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Toto Subroto
Departemen Kimia, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Padjadjaran
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Health Notions

 1 
A Computational Study of Fab CHK152 with CHK265 as Anti Chikungunya Virus for Rapid Test Components Korry Novitriani; Ade Rizki Ridwan Firdaus; Bacthi Alisjahbana; Shabarni Gaffar; Muhammad Yusuf; Toto Subroto
Health Notions Vol 7, No 5 (2023): May
Publisher : Humanistic Network for Science and Technology (HNST)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/hn70502

Abstract

The symptoms of chikungunya disease are generally similar to the symptoms of other viral diseases, except that chikungunya disease can cause joint disorders and even paralysis. Incorrect initial diagnosis will result in inappropriate treatment of the disease Thus it is necessary to study the identified antibodies that can neutralize and protect the body from alphavirus infections, including chikungunya. There are several antibodies that can neutralize chikungunya including CHK152 which neutralizes virus by inhibiting fusion with stabilizing the surface area of the virus, hindering the exposure of the fusion-loop, likely neutralizing infection by blocking fusion. Otherwise CHK265 inhibits the life cycle of the virus in a way neutralize infection by blocking entry at a post-attachment pre-fusion step. The low energy of binding between antigen-antibodies will stabilize the interaction of both. Therefore, this aims to find the best affinity energy for antibodies to be used in the rapid diagnostic component of anti-chikungunya virus (CHIKV). The binding energies were calculated using FireDock an efficient method for the refinement and rescoring of rigid-body docking solutions, through rearrangement of the interface sidechains and adjustment of the relative orientation of the molecules.The results of this study  obtained energy scores from CKH152 and CHK265 are -125.78 and -29.94, indicate that CHK265 antibody affinity energy is higher than CHK152. It can be concluded that the best affinity energy for CHIKV diagnostic component is CHK152.Keywords: energy affinity; CHK152; CHK265; E1E2 CHIKV; molecular docking
Co-Authors Abdul Alim Kahari, Abdul Alim Abu Bakar M.I. Syihab Ade Rizki Ridwan Firdaus Agus Gumilar Ahmad Fariz Maulana Alifa I. Nabila Amiruddin, Mohd. Hasril Angga Himas Setyawan Anita Yuwita Anneke Noviyanti Aprillia, Mutiara Sukma Ari Hardianto Bachti Alisjahbana Bacthi Alisjahbana Basti Andriyoko Bevi Lidya Bevi Lidya Bisri Musthofa Budi Santoso Budiana, Dian Budiantoro, Ogi Cindy Aulia Sari D Agus Yusuf Wildan Dani Permana Debby M Sumanti Defi Supriyati, Ayu DESSY NATALIA DESSY NATALIA DESSY NATALIA Desy Linasari Dewi Astriany Dewi Ratih Handayani Dhiya Salsabila Diana P Rahmawati Diana Rakhmawaty Eddy Didi Suryadi Didin Budiman, Didin DWI RAHMAWATI Dzakiyah 'Izzah Ghassani Adsumi Effendi, Syulastri EKO YULIANTO Elazmanawati Lembong Fadhilah, Muhammad Naufal Fadhlillah, Muhammad Fadillah, Lukky Farihandiandra, Yusron Fathurrohman, Muhammad Andi Fatin, Nuri Nuraini Fauzian Giansyah Febriani Aji Kusuma, Sherlynda FERNITA PUSPASARI Firdaus, Muhammad Lutfi Gifa Nur Arofah Gifa Nur Arofah Gumelar, Abih Gumilar, Agus Hafizatunnisa, Hafizatunnisa Hambali, Burhan Hamdiyanti, Meti Henry Chandra Hesti Lina Wiraswati Idar Idar Idar Idar Idar Idar Idar, Idar Iman Permana Maksum Iman Rahayu Kharimah, Nurul Ikhsan Khomaini Hasan KHOMAINI HASAN Khomairi Hasan Korry Novitriani Korry Novitriani, Korry Kusumawardhani, Shinta Laelasari Laelasari , Laelasari Laelasari Laelasari Laelasari Laelasari, Laelasari Leonardus Wiydatmoko Lesmana, Gianjar Lukky Fadillah Mamlikatu Ilmi Azizah Meti, Meti Hamdiyanti Mony, Siti Rasnawati Muchamad Subali Noto Muhamad Abidin Muhamad Zulchoir Rasyid Muhammad Fadhil Z, Rusdi Noor Rosa (p:43-50) Muhammad Fadhlillah Muhammad Hilman Daniswara Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Muhammad Yusuf Murniaty Simorangkir Murniaty Simorangkir Naufal D, Kevin Nida Yumna Nisa Fauziah Noviyanti, Anneke Nurfairuz, Hasna Siti Nurmalasari, Ratna Nurul Aida Fathya Nurul Ikhsan Karimah Nurul Ikhsan Karimah O Suprijana O Suprijana O Suprijana, O OGI BUDIANTORO Ogi Budiantoro Oo Suprijana Opik Taupiqurrohman Opik Taupiqurrohman Pertiwi, Wulan Praja, Ena Suhena Purba Upay Rahmaniar Mulyani Rahmaniar Mulyani Rahmat, Alit Ratna Yulistya Ningrum Regi Dwi Septian Riezki Amalia Rima Handiyani Risnina Wafiqoh Rizky Rosjanuardi Rochmat Rahayu Rodiana , Ivta Rodiana, Ivta Safri Ishmayana Safrl Ismayana Sahroni Sahroni Sahroni, Sahroni Santhy Wyantuti Sari Agung, Syennie Sari Syahruni Sari Syahruni Saronom Silaban Saronom Silaban Saronom Silaban SARONOM SILABAN Setyaningrum, Sinta Shabarni Gaffar Shinta Kusumawardani Siti Nuraini Siti Soidah Siti Umayah Siti Umayah, Siti Soetijoso Soemitro Soetijoso Soemitro Soetijoso Soemitro Soetijoso Soemitro Soetijoso Soemitro SOETIJOSO SOEMITRO Soetijoso Soemitro Sofyan Multazam N Aji Sri Asnawati Sri Pitriayana Sriwidodo B, Sriwidodo Sriwidodo Sriwidodo Sriwidodo, . Sukma Nuswantara Sukma Nuswantara Sukma Nuswantara Sunan M. Alpiansyah Surya Amami Pramuditya Sutarya Enus Sutarya Enus Sutarya Enus SUTARYA ENUS Syani, Mamay Syfa Nurfadilah Syfa Nurfadilah Taupiqurrohman, Opik Taupiqurrohman, Opik Tika Pradnjaparamita, Tika Tonah Tonah Triana N Meirina Umi Baroroh Umi Baroroh Unang Supratman Upay, Purba wahyu widayat Wanda Destiarani WANGSA TIRTA ISMAYA Wildatus Sholihah Windy Aulia Putri Wulan Pertiwi Yani Suryani Yeni W Hartati Yeni Wahyuni Hartati Zakiyyah, Salma Nur