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All Journal Alchemy : Journal of Chemistry Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Riset Universa Medicina Acta Pharmaciae Indonesia : Acta Pharm Indo Akta Kimia Indonesia Martabe : Jurnal Pengabdian Kepada Masyarakat Acta Biochimica Indonesiana Jambura Journal of Chemistry Jurnal Pengabdian Kepada Masyarakat Ungu ( Abdi Ke Ungu) Pharmacy Reports Pharmaceutical Sciences and Research (PSR) Indonesian Journal of Pharmacy and Natural Product Molekul: Jurnal Ilmiah Kimia TeknoKreatif: Jurnal Pengabdian kepada Masyarakat
Sarmoko Sarmoko
Department Of Pharmacy, Faculty Of Science, Institut Teknologi Sumatera, South Lampung
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Education Electrical & Electronics Engineering Energy Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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Bioinformatics Analysis of Rho GTP-ase Activating Protein 35 (ARHGAP35) in Breast Cancer Migration Febrian, Dicky Rizky; Setyono, Joko; Fareza, Muhamad Salman; Choironi, Nur Amalia; Fadlan, Arif; Sarmoko, Sarmoko
Indonesian Journal of Cancer Chemoprevention Vol 12, No 3 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss3pp161-169

Abstract

Breast cancer is a second deadly cancer after lung cancer worldwide. Progression of cancer is driven by mutated cancer drive gene such as ARHGAP35. This study aims to analyze the role of ARHGAP35 in the growth and development of breast cancer cells. ARHGAP35 expression level was analyzed using Oncomine (p-value<1E-4; gene rank top 10%). Overall survival (OS) and disease-free survival (DFS) were evaluated by using GEPIA (median cutoff; HR displayed with 95% CI). STRING was used for analyzing the protein-protein interaction network, while WEBGESTALT for KEGG pathway and gene ontology (GO) of ARHGAP35 and associated proteins and cBioPortal for gene mutation. ARHGAP35 was overexpressed in several types of breast cancer, namely invasive ductal breast carcinoma (IDC), invasive ductal and lobular breast carcinoma (IDLC), invasive lobular breast carcinoma (ILC), male breast carcinoma, and mixed ductal and lobular carcinoma (MDLC). High expression of ARHGAP35 had significantly lower OS (p=0.045) compared to low expression of ARHGAP35 and the difference in DFS was not significant (p=0.98). ARHGAP35 interacted with RHOA, RHOB, RHOC, RHOD, RASA1, RND1, RAC1, CDC42, FYN and SRC. KEGG pathway and GO analysis showed that these proteins are highly involved in actin-based processes through adherent junction, axon guidance, focal adhesion, regulation of actin cytoskeleton, and tight junction. Mutation rate analysis showed 34 missense, 29 truncating, 3 fusion, and 1 in frame on ARHGAP35. Taken together, ARHGAP35 may involve in the growth and development of breast cancer through regulation of actin cytoskeleton pathway.Keywords: ARHGAP35, breast cancer, KEGG pathway, mutation rate, actin cytoskeleton.
PEMBERDAYAAN USAHA EKONOMI KREATIF MELALUI PENDEKATAN PELATIHAN DAN PENDAMPINGAN USAHA PEMBUATAN PRODUK JAMU KEKINIAN SEBAGAI UPAYA PENCAPAIAN SDGS DI KELURAHAN YOSOREJO, KOTA METRO Yulianti Suprahman, Nisa; Hidayaturahmah, Rizky; Hermadi Saputro, Anjar; Irna Windari, Nurul; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 7, No 11 (2024): MARTABE : JURNAL PENGABDIAN MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v7i11.4924-4929

Abstract

Sebagian besar masyarakat di Kelurahan Yosorejo, Kecamatan Metro Timur memiliki pekarangan rumah atau kebun yang sebagian ditanami tanaman obat keluarga (TOGA) seperti kunyit, temulawak, temugiring, jahe kencur, sirih, kecombrang, sambiloto, binahong dan lain-lain. Kendala utama yang dihadapi adalah belum optimalnya pemanfaatan tanaman obat keluarga (TOGA), rendahnya pengetahuan dan teknologi untuk membuat jamu kekinian yang berkualitas, jumlah diproduksi masih terbatas, jenis dan variasi produk juga masih sedikit dan market share masih rendah. Selain produk jamu, tanaman TOGA belum dilakukan pengembangan teknologi menjadi produk herbal yang bernilai ekonomi tinggi seperti sabun.  Faktor tersebut yang membuat industri jamu tradisional tidak bisa berkembang. Maksud Pengabdian Kepada Masyarakat (PKM) adalah mengembangkan usaha jamu kekinian pada Ibu-ibu PKK kelurahan Yosorejo agar dapat membantu meningkatkan pendapatan masyarakat. Tujuannya Mengembangkan dan memperbaiki usaha jamu tradisional menjadi jamu kekinian yang modern yang bisa mengangkat salah satu produk warisan leluhur turun temurun. Dengan cara memproses tahap-tahapan pembuatan produk secara benar, mengedukasi Ibu-Ibu PKK untuk giat mengembangkan usaha yang menguntungkan dan memiliki peluang yang sangat terbuka. Kegiatan dilakukan dengan metode pelatihan secara langsung serta pembagian produk jamu kekinian dan sabun organik ke masyarakat. Hasil dari kegiatan ini adalah masyarakat dapat memahami dan mampu membuat jamu dan sabun organik berbahan dasar tanaman TOGA.
Synthesis and Cytotoxic Activity of Methoxylated Chalcones in Breast Cancer MCF-7 and Prostate Cancer DU-145 Cell Lines Fareza, Muhamad Salman; Samudra, Genta Hafied Naga; Asrada, Syahdan; Fischellya, Dafi; Wijaya, Triyadi Hendra; Choironi, Nur Amalia; Wasito, Hendri; Suhesti, Tuti Sri; Mustikaningtyas, Ika; Rehana, Rehana; Setiyabudi, Lulu; Sarmoko, Sarmoko
Molekul Vol 20 No 3 (2025)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.jm.2025.20.3.13612

Abstract

Chalcones, a class of naturally occurring compounds, exhibit a broad spectrum of biological activities, including anticancer properties. In this study, a series of methoxylated chalcones were synthesized via Claisen-Schmidt condensation and evaluated for cytotoxic activity against breast cancer MCF-7 and prostate cancer DU-145 cell lines. The synthetic route involved Claisen-Schmidt condensation, leading to various methoxy-substituted chalcone derivatives. The structures of the synthesized chalcones were confirmed through NMR and mass spectrometry. Cytotoxicity was assessed using the PrestoBlue assay, with 4-bromochalcone (compound 2) displaying the highest cytotoxic activity against MCF-7 cancer cell lines (IC50 = 26.99 µM). These results indicate that methoxylated chalcones hold promise as potential lead compounds for the development of new anticancer agents targeting breast and prostate cancer.
UPAYA PENINGKATAN KESEHATAN MASYARAKAT MELALUI EDUKASI DAPATKAN, GUNAKAN, SIMPAN, DAN BUANG (DAGUSIBU) OBAT DI DUSUN 006 WAY HUI LAMPUNG SELATAN Nadiah, Syaadatun; Mayefis, Delladari; Oktariza, Yasinda; Hidayaturahmah, Rizky; Hasanah, Uswatun; Dalili Akhmad, Atika; Mukaromah Khoirunnisa, Sudewi; Yulianti Suprahman, Nisa; Dirga, Dirga; Sarmoko, Sarmoko
Martabe : Jurnal Pengabdian Kepada Masyarakat Vol 9, No 1 (2026): MARTABE : JURNAL PENGABDIAN KEPADA MASYARAKAT
Publisher : Universitas Muhammadiyah Tapanuli Selatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31604/jpm.v9i1.%p

Abstract

DAGUSIBU merupakan konsep fundamental untuk meningkatkan literasi obat di masyarakat.Rendahnya literasi kesehatan dan kepatuhan terhadap terapi obat merupakan tantangan utama dalam pengelolaan penyakit tidak menular, terutama pada masyarakat dengan akses terbatas terhadap layanan kesehatan. Program Pengabdian kepada Masyarakat (PkM) ini bertujuan meningkatkan pemahaman masyarakat Dusun 006 Way Hui, Lampung Selatan mengenai penggunaan obat yang benar, kepatuhan minum obat, serta pentingnya pemeriksaan kesehatan rutin melalui pendekatan edukasi partisipatif. Kegiatan mencakup penyuluhan interaktif, praktik penyusunan jadwal obat, dan pemeriksaan kesehatan dasar meliputi gula darah, kolesterol, dan asam urat. Evaluasi dilakukan menggunakan pre-test dan post-test serta observasi praktik peserta. Sebanyak 28 peserta mengikuti pemeriksaan kesehatan dan 20 peserta menyelesaikan kedua tes evaluatif. Hasil menunjukkan peningkatan skor pengetahuan sebesar 52,22% dengan perbedaan signifikan (p 0,001). Pemeriksaan kesehatan juga mengungkapkan beberapa peserta memiliki parameter di atas batas normal, sehingga diberi konseling individual mengenai pengelolaan gaya hidup sehat. Respons peserta sangat positif, ditunjukkan oleh tingginya keterlibatan dalam diskusi dan praktik. Secara keseluruhan, pendekatan integratif yang menggabungkan edukasi, praktik, dan pemeriksaan kesehatan terbukti efektif dalam meningkatkan literasi obat, kesadaran kesehatan, serta motivasi peserta untuk menjaga kesehatan secara preventif. Program serupa direkomendasikan untuk dilaksanakan secara berkelanjutan guna memperkuat kemandirian kesehatan masyarakat pedesaan
Prognostic factors in hereditary breast cancer: A review Ziske Maritska; Sarmoko
Acta Biochimica Indonesiana Vol. 7 No. 1 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.124

Abstract

Hereditary breast cancer, primarily driven by BRCA1 and BRCA2 mutations, presents distinct challenges and prognostic factors compared to sporadic breast cancer. BRCA1-associated breast cancer is often triple-negative (TNBC), which has a more aggressive course and poorer prognosis. Despite this, BRCA mutation carriers exhibit higher sensitivity to platinum-based chemotherapy and PARP inhibitors, potentially improving outcomes. However, the risk of developing other malignancies, such as ovarian cancer and melanoma, remains elevated in BRCA mutation carriers. Studies show a significant variation in survival rates, with BRCA mutation carriers having lower overall survival compared to non-carriers. Loss of heterozygosity (LOH) in BRCA1/2 tumors is frequent but does not significantly alter overall survival rates. Identifying the presence of LOH can guide personalized treatment strategies, particularly the use of PARP inhibitors. The response to chemotherapy, especially platinum-based drugs, is influenced by genetic mutations such as TP53 and PTEN, which are common in TNBC. Surgical choices also impact prognosis; mastectomy may lower ipsilateral breast recurrence but does not affect overall survival. Pathologic complete response (pCR) following neoadjuvant chemotherapy is a critical prognostic marker, with higher rates observed in BRCA mutation carriers, particularly those with TNBC. These factors collectively influence the prognosis and guide treatment strategies for hereditary breast cancer.
Molecular docking of ferulic acid, bakuchiol and niazirin on peroxisome proliferator-activated receptor gamma (PPAR-γ) as anti-diabetic agents Anjar Hermadi Saputro; Riri Fauziyya; Sarmoko; Iwan Syahjoko Saputra
Acta Biochimica Indonesiana Vol. 7 No. 2 (2024): Acta Biochimica Indonesiana
Publisher : Indonesian Society for Biochemistry and Molecular Biology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32889/actabioina.181

Abstract

Background: Diabetes mellitus remains one of the most dangerous illnesses worldwide. The PPAR-gamma protein plays a crucial role in lipid and carbohydrate metabolism, making it a key target for diabetes therapy. Research into plant-derived active compounds for diabetes treatment is increasingly important. Objective: This study aims to evaluate and analyze the interaction of ferulic acid, niazirin, and bakuchiol with the peroxisome proliferator-activated receptor gamma (PPAR-γ) protein using molecular docking. Methods: Molecular docking was employed to assess the interactions between ferulic acid, niazirin, bakuchiol, and the PPAR-γ protein (PDB ID: 2PRG). The analysis focused on binding free energy values, amino acid residue interactions, the number of hydrogen bonds, and bond distances, comparing these results to those of the native ligand and pioglitazone, a known anti-diabetic drug targeting PPAR-γ. Results: The binding free energies for the ferulic acid-PPAR-γ, bakuchiol-PPAR-γ, niazirin-PPAR-γ, native ligand-PPAR-γ, and pioglitazone-PPAR-γ complexes were -5.54 kcal/mol, -8.47 kcal/mol, -6.56 kcal/mol, -10.08 kcal/mol, and -9.94 kcal/mol, respectively. The amino acid residue similarity percentages with the native ligand were 18.18% for ferulic acid, 27.27% for bakuchiol, 18.18% for niazirin, and 81.82% for pioglitazone. The native ligand-2PRG and pioglitazone-2PRG complexes exhibited superior hydrogen bond numbers and shorter bond distances compared to the other compounds. Conclusion: Although bakuchiol showed the most promising interaction among the tested compounds, none surpassed the binding affinity and stability of the native ligand or pioglitazone. Further research is needed to optimize these compounds for potential anti-diabetic therapy.
Co-Authors . Anindyajati Abdul Karim, Dewi Damayanti Achmad Baihaqi Ulma Adam Hermawan Adinda Salsabila Aditya Fitriasari Aditya Fitriasari Afif Hariawan Pratama Agung Endro Nugroho Agustin, Lanita Alsadila, Kalista Anandar, Salsabila Fauziah Anjar Hermadi Saputro Aprilia, Vika Arif Ashari Asrada, Syahdan Bama Tangguh Galih Binar Asrining Dhiani Cahyadi, Dzaky Raihan Charisa Nabirawati Sitindaon Choironi, Nur Amalia Dalili Akhmad, Atika Dika Pramita Destiani, Dika Pramita Dirga Dirga Dirga Dito Aditya Sasongko Dwi Aulia Ramdini Dyaningtyas D. P. Putri Dyaningtyas Dewi P. Putri Dyaningtyas Dewi Putri Pamungkas Edy Meiyanto Edy Meiyanto Endah Puspitasari Erna Harfiani Fadlan, Arif Fadlan, Arif Fareza, Muhamad Salman Farhan Fauzan Fauziyya, Riri Fazila, Safia Febrian, Dicky Rizky Fischellya, Dafi Hakim, Ahmad Zammi Autadan Hanif Nasiatul Baroroh HENDRI WASITO Heny Ekowati Hidayaturahmah, Rizky Ihsanti Dwi Rahayu Ingeswari, Aulya Vidiana Irna Windari, Nurul Iwan Syahjoko Saputra Joko Setyono Joko Setyono Khozin, Muhamad Nur Kireine Kosma Ramadhani Maharani, Putu Audi Mas Mardi Santoso Maulana Malik Mayefis, Delladari Meiyanto, Edy Muhammad Iqbal Muhammad Yogi Saputra Mukaromah Khoirunnisa, Sudewi Mustikaningtyas, Ika Nabila, Novrilia Atika Nabila, Sofia Zahra Nadiah, Syaadatun Nisa Yulianti Suprahman Novrilia Atika Nabila Nugraha, Yudhi Nugraheni, Zjahra Vianita Nur Adliani Nur Amalia Choironi Nur Ismiyati Nur Ismiyati Oktariza, Yasinda Pamungkas P, Dyaningtyas Dewi Pane, Esteria Christina Putra, Okta Nama Rahayyu, Annisa Maulidia Ramadhan Triyandi Ratna Asmah Susidarti Refsya Azanti Putri Rehana, Rehana Retno Wahyuningrum Retno Widiastuti Rifki Febriansah Rifki Febriansah Riri Fauziyya Rispriandari, Aulia Ayu Rooswita, Putri Amelia Safei, Imam Samudra, Genta Hafied Naga Sekar Cahyo Nurani Setiyabudi, Lulu Silvia Damayanti Siregar, Fajri Marindra Sukrasno Sukrasno Tantri Liris Nareswari Tri Warsito Tri Warsito Tri Warsito Tria Putriani Triyadi Hendra Wijaya Tuti Sri Suhesti Uswatun Hasanah Vigo Atsil Nugraha Wenda Reka Pratama Wibowo, Muhammad Rizky Windari, Nurul Irna Winni Nur Auli Wisesa, Sindhu Yudhi Nugraha Yulianto, Akbar Zahra, Miralda Ziske Maritska