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All Journal Jurnal Kedokteran Brawijaya MANDALA of Health Journal of Biomedicine and Translational Research Jurnal NERS MEDISAINS Majalah Kedokteran Universa Medicina Jurnal Pengabdian Pada Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Scripta Biologica Jurnal Informatika dan Rekayasa Elektronik Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Of Bionursing Jurnal Comprehensive Health Care BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Indonesian Journal of Global Health research Insights in Public Health Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Mandala of Health : A Scientific Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Jurnal Ekonomi, Bisnis, dan Akuntansi Medical and Health Journal Indonesian Journal of Dentistry Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia Linggamas: Jurnal Pengabdian Masyarakat Indonesian Journal of Global Health Research
Lantip Rujito
Departemen Genetika Dan Biologi Molekuler, Fakultas Kedokteran Universitas Jenderal Soedirman
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Korelasi Feritin dengan Sitokin Proinflamasi pada Pasien Talasemia Beta Di Kota Samarinda Kalimantan Timur Muhammad Fahmi Aminuddin; Anton Budhi Darmawan; Lantip Rujito
Majalah Kedokteran Indonesia Vol 72 No 2 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.2-2022-608

Abstract

Introduction: Ferritin is a routine parameter used in the evaluation of iron overload in thalassemia patients. Excess iron causes the formation of ROS, resulting in an oxidative reaction that triggers inflammation. This study aims to determine the correlation of ferritin levels with proinflammatory cytokines in beta thalassemia. Methods: A cross-sectional analytical study was conducted on 33 beta thalassemia patients who received routine blood transfusions at I.A. Moeis Samarinda. Spearman rank correlation test was used to determine the correlation between ferritin and TNF-α and IL-6. Results: The results of this study showed that there was no relationship between ferritin and TNF- (p=0.580) and IL-6 (p=0.924). Meanwhile, there was a significant relationship between TNF- and IL-6 (p less than 0.0001) which had a strong positive correlation (r=0.621). Conclusion: This study showed that there was no correlation between ferritin levels with TNF-α and IL-6. Meanwhile, proinflammatory cytokines showed a correlation between TNF-α and IL-6 in thalassemia patients in Samarinda City.
Biochemical and Histopathological Effect of Combination Extract Ethanolic Turmeric (Curcuma longa) and Kalmegh (Andrographis paniculata) in Iron Overload Rat Model Prastiyo, M. Dodik; Rujito, Lantip; Hernawati, Hernawati
Journal of Biomedicine and Translational Research Vol 12, No 1 (2026): April 2026
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v12i1.28945

Abstract

Background: Thalassemia-β patients have erythrocyte damage that requires blood transfusion treatment. Blood transfusion treatment that is undergone has an impact on the condition of iron overload in the body. The condition of iron overload will result in oxidative stress and organ damage that requires additional therapyObjective: aimed to compare the effectiveness of turmeric and kalmegh extract doses against biochemical parameters and histopathological features of iron-induced liver Rattus Norvegicus.Methods: This study used a True-experiment research design with a post-test-only control group. A total of 30 rats were used and divided into six treatment groups, normal, deferiprone drugs, turmeric, and kalmegh extracts 100mg/KgBW, 200mg/KgBW, and 400mg/KgBW. Malondialdehyde, catalase, superoxide dismutase, and ferritin are used as biochemical parameters and hepatic histopathology is documented.Results: The results showed that there were significant improvements and differences in iron-induced rats.Conclusion: The study also showed that turmeric and kalmegh extracts had similar effects to deferiprone.
The Interplay between Hepcidin, Il-6, and NF-ΚB in Transfusion-Dependent Thalassemia-Β Patients Assha Luthfianie Alifah; Lantip Rujito; Wahyu Siswandari
Indonesian Journal of Global Health Research Vol 7 No 2 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i2.5630

Abstract

Hepcidin, a key regulator of iron metabolism, interacts with inflammatory cytokines like IL-6 and transcription factors such as NF-κB, which play crucial roles in the body's response to inflammation and iron homeostasis especially in transfusion-dependent Thalassemia-β patient. Their interplay in transfusion-dependent thalassemia-β patients, particularly in the context of iron chelation therapy, remains underexplored. Understanding these dynamics could provide insights into optimizing treatment strategies for better patient outcomes. Objective: Determine the relationship between hepcidin levels and IL-6 and NFκB in β-thalassemia sufferers who underwent blood transfusions and determine the effect of the type of iron chelation, and the regularity of iron chelation consumption with the relationship between hepcidin, IL-6 and NFκB levels in β-thalassemia sufferers who underwent transfusions blood. Method: A cross-sectional, quantitative correlation study involving transfusion-dependent thalassemia-β patients was conducted. Serum levels of hepcidin, IL-6, and NF-κB were measured, and the relationships among these biomarkers were analyzed using Pearson correlation. The impact of iron chelation therapy type and adherence on these relationships was also assessed using stratified statistical analysis. Results: Hepcidin levels with IL-6 were found with p = 0.757. The next analysis is the relationship between Hepcidin levels and NFκB with p = 0.029. Conclusions: The relationship between hepcidin levels and IL-6 did not contribute significantly, while there was a significant relationship between hepcidin levels and NFκB. The relationship was influenced by moderating variables, namely the type of iron chelation and the regularity of iron chelation consumption.
Systematic Review: Side Efffects of Ramipril and Spironolactone Drug Combination in Cardiovascular Patients Fadhilah Nurul Hayati; Lantip Rujito
Indonesian Journal of Global Health Research Vol. 7 No. 6 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i6.1141

Abstract

Cardiovascular disease is one of the leading causes of death worldwide, especially in developing countries. Combination therapy of ramipril, an ACE inhibitor, and spironolactone, an aldosterone antagonist, is widely used in hypertension and heart failure patients, offering clinical benefits such as blood pressure control and organ protection, but it also poses risks of hyperkalemia and renal dysfunction. This systematic review aimed to evaluate and identify the adverse effects of ramipril–spironolactone combination therapy. A systematic search was conducted in Google Scholar and PubMed NIH Central for articles published between 2020–2024 using the keywords “Ramipril” AND “Spironolactone” AND “Adverse Effect” and “Combination Therapy” AND “Cardiovascular Disease.” From an initial 1,026 articles, 38 were screened, 37 remained after duplicate removal, and 3 studies (2 from Google Scholar and 1 from PubMed) met the inclusion criteria. Article selection followed PRISMA 2020 guidelines, and data were extracted on study design, population, interventions, outcomes, and adverse effects. The results indicate that although ramipril–spironolactone combination therapy provides significant cardiovascular benefits, it is consistently associated with hyperkalemia, hypotension, and renal dysfunction; therefore, close monitoring of potassium levels, renal function, and blood pressure is strongly recommended to minimize adverse outcomes.
Co-Authors A. Haris Budi Widodo Abdul Aziz Agus Suroso Alfi Muntafiah Ali Taqwim Amalia Muhaimin Amilia Ramadhani Anton Budhi Darmawan Anton Budhi Darmawan Arfi Nurul Hidayah Ariadne Tiara Hapsari Ariadne Tiara Hapsari Ariadne Tri Hapsari Arif Imam Hidayat Arini Dewi Setyowati Assha Luthfianie Assha Luthfianie Alifah Basalamah, Muhammad Darmawan, Anton Budhi Desiyani Nani Dhadhang Wahyu Kurniawan Dinar Faiza Diyah Woro Dwi Lestari Dwi Kustiani, Dwi Dwi Utami Anjarwati Dyla Annisa Putri Eman Sutrisna Eman Sutrisna Fadhilah Nurul Hayati Faiza, Dinar Farah Coutrier Filliana Savitri Fitranto Arjadi Fitranto Arjadi Fitranto Arjadi Fitranto Arjadi Gembong Satria Mahardhika Gembong Satria Mahardhika Hatmoko, Sito Hernawati Hernawati Hidayat Sulistyo Ika Murti Harini Ika Ristianingrum, Ika Ina Permata Dewi Indah Pusparini Indah Rahmawati Intani Kurnia Savitri Izzati Muhimmah Joko Mulyanto Joko Mulyanto Joko Mulyanto, Joko Joko Setyono Khafid Nawawi Kotale, Nichola Noelle Krisniawati, Nia Lalu Mutawalli Leily Trianty Lestari , Diyah Woro Dwi Lestari, Diyah Woro Dwi Lies Anne Severijnen, Lies Anne Metta Ayu Susanti Metta Ayu Susanti Miko Ferine Moh Reza Syaifur Rizal Monika Putri Solikah Muhammad Dodik Prastiyo Muhammad Fahmi Aminuddin Muhammad Nur Hanief Muhammad Nur Hanief, Muhammad Nur Mujiburrahman, Husnan Nendyah Roestijawati Norina Agatri Nouval Keandre Nur Signa Aini Gumilas Nurcahyani, Putri Silvia Pamela Sandhya De Jaka Paulus Gozali Paulus Gozali, Paulus Peter Hanzon, Peter Pramuditya, Hafizh Zufar Pugud Samodro Purwoko, Ari Qodri Santosa Qodri Santosa, Qodri Rani Afifah Nur Histiyani Rendi Retissu Rintis Noviyanti Rizki Rijatullah Rob Willemsen, Rob Rohmatul Fajriyah Saien Saien Sakina, Ghaida Saryono Saryono Siti Aminah Siti Munfiah SIWI PRAMATAMA MARS WIJAYANTI Siwi Pramatama Mars Wijayanti Sjafril Sanusi Sultana MH Faradz Suprihatin Suprihatin Teguh Haryo Sasongko Thianti Sylviningrum Vitasari Indriani Wahyu Siswandari Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin Wayan Tunas Artama Widodo, Yundandhika Rizki Wijaya, Helmi Aditya Wiwiek R Adawiyah Yudhi Wibowo Zaenal Adi Susanto Zulfa Zahra Salsabila