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Journal : HAYATI Journal of Biosciences

In vitro and In vivo Antiplasmodial of Stem Bark Extract of Garcinia husor Healthy Kainama; Sri Fatmawati; Mardi Santoso; Pieter Kakisina; Taslim Ersam
HAYATI Journal of Biosciences Vol. 26 No. 2 (2019): April 2019
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (407.117 KB) | DOI: 10.4308/hjb.26.2.81

Abstract

Garcinia husor is one of the folk medicines in Maluku-Indonesia. This species has been used for the treatmet of Malaria disease. The phytochemical contents and antiplasmodial activity not reported yet. In this study we evaluated the quantitative phytochemicals, in vitro and in vivo antiplasmodial activity of stem bark ethyl acetate extract. In vitro assay was done using P. falciparum 3D7 strain sensitive of chloroquine. For in vivo analysis, four groups of M. musculus were infected by P. berghei and their parasitemia levels were for 7 days of treatment with ethyl acetate extract; hematological and biochemical parameter were analyzed at the end of experiment. The result showed ethyl acetate extract with the TPC (169.47 mg GAE/100 g ±0.61) and TPC (167.37 mg QE/100 g ±1.05) was active against P. falciparum 3D7 strain (IC50 value of 0.31±0.43 μg/ml). The animal treated with extract showed suppression of parasitemia to 87.57±1.41% compared with the P. berghei infected-mice (negative control), ED50 value of 22.30 mg/kg BW. The dose of extract in 200 mg/kg BW was reduce parasitemia of infected mice with P. berghei more potential. The ethyl acetate of the stem bark G. husor with has antiplasmodial properties and future investigation are necessary to elucidate its mechanism of action.
Co-Authors Aang Wahidin Adama, Amelia Bella Putri Adianto Adianto Adityo Pratomo Putro Afifah, Rizqi Nur Agustina Merdekawati Ahmad Rizqi Alima Fabri Alam, Yusuf Syahril Alfanda, Benedcita Dian Aminatus Sa’diyah Ananda Krisna Aldianita Andifa, Vinda Aprilia Nurul Angelia Angelia Ani Iryani Anisa Rahma Maharani Anton Royanto Ahmad Ardi Lukman Hakim Arif Fadlan Ariwiyono, Nopem Aunurohim Aunurohim Awik P.D. Nurhayati Azhaar, Nadia Bambang Antoko Benedicta Dian Alfanda C. I. Sutrisno Cahyaningati, Desi Cahyono, Luqman Cicilia Puspa Rini Dahlena Ariyani David StC Black Dewi Kurniasih Dheva Noveilya Didik Prasetyoko Didik Sukoco Djoko Hartanto Duhita, Shinta Ratna Edi Haryono Eko Julianto Eky Novianarenti Eky Novianarenti Endro, R. Dimas Eva Melinda Evan Evan Fadlan, Arif Fahimah Martak Fatimatul Munawaroh Fatimatul Munawaroh Fendra Wician Fendra Wician Fiqey Indriati Eka Sari FITRIA, NURAINI Ghaissani, Shabrina Syifa Gusma Hamdana Putra Hadi Nur Hadi Nur Haidhar Wahyu S Hakam, M Hanafi Hanafi Haniarta Gemilang Sari Hartati Hartati Hartono Gunarso Hasliza Bahruji Healthy Kainama Helena Fabiani Hendro Agus Widodo, Hendro Agus Henny Tanadi Tan Herdayanto Sulistyo Putro Herijono, Boedi Heriyansyah, Rafi Akbar I Made Putra Ananta W Ikang Martin Trasnowo Imelda Imelda Imelda Priskila Simanjuntak Imroatul Qoniah Ingeswari, Aulya Vidiana Ivan DP Sunardi Jesika Setiawan Jovita Jovita KAMILIA MUSTIKASARI Kamilia Mustikasari Kavin, Layli Adha Nadira kholifatu rosyidah Kholifatu Rosyidah Khozin, Muhamad Nur Kristian Ariya Sedayu Kusdiantomo Kusdiantomo Kusminah, Imah Luluk Kusuma, George Endri Laila Khamsatul Muharrami, Laila Khamsatul Leaw Wai Loon Lingga Kamadatu Lukman Atmaja M Anis Mustaghfirin M Daffa Aditya M Hakam M. Rizal Fahmi Maharani, Aditya Maria Dewi Astuti Marshel Tendean Marshell Tendean Marshell Tendean Maya Damayanti Mochamad Luqman Ashari Mochammad Choirul Rizal Mochammad Purwanto Mohammad Abu Jami'in Monica Puspa Sari muhammad fatoni, muhammad Muhammad Nur Kholis Muhammad Nur Kholis Mustaghfirin, M Anis Nabilah Dita Anaqah Nadia Sasanti Naufal Salehtra Ghalib Ni Kadek Githa Kartika Gunadyani Nindyapuspa, Ayu Ni’matut Tamimah Noer Komari Nor Farida Novpi Susanto Nugraeni, Christine Dyta Nugraheni, Zjahra Vianita Nur Hayati Nur Hayati Nurjanah, Ana Nurkholis Hamidi Pieter Kakisina Ponti Almas Karamina Pramesti, Lely Pranowo Sidi Purnami Purwanto, Mochammad Puspitasari Puspitasari Rafi Akbar Heriyansyah Rahma Rahayu Dinarlita Rahmat Rosid Ratna Ediati Regie Santoso Reynaldi Aurel Fadiilah Rini Indarti RR. Ella Evrita Hestiandari Ruzain Rafie Sukma Putra Salsabila, Yofinta I Salsabilla, Shava Alifia Sarmoko Sarmoko Sa’diyah, Aminatus Sembiring, Rinawati Sinurat, David Fernando Sri Fatmawati Sugeng Triwahyono Sumardiono . Susan Susan Susana Chandra Susanna Ndraha Susi Agustina Wilujeng Susy Budi Astuti SUYATNO Suzanna Ndraha Syafiuddin Syafiuddin Syamsiar, Syamsiar Tamimah, Nimatut Taslim Ersam Taslim Ersam Umbara, Albert Wida Utomo, Agung Prasetyo Vanuella Tresnaning Budi Wati, First Ambar Wong Hendra Widjaja Yani Cahyo Susilo Yaqdhan Nufal Rafi Yatim Lailun Ni’mah Yuli Kusumawati Yuli Kusumawati Zainul Mujib Zulqurnain, Muhammad