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All Journal HAYATI Journal of Biosciences IPTEK Journal of Proceedings Series Jurnal Matematika & Sains The Journal of Pure and Applied Chemistry Research Jurnal Riset Kimia Jurnal Riset Industri Hasil Hutan PENA SAINS INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Indonesian Journal of Chemistry Jurnal Ilmu Kefarmasian Indonesia Metta : Jurnal Ilmu Multidisiplin Society: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Berkala: Sains dan Terapan Kimia The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy Sewagati International Journal of Cell and Biomedical Science Jurnal Pengabdian Sosial Jurnal Kedokteran Meditek Jurnal Teknologi Maritim International Conference on Maritime Technology and Its Application Proceedings Conference on Marine Engineering and its Application
Mardi Santoso
Department Of Chemistry Institut Teknologi Sepuluh Nopember, Surabaya
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Journal : International Journal of Cell and Biomedical Science

 1 
Trisindoline 5 Compound Inhibits Human Breast Cancer Stem Cell Formation by Downregulating the BCL-2 Gene Expression Fatoni, Muhammad; Salsabila, Yofinta I; Nurhayati, Awik P.D.; Ghaissani, Shabrina Syifa; Santoso, Mardi; Martak, Fahimah
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.19

Abstract

Background: Breast cancer cell's growth and survival are supported by breast cancer stem cells (bCSCs) mammosphere formation. bCSCs represent a subpopulation of undifferentiated cancer cells which associated with self-renewing abilities, tumor initiation, drug resistance, and metastasis. Overexpression of the B Cell Lymphoma 2 (BCL-2) family in many tumor cells contributes to apoptosis resistance. Trisindoline is an indole trimer alkaloid natural compound that provides a cytotoxic effect on cancer cells. A new modification of trisindoline has been synthesized into trisindoline 5 in 2021. Objective: This study purposed to investigate the effect of trisindoline 5 compounds against BCL-2 gene expression in bCSCs in vitro. Methods: The bCSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, the results showed that trisindoline 5 may decrease the expression of BCL-2 in MDA-MB-231 cells. Conclusion: This study concludes that trisindoline 5 could downregulate the antiapoptotic BCL-2 gene expression in bCSCs in vitro.
Upregulation of P53 Gene Expression on Breast Cancer Stem Cells Treated with Trisindoline 5 Compound Salsabila, Yofinta I; Azhaar, Nadia; Fatoni, Muhammad; Nurhayati, Awik P.D.; Ghaissani, Shabrina Syifa; Andifa, Vinda Aprilia Nurul; Santoso, Mardi; Martak, Fahimah
International Journal of Cell and Biomedical Science Vol 1 No 2 (2022)
Publisher : Stem Cell and Cancer Research (SCCR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59278/cbs.v1i2.20

Abstract

Background: Cancer stem cells (CSCs) are the subpopulation of cancer cells that have been demonstrated as the cause of tumor formation. The most common cancer for women and the second leading cause of death in breast cancer. Numerous genes have been involved in breast cancers, including p53. In cancer cells, p53 as well-known as the tumor suppressor gene plays an important role in directing cells with DNA damage into apoptosis. Trisindolines are heterocyclic nitrogen compounds consisting of an isatin core bearing two indole moieties that provide cytotoxic effects on cancer cells. Recently research had led to the development of the new modification of trisindoline compound into trisindoline 5. Objective: This study aims to investigate the effect of trisindoline 5 compounds against p53 gene expression in CSCs MDA-MB-231 in vitro. Methods: CSCs MDA-MB-231 were divided into control and treatment groups which were further analyzed in gene expression using the qPCR Livak method. Results: Based on gene expression analysis, trisindoline 5 increases the expression of p53 in CSCs MDA-MB-231. Conclusion: This study informed that trisindoline 5 could upregulate the expression of tumor suppressor gene p53 in CSCs MDA-MB-231 in vitro.
Co-Authors Aang Wahidin Adityo Pratomo Putro Afifah, Rizqi Nur Agustina Merdekawati Ahmad Rizqi Alima Fabri Alfanda, Benedcita Dian Aminatus Sa’diyah Ananda Krisna Aldianita Andifa, Vinda Aprilia Nurul Angelia Angelia Ani Iryani Anisa Rahma Maharani Ardi Lukman Hakim Arif Fadlan Ariwiyono, Nopem Ashari, Moch. Luqman Aunurohim Aunurohim Awik P.D. Nurhayati Azhaar, Nadia Bambang Antoko Benedicta Dian Alfanda Cahyaningati, Desi Cahyono, Luqman Cicilia Puspa Rini Dahlena Ariyani David StC Black Dewi Kurniasih Dheva Noveilya Didik Prasetyoko Didik Sukoco Djoko Hartanto Edi Haryono Eko Julianto Eky Novianarenti Eky Novianarenti Endro, R. Dimas Eva Melinda Evan Evan Fadlan, Arif Fahimah Martak Fatimatul Munawaroh Fatimatul Munawaroh Fendra Wician Fendra Wician Fiqey Indriati Eka Sari Ghaissani, Shabrina Syifa Gusma Hamdana Putra Hadi Nur Hadi Nur Haidhar Wahyu S Hakam, M Hanafi Hanafi Haniarta Gemilang Sari Hartati Hartati Hartono Gunarso Hasliza Bahruji Healthy Kainama Helena Fabiani Hendro Agus Widodo, Hendro Agus Henny Tanadi Tan Herdayanto Sulistyo Putro Heriyansyah, Rafi Akbar I Made Putra Ananta W Ikang Martin Trasnowo Imelda Imelda Imelda Priskila Simanjuntak Imroatul Qoniah Ingeswari, Aulya Vidiana Ivan DP Sunardi Jesika Setiawan Jovita Jovita KAMILIA MUSTIKASARI Kamilia Mustikasari Kavin, Layli Adha Nadira kholifatu rosyidah Kholifatu Rosyidah Khozin, Muhamad Nur Kristian Ariya Sedayu Kusdiantomo Kusdiantomo Kusminah, Imah Luluk Kusuma, George Endri Laila Khamsatul Muharrami, Laila Khamsatul Leaw Wai Loon Lingga Kamadatu Lukman Atmaja M Anis Mustaghfirin M Daffa Aditya M Hakam M. Rizal Fahmi Maharani, Aditya Maria Dewi Astuti Marshel Tendean Marshell Tendean Marshell Tendean Maya Damayanti Mochammad Choirul Rizal Mochammad Purwanto Mohammad Abu Jami'in Monica Puspa Sari muhammad fatoni, muhammad Muhammad Nur Kholis Muhammad Nur Kholis Mustaghfirin, M Anis Nabilah Dita Anaqah Nadia Sasanti Naufal Salehtra Ghalib Ni Kadek Githa Kartika Gunadyani Nindyapuspa, Ayu Ni’matut Tamimah Noer Komari Nor Farida Novpi Susanto Nugraeni, Christine Dyta Nugraheni, Zjahra Vianita Nur Hayati Nur Hayati Nurjanah, Ana Pieter Kakisina Ponti Almas Karamina Pramesti, Lely Purwanto, Mochammad Puspitasari Puspitasari Rafi Akbar Heriyansyah Rahma Rahayu Dinarlita Rahmat Rosid Ratna Ediati Regie Santoso Reynaldi Aurel Fadiilah RR. Ella Evrita Hestiandari Ruzain Rafie Sukma Putra Salsabila, Yofinta I Sarmoko Sarmoko Sa’diyah, Aminatus Sembiring, Rinawati Sri Fatmawati Sugeng Triwahyono Sumardiono . Susan Susan Susana Chandra Susanna Ndraha Susi Agustina Wilujeng Susy Budi Astuti SUYATNO Suzanna Ndraha Syafiuddin Syafiuddin Tamimah, Nimatut Taslim Ersam Taslim Ersam Umbara, Albert Wida Utomo, Agung Prasetyo Vanuella Tresnaning Budi Wati, First Ambar Wong Hendra Widjaja Yani Cahyo Susilo Yaqdhan Nufal Rafi Yatim Lailun Ni’mah Yuli Kusumawati Yuli Kusumawati Zainul Mujib Zulqurnain, Muhammad