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All Journal ASEAN Journal of Systems Engineering MEDIA KOMUNIKASI TEKNIK SIPIL Management of Aquatic Resources Journal (Maquares) BIOTROPIA - The Southeast Asian Journal of Tropical Biology Afkaruna: Indonesian Interdisciplinary Journal of Islamic Studies Jurnal Teknologi Pendidikan Journal of Degraded and Mining Lands Management Conciencia Tajdida Jurnal Pengabdian Kepada Masyarakat (Indonesian Journal of Community Engagement) MODELING: Jurnal Program Studi PGMI Syntax Literate: Jurnal Ilmiah Indonesia Ganaya: Jurnal Ilmu Sosial dan Humaniora Jurnal Otomasi Kontrol dan Instrumentasi Jurnal Nusa Sylva IRJE (Indonesian Research Journal in Education) CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Ecoment Global: Kajian Bisnis dan Manajemen Journal of Environmental Science and Sustainable Development Indonesian Journal of Intellectual Publication (IJI Publication) Edupedia: Jurnal Studi Pendidikan dan Pedagogi Islam Historia Jurnal Kependidikan Islam Journal of Renewable Energy, Electrical, and Computer Engineering Procedia of Social Sciences and Humanities Asian Journal of Health Research Majalah Cendekia Mengabdi Al Kafaah : Journal of arabic Language and Linguistics Education JIM: Jurnal Ilmiah Mahasiswa Pendidikan Sejarah Atthiflah: Journal of Early Childhood Islamic Education ABDIMAS KAUNIAH ISTIFHAM Al-Busyro Jurnal Archipelago Jurnal Jurnal Al-Muharrik: Jurnal Pendidikan Agama Islam An-nisa: Journal of Islamic Family Law Cakrawala: Journal of Religious Studies and Global Society Jurnal Pengabdian, Riset, Kreativitas, Inovasi, dan Teknologi Tepat Guna (Parikesit) Indonesian Journal of Intellectual Publication (IJI Publication)
Muhammad Sulaiman
Jurusan Penangkapan Ikan, Politeknik Pertanian Negeri Pangkep, Pangkep
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Journal : Asian Journal of Health Research

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KRAS Inhibition in Colorectal Cancer: Current Insights, Clinical Successes, and Ongoing Challenges Memon, Furqan; Nadeem, Momina; Bah, Chernor Sulaiman; Sulaiman, Muhammad; Hani, Umm-E; Silumbwe, Ceaser Wankumbu; Khan, Muhammad Ali Amin; Mulumba, Julius; Zou, Jianjun; Yuan, Shengtao
Asian Journal of Health Research Vol. 3 No. 3 (2024): Volume 3 No 3 (December) 2024
Publisher : Ikatan Dokter Indonesia Wilayah Jawa Timur

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55561/ajhr.v3i3.180

Abstract

ABSTRACT Introduction: Recent advancements in colorectal cancer (CRC) treatment have been significantly impacted by KRAS-targeted therapies, notably sotorasib and adagrasib, which specifically inhibit the KRAS G12C mutation. Despite these advancements, challenges persist, such as the rare occurrence of the KRAS G12C mutation in some tumors and complex resistance mechanisms. This review aims to assess recent developments in KRAS-targeted therapies, address ongoing challenges, and explore innovative strategies to improve treatment outcomes. Material and Methods: The review examined recent studies on KRAS-targeted therapies, focusing on sotorasib and adagrasib’s efficacy and resistance mechanisms. It explored emerging strategies like immune checkpoint inhibitors, RAS-related pathway inhibitors, PROTACs, and CRISPR interventions, and assessed personalized, multidisciplinary approaches integrating surgery, chemotherapy, and tailored therapies. Results: Sotorasib and adagrasib have demonstrated effectiveness in targeting KRAS G12C, although success varies with individual patient profiles. Resistance to these therapies often involves secondary mutations or activation of alternative pathways. Innovative strategies, including immune checkpoint inhibitors and PROTACs, hold promise for overcoming these resistance challenges. Personalized, multidisciplinary approaches that incorporate KRAS mutation profiles and tissue-specific characteristics are proving beneficial. Conclusion: KRAS-targeted therapies, such as sotorasib and adagrasib, represent significant advancements in CRC treatment, though challenges like mutation rarity and resistance persist. Emerging strategies and personalized, multidisciplinary treatment plans offer hope for overcoming these obstacles and improving patient outcomes. Continued research and innovation are essential for addressing these challenges and enhancing treatment efficacy.
Co-Authors Adhitia, Pius Adiyati, Noor Agung P, Maulana Agus Prasetya Aini, Muhammad Noor Amastini, Fitria Anwar Abidin, Achmad Ardik Ardianto Asemani, Omid Aspriadi, Feri Ayu Fahimah Diniyah Wathi Azhari Azhari Azisi Badri Bah, Chernor Sulaiman Bakti Dwi Waluyo Bambang Sulardiono Bintang, Muhammad Audya Brillianing Pratiwi Churun Ain Dian Hudawan Santoso Edy Saputra Engkos Kosasih Fadliyah, Nurul fatholla, fatholla Fathor Rosi Firmansyah Firmansyah Fitri Nabila, Zakia H Hasmawati Habibie, Ramadhani Alfin Hani, Umm-E Hasanah, Jamingatun Hidayatunnisa, Nurul Fadhlya Hutahaean, Harvei Desmon Idris, M. Arif Iga Maliga Ihsan Ihsan Imam Wahyudi Indrawan, Imam Wahyudi Jaya, Risman Khan, Muhammad Ali Amin Kisnanto, Indro Kusworo, Zulfikar Aji Lianasari, Lianasari Mardi, Isra Maria Kristina, Maria Marjan Bato Masbukhin, Faizal Akhmad Adi Maysarah, Maysarah Memon, Furqan Muhammad Aditya, Muhammad Muhammad Amin Muhammad Dani Solihin Muhammad Isnaini Muhammad Taufiq Muhammad, Usman Jimoh Mulumba, Julius Nadeem, Momina Ni’mah, Rizka Manzilatun Nurdin Nurdin Nurfaiza Nurfaiza, Nurfaiza Nurhadi Sasmita Oktarina, Vivin Ermia Sarinari Yopan Prastica, Rian Mantasa Salve Pratama, Deskas Adi Priyono, Dwi Juli Pujo Widiyantoro, Wahid Rachmawan Budiarto Rahman Kosasih, Fauzy Royhan, Fahmi Safitri, Icmi Alif Sartika, Heni Wahyu Setiarno, Muhammad Luthfi Sigit Heru Murti sigit prasojo Silumbwe, Ceaser Wankumbu Suci Madiarti Isman Suci Nurhayati Sucipto, Imam Sudaryatno Sudaryatno Suparti Suparti Supartono, Toto Supratmi, Nunung Suripto Suripto SUWARNO HADISUSANTO Suyadi Suyadi Syafruddin*, Syafruddin Syahidin Syahidin, Syahidin Tajul Arifin Tjahyo Nugroho Adji Umi Fadilah, Umi Urbaningkrum, Santi Mahmuda UthmanSulaiman, Kabuye Wahyu Sartika, Heni Wahyu Wilopo Wardatul Karimah, Intan Wardianto, K Bagus WILDAN, LABIBUL Wulandari, Riski Peni Yuan, Shengtao Yulia Ningsih Yunianika, Ika Tri Zainuri Zou, Jianjun