 1-1, ALAD 1-2 or ALAD 2-2) in gas station workers. METHODS Seventy six probands from gas station workers were recruited to participate in this research. Each probands was carried out ALAD genotyping using polymerase chain reaction-restriction fragment length polymorphism (PCRRFLP) method, lead serum level using atomic absorbent spectrophotometer (AAS), and short term memory was measurement by intelligence structure test (IST). RESULTS Proportion of δ ALAD 1-1, 1-2, and 2-2 were 91.8%, 8.2% and 0% respectively. Lead serum showed 15.84 ppb in homozygous 1-1, and 20.79 ppb in heterozygous. Short term memory in the probands varied from 85 until 117, with average in 99.71. There was significant negative relationship between lead serum and short term memory (r=-0.24; p=0.038). However, we could not find any significant correlation in each δ ALAD genotypes. CONCLUSION The δ ALAD genotypes did not modified the relationship between serum lead level and short term memory in gas station workers.

Efektivitas Pengobatan Massal Filariasis Setelah Empat Tahun Pengobatan Massal di Desa Ploso, Demak, Jawa Tengah Monika Putri Solikah; Siwi Pramatama Mars Wijayanti; Lantip Rujito
BALABA: JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA Volume 17 Nomor 1 Juni 2021
Publisher : Balai Penelitian dan Pengembangan Kesehatan Banjarnegara Badan Litbangkes Kemenkes RI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/blb.v17i1.4096

TThe filariasis elimination program is carried out through mass treatment with Diethylcarbamazine Citrate (DEC) and albendazole once a year for five years. Filariasis mass treatment, which was carried out for five years, aims to reduce the prevalence rate of microfilaria < 1%. Evaluation of community treatment needs to be done, one of which is the Finger Blood Preparation (SDJ) and Polymerase Chain Reaction (PCR) methods. The purpose of this research was to know the effectiveness of mass treatment of filariasis after four years in Karang Ploso Village, Demak, Indonesia. This study is a descriptive study with a cross-sectional approach with a sample of 350 people. The study variables were an examination of SDJ microfilariae, PCR molecular examination, and interviews about filariasis knowledge. The examination methods used were SDJ and PCR. The data analysis used was univariate, microfilaria rate. The results of SDJ and PCR examinations were not found microfilariae, so that the Mf rate was 0%. As many as 97.4% of people adhered to taking medication, 91.1% of people had moderate knowledge of filariasis, 98.3% had an average experience of the Mass Drug Administration (MDA). The Mf rate results by SDJ and PCR in Demak after the fourth filariasis treatment program in 2019 was 0%. There was a decrease in SDJ results from 2016-2019, namely 1% to 0% in 2019.

The Hepatotoxic and Nephrotoxic Effects of Purwoceng (Pimpinella pruatjan Molk.) Roots Ethanol Extract Administration in Subchronic Dose Fitranto Arjadi; Nur Signa Aini Gumilas; Ika Murti Harini; Vitasari Indriani; Lantip Rujito
Molekul Vol 16, No 2 (2021)
Publisher : Universitas Jenderal Soedirman

Purwoceng (Pimpinella pruatjan Molk) is an original Indonesian herb which is known to have an aphrodisiac effect. The active compounds in Purwoceng potentially have hepatotoxic and nephrotoxic effects.This study was aimed to analyze the effect of subchronic administration of Purwoceng roots ethanol extract to Wistar Strain of Rattus norvegicus rats. The method of this subchronic toxicity study was an experimental post test only with control group design. Forty male Rattus norvegicus were randomly divided into four groups and get 28-days treatment. Group A as control received aquadest and 1% CMC (carboxymethyl cellulose), group B, C, and D were given Purwoceng roots ethanol extract of 42, 84, and 168 mg/KgBW/day and 1% CMC. Parameters tested were the levels of urea, creatinine, SGPT (serum glutamic pyruvic transaminase), SGOT(serum oxaloacetic pyruvic transaminase), kidney and hepar histopatology.The results showed a statistically significant for the liver histopathological in group B, creatinine, urea, and kidney histopathology in group C. Our study concluded that subchronic administration of Purwoceng (Pimpinella pruatjan Molk) roots ethanol extract could induce hepatotoxicity at the 42 mg/KgBW/day dose level and nephrotoxicity at the 84 mg/KgBW/day dose level.

No Acute Toxicity Tests of Purwoceng (Pimpinella pruatjan Molk.) Ethanolic Extract on Male Albino Rat by Determined Hepatorenal Function Test and Histopathology Fitranto Arjadi; Dhadhang Wahyu Kurniawan; Yudhi Wibowo; Wahyu Siswandari; Lantip Rujito
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Pimpinella pruatjan Molkis a local indegineuos plant speciescommonly used aphrodisiac.This studywas performed to analyze the effect of acute administration of purwoceng (Pimpinella pruatjan Molk.) roots ethanol extract to liver and kidney histological damagein rats. The study used an experimental approachusing post test only with control group design. Rats were randomly divided into five groups; 3 rats in each group. Group A as a control group received aquadest, group B, C, D, and E were given purwoceng roots ethanol extract dose of 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, and 2000 mg/kgBW respectively.Liver histological damage was assessed by a modification of the Roenigk score, whereaskidney damage was by the semiquantitative scoring of proximal tubular necrosis. UV test was used to quantify the AST and ALT levels, the measurement of blood urea levels was using the Urease-GLDH method, and Jaffe methodwas used to access the creatinine levels.Kruskal-Wallis test showed that liver and kidney histologicalparameterswere not significantly affected, as well as theblood urea and creatinine levels (p>0.05).Meanwhile,ALT level wasonly parameters which showed the significant test (p <0.05)among groups. Study concluded that the liver and kidney histological appearance, AST, blood urea, and creatinine levels in the male albino rat were not significantly affected by acute administration of Purwoceng roots in various dosesbut the ALT level was significantly affected

PERBEDAAN PROFIL LIPID DAN KADAR ASAM URAT PADA PASIEN DIABETES MELITUS TIPE II DENGAN DAN TANPA HIPERTENSI Filliana Savitri; Intani Kurnia Savitri; Pugud Samodro; Lantip Rujito
Scripta Biologica Vol 4, No 3 (2017)
Publisher : Fakultas Biologi | Universitas Jenderal Soedirman

Diabetes Mellitus type 2 is the 7th world of death problem with the 95% proportion rate. Hypertension has also a correlation with this condition. The mortality of cardiovascular is 2-3 times over from diabetics with hypertension than diabetics with normotension which caused by lipid and aciduric disturbations. This study was conducted using cross-sectional design. Twenty-five sample of diabetics normotension and 25 sample of diabetics patient along with hypertension in Ajibarang Hospital District Banyumas and comply with inclusion-exclusion criteria were taken suing consecutive sampling. Data from the cholesterol and triglyceride total test were collected and analyzed with Mann-Whitney test. Additionally, HDL cholesterol and LDL was analyzed using T-Test. This Study showed that average total cholesterol from diabetics along with hypertension patients was in a range of 185.16 ± 36.59 and Diabetics patient without hypertension was 196.76 ± 44.62 (p = 0,503). Besides, the average rate of triglyceride level on diabetics patient with hypertension was 181.76 ±72.68 and diabetics patient along without hypertension was 180.28 ± 125.75 (p=0,367). The average rate of HDL cholesterol level on diabetics patient with hypertension was 39.12 ± 11.07 and diabetics patient along without hypertension was 42.37 ± 14.98 (p = 0,387). In addition, Average rate of LDL level on diabetics patient with hypertension was 112.57 ± 24.77 and diabetics patient along without hypertension was 118.33 ± 37.41 (p = 0,524). The average rate of uric acid on diabetics patient with hypertension was 6,120 ± 1,45 and diabetics patient along without hypertension was 5,768 ± 2,45 (p=0,200). As a conclusion, there is no difference with total cholesterol, triglyceride, HDL, LDL cholesterol, and uric acid significant from diabetics patient with or without hypertension in Ajibarang Hospital District Banyumas in 2016.

Pemberdayaan Ekonomi Pasien Thalassemia Melalui Kegiatan Bisnis Online di Banyumas Lantip Rujito; Diyah Woro Dwi Lestari; Qodri Santosa; Ariadne Tiara Hapsari
Jurnal Pengabdian Pada Masyarakat Vol 2 No 2 (2017)
Publisher : Universitas Mathla'ul Anwar Banten

ECONOMIC EMPOWERING OF THALASSEMIA PATIENTS THROUGH ONLINE ENTREPREUNERS ACTIVITIES IN BANYUMAS. Thalassemia in Banyumas is a part of portrait of Indonesia’s problems. Todays, there is not yet any national thalassemia countermeasures program so that thalassemia prevalence is getting increased year by year. Increasing life expectancy of thalassemia patients brings economical problem consequence. Social stigma and businessmen support Thalassemia patients to be powered economically in their productive age. Entrepreneurship autonomy becomes an alternative to overcome it. Online entrepreneurs has flexibility, creative space, global range and unlimited time that support it to be an optional solution for preparing thalassemia patients welcoming productive age.

Sosialisasi Thalassemia Kepada Guru Biologi di Banyumas: Upaya Pencegahan Terintegrasi Melalui Kurikulum Sekolah Lantip Rujito; Diyah Woro Dwi Lestari; Abdul Aziz; Dinar Faiza
Jurnal Pengabdian Pada Masyarakat Vol 3 No 1 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

THALASSEMIA SOCIALIZATION TO BIOLOGY TEACHERS IN BANYUMAS: EFFORT OF INTEGRATED PREVENTION THROUGH SCHOOL CURRICULUM. Thalassemia is a hematologic disease that causes hemoglobin blood defects. As a result, red blood cells become fragile and unable to perform their standard functions. Thalassemia in Indonesia is a quite lot. Recorded data, the carrier traits are about 3-10%, spread across all provinces. Currently, no final treatment can cure this disease altogether. Regular transfusion and iron chelating drugs are still survival of thalassemia patients. Prevention program is one of efficient handling. The pattern of thalassemia gene decline follows the laws of the recessive Mendel. Prevention is done by campaigning premarital screening to married couples or further to younger individuals so they can plan marriages wisely. High School Biology teachers are an essential factor in preventing thalassemia. They can deliver prevention programs through lessons at school. They can also be pioneers in an early self-detection carrier to teenagers before they plan a marriage. Because of its strategic role, the socialization of thalassemia in high school teachers becomes very important.

Pelatihan PMR Sadar Thalassemia pada Kegiatan Jumbara XXV Kabupaten Banyumas Lantip Rujito; Diyah Woro Dwi Lestari; Fitranto Arjadi; Dinar Faiza
Jurnal Pengabdian Pada Masyarakat Vol 3 No 2 (2018)
Publisher : Universitas Mathla'ul Anwar Banten

TRAINING OF THALASSEMIA-AWARE PMR IN XXV JUMBARA EVENT OF BANYUMAS REGENCY. Thalassemia is a health condition that still needs treatment and serious attention for the Indonesian government. As part of the thalassemia belt, Indonesia must act immediately to prevent the addition of thalassemia patients in the future. One of the mass educations that can be done is by self-awareness movement among school students. Palang Merah Remaja (PMR) became a potential youth organization as the educator agent. Intense training and debriefing on them can be a superior program for prevention among school students. Students, in this case, the Red Cross Youth who are at the junior and senior high school level are potential cadres to spread the right information about thalassemia to their peers.

Pelatihan Deteksi Karier Thalassemia kepada Bidan di Banyumas Lantip Rujito; Qodri Santosa; Diyah Woro Dwi Lestari; Eman Sutrisna; Ariadne Tri Hapsari
Dinamisia : Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 5 (2021): Dinamisia: Jurnal Pengabdian Kepada Masyarakat
Publisher : Universitas Lancang Kuning

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31849/dinamisia.v5i5.4659

Thalassemia ranks top on the list of diseases caused by the monogenic mechanism, especially in hematology disorders. Currentlly, Thalassemia ranks 5th in the national health insurance coverage. Prevention is the only effective way to control the clinical, psychological and financial burden of the country. One aspect of prevention is the discovery and genetic counseling process of persons who carry the mutan gene or carier of thalassemia. Midwives as the most peripheral health workers in the national health system are very important in their role in the discovery and counseling of these people. Provision of sufficient knowledge and skills of midwives can be a reliable tool in efforts to prevent thalassemia in the community.

Genetic Counseling in Indonesia as a Mandatory Service Lantip Rujito
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 9, No 1, (2018)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol9.Iss1.art1

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Co-Authors A. Haris Budi Widodo Abdul Aziz Agus Suroso Alfi Muntafiah Ali Taqwim Alifah, Assha Luthfianie Amalia Muhaimin Amilia Ramadhani Aminuddin, Muhammad Fahmi Anton Budhi Darmawan Arfi Nurul Hidayah Ariadne Tiara Hapsari Ariadne Tiara Hapsari Ariadne Tri Hapsari Arif Imam Hidayat Arini Dewi Setyowati Assha Luthfianie Basalamah, Muhammad Darmawan, Anton Budhi Desiyani Nani Dhadhang Wahyu Kurniawan Dinar Faiza Diyah Woro Dwi Lestari Dwi Kustiani, Dwi Dwi Utami Anjarwati Dyla Annisa Putri Eman Sutrisna Eman Sutrisna Faiza, Dinar Farah Coutrier Filliana Savitri Fitranto Arjadi Fitranto Arjadi Fitranto Arjadi Fitranto Arjadi Gembong Satria Mahardhika Gembong Satria Mahardhika Hatmoko, Sito Hidayat Sulistyo Ika Murti Harini Ika Ristianingrum, Ika Ina Permata Dewi Indah Pusparini Indah Rahmawati Intani Kurnia Savitri Izzati Muhimmah Joko Mulyanto Joko Mulyanto Joko Mulyanto, Joko Joko Setyono Khafid Nawawi Kotale, Nichola Noelle Krisniawati, Nia Lalu Mutawalli Leily Trianty Lestari , Diyah Woro Dwi Lestari, Diyah Woro Dwi Lies Anne Severijnen, Lies Anne Metta Ayu Susanti Metta Ayu Susanti Miko Ferine Moh Reza Syaifur Rizal Monika Putri Solikah Muhammad Nur Hanief Muhammad Nur Hanief, Muhammad Nur Mujiburrahman, Husnan Nendyah Roestijawati Norina Agatri Nouval Keandre Nur Signa Aini Gumilas Nurcahyani, Putri Silvia Pamela Sandhya De Jaka Paulus Gozali Paulus Gozali, Paulus Peter Hanzon, Peter Pramuditya, Hafizh Zufar Pugud Samodro Purwoko, Ari Qodri Santosa Qodri Santosa, Qodri Rani Afifah Nur Histiyani Rendi Retissu Rintis Noviyanti Rizki Rijatullah Rob Willemsen, Rob Rohmatul Fajriyah Saien Saien Sakina, Ghaida Saryono Saryono Siti Aminah Siti Munfiah SIWI PRAMATAMA MARS WIJAYANTI Siwi Pramatama Mars Wijayanti Sjafril Sanusi Sultana MH Faradz Suprihatin Suprihatin Teguh Haryo Sasongko Thianti Sylviningrum Vitasari Indriani Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin Wayan Tunas Artama Widodo, Yundandhika Rizki Wijaya, Helmi Aditya Wiwiek R Adawiyah Yudhi Wibowo Zaenal Adi Susanto Zulfa Zahra Salsabila

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