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The impacts of stimulation in protracted labor to cortisol levels and incidence of post-partum blues Soetrisno, Soetrisno; Respati, Supriyadi Hari; Sulistyowati, Sri; Kurniawan, Hendro
Folia Medica Indonesiana Vol. 53, No. 1
Publisher : Folia Medica Indonesiana

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Abstract

Delivery, induction, stimulation, cesarean section with the aid of a vacuum extraction, for example, can reduce maternal confidence on the smooth delivery process, as well as improve postpartum stress. These stressors stimulate the HPA axis (hypothalamus-pituitary-adrenal), so that the adrenal cortex produces more cortisol hormone, it can increase postpartum blues. The objective of this study was to analyze the effect of delivery stimulation on protracted labor on cortisol levels and the occurrence of postpartum baby blues. This was an experimental study of non-randomized post-test control group. The subject of the study 30 patients in labor taken consecutive sampling, divided into 2 groups (normal delivery and stimulation) each group consist of 15 patients. In stimulation delivery group, it is examined of cortisol serum levels after five days and then continued for postpartum blues occurrence measurement. Statistical analysis using t-test for differences in levels of cortisol and chi square for analyzing the effect on the occurrence of post-partum blues (a=0.05). Mean level of cortisol in delivery stimulation group is 40.29 ± 5.58, in normal delivery is 33.59 ± 11.17, with p=0.047, meaning there are significant differences both study groups. Stimulation delivery increases the occurrence of post-partum blues 5.50 times compared to normal delivery (OR=5.50 and p=0.028). Mean cortisol levels on post-partum blues higher at 42.90 ± 6.97 compared to no post-partum blues 30.14 ± 6.66, p=0:00, which means there are significant differences both groups. In conclusion, there was significant relationship between stimulation in protrated labor that increases cortisol serum level and post partum blues incidence.
Expression of human leukocyte antigen-e and natural killer cells in intra uterine fetal death Sulistyowati, Sri; Nugroho, Muhammad Anggit; Respati, Supriyadi Hari; Soetrisno, Soetrisno
Folia Medica Indonesiana Vol. 53, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Intra Uterine Fetal Death (IUFD) is one contributor to infant mortality. Human Leukocyte Antigen-E (HLA-E) and Natural Killer Cells (NK cells) are believed to play an important role towards IUFD associated with immune maladaptation. This study aimed to determine the expression of HLA-E and NK cells on trophoblast on IUFD and normal pregnancy. The study used cross sectional approach undertaken at Department of Obstetrics and Gynecology, Dr. Moewardi Hospital, Surakarta, networking hospitals, and Anatomic Pathology Laboratory of Faculty of Medicine, Sebelas Maret University. The number of samples were 32 subjects consisting of 16 subjects with normal pregnancy and 16 subjects with IUFD. The expression of HLA-E and NK cells on trophoblast of subjects who met the inclusion and exclusion criteria were examined using immunohistochemistry method and t-test statistical analysis. The mean value of HLA-E expression in the trophoblast of IUFD group was 17.30±6.69, in normal pregnancy was 57.06±32.04, with p=0.00 (p<0.05). The mean value of NK cell expression in trophoblast in IUFD group was 78.62±36.43, in normal pregnancy was 19.87±6.43, with p=0.00 (p<0.05). This study concluded that the expression of HLA-E was lower and NK cells wass higher in IUFD compared to those in normal pregnancy.
Effect of cognitive behavioral therapy for serotonin level, depression score and quality of life in cervical cancer patients Soetrisno, Soetrisno; Sulistyowati, Sri; Respati, Supriyadi Hari; Nasrudin, Muhamad
Folia Medica Indonesiana Vol. 52, No. 3
Publisher : Folia Medica Indonesiana

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Abstract

Cervical cancer is the most common cause of death among gynaecological neoplasms. Management of advanced cervical cancer currently has not been able to improve the prognosis. Standard intervention therapy, chemotherapy and radiotherapy, as well as the emerging pain could lead to psychological stress till depression, thus reduce patients' quality of life. CBT for psychological stress and depression is expected to improve the fruitfulness of standard therapy. Serotonin is a neurotransmitter which plays a role in the patophysiology of depression. The aim of this study is to analyze the effect of cognitive behavioral therapy on serotonin level, depression score and quality of life in advanced cervical cancer patient with experimental quasi pre and post test design methods. The samples are 15 subjects in both intervention and control groups. Intervention group was given CBT and standard therapy, while control group was given standard therapy only. Study was held in Department of Obstetric and Gynecologic Dr. Moewardi Hospital Surakarta and Prodia Laboratory, in January to March 2015. Independent variable was advanced cervical cancer patients underwent CBT intervention and dependent variables were serotonin level, depression score and quality of life score. The result, serotonin level and quality of life scores were higher after intervention compared with control, (219.43±33,42 vs 89.57±23.23) and (85.13±14.62 vs 41.86±7.24), respectively. Depression score was lower after intervention than without CBT intervention (11.20±4.94 vs 17.00±4.86) and statistically significant (p < 0.05). So, there were effects of cognitive behavioural therapy on serotonin level, depression score and quality of life score in cervical cancer patients and were statistically significant.
Co-Authors - Soetrisno, - -, Soetrisno - Abd. Rasyid Syamsuri Adhi Pribadi Adiyana, Febrian Andhika Agan, Lie Aji P Wibowo, Aji P Akbar, Uchti Alamsyah, Meuthia Aldiansyah, Dudy Aldika Akbar, Muhammad Ilham Aloysius Suryawan Anak Agung Eka Andonotopo, Wiku Anwar Sandi Wibowo, Anwar Sandi Ari Natalia Probandari Asih Anggraeni Astetri, Lini Bachnas, Muhammad Adrianes Bambang Eko Wiyono, Bambang Eko Bambang Rahardjo Besar, Dwi Sakti Berlian Besari Adi Pramono Cahyanto, Erindra Budi Carissa, Dinda Cut Meurah Yeni Damayanti, Sintia Donny Irawan, Donny Dono Indarto Endang Sri Kurniatun, Endang Sri Endang, Rini Enik Sulistyowati Eriana Melinawati Eric Edwin Yuliantara Evert Solomon Pangkahila Fajariyah, Luthfiana Fitri, Niswatul Fitriana Fitriana Grandis, Bunga Silvia Hadi, Cahyono Hari Wujoso Herman Kristanto Heru Priyanto Heru Priyanto I Nyoman Hariyasa Sanjaya Ida Nurwati Isharyadi, Isharyadi John Arianto Sondakh, John Arianto Jonathan, Andreas Julian Dewantiningrum Khoeronisa, Siti Kiriwenno, Erlin Kurjak, Asim Kurniawan, Hendro Kusnadi, Noferi Laqif, Abdurahman Mahandaru, Araafi Hariza Marbun, Yohan Pamuji Mega, Aryanti Muhammad Adrianes Bachnas Musyarofah, Nova Riyan Nababan, Ronald Nanik Setiyawati, Nanik Nasrudin, Muhamad Ningrum, Wike Aprilia Nizar Hero K, Nizar Hero Nugroho, Muhammad Anggit Nurchalisha, Siti Nada Nurinasari, Hafi Nuswil Bernolian Nutria Widya Purna Anggraini Nuur, Aliffudin Pradana, Muhammad Denny Gagah Pramono, Mochammad Besari Adi Prasetya, Hanung Pujojati, Ferri Waluyo Wiwoho Putri, Nadhifa Kusuma Rahmawati, Oktantia Dyah Ridwan, Robert Rizkiani, Inne Ryan Saktika Mulyana Sapja Anantanyu, Sapja Saptaningtyas, Haryani Saputra, Ricky Bernadi Sesunan, Arfan Syahfani Siagian, Grace Siregar, Paulina Soetrisno Soetrisno Khasan, Soetrisno Soetrisno Soetrisno Stanojevic, Milan Subina, Totong Suhartini Sumarno . Supriyadi H Respati Supriyadi Hari Respati Supriyadi Hari, Supriyadi Suryoningrat, Dewanto Theresia Monica Rahardjo Tjiang, Rubin Enhui Uki Retno Budihastuti Wesliaprilius, Todung Antony Wiradnyana, Anak Agung Gede Putra Wiraswesty, Ika Wisdayanti, Syah Rini WISNU PRABOWO Yuliani, Saffana Oka Yulyanti, Yulyanti Yuniarsih Zakia, Yuniarsih Yuniarti Yuniarti Yusuf Antoni, Yusuf