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All Journal Jurnal Kedokteran Brawijaya MANDALA of Health Journal of Biomedicine and Translational Research Jurnal NERS MEDISAINS Majalah Kedokteran Universa Medicina Jurnal Pengabdian Pada Masyarakat Dinamisia: Jurnal Pengabdian Kepada Masyarakat Molekul: Jurnal Ilmiah Kimia Scripta Biologica Jurnal Informatika dan Rekayasa Elektronik Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Of Bionursing Jurnal Comprehensive Health Care BALABA (JURNAL LITBANG PENGENDALIAN PENYAKIT BERSUMBER BINATANG BANJARNEGARA) Indonesian Journal of Global Health research Insights in Public Health Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Mandala of Health : A Scientific Journal Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) Jurnal Ekonomi, Bisnis, dan Akuntansi Medical and Health Journal Indonesian Journal of Dentistry Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia Linggamas: Jurnal Pengabdian Masyarakat

Lantip Rujito

Departemen Genetika Dan Biologi Molekuler, Fakultas Kedokteran Universitas Jenderal Soedirman

Author-ID : 365313

Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Exploring Perceptions of Marriage and Reproductive Health Among Thalassemia Patients in Banyumas Regency Kotale, Nichola Noelle; Wijayanti, Siwi Pramatama Mars; Rujito, Lantip
Insights in Public Health Journal Vol 5 No 1 (2024): Insights in Public Health Journal
Publisher : Department of Public Health, Faculty of Health Sciences, Jenderal Soedirman University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.iphj.2024.5.1.12880

Abstract Background: Thalassemias are a large group of autosomal recessive disorders characterized by imbalanced globin chain production, resulting in and haemolytic anaemia. The complications of thalassemia arise due to iron overload in the bodily organs. Iron overload in the endocrine glands causes hypogonadism, which then affects the growth of reproductive organs. As a result, reproduction in thalassemia patients is not a normal procedure. Thalassemia patients considering marriage and having a family go through so many psychological problems in life, which are influenced by factors such as their socioeconomic status, adherence to treatment and complications. These factors play a role in shaping the perceptions towards marriage and reproduction of thalassemia patients. Method: This study was aimed at exploring the perceptions surrounding marriage and reproduction. This research was a descriptive study design conducted in Purwokerto, Central Java. Data was collected for 37 participants through interviews and questionnaires, for variables on sociodemographic, attitude to treatment, and perceptions surrounding marriage and reproduction. Data was analyzed using Microsoft excel and Minitab software version 22. Results: The results demonstrated that the average age of the participants was 26.41 with a standard deviation of 5.93. The youngest participant was 16 years and the oldest was 39 years old. 84% of the participants were female and 16% were male. 75% of the participants had an education level of high school or lower, 81% had economic support, and 56% had jobs with income. Most participants never abandoned blood transfusion therapy, iron chelation, and other necessary treatments. Many reported of experiencing negative impacts in their lives, despite the absence of complications. Married participants still report of experiencing infertility, while some have children. Many participants agree for prenatal diagnosis of thalassemia foetus but disagree on abortion of thalassemia foetus. Participants interviewed about their perception regarding male and female contraceptive methods, had little knowledge regarding the subject. Conclusion: More studies are needed to fully explore the perceptions on marriage and reproductive health of thalassemia patients. Thalassemia patients willing to start a family go through so many challenges, and need collective support from the society and caregivers, for them to live a normal life. Thalassemia patients should also understand reproductive health through counselling. Keywords: Marriage, Thalassemia, Reproductive Health, Fertility

PREVALENSI Candida albicans PADA PASIEN OTOMIKOSIS DI RSUD MARGONO SOEKARJO Wijaya, Helmi Aditya; Darmawan, Anton Budhi; Nur Hestiyani, Rani Afifah; Krisniawati, Nia; Rujito, Lantip
Medical and Health Journal Vol 3 No 1 (2023): August
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.mhj.2023.3.1.8643

Background: Otomycosis is an infection of the ear caused by various fungi. One of the most common fungi that cause Otomycosis is Candida albicans. Otomycosis is a challenge for the medical world and patients because it requires long-term treatment and has a high recurrence rate. It causes the importance of an overview of the prevalence in a place as planning health services, description of cases, and eradication programs. Banyumas Regency has a climate that supports the growth of mushrooms. One of the major hospitals in Banyumas is RSUD Margono Soekarjo. Objective: Knew the prevalence of Candida albicans on Otomycosis at Margono Soekarjo Hospital. Method: This research is a descriptive observational study on the target population of patients at the ENT clinic at RSUD Margono Soekarjo—sampling technique using a total sampling of as many as 42 subjects with 46 samples. Data analysis techniques use univariate analysis to describe the characteristics of each variable. Results: The results of otomycosis sufferers at Margono Soekarjo Hospital were male compared to female by 50:50, namely 21 of 42 subjects (50.00%), respectively. The age group that suffered the most from Otomycosis was the 26-35 age group, with 12 out of 42 subjects (28.57%). The prevalence of Candida albicans in Otomycosis of 2.17% or 1 of 46 patient samples with a clinical diagnosis of Otomycosis at Margono Soekarjo Hospital was caused by a fungus Candida albicans. Conclusion: Prevalence Candida albicans as a cause of Otomycosis in patients at the ENT polyclinic at Margono Soekarjo Hospital in the Januari-February 2023 period of 2.17%, namely 1 out of 46 samples, with 26 years of age included in the 26-35 years age group and female.

Educational Intervention to Improve Knowledge and Attitudes about Thalassemia Premarital Screening Surveys among Muslim Societies: A Pilot Study in Indonesia Rujito, Lantip; Pusparini, Indah; Lestari, Dyah Woro Dwi; Mulyanto, Joko
Jurnal Keperawatan Soedirman Vol 18 No 1 (2023): Jurnal Keperawatan Soedirman (JKS)
Publisher : Fakultas Ilmu-ilmu Kesehatan

Premarital screening is an effective preventive intervention to decrease the prevalence of thalassemia. However, the use of premarital screening is still low in Indonesia. This study assesses the effect of educational interventions on the knowledge and attitudes of Muslim couples regarding premarital screening for thalassemia in Indonesia. This pilot study used a pre-posttest design that included 17 premarital couples in Banyumas District. The participant’s knowledge and attitude regarding premarital screening for thalassemia were measured using a paper-based questionnaire before and after the intervention. The participants received a class-based lecture about thalassemia screening and were provided a handbook containing lecture material to read at home. The knowledge and attitude score was analyzed using Wilcoxon and Kruskal-Wallis test. The knowledge score significantly increased after the intervention, but the proportion of positive attitudes did not differ significantly. The participants knew that premarital screening for thalassemia was necessary; however, it did not affect their marriage decision. Thus, educational intervention increases the knowledge and shapes the attitude of couples toward thalassemia premarital screening but is inadequate for changing their behavior. Further exploration of the factors that affect the behavior of couples is needed to increase the use of premarital screening among couples in Indonesia.

Investigating the level of Hba1c and insulin level in β-thalassemia patients Mujiburrahman, Husnan; Santosa, Qodri; Setyono, Joko; Roestijawati, Nendyah; Rujito, Lantip
MEDISAINS Vol 21, No 3 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i3.18362

Background: β-thalassemia is an inherited blood disorder characterized by reduced or no synthesis of β globin chain, resulting in chronic anemia, so blood transfusion is required as curative therapy. Repeated blood transfusions lead to iron overload that can lead to multiple organ damage, including pancreatic organs.Objective: This study aimed to describe HbA1c and insulin levels of β-thalassemia patients. The study also tested whether there was a significant difference in insulin and HbA1c levels among patients with different β-thalassemia categories. Method: This research was an analytic observational study. The samples were taken by total sampling and involved 30 patients, and the examination was carried out using the patient's blood plasma.Result: The study found that samples had low HbA1c levels. There was no significant mean difference (p>0.05) between insulin and HbA1c in the mild, moderate, and severe clinical degree groups. There was no significant difference in average (p>0.05) insulin and HbA1c in the thalassemia sufferers with allele β+ and β0 types.Conclusion: There was a decrease in insulin and HbA1c in patients with β-thalassemia, which may be caused by damage pancreatic organ damage.

Peran Kegiatan “Family Gathering” dalam Membangun Emosi Sosial Penyandang Thalassemia di Banyumas Faiza, Dinar; Lestari , Diyah Woro Dwi; Suprihatin, Suprihatin; Purwoko, Ari; Aminah, Siti; Rujito, Lantip
Karunia: Jurnal Hasil Pengabdian Masyarakat Indonesia Vol. 2 No. 3 (2023): September : Jurnal Hasil Pengabdian Masyarakat Indonesia
Publisher : Fakultas Teknik Universitas Maritim AMNI Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58192/karunia.v2i3.1108

Thalassemia is a genetic disease that is still a problem in Indonesia. Patients often face emotional problems and difficulties in social relationships. This condition can affect the management and treatment of thalassemia. Family gatherings play an important role in strengthening the support system for thalassemia patients and their families. The collective strength and determination gained from this family gathering helps thalassemia patients and their families face the challenges of this condition head-on, bringing a sense of hope and optimism for the future. Family gathering activities were carried out which were attended by more than 200 patients and their families. Overall, family gatherings focused on strengthening thalassemia families and patients provide an important platform for support, education, and empowerment. Family gatherings increase emotional support, belonging, remove stigma, and motivate to always be better.

Pemberdayaan Ekonomi Penyandang Thalasemia di Banyumas Raya Melalui Kegiatan Pelatihan Usaha Kain Ecoprint dan Shibotik Lestari, Diyah Woro Dwi; Rujito, Lantip; Sulistyo, Hidayat; Faiza, Dinar; Sylviningrum, Thianti
Linggamas: Jurnal Pengabdian Masyarakat Vol 2 No 2 (2025): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2025.2.2.13478

Penyandang thalassemia menghadapi tantangan yang signifikan terutama tantangan fisik, psikologis dan ekonomi. Keterbatasan fisik dan kewajiban melakukan transfusi darah secara rutin membatasi para penyandang dalam kegiatan ekonomi. Keterbatasan partisipasi ini dimungkinkan berpengaruh pada kondisi perekonomian mereka. Tim pengabdian masyarakat dari Fakultas Kedokteran Universitas Jenderal Soedirman berinisiatif untuk menginisiasi kegiatan yang sekiranya dapat menjawab tantangan ini. Kegiatan yang dimaksudkan ialah pelatihan keterampilan pembuatan kain shibori dan ecoprint bagi anggota perkumpulan penyandang thalasemia di Banyumas Raya. Tujuan dilakukan kegiatan ini selain untuk meningkatkan kemampuan dan keterampilan usaha kain shibori dan ecoprint, juga untuk mengakrabkan sesama anggota perkumpulan dan memperluas jejaring. Tim Pengabdi berkerja sama dengan Perkumpulan Penyandang Talasemia Indonesia (PPTI) cabang Banyumas. Metode yang dilakukan meliputi pemberian materi di kelas, praktek bersama ahli dan diskusi mengenai potensi pengembangan usaha. Peserta pelatihan mengapresiasi upaya tim pengabdi dan memberikan evaluasi secara kualitatif.

Marker Biokimia Penyakit Talasemia-β: Tinjauan Sistematis tentang Diagnosis, Pemantauan, Anemia, Ferritin, Hepcidin, MCV, dan MCHC Assha Luthfianie; Lantip Rujito
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 2 (2025): Agustus : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i2.6447

Thalassemia is a genetic disorder characterized by impaired hemoglobin synthesis. This disease is caused by mutations in the globin gene, leading to disrupted production of globin chains. As a result, the red blood cells produced are dysfunctional and have a shorter lifespan, causing anemia. This condition requires proper medical management, including blood transfusions and other treatments. One way to detect and monitor the progression of thalassemia is by using biochemical markers that can identify changes in the patient’s body. Therefore, the aim of this systematic literature review is to identify biochemical markers that can be used for the diagnosis and monitoring of thalassemia. The literature used in this study includes articles on human thalassemia research published in the last 10 years. Literature searches were conducted in several academic databases using relevant keywords such as “biochemical markers for thalassemia,” “diagnosis of thalassemia,” and “thalassemia monitoring.” Based on the search results, several biochemical markers related to thalassemia were identified, including hepcidin, ferritin, and lipid profile. Ferritin plays a role in monitoring iron levels, which are often elevated in thalassemia patients, while hepcidin regulates iron homeostasis in the body. Additionally, other components involved in thalassemia diagnosis and monitoring include Mean Corpuscular Volume (MCV), Mean Corpuscular Hemoglobin (MCH), Mean Corpuscular Hemoglobin Concentration (MCHC), and hemoglobin levels. The findings of this systematic literature review are expected to provide a comprehensive overview of biochemical markers that can be used in the diagnosis and monitoring of thalassemia. By identifying relevant markers, it is hoped that more accurate and effective diagnostic methods will be developed in the future, leading to better monitoring of thalassemia patients.

IRON OVERLOAD, COMPROMISED SALIVARY FUNCTION, AND DENTAL CARIES RISK IN BETA-THALASSEMIA MAJOR: A CROSS-SECTIONAL Ramadhani, Amilia; Pramuditya, Hafizh Zufar; Nurcahyani, Putri Silvia; Taqwim, Ali; Basalamah, Muhammad; Widodo, A. Haris Budi; Rujito, Lantip
Indonesian Journal of Dentistry Vol 5, No 2 (2025): August 2025
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/ijd.v5i2.17807

Background: β-thalassemia major patients exhibit higher dental caries prevalence due to systemic complications including iron overload from regular blood transfusions. This study aimed to assess dental caries status, salivary pH, and buffer capacity in β-thalassemia major patients and investigate correlations with ferritin blood concentration.Method: A cross-sectional analytical study was conducted on 24 β-thalassemia major patients aged 12-17 years. Salivary function was assessed by salivary pH and buffer capacity. Dental caries status was evaluated using the DMF-T index. Ferritin blood concentrations were correlated with salivary function and dental caries using Pearson analysis.Outcome: Mean salivary pH was 5.74±0.63 (acidic), buffer capacity was 3.98±0.21, DMF-T score was 6.17±1.97, and ferritin level was 5830.54±2823.91 ng/mL. Ferritin levels showed moderate negative correlations with salivary pH (r=-0.718, p<0.001) and buffer capacity (r=-0.737, p<0.001), and positive correlation with DMF-T scores (r=0.696, p<0.001). Strong negative correlations were found between DMF-T scores and salivary pH (r=-0.915, p<0.001) and buffer capacity (r=-0.913, p<0.001).Conclusion: Iron overload significantly compromises salivary parameters, creating an acidogenic oral environment that promotes dental caries development in β-thalassemia major patients, emphasizing the need for integrated oral health monitoring in thalassemia management protocols.

The Interplay between Hepcidin, Il-6, and NF-ΚB in Transfusion-Dependent Thalassemia-Β Patients Alifah, Assha Luthfianie; Rujito, Lantip; Siswandari, Wahyu
Indonesian Journal of Global Health Research Vol 7 No 2 (2025): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v7i2.5630

Hepcidin, a key regulator of iron metabolism, interacts with inflammatory cytokines like IL-6 and transcription factors such as NF-κB, which play crucial roles in the body's response to inflammation and iron homeostasis especially in transfusion-dependent Thalassemia-β patient. Their interplay in transfusion-dependent thalassemia-β patients, particularly in the context of iron chelation therapy, remains underexplored. Understanding these dynamics could provide insights into optimizing treatment strategies for better patient outcomes. Objective: Determine the relationship between hepcidin levels and IL-6 and NFκB in β-thalassemia sufferers who underwent blood transfusions and determine the effect of the type of iron chelation, and the regularity of iron chelation consumption with the relationship between hepcidin, IL-6 and NFκB levels in β-thalassemia sufferers who underwent transfusions blood. Method: A cross-sectional, quantitative correlation study involving transfusion-dependent thalassemia-β patients was conducted. Serum levels of hepcidin, IL-6, and NF-κB were measured, and the relationships among these biomarkers were analyzed using Pearson correlation. The impact of iron chelation therapy type and adherence on these relationships was also assessed using stratified statistical analysis. Results: Hepcidin levels with IL-6 were found with p = 0.757. The next analysis is the relationship between Hepcidin levels and NFκB with p = 0.029. Conclusions: The relationship between hepcidin levels and IL-6 did not contribute significantly, while there was a significant relationship between hepcidin levels and NFκB. The relationship was influenced by moderating variables, namely the type of iron chelation and the regularity of iron chelation consumption.

Peran Serta Akademisi dalam Aktivasi Yayasan Thalassemia Indonesia Cabang Banyumas Rujito, Lantip; Siswandari, Wahyu; Lestari, Diyah Woro Dwi; Faiza, Dinar; Aminah, Siti; Purwoko, Ari; Suprihatin, Suprihatin
Linggamas: Jurnal Pengabdian Masyarakat Vol 1 No 2 (2024): Linggamas: Jurnal Pengabdian Masyarakat
Publisher : Fakultas Kedokteran Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.linggamas.2024.1.2.10561

Thalassemia telah menjadi masalah kesehatan yang mendesak di Indonesia karena tingginya prevalensi pembawa dan individu yang terkena. Keberagaman kelompok etnis di nusantara berkontribusi pada distribusi jenis thalassemia yang bervariasi, dengan beta-thalassemia menjadi yang paling umum. Data epidemiologi menggarisbawahi kebutuhan mendesak untuk strategi komprehensif untuk memerangi thalassemia dan meningkatkan kualitas hidup individu yang terkena. Gerakan thalassemia di Indonesia diprakarsai oleh Yayasan Thalassemia Indonesia (YTI). YTI telah muncul sebagai kekuatan pendorong di balik peningkatan kesadaran, mengadvokasi kebijakan perawatan kesehatan yang lebih baik, dan mendorong jaringan dukungan untuk pasien dan keluarga mereka. Kegiatan yayasan mencakup berbagai bidang, termasuk kampanye publik, program pendidikan, dan inisiatif penelitian. Upaya kolaboratif antara yayasan dan akademisi telah mendorong pendekatan sinergis, menggabungkan keahlian ilmiah dengan advokasi akar rumput dan keterlibatan masyarakat. Partisipasi akademisi memainkan peran penting dalam membentuk kegiatan yayasan, mulai dari penelitian dan peningkatan kapasitas hingga konseling dan skrining genetik. Kekuatan kemitraan interdisipliner dalam mengatasi tantangan kesehatan yang kompleks diharapkan dapat meningkatkan kehidupan individu yang terkena thalassemia.

Co-Authors A. Haris Budi Widodo Abdul Aziz Agus Suroso Ahdi, Muwaffiyul Alfi Muntafiah Ali Taqwim Alifah, Assha Luthfianie Amalia Muhaimin Amilia Ramadhani Aminuddin, Muhammad Fahmi Anton Budhi Darmawan Arfi Nurul Hidayah Ariadne Tiara Hapsari Ariadne Tiara Hapsari Ariadne Tri Hapsari Arif Imam Hidayat Arini Dewi Setyowati Assha Luthfianie Basalamah, Muhammad Darmawan, Anton Budhi Desiyani Nani Dhadhang Wahyu Kurniawan Dinar Faiza Diyah Woro Dwi Lestari Dwi Kustiani, Dwi Dwi Utami Anjarwati Dyla Annisa Putri Eman Sutrisna Eman Sutrisna Faiza, Dinar Farah Coutrier Ferrine, Miko Filliana Savitri Fitranto Arjadi Fitranto Arjadi Fitranto Arjadi Fitranto Arjadi Gembong Satria Mahardhika Gembong Satria Mahardhika Hatmoko, Sito Hidayat Sulistyo Ika Murti Harini Ika Ristianingrum, Ika Ina Permata Dewi Indah Pusparini Indah Rahmawati Intani Kurnia Savitri Izzati Muhimmah Joko Mulyanto Joko Mulyanto Joko Mulyanto, Joko Joko Setyono Khafid Nawawi Kotale, Nichola Noelle Krisniawati, Nia Lalu Mutawalli Leily Trianty Lestari , Diyah Woro Dwi Lestari, Diyah Woro Dwi Lies Anne Severijnen, Lies Anne Metta Ayu Susanti Metta Ayu Susanti Miko Ferine Moh Reza Syaifur Rizal Monika Putri Solikah Muhammad Nur Hanief Muhammad Nur Hanief, Muhammad Nur Mujiburrahman, Husnan Nendyah Roestijawati Norina Agatri Nouval Keandre Nur Signa Aini Gumilas Nurcahyani, Putri Silvia Pamela Sandhya De Jaka Paulus Gozali Paulus Gozali, Paulus Peter Hanzon, Peter Pramuditya, Hafizh Zufar Pugud Samodro Purwoko, Ari Qodri Santosa Qodri Santosa, Qodri Rani Afifah Nur Histiyani Rendi Retissu Rintis Noviyanti Rizki Rijatullah Rob Willemsen, Rob Rohmatul Fajriyah Saien Saien Sakina, Ghaida Saryono Saryono Siti Aminah Siti Munfiah Siwi Pramatama Mars Wijayanti SIWI PRAMATAMA MARS WIJAYANTI Sjafril Sanusi Sultana MH Faradz Suprihatin Suprihatin Teguh Haryo Sasongko Thianti Sylviningrum Thianti Sylviningrum Vitasari Indriani Wahyu Siswandari Wahyudin Wahyudin Wahyudin Wahyudin Wayan Tunas Artama Widodo, Yundandhika Rizki Wijaya, Helmi Aditya Wiwiek R Adawiyah Yudhi Wibowo Zaenal Adi Susanto Zulfa Zahra Salsabila

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