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All Journal Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Akta Kimia Indonesia Martabe : Jurnal Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana Jambura Journal of Chemistry Jurnal Pengabdian Kepada Masyarakat Ungu ( Abdi Ke Ungu) Pharmacy Reports Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Pharmacy and Natural Product Molekul: Jurnal Ilmiah Kimia TeknoKreatif: Jurnal Pengabdian kepada Masyarakat
Sarmoko Sarmoko
Department Of Pharmacy, Faculty Of Science, Institut Teknologi Sumatera, South Lampung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Inhibition breast carcinogenesis via PI3K/AKT pathway using bioactive compounds of Strychnine tree (Strychnos nux-vomica): in silico study Rispriandari, Aulia Ayu; Sarmoko, Sarmoko; Setyono, Joko; Wisesa, Sindhu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28242

Abstract

Breast cancer poses a significant global health challenge, with a notable prevalence in Indonesia. Given the intricate nature of breast cancer progression and classification, precise treatment strategies are imperative, particularly targeting signaling pathways like PI3K/AKT, pivotal in cell growth, proliferation, survival, and apoptosis. Bioactive compounds from the Strychnine tree demonstrate potential in enhancing apoptotic effects and inhibiting breast carcinogenesis. This potential is explored through in silico studies. This research aims to analyze potential targets of Strychnine tree compounds, along with binding energy and stability between ligands and receptors. Employing bioinformatics target analysis, molecular docking, and molecular dynamics simulation, the study reveals AKT1 as a potential target of Strychnine tree compounds. These compounds inhibit AKT1 at both active and allosteric sites, displaying notably low binding energy scores. For example, brucine exhibits a binding energy of -10.83 kJ/mol at the active site, surpassing the standard capivasertib. However, lupeol, with a binding energy of -11.14 kJ/mol, falls short of the MK-2206 standard at the allosteric site. Molecular dynamics simulations expose fluctuations in parameters like RMSD, RMSF, and binding energy within the initial 5 ns. In conclusion, Strychnine tree compounds, such as brucine and lupeol, showcase potential AKT1 inhibition at both active and allosteric sites, enhancing apoptotic effects. However, the stability of these compounds in binding to their receptors within the first 5 ns of the simulation warrants further investigation for prolonged interactions.   
Penyuluhan dan Pemeriksaan Kadar Kolesterol sebagai Upaya Pencegahan Penyakit Kolesterol pada Lansia di Pekon Gadingrejo Utara, Kecamatan Gadingrejo, Kabupaten Pringsewu Abdul Karim, Dewi Damayanti; Dirga; Sarmoko; Novrilia Atika Nabila; Imam Safei; Charisa Nabirawati Sitindaon; Wenda Reka Pratama; Bama Tangguh Galih; Farhan Fauzan; Tria Putriani; Kireine Kosma Ramadhani; Silvia Damayanti; Adinda Salsabila; Dito Aditya Sasongko; Vigo Atsil Nugraha
Jurnal Pengabdian Kepada Masyarakat Ungu( ABDI KE UNGU) Vol. 6 No. 3 (2024): Jurnal Pengabdian Kepada Masyarakat Ungu ( ABDI KE UNGU)
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/abdi.v6i3.1798

Abstract

High cholesterol or hyperlipidemia is a major risk factor for cardiovascular disorders such as coronary heart disease. Managing high cholesterol can involve lifestyle changes and pharmacological treatment, but many people still lack an understanding of the importance of effective cholesterol management. This Community Service activity aims to raise awareness and knowledge about cholesterol, including risk factors, health impacts, and management strategies through community-based health education programs. The methods of this activity include counseling, open discussions, and health screenings. This community service program was conducted in Pekon Gadingrejo Utara, Gadingrejo District, Pringsewu Regency, with a target specifically aimed at the elderly. The results of this activity showed an increase in public understanding of hyperlipidemia, evidenced by an increase in post-test scores from the pre-test (42,6%). In health screenings with 50 participants, 90% were found to have high cholesterol. This activity was deemed effective in increasing community knowledge and identifying the prevalence of hyperlipidemia among the local elderly population.
Evaluation of natural compounds as VEGFR-2 inhibitors for breast cancer therapy: insights from molecular docking and drug-likeness analysis Aprilia, Vika; Sarmoko; Fareza, Muhamad Salman; Baroroh, Hanif Nasiatul; Choironi, Nur Amalia
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.82

Abstract

Breast cancer remains one of the most common cancers worldwide, with VEGFR-2 (KDR) playing a key role in tumor angiogenesis. Inhibiting VEGFR-2 is a promising therapeutic strategy. Natural compounds are increasingly studied for their potential to inhibit VEGFR-2. This study aims to assess the binding affinity of 11 natural compounds (andrographolide, alpha-mangostin, pinostrobin, pinocembrin, ethyl-p-methoxycinnamate (EPMS), xanthorrhizol, galangin, gamma-mangostin, curcumin, cinnamaldehyde, and alashanoid B) to the VEGFR-2 protein through molecular docking and Lipinski's rule analysis, identifying promising candidates for breast cancer treatment. Molecular docking simulations were performed for 11 compounds and sunitinib as a control, with binding energies and interactions analyzed. The compounds were also evaluated for drug-likeness using Lipinski’s rule of five. Curcumin showed the highest binding affinity to VEGFR-2 with a binding energy of -9.9 kcal/mol, surpassing sunitinib (-9.4 kcal/mol). Key interactions were observed with active site residues Cys919 and Asp1046. All tested compounds met the criteria for oral bioavailability per Lipinski’s rules. Curcumin demonstrates potential as a VEGFR-2 inhibitor due to its favorable binding affinity and drug-like properties. Enhancing curcumin’s bioavailability is recommended for effective therapeutic application.
Pemberdayaan Masyarakat Desa Sabah Balau Melalui Pendampingan Pelatihan Pembuatan Produk Bawang Hitam Rahayyu, Annisa Maulidia; sarmoko, Sarmoko; Nabila, Novrilia Atika; Hidayaturahmah, Rizky; Rooswita, Putri Amelia
TeknoKreatif: Jurnal Pengabdian kepada Masyarakat Vol 4 No 2 (2024): TEKNOKREATIF : Jurnal Pengabdian kepada Masyarakat Volume 4 No 2
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LP2M), Institut Teknologi Sumatera, Lampung, Indonesia.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35472/teknokreatif.v4i2.1770

Abstract

Kondisi ekonomi pasca-pandemi saat ini telah mengakibatkan banyak masyarakat menghadapi berbagai kesulitan termasuk berkurangnya kesempatan kerja. Program pengabdian ini bertujuan untuk memberikan solusi masalah ekonomi pasca-pandemi dengan memperkenalkan peluang pendapatan baru melalui pembuatan produk kesehatan herbal bawang hitam. Metode pembuatan produk kesehatan bawang hitam ini melalui proses fermentasi bawang putih dengan suhu dan waktu yang telah dioptimasi. Metode pengabdian yang dilakukan adalah melakukan penyuluhan dan demo pendampingan pembuatan produk pada ibu-ibu masyarkat di desa Sabah Balau, Lampung Selatan. Dari pre-test dan post-test didapatkan hasil bahwa pengetahuan masyarakat di desa Sabah Balau mengenai cara pembuatan, proses fermentasi, dan manfaat bawang hitam mengalami peningkatan pengetahuan. Kesimpulan dari program pendampingan dan pelatihan mengenai produk kesehatan ini dapat meningkatkan pengetahuan dan kesadaran masyarakat.
PEMBERDAYAAN USAHA EKONOMI KREATIF MELALUI PENDEKATAN PELATIHAN DAN PENDAMPINGAN USAHA PEMBUATAN PRODUK JAMU KEKINIAN SEBAGAI UPAYA PENCAPAIAN SDGS DI KELURAHAN YOSOREJO, KOTA METRO Yulianti Suprahman, Nisa; Hidayaturahmah, Rizky; Hermadi Saputro, Anjar; Irna Windari, Nurul; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 11 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i11.4924-4929

Abstract

Sebagian besar masyarakat di Kelurahan Yosorejo, Kecamatan Metro Timur memiliki pekarangan rumah atau kebun yang sebagian ditanami tanaman obat keluarga (TOGA) seperti kunyit, temulawak, temugiring, jahe kencur, sirih, kecombrang, sambiloto, binahong dan lain-lain. Kendala utama yang dihadapi adalah belum optimalnya pemanfaatan tanaman obat keluarga (TOGA), rendahnya pengetahuan dan teknologi untuk membuat jamu kekinian yang berkualitas, jumlah diproduksi masih terbatas, jenis dan variasi produk juga masih sedikit dan market share masih rendah. Selain produk jamu, tanaman TOGA belum dilakukan pengembangan teknologi menjadi produk herbal yang bernilai ekonomi tinggi seperti sabun.  Faktor tersebut yang membuat industri jamu tradisional tidak bisa berkembang. Maksud Pengabdian Kepada Masyarakat (PKM) adalah mengembangkan usaha jamu kekinian pada Ibu-ibu PKK kelurahan Yosorejo agar dapat membantu meningkatkan pendapatan masyarakat. Tujuannya Mengembangkan dan memperbaiki usaha jamu tradisional menjadi jamu kekinian yang modern yang bisa mengangkat salah satu produk warisan leluhur turun temurun. Dengan cara memproses tahap-tahapan pembuatan produk secara benar, mengedukasi Ibu-Ibu PKK untuk giat mengembangkan usaha yang menguntungkan dan memiliki peluang yang sangat terbuka. Kegiatan dilakukan dengan metode pelatihan secara langsung serta pembagian produk jamu kekinian dan sabun organik ke masyarakat. Hasil dari kegiatan ini adalah masyarakat dapat memahami dan mampu membuat jamu dan sabun organik berbahan dasar tanaman TOGA.
A bibliometric analysis of ginger's anticancer potential: bioactive compounds, cancer types, and mechanisms of action Maharani, Putu Audi Mas; Sarmoko
Pharmacy Reports Vol. 4 No. 2 (2024): Pharmacy Reports
Publisher : Indonesian Young Scientist Group and UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51511/pr.91

Abstract

This study explores the anticancer properties of ginger (Zingiber officinale) through comprehensive bibliometric analysis of literature published from 2015 to 2024. Using PRISMA methodology, 49 relevant articles were identified from PubMed and analyzed through Biblioshiny and VOSviewer software. The International Journal of Molecular Sciences emerged as the leading publication source. Network visualization identified three major research clusters: antioxidant mechanisms, cancer biology, and phytochemical applications. Triple-negative breast cancer and colorectal cancer represent the most extensively studied malignancies. Mechanistically, ginger compounds (particularly gingerols and shogaols) demonstrate anticancer effects through multiple pathways including apoptosis induction, cell cycle arrest, anti-metastatic activity, oxidative stress modulation, and angiogenesis inhibition. While in vitro and preclinical evidence is robust, clinical translation remains limited. This analysis provides a comprehensive overview of ginger's anticancer research landscape, highlighting established mechanisms, identifying knowledge gaps, and suggesting future directions. The findings support ginger's potential as a complementary therapeutic agent and source of lead compounds for anticancer drug development, while emphasizing the need for advanced clinical investigations.
Porang flour optimization as a natural tablet binder for bay leaf extract formulation Nareswari, Tantri Liris; Anandar, Salsabila Fauziah; Putra, Okta Nama; Sarmoko, Sarmoko; Adliani, Nur
Acta Pharmaciae Indonesia Vol 12 No 2 (2024): Acta Pharmaciae Indonesia: Acta Pharm Indo
Publisher : Pharmacy Department, Faculty of Health Sciences, Jenderal Soedirman University, Purwokerto, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.api.2024.12.2.15894

Abstract

Background: The Indonesian pharmaceutical industry relies heavily on imported pharmaceutical raw materials (PRMs), with 90-95% of materials sourced from abroad, leading to increased production costs. Porang tuber (Amorphophallus oncophyllus) contains glucomannan with adhesive properties, making it a potential local alternative for tablet binding agents. Purpose: To optimize bay leaf extract (Syzygium polyanthum) tablet formulation using porang tuber flour and polyvinylpyrrolidone (PVP) as binders through simplex lattice design (SLD). Methods: Porang flour was prepared and characterized for moisture and calcium oxalate content. A tablet formulation optimization study was conducted using Design Expert 13 with porang flour (5-10%) and PVP (0-5%) as independent variables. Responses evaluated included angle of repose, tablet hardness, and disintegration time. The optimized formula was verified and comprehensively characterized. Results: The optimum formula contained 9.86% porang flour and 0.14% PVP, with a desirability value of 0.98. The tablets exhibited satisfactory physical properties: angle of repose 24.70±0.36°, hardness 6.29±0.19 kg, friability 0.51±0.03%, and disintegration time 8.46±0.69 minutes. Statistical analysis confirmed no significant differences between predicted and experimental values (p>0.05). Conclusion: Porang flour can effectively replace synthetic binders in tablet formulations, producing tablets that meet Indonesian Pharmacopoeia standards while reducing dependence on imported excipients.
Inhibition breast carcinogenesis via PI3K/AKT pathway using bioactive compounds of Strychnine tree (Strychnos nux-vomica): in silico study Rispriandari, Aulia Ayu; Sarmoko, Sarmoko; Setyono, Joko; Wisesa, Sindhu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.28242

Abstract

Breast cancer poses a significant global health challenge, with a notable prevalence in Indonesia. Given the intricate nature of breast cancer progression and classification, precise treatment strategies are imperative, particularly targeting signaling pathways like PI3K/AKT, pivotal in cell growth, proliferation, survival, and apoptosis. Bioactive compounds from the Strychnine tree demonstrate potential in enhancing apoptotic effects and inhibiting breast carcinogenesis. This potential is explored through in silico studies. This research aims to analyze potential targets of Strychnine tree compounds, along with binding energy and stability between ligands and receptors. Employing bioinformatics target analysis, molecular docking, and molecular dynamics simulation, the study reveals AKT1 as a potential target of Strychnine tree compounds. These compounds inhibit AKT1 at both active and allosteric sites, displaying notably low binding energy scores. For example, brucine exhibits a binding energy of -10.83 kJ/mol at the active site, surpassing the standard capivasertib. However, lupeol, with a binding energy of -11.14 kJ/mol, falls short of the MK-2206 standard at the allosteric site. Molecular dynamics simulations expose fluctuations in parameters like RMSD, RMSF, and binding energy within the initial 5 ns. In conclusion, Strychnine tree compounds, such as brucine and lupeol, showcase potential AKT1 inhibition at both active and allosteric sites, enhancing apoptotic effects. However, the stability of these compounds in binding to their receptors within the first 5 ns of the simulation warrants further investigation for prolonged interactions.   
Bioinformatic and Molecular Docking Study of Zerumbone and Its Derivates against Colorectal Cancer Fauziyya, Riri; Auli, Winni Nur; Suprahman, Nisa Yulianti; Sarmoko, Sarmoko; Ashari, Arif; Alsadila, Kalista; Agustin, Lanita; Fazila, Safia; Zahra, Miralda; Pane, Esteria Christina; Sukrasno, Sukrasno
Indonesian Journal of Cancer Chemoprevention Vol 14, No 1 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss1pp39-48

Abstract

The prevalence of colorectal cancer (CRC) is ranked third among all cancer types in both men and women, highlighting the urgency for drug exploration. Zerumbone and its derivatives have gained attention for their ability to inhibit angiogenesis, invasion, and metastasis and have been tested for their efficacy against various cancer cells. This study aimed to investigate the potential targets and mechanism of action of zerumbone derivatives in colon cancer invasion and migration. Bioinformatic analysis was conducted using STITCH and STRING to identify potential target genes, and molecular docking was used to search for anticancer candidates from 20 zerumbone derivatives. The results revealed that six proteins were targeted by zerumbone derivatives, including XIAPBIR3 (1TFT), AKT1 (3O96), JAK2 (6VGL), HASP90AA (2XJX), MDM2 (4MDN), and XIAPBIR2 (4KJU). Compound 4 was found to have a lower binding energy than zerumbone as well as AZD5363 (pan-Akt inhibitor) when interacting with the protein target AKT1. This makes it the most promising candidate among the zerumbone derivatives for treating colorectal cancer. Further development, such as the addition of an amine functional group, is expected to improve the potency of this molecule through the formation of hydrogen bonds and other interactions with lower bond energy.Keywords: Bioinformatic, molecular docking, zerumbone derivatives, colorectal cancer.
In Silico Analysis of Cucurbitacin IIa and Cucurbitacin IIb as Potential Modulators of Oxidative Stress Regulatory Proteins Sarmoko, Sarmoko; Suprahman, Nisa Yulianti; Putri, Refsya Azanti; Hakim, Ahmad Zammi Autadan; Cahyadi, Dzaky Raihan; Saputra, Muhammad Yogi
Indonesian Journal of Cancer Chemoprevention Vol 15, No 3 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss3pp224-236

Abstract

Oxidative stress, resulting from imbalance between rective oxygen species (ROS) production and antioxidant defenses, contributes significantly to numerous pathological conditions, including inflammation, cancer and neurodegeneration. Natural compounds with antioxidant properties offer promising therapeutic potential. This study aims to investigate the potential of Cucurbitacin IIa and IIb to modulate oxidative stress regulatory proteins (NOS2, Lipoxygenase, KEAP1, and Xanthine oxidase) using molecular docking approaches. Target protein structures were retrieved from the RSCB Protein Data Bank. Ligand geometries were constructed and optimized using density functional theory. Molecular docking was performed using AutoDock 1.5.6 with a validated docking protocol (RPMS<2Å). Our results demonstrated favorable binding energies for both compounds with NOS2 (-9.75 and -9.57 kcal/mol) and KEAP1 (-8.52 and -9.34 kcal/mol), approaching the affinities of their respective native ligands. Moderate binding was observed with Lipoxygenase (-6.14 and -5.54 kcal/mol), while both compounds showed incompatibility with Xanthine oxidase, as evidenced by highly positive binding energies. The interaction between Cucurbitacins with NOS2, KEAP1 and Lipoxygenase was mediated through hydrogen and hydrophobic interaction. These findings provide mechanistic insight into their bioactivity and support further experimental studies for therapeutic development in oxidative stress-related disorders.Keywords: Cucurbitacin, Molecular docking, Oxidative stress, NOS2, KEAP1.
Co-Authors . Anindyajati Abdul Karim, Dewi Damayanti Achmad Baihaqi Ulma Adam Hermawan Adinda Salsabila Aditya Fitriasari Aditya Fitriasari Afif Hariawan Pratama Agung Endro Nugroho Agustin, Lanita Alsadila, Kalista Anandar, Salsabila Fauziah Anjar Hermadi Saputro Aprilia, Vika Arif Ashari Asrada, Syahdan Bama Tangguh Galih Binar Asrining Dhiani Cahyadi, Dzaky Raihan Charisa Nabirawati Sitindaon Choironi, Nur Amalia Dalili Akhmad, Atika Dika Pramita Destiani, Dika Pramita Dirga Dirga Dirga Dito Aditya Sasongko Dwi Aulia Ramdini Dyaningtyas D. P. Putri Dyaningtyas Dewi P. Putri Dyaningtyas Dewi Putri Pamungkas Edy Meiyanto Edy Meiyanto Endah Puspitasari Erna Harfiani Fadlan, Arif Fadlan, Arif Fareza, Muhamad Salman Farhan Fauzan Fauziyya, Riri Fazila, Safia Febrian, Dicky Rizky Fischellya, Dafi Hakim, Ahmad Zammi Autadan Hanif Nasiatul Baroroh HENDRI WASITO Heny Ekowati Hidayaturahmah, Rizky Ihsanti Dwi Rahayu Ingeswari, Aulya Vidiana Irna Windari, Nurul Iwan Syahjoko Saputra Joko Setyono Joko Setyono Khozin, Muhamad Nur Kireine Kosma Ramadhani Maharani, Putu Audi Mas Mardi Santoso Maulana Malik Mayefis, Delladari Meiyanto, Edy Muhammad Iqbal Muhammad Yogi Saputra Mukaromah Khoirunnisa, Sudewi Mustikaningtyas, Ika Nabila, Novrilia Atika Nabila, Sofia Zahra Nadiah, Syaadatun Nisa Yulianti Suprahman Novrilia Atika Nabila Nugraha, Yudhi Nugraheni, Zjahra Vianita Nur Adliani Nur Amalia Choironi Nur Ismiyati Nur Ismiyati Oktariza, Yasinda Pamungkas P, Dyaningtyas Dewi Pane, Esteria Christina Putra, Okta Nama Rahayyu, Annisa Maulidia Ramadhan Triyandi Ratna Asmah Susidarti Refsya Azanti Putri Rehana, Rehana Retno Wahyuningrum Retno Widiastuti Rifki Febriansah Rifki Febriansah Riri Fauziyya Rispriandari, Aulia Ayu Rooswita, Putri Amelia Safei, Imam Samudra, Genta Hafied Naga Sekar Cahyo Nurani Setiyabudi, Lulu Silvia Damayanti Siregar, Fajri Marindra Sukrasno Sukrasno Tantri Liris Nareswari Tri Warsito Tri Warsito Tri Warsito Tria Putriani Triyadi Hendra Wijaya Tuti Sri Suhesti Uswatun Hasanah Vigo Atsil Nugraha Wenda Reka Pratama Wibowo, Muhammad Rizky Windari, Nurul Irna Winni Nur Auli Wisesa, Sindhu Yudhi Nugraha Yulianto, Akbar Zahra, Miralda Ziske Maritska