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Antibacterial Activity of Foot Spray Preparations Extract of Jeruk Purut Leaves (Citrus Hystrix) and Robusta Coffee Leaves (Coffea canephora) Against Staphylococcus epidermidis Lestari, Seri; Nasution, Muhammad Amin; Dalimunthe, Gabena indrayani; Lubis, Minda Sari
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8736

Abstract

A problem that is often found in Indonesia, especially on the feet and causes many people to lack self-confidence, is smelly feet. This odor is caused by bacteria on the skin and inside shoes. Bacteria like Staphylococcus epidermidis produce an unpleasant smell by degrading leucine from sweat, leading to the formation of isovaleric acid, which emits a foul odor. This issue can be addressed using plant materials such as jeruk purut leaves (Citrus hystrix) and robusta coffee leaves (Coffea canephora). This research uses an experimental method. Jeruk purut leaves and robusta coffee leaves are extracted through maceration and then formulated into a foot spray with extract concentrations of 1.5%, 2%, and 2.5%. The evaluation results indicate that the foot spray formulation meets the stability test parameters, including organoleptic properties and pH. In terms of hedonic testing, panelists preferred Formula 1, and no formula caused skin irritation. Antibacterial testing of all formulations showed strong antibacterial activity, with inhibition zone diameters of 11.9 mm for Formula 1 (1.5% concentration), 12.4 mm for Formula 2 (2% concentration), and 12.8 mm for Formula 3 (2.5% concentration) against Staphylococcus epidermidis. Statistical analysis using One-Way ANOVA showed that the antibacterial activity of the foot spray in inhibiting bacterial growth was significant at a 0.005 level, with a probability value (significance) of 0.00 < 0.05, indicating that the antibacterial activity of the foot spray can affect the growth of Staphylococcus epidermidis.
DETERMINATION OF METRONIDAZOLE MICROPARTICLE CONTENTS IN THE HEMISELLULOSE MATRIX OF CORN COB USING ULTRAVIOLET SPECTROPHOTOMETRY Dalimunthe, Gabena Indrayani; Rani, Zulmai; Rambe, Robiatun
Jurnal Aisyah : Jurnal Ilmu Kesehatan Vol 9, No 2 (2024): September
Publisher : Universitas Aisyah Pringsewu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30604/jika.v9i2.2607

Abstract

Microparticles can be an accurate drug delivery agent, reducing drug concentration in the target and providing an effective delivery system for substances that are slightly soluble in water. Corn cobs contain the most hemicellulose, and this hemicellulose can be employed as a matrix to restrict medication release if administered orally. The purpose of this study is to use UV spectrophotometry to evaluate the concentration of metronidazole microparticles in the hemicellulose matrix of corn cobs. This research is divided into two stages: separating hemicellulose from corn cobs and characterization of hemicellulose, which includes visual organoleptics, taste, smell, and form. Solubility test in alkaline conditions (NaOH), followed by FTIR test using the KBr pellet method with typical peaks seen in the FTIR spectrum, SEM test to get structural morphology, and PSA test to determine particle size and distribution of representative samples. After the microparticles are formed, further characterization is carried out, including an organoleptic test, solubility test, PSA test, FTIR test, and SEM test. Next, the levels of metronidazole microparticles in the corncob hemicellulose matrix were determined using ultraviolet spectrophotometry by comparing metronidazole tablets on the market. The concentration of metronidazole microparticle sample in the corncob hemicellulose matrix was determined to be 80.12 0.5290%, and the concentration of metronidazole tablets on the market was 100.51 0.7576%, which meets the requirements for metronidazole tablet concentration, namely not less than 90.0% and not more than 110% of the amount stated on the label.
Pembuatan Sediaan Roll On Penghilang Bau Badan Dari Kulit Jeruk Purut Di Kalangan Mahasiswa Universitas Harapan Medan Indrayani Dalimunthe, Gabena; Sartika Daulay, Anny; Rani, Zulmai; Rambe, Robiatun
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 4 No. 1 (2024): Edisi Januari 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v4i1.797

Abstract

Bau badan merupakan keluhan umum yang sering diungkapkan oleh masyarakat di daerah tropis, seperti Indonesia, dan seringkali menjadi gangguan dalam kehidupan sehari-hari. Orang dapat kehilangan kepercayaan diri jika mereka memiliki bau tubuh yang tidak sedap. Salah satu cara untuk mengatasi masalah ini adalah dengan menggunakan deodoran, tetapi deodoran biasanya mengandung bahan kimia yang dapat menyebabkan iritasi kulit. Untuk mengatasi masalah ini, kita bias membuat deodoran yang terbuat dari bahan-bahan alami. Sasaran kegiatan ini adalah mahasiswa dari Fakultas Bahasa dan Komunikasi di Universitas Harapan Medan. Kegiatan ini melibatkan pelatihan pembuatan deodoran menggunakan bahan alami, khususnya daun jeruk purut. Tujuan dari inisiatif ini adalah untuk mengoptimalkan pengelolaan sumber daya alam, mendorong mahasiswa untuk terlibat dalam wirausaha melalui pembuatan deodoran ala home industri. Selain itu, kegiatan ini bertujuan untuk mengajarkan cara membuat deodoran stik secara sederhana, terutama untuk mahasiswa jurusan bahasa dan komunikasi yang mungkin belum familiar dengan formulasi bahan alami. Penambahan komponen-komponen alami ini dapat meningkatkan efektivitas deodoran sambil meminimalkan risiko iritasi kulit. Tujuan dari kegiatan pengabdian kepada masyarakat ini adalah untuk mendorong penggunaan sumber daya lokal dan mendukung praktik berkelanjutan dalam pengembangan produk perawatan pribadi.
Utilization Of Natural Materials As Universal Natural Food Colors Red Yellow Green In The Community Of Sidomulyo Village Biru-Biru District: Pemanfaatan Bahan Alam Sebagai Pewarna Pangan Alami Universal Merah Kuning Hijau Pada Masyarakat Desa Sidomulyo Kecamatan Biru-Biru Sartika Daulay, Anny; Ridwanto, Ridwanto; Dison Silalahi, Alistraja; Wahyuni, Sri; Indrayani Dalimunthe, Gabena; Fadhilah M, Ihsan
Jukeshum: Jurnal Pengabdian Masyarakat Vol. 5 No. 1 (2025): Edisi Januari 2025
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/jukeshum.v5i2.1012

Abstract

Food coloring is an additional ingredient used to produce food products so they are more attractive to consume. Synthetic food coloring comes from chemicals, can contain dangerous metals and/or benzene rings which have the potential to cause various diseases in humans. Meanwhile, natural dyes are obtained from natural ingredients so they are safer to use. The aim of this community service is to provide understanding to the public about the benefits of plants in the form of fruit, leaves and fruit skins that are no longer used as natural food coloring. This community service (PkM) is carried out by socializing the use of fruit and/or fruit waste, fresh leaves which are commonly found in the community, such as dragon fruit peel as waste. Other ingredients used are turmeric rhizomes and bay leaves, suji leaves and pandan leaves. Socialization of making food coloring materials is carried out using electronic media such as videos. Meanwhile, the explanation of the material is carried out using the presentation and discussion method. Based on the results of the implementation of this PkM, the people of Sidomulyo Village, Biru-Biru District, were very enthusiastic and eager to take part in this activity. The people of Sidomulyo Village can understand and comprehend the dangers of using synthetic dyes and understand the benefits of using natural dyes in food produced in the household. Then in the future, the results of this community service can be applied to products that can be marketed commercially to increase family income.
Penentuan Kadar Vitamin C Pada Sediaan Krim Pemutih Wajah yang Beredar di Pasar Online Dengan Metode Titrasi 2,6-Diklorophenol Indophenol Anugrah, Bayu; Lubis, Minda Sari; Dalimunthe, Gabena Indrayani; Daulay, Anny Sartika
Journal of Health and Medical Science Volume 3 Nomor 1 Januari 2024
Publisher : CV. Pusdikra Mitra Jaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51178/jhms.v3i1.1963

Abstract

Krim pemutih wajah merupakan produk yang tersusun dari beberapa bahan kimia atau bahan lainnya yang mampu memutihkan wajah dalam waktu yang singkat. Untuk mengetahui kadar Vitamin C yang terdapat pada sediaan krim wajah yang beredar di pasar online diuji dengan metode analisis kuantitatif. Tujuan penelitian ini adalah untuk mengetahui kadar Vitamin C pada sediaan krim pemutih wajah yang beredar di pasar online. Tujuan penggunaannya dalam jangka waktu lama agar dapat mengurangi hiperpegmentasi pada kulit. Tetapi penggunaan yang terus-menerus justru akan menimbulkan pigmentasi dengan efek permanen. Metode yang digunakan dalam penelitian ini adalah metode 2,6-Diklorophenol Indophenol. Metode ini merupakan metode yang paling baik digunakan pada penetapan kadar Vitamin C karena spesifik sehingga tidak dipengaruhi oleh senyawa lainnya. Kelebihan metode ini yaitu reaksi yang terjadi secara kauntitatif sehingga dapat diketahui jumlah atau kadarnya. Dari hasil penelitian menunjukkan kadar Vitamin C pada sampel kosmetik pemutih wajah yaitu Amos Siang dan Amos Malam, Collagen Siang dan Collagen Malam, Walet Siang dan Walet Malam, Temulawak Siang dan Temulawak Malam. Perolehan kadar Vitamin C pada Amos Siang 0,0298% sedangkan kadar Vitamin C pada Amos Malam 0,0245% kadar Vitamin C pada Collagen Siang 0,0355% kadar Vitamin C pada Collagen Malam 0,0350% kadar Vitamin C pada Walet Siang 0,0298% kadar Vitamin C pada Walet Malam 0,0528% kadar Vitamin C pada Temulawak Siang 0,023% kadar Vitamin C pada Temulawak Malam 0,023%.
Uji Aktivitas Antibakteri Sabun Transparan Putik Saffron (Crocus sativus L) terhadap Bakteri Staphylococcus aureus Emmy Wiriandini; Gabena Indrayani Dalimunthe; Minda Sari Lubis; Haris Munandar Nasution
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2024): March : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i2.343

Abstract

Transparent soap is a variation of solid bar soap that not only functions to clean dirt but also has a scrubbing function. Transparent solid soap is one of the soap innovations that has become an attractive soap. Saffron also has antibacterial properties due to the presence of flavonoids, tannins and saponins. Flavonoids are compounds that can have anti-inflammatory, anticancer and antioxidant effects, because they can inhibit the formation of free radicals. It has been used traditionally to treat various ailments including depression, cardiovascular disease, menstrual disorders, asthma, insomnia, digestive ailments, bone pain and several other ailments. Saffron pistil juice is made by dissolving in CO₂-free distilled water. Phytochemical screening was carried out on saffron pistil extract. Saffron pistil juice is made in various soap formulas, namely formula I, formula II and formula III. The positive control used was chloramphenicol antibiotic and the negative control was DMSO. There were several tests carried out on Saffron pistil extract in addition to phytochemical screening, namely antibacterial testing on transparent soap with Saffron pistil extract as a soap additive. The results of phytochemical screening showed that the pistil of saffron (Crocus sativus L) contained secondary metabolites, namely: flavonoids, alkaloids, tannins, and saponins. And for the results of the antibacterial activity research also showed that the Saffron pistil extract against transparent soap which can be used as a soap additive, the antibacterial results had a strong inhibition at the average value of formula III which was 20.5 and formula II was 18.4 mm and formula I 16.1 mm, against Staphylococcus aureus bacteria.
Produksi Protein Sel Tunggal dari Aspergillus niger Kultur dengan Kulit Nanas (Ananas comosus L. MERR) Media Limbah Yuli Apriani Br.Lubis; Yayuk Putri Rahayu; Gabena Indrayani Dalimunthe; Haris Munandar Nasution
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.602

Abstract

Introduction: Single Cell Protein (SCP) is a term used for proteins produced from microbes such as bacteria, algae, yeasts, and fungi. One of the fungi known to produce PST is Aspergillus niger. Objective: The purpose of this study was to determine whether pineapple peel waste could produce single cell protein from A. niger culture and to determine differences in protein production with the addition of nutrients in the fermentation medium. Methods: This research method is an experimental method with the independent variables being MFKN1 medium (Pineapple Skin Fermentation Medium with the addition of KH2PO4 and sugar), and MFKN2 medium (Pineapple Skin Fermentation Medium with the addition of KH2PO4, (NH4)2SO4 and sugar); and the length of fermentation time used are days-0, 2, 4, and 6. The dependent variables of this study were analysis of protein content, dry weight of cells, glucose levels, pH and temperature. The data from this study were statistically analyzed using the two way Anova method. Results: The results of this study obtained the highest protein content in MFKN2 media, namely 0.80% (day-2); cell dry weight 0.473 g; glucose level 1.3406%; pH 4.6 and temperature 31 oC. Meanwhile, the highest protein content in MFKN1 media was 0.59% (day- 4); cell dry weight 0.346 g; glucose level 1.3406%; pH 3.7 and temperature 26.6 oC. Conclusion: The conclusion of this study is that pineapple peel waste can produce single cell protein from A. niger culture and there are differences in protein production results with the addition of nutrients, where protein content in MFKN2 medium is higher than protein content in MFKN1 medium.
Formulasi dan uji aktivitas antibakteri sediaan salep daging daun lidah buaya (Aloe vera L.) terhadap bakteri Staphylococcus aureus pada penyembuhan luka bernanah Dena, Mutia; Dalimunthe, Gabena Indrayani; Lubis, Minda Sari; Rahayu, Yayuk Putri
Journal of Pharmaceutical and Sciences Suppl. 1, No. 1 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v6i5-si.388

Abstract

Staphylococcus aureus is one of the bacteria that can cause infectious diseases of the skin, one of which is purulent wound disease. Aloe vera (Aloe vera L.) belongs to the family Asphodelaceae, which is a plant known to have antibacterial compounds. The study was conducted experimentally. The independent variable is the concentration of aloe vera leaf flesh, 20%, 30% and 40%. The concentration of aloe leaf meat ointment is 20%, 30%, and 40%. The dependent variables are the antibacterial activity of aloe vera leaf meat ointment preparations against staphylococcus aureus bacteria. The results of the antibacterial Zone of Inhibition (ZOI) value of aloe vera leaf meat against staphylococcus aureus of 8.1 mm (20% concentration); 8.5 mm (concentration 30%); and 10.5 mm (concentration 40%). Antibacterial ZOI value of aloe leaf meat ointment against staphylococcus aureus by 10.6 mm (F1 20%), 11.5 mm (F2 30%), and 12.5 mm (F3 40%). The test results on purulent wounds in rat test animals get moderate healing scores on F1, F2, F3 and K + (gentamicin sulfate 0.1%) strong, so it can be said that aloe vera leaf meat ointment preparations can inhibit antibacterial growth in purulent wound healing even with a moderate category compared to Gentamicin ointment 0.1% with a strong (sensitive) category.  
Pembuatan nanoekstrak dari kulit buah jeruk kasturi (Citrus microcarpa) dan formulasinya sebagai pasta gigi Hasibuan , Fika Miah Sasmitha; Dalimunthe, Gabena Indrayani; Lubis , Minda Sari; Rani, Zulmai
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 1 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i1.694

Abstract

Dental caries is a common oral health problem among the Indonesian population, and its primary cause is the bacterium Streptococcus mutans. The peel of the Kasturi orange (Citrus microcarpa) fruit has been known to contain antibacterial properties, which may help prevent the occurrence of dental caries. This study aims to evaluate the toothpaste formulation with the active ingredient of nano-extract from kasturi orange peel (Citrus microcarpa). The extract of Kasturi orange peel was obtained through a maceration method, followed by phytochemical screening that identified the presence of flavonoids, steroids, alkaloids, saponins, glycosides, and essential oils. The extract was then processed into a nano-extract, and its particle size was measured using a Particle Size Analyzer (PSA) with a dynamic light scattering technique. The nano-extract was formulated into toothpaste at concentrations of 7.5%, 10%, and 12.5%, and its antibacterial activity was tested. Physical evaluations showed that the toothpaste maintained its shape, color, odor, and taste during storage, was homogeneous, had a pH within the acceptable range (4.5–10.5), viscosity within the required range (20,000–50,000 cps), and passed organoleptic testing (color, aroma, taste, and texture) on respondents.
Formulation of nanocream whitening preparation from a combination of yam starch (Pachyrhizus erosus L.) and rice starch (Oryza sativa L.) Nur, Hijrotun; Dalimunthe, Gabena Indrayani; Rani, Zulmai; Yuniarti, Rafita
Journal of Pharmaceutical and Sciences JPS Volume 7 Nomor 4 (2024)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v7i4.698

Abstract

Whitening cosmetics have become a popular choice in modern society, with the perception that beauty is associated with white skin. The high market demand is an opportunity for cosmetic business actors but it also increases the risk of illegal cosmetic production containing hazardous materials such as hydroquinone. One of the cosmetic ingredients that is often found in whitening creams containing hydroquinone, which is effective in removing dark spots, has the risk of serious side effects. Therefore, it is advisable to find a safe, natural alternative for long-term skin whitening. Jicama starch and rice water starch are natural choices for whitening cosmetics. Nanoparticle-based cosmetics are superior to micro-scale cosmetics. The objective of the research was to determine whether a combination of jicama starch and rice water starch whitening cream can meet the characteristic requirements of a nano cream, to determine all concentrations of jicama starch and rice water starch whitening nano cream that meet the physical quality requirements and to determine all concentrations of jicama starch and rice water starch whitening nano cream have different effectiveness. This research method was True Experimental with Post Test Only Control Group Design research design. The independent variables are variations in the concentration of yam starch and rice water starch. The dependent variables were sample characteristics, characteristics of the whitening nano cream formulation and nano cream effectiveness test. The results showed that yam starch and rice water starch had effectiveness as whitener with a concentration of f3 (5:5) water content of 55.67%, sebum of 16% and pigment of 15.67%. The whitening cream met the characteristics of a nano cream with particle sizes of f0: 134.04, f1: 1849.20, f2: 147.64 and f3: 188.14 nm. Yam starch and rice water starch in the preparation of the whitening nano cream meet the physical quality requirements.
Co-Authors Adani, Bazlina Adela Octi Dwiyani Adli Nuzula Rahmah Agustina, Meri Ahmad darwis Alma Dhita Shafira Anny Sartika Daulay Anugrah, Bayu Arianti, Sellin Arina Ashar, Diya Asparyzha, Rhyzha Aulia Fitri, Aulia Aulia, Meisyah Bambang Hermanto Basaniah Basaniah Chairina Milda Chandra, Putra Cindy Marlina Tambunan Claudy Friesta Melanie Cut Erika Maulydya D Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang D. Elysa Putri Mambang Debi Meilani Dena, Mutia Dewa, Fasca Dikki Miswanda Dina Sri Novita Dina Veranika Dinda Sari Utami Dison Silalahi, Alistraja Emmy Wiriandini Fadhilah M, Ihsan Fadillah, Nike Fathur Rahman Febiyani, Rica Fithri Pulungan, Ainil Fitri Febriani Fitri, Raissa Ginting, Ovalina Sylvia Br. Girsang, Raflika Azwanda Gita Dwi Puspa Fadillah Hamda, Haikal Handayani, Riska Haris Munandar Nasution Hasibuan , Fika Miah Sasmitha Hendraputra, Hardy Handoko Heru Adha Prayogo Humairah, Dwina Angelina Husna, Miftahul husna, nadiatul Ilmi Widya Sari Isnaria, Vita Jurida, Wike Juwita, Sukma Karlina Butar Butar Kartika, Dinda Dwi Khairil Pahmi Khairunnisa , Ardina Kiki Rawitri Latifah Sahara Pulungan Lestari, Amanda Putri Lestari, Seri Lestari, Sri Indah Linda, Rosa Lisa Amalia Lubis, Minda Sari M. Arya Wiguna Madani Sirait maghfirah, Suci Mambang, D Elysa Putri Mambang, Elysa Putri Misna Rosalinda Hutabarat Muhammad Amin Nasution Muhammad Ricky Ramadhian Muhammad Tegar Tri Rizky Mutiara Rahmah Nasution, M. Pandapotan Nasution, Nur Sahadah Nasution, Shamila Sufi Aulia Nasution, Vevi Sarah Nia Novranda Pertiwi Nindya Indah Damayanti Ningtias, Anggitha Niswa, Khairun Novita Sari, Helsa Nur Asia, Nur Nur, Hijrotun Nuraisyah Nurfadilla, Kiki Nurliansyah, Nurliansyah Nurmala, Dewi Nurul Haliza Lubis Nurul Hidayah Nurul Salsa Abya Ritonga Olita, Apen Peri , Peri Peri, Peri Puteri, Cut Intan Annisa Rafita Yuliarti Rafita Yuniarti Rafita Yuniarti Rahma Dona Rahma Maulidia Fitri Rahmi , Ulfa Rambe, Robiatun Rambe, Sitiapsah Rangkuti, Cindy Rahayu Rawitri, Kiki Riani, Nur Aslin Ricky Andi Syahputra Ricky Andi Syahputra Ridwan Taher Lubis Ridwanto Ridwanto Rima Marwarni Rina Azhari Risnayanti Ritonga, Oktavia Riza Syafira Robiatun Rambe Rosalinda Mahdalena Sinaga Rosalinda Mahdalena Sinaga sahrianti, Hikmah Samosir, Anzly Hasian Samran, Samran Saragih, Aqilah Mutmainnah Sari Lubis , Minda Sari Lubis, Winda Sari, Syilvi Rinda Sartika Daulay, Anny Savika, Anggraini Selvicahyani, Selvicahyani Shinta Mida Ariani Harahap Sihotang, Laura Indah Restu Silvia Sinaga, Rosalinda Mahdalena Siregar, Hikmatussabaria Siti Anisa Siti Anisa Sitinjak, Iyustri Ririn Situmorang, Lusi Grasia Sri Mulia Ningsih Siregar Sri Wahyuni Sri Wahyuni Sulaiman Riadi Sulwiyatul K Sani Syahputri, Maulida Syarifah Aulia Syarifah Mauliza Tasya Ardana Ummu Safura Sirait Wardah Tulail Nadila Widya Sari Winda Aulia Yayuk Putri Rahayu Yayuk Putri Rahayu Yuli Apriani Br.Lubis Yuni Sartika Yuniarti , Rafita Yuniarti, Rafita Yuniarti, Rapita Zahara, Anisa Zahira Ahmad, Madani Ziza Putri Aisyia Fauzi Zulmai Rani