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All Journal HAYATI Journal of Biosciences Farmaka Indonesian Journal of Applied Sciences Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia MPI (Media Pharmaceutica Indonesiana) CHEMPUBLISH JOURNAL Pharmascience The Indonesian Biomedical Journal Jurnal Kimia Terapan Indonesia JSFK (Jurnal Sains Farmasi & Klinis) FITOFARMAKA: Jurnal Ilmiah Farmasi JFIOnline Jurnal Ilmiah Farmako Bahari Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Sains dan Praktis Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Farmasi Indonesia Journal of Pharmaceutical and Sciences. Medical Sains : Jurnal Ilmiah Kefarmasian

Sri Adi Sumiwi

Fakultas Farmasi Universitas Padjadjaran

Author-ID : 385470

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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PENDIDIKAN KESEHATAN DENGAN METODE HYBRID TENTANG COVID-19 DAN PENYAKIT HIPERTENSI PADA KADER PKK DESA CIKIDANG KECAMATAN LEMBANG Jutti Levita; Sri Adi Sumiwi; Mutakin Mutakin; Tiana Milanda; Irma Melyani Puspitasari; Sriwidodo Sriwidodo; Ellin Febrina; Yasmiwar Susilawati; Indah Suasani Wahyuni; Irma Erika Herawati; Renny Amelia; Gofarana Wilar
Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Vol 11, No 2 (2022): Juni. 2022
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/dharmakarya.v11i2.34927

Kegiatan Pengabdian Kepada Masyarakat (PPM) di Desa Cikidang sudah dilaksanakan selama tiga tahun berturut-turut. Masyarakat berpartisipasi sangat baik dan menginginkan kegiatan dapat dilakukan secara kontinu serta melibatkan masyarakat yang lebih luas. Desa Cikidang belum memiliki sarana kesehatan dan lokasi Puskesmas terdekat adalah di Desa Cikole, berjarak 3,5 km. Berdasarkan data dari Puskesmas Cikole periode tahun 2019, tercatat bahwa penyakit hipertensi memiliki angka kejadian tertinggi yaitu 135 kejadian. Kegiatan PPM ini bertujuan untuk meningkatkan pemahaman kader PKK tentang penyakit hipertensi dan juga tentang COVID-19. Kegiatan dilakukan dengan menerapkan metode hybrid luring dan daring (gabungan sinkronus dan asinkronus menggunakan media leaflet dan video). Dari sejumlah enam puluh undangan yang disebarkan, kegiatan PPM dihadiri oleh tiga puluh lima peserta. Hasil pre-test dan post-test menunjukkan adanya peningkatan pengetahuan peserta, sehingga dapat disimpulkan bahwa pendidikan kesehatan secara hybrid berhasil meningkatkan pengetahuan kader PKK tentang COVID-19 dan Penyakit Hipertensi sebesar 13,56%.Â

ANTIHYPERURICEMIA ACTIVITY OF ETHANOL EXTRACT AND FRACTIONS OF AZADIRACHTA INDICA LEAF IN VIVO AND MECHANISM OF ACTION OF ACTIVE FRACTIONS IN VITRO Deden Winda Suwandi; Anas Subarnas; Sri Adi Sumiwi
Jurnal Ilmiah Farmako Bahari Vol 12, No 2 (2021): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v12i2.1207

Azadirachta indica, A.,Juss is a medicinal plant that is used traditionally for some disease, especially its leaves to treat a rheumatic diseases and lower blood uric acid levels. This study was carried out to examine antihyperuricemia activity of ethanol extract, water fraction, ethyl acetat fraction and n-hexane fraction of the A. Indica leaves in male mice of Swiss-Webster strain. Extract and fraction doses used were 250 and 500 mg/kg of body weight and the doses of allopurinol as a standard drug was 13 mg/kg of body weight. The tests were conducted on mice suffering from hyperuricemia induced by potassium oxonat at adose of 300 mg/kg of body weight intraperitoneally and chicken liver juice orally. Measurement of blood uric acid levels were performed using an Easy Touch® every hour for 4 hours after being given test preparations. The results showed that the ethanol extract and the fractions lowered blood uric acid levels in the same way as allopurinol did. The n-hexane fractions at the all doses showed the highest activity, followed by ethanol fraction, and water fraction at the dose of 250 mg/kg at the 4th hour. These results illustrated that the A. Indica leaves might be potential to be used as antihyperuricemia. The active compounds which possibly reduce blood uric acid levels in mice are believed to be flavonoid or polyphenolic compounds because they are reported to be able to inhibit the action of the xanthine oxidase enzyme that converts purines into uric acid. Then, the most active fraction, n-hexane fraction, was tested for its inhibitory activity on xanthine oxidase enzyme to determine its mechanism of action. The results showed that the n-hexane fraction, like allopurinol, inhibited uric acid biosynthesis through inhibiting the activity of xanthine oxidase enzyme with the IC50 value of 132 μg/mL lower than that of allopurinol IC50 58.35 μg/mL. Key words: A. indica leaves, antihyperuricemia, chicken liver juice, potassium oxonat, xanthine oxidase.

Penelitian Antiimplantasi Ekstrak Etanol Daging Buah Burahol (Stelechocarpus burahol Hook F. & Thomson) Pada Tikus Putih Sunardi, Clara; Sumiwi, Sri Adi; Hertati, Ai
Majalah Ilmu Kefarmasian Vol. 7, No. 1
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

We examined antiimplantation effect of ethanol extract from ripening burahol flesh (Stelechocarpus burahol Hook f. & Thomson) using doses 1g and 0.5g per Kg Body Weight (BW) on White Female Rats Wistar Strain. The ethanol extract was given orally on daily basis from diestrus phase until 7th day of pregnancy. Two parameter used in this investigation were number of implants and number of born fetus. The fetus were examined by observing their morphology to identify the existence of teratogenic effect. The result showed that the two doses reduced both the number of implants and born fetus significantly. In addition, the burahol flesh as an antifertility agent has two functions: as antiimplantation and abortifacient. Lastly morphological examination on the fetus did not show any teratogenic effect.

LITERATURE REVIEW: CHEMICAL CONTENT AND PHARMACOLOGICAL ACTIVITY OF KERSEN LEAF (Muntingia calabura L.) Asman Sadino; Sri Adi Sumiwi; Sari Sumarni
Jurnal Farmasi Sains dan Praktis Vol 8 No 1 (January-April 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i1.3802

Kersen (Muntingia calabura L.) is known as a plant that is often used as a tree to absorb air pollution and shade on the roadside. Low economic value and public knowledge about the benefits of cherry as a medicinal and food ingredient is still minimal. The part that can be used as a medicinal ingredient comes from cherry leaves. The purpose of this review article is to provide information related to the chemical content and pharmacological activity of cherry leaves that can treat various diseases. The method used in making this article review is a literature study. The literature sources in this article review were obtained from national journals and international journals published in the last 10 years (2010-2020), which were carried out online through the search engines Google Scholar, Pubmed, and NCBI, using the keywords "Kersen leaves", "Activities cherry leaf”, “Pharmacological activity of Muntingia calabura”, “Chemical content of cherry leaf”, “Muntingia calabura L.”. Journals that enter the inclusion criteria are national and international journals that discuss the pharmacological activity and chemical content of cherry leaves, journals published in the last 10 years (2010-2020), and journals in full text. The chemical constituents contained in cherry leaves are flavonoids, saponins, tannins, and terpenoids. Cherry leaves are scientifically proven to have several pharmacological activities as antidiabetic, antioxidant, antibacterial, anthelmintic, antihyperlipidemic, and anti-inflammatory.

PENGUJIAN SALAH SATU PRODUK SEDIAAN KAPSUL EKSTRAK KULIT BUAH MANGGIS TERHADAP IMPLANTASI TIKUS GALUR WISTAR Maria - Ulfah; Kana Lina Sinaga; Sri Adi Sumiwi
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 4, No 1 (2015)
Publisher : Sekolah Tinggi Farmasi Indonesia

AbstrakProduk sediaan kapsul yang berisi ekstrak kulit buah manggis semakin banyak beredar dipasaran dan dikonsumsi oleh banyak wanita. Salah satu khasiat ekstrak kulit manggis yaitu untuk kesehatan karena mengandung zat aktif utama yang benama xanthon. Obat bahan alam yang mempunyai efek antiimplantasi yang berguna bagi pengaturan jumlah kelahiran belum banyak diketahui. Tujuan penelitian yaitu untuk mengetahui khasiat antiimplantasi dari produk yang berisi ekstrak kulit buah manggis. Pada penelitian ini dilakukan pengujian salah satu sediaan yang mengandung ekstrak kulit buah manggis yang beredar di pasaran terhadap implantasi tikus betina Galur Wistar. Kelompok hewan terdiri dari kelompok kontrol dan kelompok uji yang terdiri dari tiga ekor tikus tiap kelompok. Kelompok kontrol diberi suspensi PGA 2% secara oral, dan kelompok uji yang diberikan suspensi sediaan uji secara oral dengan dosis 100, 75 dan 50mg/kgbb yang selama 10 hari sejak tikus dinyatakan hamil jika setelah dikawinkan ditemukan sperma pada cairan vaginanya. Tikus dibedah pada hari kehamilan ke-11 untuk dihitung jumlah implantasinya. Hasil penelitian menunjukkan tidak terdapat perbedaan yang bermakna antara kelompok uji sediaan dibandingkan terhadap kelompok kontrol negatif (p > 0,05). Dengan demikian dapat disimpulkan bahwa pemberian sediaan ekstrak kulit manggis pada dosis tersebut di atas tidak berpengaruh terhadap jumlah implantasi yang dihasilkan. Kata Kunci : Implantasi, Ekstrak kulit manggis, mangostin, AbstractCapsule products containing mangosteen rind extract many outstanding in the market and consumed by many women. One of the benefits of mangosteen peel extract is efficacious for beauty, because it contains xamthon as active substances. Natural medicines that have the effect anti-implantation useful for setting the number of births has not been known. The purpose of research is to determine the efficacy anti-implantation of products containing extracts of mangosteen rind. In this study tested one preparation containing extracts of mangosteen rind on the market towards the implantation of female rats Wistar strain. Animal group consists of the control group and the test group consisting of three rats each group. The control group was given a 2% suspension PGA orally, and the test group were given suspension of the test preparation orally at a dose of 100, 75 and 50 mg / kg for 10 days from the confirmed pregnant mice if after breeding was found sperm in vaginal discharge. Mice dissected on the 11th day of pregnancy to quantify the number of implantation. The results showed no significant difference between the test group dosage as compared to the negative control group (p> 0.05). It can be concluded that the administration of a preparation of mangosteen peel extract at doses above does not affect the amount of implantation produced. Keywords : Implantation, Garcinia mangostana extract, mangosteen

PENGARUH KONSELING TERHADAP KEPATUHAN MINUM OBAT DAN TEKANAN DARAH PASIEN HIPERTENSI TERAPI KOMBINASI DI POLIKLINIK TASIKMALAYA Resha Resmawati Shaleha; Sri Adi Sumiwi; Jutti Levita
JURNAL SAINS DAN TEKNOLOGI FARMASI INDONESIA Vol 8, No 2 (2019)
Publisher : Sekolah Tinggi Farmasi Indonesia

Hipertensi merupakan kondisi tekanan darah melebihi 140/90 mmHg, oleh karena itu pemeriksaan rutin diperlukan untuk memantau kestabilan nilai sistolik dan diastolic. Penelitian ini bertujuan menelaah pengaruh konseling terhadap kepatuhan minum obat serta tekanan darah pasien hipertensi terapi kombinasi di poliklinik Tasikmalaya. Metode yang digunakan yaitu observasional prospektif menggunakan analisis deskriptif rancangan Non-Equivalent Control Group, pada Desember 2018-Januari 2019 terhadap pasien hipertensi rawat jalan yang diberi terapi kombinasi. Pada penelitian ini responden diminta untuk mengisi kuesioner sebelum intervensi dan setelah intervensi dengan menggunakan Medication Adherence Rating Scale. Jumlah responden adalah 60 pasien hipertensi yang dibagi menjadi kelompok kontrol dan intervensi. Karakteristik demografi responden dari 60 pasien menunjukkan: responden perempuan = 39 orang (65,0%); berusia 50-59 tahun = 30 orang (50,0%); berpendidikan SD = 19 orang (31,67%); tidak bekerja = 28 orang (46,7%). Responden tidak mengetahui dan tidak melaksanakan diet rendah garam (48,3%); mengetahui tetapi tidak melaksanakan olahraga 51,7%; tidak merokok (96,7%); dan tidak mengkonsumsi alkohol (96,7%). Rata-rata skor MARS pre-test 4,53 dan post-test 4,70, sedangkan rata-rata sistolik responden sebelum intervensi adalah 157,27 mm Hg dan diastolik 86,45 mm Hg. Setelah intervensi, rata-rata sistolik 148,56 mmHg dan diastolik 83,45 mmHg. Pemberian konseling dapat meningkatkan kepatuhan dan menurunkan nilai tekanan darah T2 hitung 44,54 lebih besar dari T2 tabel 6,92. Dapat disimpulkan bahwa konseling berpengaruh dalam meningkatkan kepatuhan minum obat pasien hipertensi terapi kombinasi sebesar 6,18%, serta menurunkan nilai sistolik sebesar 15,93% dan diastolik sebesar 5,5% (p = 0,0001).Kata kunci: hipertensi, kepatuhan minum obat, konseling, diastolik, sistolik, MARS (Medication Adherence Report Scale).

Kajian Interaksi Obat Pada Peresepan Pasien Diabetes Melitus Di Salah Satu Rumah Sakit Di Kota Bandung Ameilia Ameilia; Sri Adi Sumiwi
Journal of Pharmaceutical and Sciences JPS Volume 6 Nomor 2 (2023)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Introduction: Drug interactions are events that occur if the use of drugs in a shared time. The drug interactions that occur can produce adverse or beneficial effects. Purpose: to determine the potential interaction of drugs given to outpatients with diabetes mellitus diagnosis in one of the hospitals. Method: the study was conducted using a descriptive analysis design, by collecting retrospective data using prescription documents for diabetic patients in outpatient pharmacy installations in hospitals in the city of Bandung. Results: the study showed that the Biguanida group was often used as much as 82.4% and the interaction of the use of Glimepirid with metformin as many as 25 cases (21.2%) with a moderate level of interaction. Conclusion: The antidiabetic drug that is often used is the Biguanida group with a frequent interaction is Glimepirid with metformin.

KADAR FENOLIK TOTAL EKSTRAK TEMUKUNCI (Boesenbergia rotunda L) ASAL LEMBANG JAWA BARAT DENGAN METODE FOLIN-CIOCALTEU: TOTAL PHENOLIC CONTENT OF TEMUKUNCI (Boesenbergia rotunda L) EXTRACT ORIGIN IN WEST JAVA USING FOLIN-CIOCALTEU METHOD Dani Sujana; Nyi Mekar Saptarini; Sri Adi Sumiwi; Jutti Levita
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 7 No 3 (2022)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v7i3.436

Metabolit sekunder yang paling melimpah dan berperan penting dalam pertumbuhan, pigmentasi dan reproduksi pada tumbuhan yaitu senyawa fenolik. Senyawa ini telah menjadi fokus utama dalam beberapa penelitian karena efek biologis yang menguntungkan. Lokasi tumbuh tanaman merupakan salah satu yang dapat mempengaruhi kandungan senyawa aktif pada tumbuhan. Lembang, Bandung, Jawa Barat berada di daratan tinggi, memiliki suhu rendah, kondisi tanah yang subur dan sehingga cocok untuk budidaya tanaman herbal, termasuk temukunci. Polifenol dalam ekstrak tumbuhan bereaksi dengan pereaksi redoks spesifik, dalam hal ini yaitu pereaksi F-C dapat membentuk kompleks biru yang dapat diukur dengan spektrofotometri. Dalam penelitian ini dilaporkan bahwa kandungan fenolik total EEBR adalah 18.32± 0.615 atau setara dengan 183,83 mgGAE/100 g.

FORMULATION AND NUTRITIONAL EVALUATION OF HIGH-FAT DIET FEED FOR FATTY LIVER INDUCEMENT IN RODENT MODELS Putri Anggreini; Jutti Levita; Hadi Kuncoro; Andi Tenri Kawareng; Sri Adi Sumiwi
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 9 No 2 (2024)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v9i2.1233

Non-alcoholic fatty Liver Disease (NAFLD) is one of the most prevalent lipid disorders worldwide. In the pursuit of drug discovery and development, animal modeling is crucial to elucidate the mechanisms underlying a disease. One form of animal model of NAFLD involves the induction of a high-fat diet (HFD). However, most HFDs exhibit complexity in the formulation, and commercial HFDs tend to be costly. This study aimed to formulate an HFD feed with minimal ingredients that are capable of inducing liver steatosis. This study commenced with the development of 4 dietary formulations (F1, F2, F3, and F4) comprising various food components with specific proportions and treatments. A proximate analysis was conducted for each formulation. Subsequently, the most promising formulation was administered to the rats for 14 days. On day 15, liver organs were harvested for histological analysis. The results showed that among the four formulations developed, HFD F4 exhibited the best physical appearance and nutritional proximate components, characterized by its stability in form and high fat (41.8%), high protein (21.5%), and low carbohydrate (23.2%) content. Histology examination revealed that two weeks of administration of F4 administration led to severe degeneration, inflammation, and necrosis in rat hepatocytes compared to the normal group (p < 0.001), thus confirming that HFD F4 may be developed as an inducer of steatosis in rats. Keywords: experimental animal model; high-fat diet; liver steatosis ; NAFLD

Tinjauan Pustaka : Efek Jangka Panjang Penggunaan Kortikosteroid Inhalasi Pada Pasien Asma Azzahra, Nabila Putri; Yohanes, David Christianto; Sumiwi, Sri Adi
Farmaka Vol 21, No 2 (2023): Farmaka (Juli)
Publisher : Fakultas Farmasi, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/farmaka.v21i2.45938

Kortikosteroid inhalasi (ICS) direkomendasikan sebagai pengobatan lini pertama untuk pasien dengan penyakit inflamasi saluran pernafasan persisten seperti asma. Penggunaan kortikosteroid inhalasi memiliki keuntungan lebih dibandingkan dengan kortikosteroid oral karena memungkinkan pengobatan dengan dosis lebih rendah, mengoptimalkan efek inflamasi lokal, serta penurunan yang signifikan dalam paparan sistemik terhadap obat. Namun, terdapat efek jangka panjang dari penggunaan kortikosteroid inhalasi, baik efek lokal maupun sistemik. Tujuan dari tinjauan literatur ini yaitu untuk mengidentifikasi dan mendeskripsikan studi yang melaporkan terkait risiko efek samping penggunaan kortikosteroid inhalasi (ICS) jangka panjang pada pasien asma. Metode yang digunakan dalam pembuatan artikel ini yaitu dengan meninjau literatur melalui sumber-sumber pustaka elektronik dengan basis data Google Scholar dan Pubmed®, kata kunci yang digunakan yaitu “Inhaled Corticosteroid”, “Long-term effect” “Asthma”. Dari hasil tinjauan literatur diperoleh 33 artikel yang disertakan dalam penulisan terkait dengan efek samping jangka panjang penggunaan kortikosteroid inhalasi. Efek samping yang ditemukan diantaranya pneumonia, tuberkulosis, supresi adrenal, osteoporosis, gangguan optalmik, dan diabetes dengan masing-masing mekanisme yang mendasarinya.

Co-Authors Ade Zuhrotun Ahmad Muhtadi Ai Hertati Ai Hertati, Ai Ajeng Diantini, Ajeng Aliya Nur Hasanah Ameilia Ameilia Ami Tjitraresmi, Ami Anas Subarnas Andi Tenri Kawareng Anna Yuliana, Anna Anni Anggraeni Anni Anggraeni, Anni Anni Aoggraeoi" Apriali, Kirka Dwi Aryanti, Ninda Asman Sadino Azzahra, Nabila Putri Clara Sunardi Clara Sunardi Clara Sunardi Dani Sujana Darmawan, Michelle Darwati Darwati Darwati Darwati Darwati, Darwati Eli Halimah, Eli Ellin Febrina Fahriza Ardiansyah FAUZI, DIANE FITRI NURJANAH Gofarana Wilar Hadi Kuncoro Hartono, Ayu Previani Hazna Putri Salsabilla Hendrayana, Jemmy Hendrayana, Jemmy Ida Musfiroh -, Ida Musfiroh Iis Leniawati Indah Suasani Wahyuni Irma Erika Herawati Irma Melyani Puspitasari Irma Meylani Puspitasari Istiqomah, Aulia Nurfazri Izzatul Khoirunnisa Jennifer Kolina Julisiana Sanggelorang Jutti Levita Kana Lina Sinaga KHOIRINA NUR SA'IDAH Kokom, Asep Kolina, Jennifer Kusuma, Winny Lutfi Sulaiman MANUELA GLENATALIE PAKPAHAN Mardhiani, Yanni Dhiani Maria Ulfah Marline Abdassah Bratadiredja Marline Abdassah, Marline MEGANTARA, SANDRA Mochamad Rizal Moelyono, M W Moelyono, M W Mohamad Taufik Ismullah Muchtaridi Muchtaridi Muhammad Ryan Radix Rahardhian Muhammad Ryan Radix Rahardhian Mutakin Mutakin Mutakin Mutakin Nisa Masyitah NUR RAMADHANI MAUNG MANURUNG Nurfadillah, Nisrina Nurike Susendi Nyi Mekar Saptarini Okta Nama Putra Pangestu, Lauren PERTIWI, INTAN Putri Anggreini Putri, Chintiana Nindya Rahadianti Khofii Suwanditya Ramadaini, Tiara Ramonah, Dewi Renny Amelia Resha Resmawati Shaleha Riezki Amalia Rini Hendriani Ririn Suharsanti, Ririn Rochjana, Anna Uswatun Hasanah Ronny Lesmana Saeful Amin, Saeful SAFIRA ANNISSA Sari Sumarni Shaleha, Resha Resmawati Siti Saleha Sriwidodo Sriwidodo Steffi Liem Supriyatna Supriyatna Susilawati, Elis Susilawati, Yasminwar Suwandi, Deden Winda Taofik Rusdiana TIANA MILANDA Tina Rostinawati WAHYU EKA SAPUTRI Winny Kusuma Yasmiwar Susilawati Yoga Windhu Wardhana Yohanes, David Christianto Yoppi Iskandar Yuli Andriani Yunita .

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