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Tissue Engineering and Regenerative Medicine: A Review Wardhana, Aditya; Valeria, Michelle
Jurnal Plastik Rekonstruksi Vol. 7 No. 1 (2020): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1264.186 KB) | DOI: 10.14228/jpr.v7i1.278

Abstract

Summary: The concept of tissue engineering has now been accounted for one of the most prospective answers to the growing needs of tissue and organ replacements. Many studies and researches are continuously done to achieve a paramount strategy in tissue engineering and regenerative medicine. This review emphasizes the concept, strategies, current application, and current challenges in tissue engineering. The strategy in tissue engineering has much improved and successfully applied in several reconstructive cases. Understanding of isolated cells’ behaviors, materials suitable for its’ scaffolds, in adjuncts with specific growth-inducing factors for each specific tissue or organ built is the key for successful tissue engineering. Ringkasan: Konsep tissue engineering merupakan salah satu jawaban yang paling diharapkan dapat memenuhi kebutuhan pengganti jaringan dan organ yang terus meningkat pada saat ini. Beragam studi dan penelitian secara terus-menerus dilakukan agar dapat memperoleh strategi terbaik dalam tissue engineering dan regenerative medicine. Artikel ini berfokus pada konsep, strategi, aplikasi terkini, dan tantangan di masa mendatang pada tissue engineering. Strategi tissue engineering telah banyak berkembangan dan berhasil diterapkan pada kasus-kasus rekonstruksi. Pemahaman mengenai perilaku sel, kecocokan material dengan scaffolds, serta faktor pendukung pertumbuhan untuk masing-masing jaringan atau organ spesifik yang akan diciptakan merupakan kunci keberhasian tissue engineering.
Antioxidants Reduce Tissue Necrosis in The Zone of Stasis: Review of Burn Wound Conversion Wardhana, Aditya; Halim, Jessica
Jurnal Plastik Rekonstruksi Vol. 7 No. 1 (2020): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (512.337 KB) | DOI: 10.14228/jpr.v7i1.292

Abstract

Summary: Severe burns are devastating condition identified by loss of hemodynamic stability and intravascular volume. Adequate fluid replacement, nutritional support, and immediate wound grafting can reduce the risk of infection and mortality. Oxidative stress was shown to have significant role in the burn wound conversion, which happens when the zone of stasis can’t be salvaged and progresses to necrosis. Decreasing the level of oxidative stress early may be fundamental in reducing burn injury progression into deeper tissue. Several animal studies have demonstrated the advance of antioxidant supplementation for burns outcomes. Approach to this salvageable burn tissue is a breakthrough for new directions in burn management. Antioxidant supplementations was proven to prevent burn conversion on the ischemic zone. Administering antioxidant post-burn is linked with less progression of burn depth and inflammatory cytokine release, which alleviates burn-related morbidity and mortality and improves patient’s quality of life. To date, no clinical trials have been done to reproduce similar outcomes of this ROS-scavenging therapy as successfully observed in murine models. Antioxidant supplementation is a promising treatment avenue to halt burn wound conversion following severe burns. Keywords: Burn wound, wound conversion, burn management, antioxidant
The Effect of Early Tangential Excision and Split Thickness Skin Graft in Reducing Length of Stay in Burns Patients in Jakarta Islamic Hospital Cempaka Putih Wardhana, Aditya; Winarno, Gammaditya Adhibarata; Tanjunga, Sanjaya Faisal; Augiani, A. S; Zidna, An’umillah Arini
Jurnal Plastik Rekonstruksi Vol. 8 No. 1 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i1.309

Abstract

Introduction: Early tangential excision (TE) and split-thickness skin graft (STSG) have increased the outcome in burn patients treated at specialized burn centers. This study was conducted to compare the length of stay (LOS) in burn patients undergoing early TE & STSG and delayed TE & STSG. Method: This is a retrospective cross-sectional study including 42 patients with varied burn degrees, and TBSA admitted to Jakarta Islamic Hospital Cempaka Putih (JIHCP) Burn Unit. Patients were assigned to two study groups, the early TE & STSG group including 32 patients and the delayed TE & STSG group including 10 patients. All data were collected from the medical record and compared between two study groups. Result: The mean of LOS in a group with early TE & STSG was shorter (9.81±6.41 days) than LOS in the delayed TE & STSG group (15.80±5.67 days). The data of LOS between these groups were compared using an independent T-test. The LOS in the early TE & STSG group was significantly shorter than the delayed TE & STSG group (p=0.012). Conclusion: In patients with burn injuries, early TE & STSG is associated with a shorter length of stay than the delayed TE & STSG. Our study indicates that early excision within five days after burn injury is optimal to reduce the length of stay in burn patients.
The Difference in TBSA Estimation Between Emergency Room and Burn Unit in Second Tier Hospital in Central Jakarta Wardhana, Aditya; Winarno, Gammaditya A.; Tanjunga, Sanjaya F.; Zidna, An’umillah Arini; Augiani, Amani S.
Jurnal Plastik Rekonstruksi Vol. 8 No. 1 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i1.310

Abstract

Introduction: Burn TBSA estimation is essential to administer fluid resuscitation. There are some methods, including Rule of 9 and Lund-Browder Chart. This study aims to identify the difference in TBSA estimation in Emergency Room & Burn Unit. Method: We conducted a retrospective cross-sectional study in design. The Inclusion criteria are patients admitted to the Jakarta Islamic Hospital Cempaka Putih (JIHCP) burn unit between April 2015-September 2018, acute patients who have complete demographic data, complete TBSA estimation in the emergency room (ER) and burn unit (BU). Exclusion criteria are patients who do not have complete demographical data and incomplete TBSA estimation between the emergency room and burn unit. The estimation of TBSA in the emergency room is done by General Practitioner, while in the burn unit is done by Plastic Surgeon. Result: Of all 160 patients admitted, 142 patients are eligible in the inclusion criteria.  Most of it was adult males with an average of 28.3 years old, suffering a grade II burn injury caused by scald. There is a higher mean of TBSA estimation in the Emergency room with 15.83 (SD 12.21) compared to the Burn Unit with 12.92 (SD 12.00). The maximum TBSA overestimation in ER reaches 24% TBSA than BU, while the minimum is 0.5%. The Maximum TBSA underestimation in ER reaches 20% TBSA than BU, while the minimum underestimation is also 0.5%. On average, ER overestimates about 6.7% TBSA and underestimates about 2.8% TBSA compared to BU. Conclusion: The emergency room tends to overestimate the TBSA, with an almost 3% difference in mean (p<0.05). There is an occurrence of a maximum 24% TBSA overestimation while averaging 6.7% TBSA.
Nutrition Therapy in Type 2 Diabetic Burn Patient Ramadhania, Dian Araminta; Wardhana, Aditya; Sinaga, Wina; Wulandari, Yohannessa; Daya, Mulianah; Octovia, Lily Indriani
Jurnal Plastik Rekonstruksi Vol. 8 No. 1 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i1.314

Abstract

Summary: Severe burn patients experience pronounced metabolic changes that caused hyperglycemia. Other existing metabolic conditions such as diabetes mellitus may worsen this condition. Early, adequate, and personalized nutrition therapy may result in better glycemic control and prognosis.A 44-year-old male with severe burn injury involving 27,5% total body surface area (TBSA) and type 2 diabetes mellitus (T2DM) was given early and diabetes-specific nutrition therapy to meet the recommended energy and protein needs. Lower carbohydrate contents and higher mono-unsaturated fatty acids (MUFA) were components of diabetes-specific nutrition therapy. Desirable blood glucose levels, a positive trend of albumin levels, and reduced inflammatory markers were achieved while being given this nutrition therapy. Sepsis was not diagnosed in this patient. The patient was discharged from the hospital after an improvement in clinical condition. Hyperglycemia commonly occurs in critically ill patients, especially with pre-existing T2DM. The provision of prompt and personalized nutrition therapy will improve clinical outcomes.
Dietary Soluble Fiber Improved Fecal Consistency in Burned Patients with Diarrhea Setiawan, Evania; Wardhana, Aditya; Sinaga, Wina; Sari, Ayu Diandra; Satyani, Metta; Octovia, Lily Indriani
Jurnal Plastik Rekonstruksi Vol. 8 No. 2 (2021): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14228/jprjournal.v8i2.330

Abstract

Backgrounds: Diarrhea frequently occurs in severely burned patients attributable to impaired intestinal integrity and dysbiosis. Soluble fiber may improve intestinal barrier function, avoid bacterial translocation, then subsequently prevent and treat diarrhea. Soluble fiber is rapidly fermented by commensal bacteria and produces short-chain fatty acids (SCFA). Case Reports: A 51-year-old male with severe burn injury involving 53,5% total body surface area (TBSA) and diarrhea were given soluble fiber as part of his diet. Results: Administration of 6–10 g/d soluble fiber clinically improves stool consistency, assessed by Bristol Stool Scale, in the severely burned patient. The patient was discharged after 19 days of hospitalization with improvement in clinical condition. Summary: SCFA maintains intestinal integrity, supports the growth of commensal bacteria, and inhibits pathogens. There is no specific recommendation regarding fiber intake in burned patients
Social Media Followers Influence Banking Stock Prices in Indonesia Kartawinata, Budi Rustandi; Akbar, Aldi; Wardhana, Aditya; Maharani, Dyah
Journal of Social Science Utilizing Technology Vol. 1 No. 1 (2023)
Publisher : Yayasan Pendidikan Islam Daarut Thufulah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/jssut.v1i1.592

Abstract

Background. Progress in a country can be seen from the development of the capital market, because the capital market plays a very important role in transforming and advancing a country's economy so that it grows and develops. Indonesia is a country known to be rich in natural resources, so the development of capital markets in Indonesia is a step towards sustainable economic development. Purpose. The purpose of this study is to determine the effect of social media on the economic, social and political sectors. Method. The research used is quantitative research with descriptive and verification research methods. Results. The result of this study is that the influence of the number of social media followers on the share price of banks in Indonesia shows a positive correlation between the two. In this context, banks need to utilise social media more effectively as a marketing tool, pay attention to reputation risk management, improve transparency and communication with investors, and strengthen the role of regulators in monitoring the impact of social media.. Conclusion. With this research, there is a finding that in the field of social media, there are variables that influence the financial sector, in this case, company finances, namely the number of followers of a social media platform will influence stock prices. This should be a concern for stakeholders in the business sector to pay attention to social media developments occurring in Indonesia
Effect of Zinc Supplementation on Fasting Blood Glucose Control in Burn Injury Patients with Type 2 Diabetes Mellitus: a Case Report Tedjaatmadja, Chintya; Rasyid, Nurhayati M; Wulandari, Yohannessa; Octovia, Lily Indriani; Sinaga, Wina; Wardhana, Aditya
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 7 No. - (2023): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v7i-.194

Abstract

Burn injury is the second leading cause of injury in Indonesia. Patients with burn injury may develop zinc deficiency due to loss of exudate and decreased carrier proteins, leading to impaired glucose regulation and inadequate wound healing. Jayawardena et al. showed that zinc supplementation can help regulate blood glucose in patients with diabetes mellitus. This case aims to see the effect of zinc supplementation on fasting blood glucose control in burn injury patients with type 2 diabetes mellitus. A 47-year-old Male with diabetes mellitus and a history of COVID-19 presented with 34% second to third-degree burn injury. The patient was given short-acting insulin 6 IU thrice a day and long-acting insulin 10 IU once a day. Nutrition was increased gradually until it reached 30 kcal/kgBW with protein 1,2 g/kgBW on the 28th day of hospitalization, referring to a diabetes-specific formula, 6x300 kcal. The patient also received zinc sulfate supplementation, 40 mg per day. The patient’s daily zinc intake was 47 mg/dL, and it was analyzed using Nutrisurvey. Fasting blood glucose in the first 28 days was not well-regulated (92-348 mg/dL). After 28 days of zinc supplementation, the patient's fasting blood glucose was stable. (140-180 mg/dL). Uncontrolled blood glucose leads to bacteremia, decreased skin graft takes, and increased mortality. Zinc deficiency can cause greater insulin resistance that can lead to hyperglycemia. Fasting blood glucose was stable after 28 days of zinc supplementation, similar to the previous study. Supplementation can help to regulate fasting blood glucose in burn patients with diabetes mellitus.
Pengaruh Kemudahan Penggunaan Aplikasi dan Promosi terhadap Keputusan Pembelian pada E-Commerce Shopee Pratama, Aulya Rahman Putri; Wardhana, Aditya
YUME : Journal of Management Vol 5, No 2 (2022)
Publisher : Pascasarjana STIE Amkop Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37531/yum.v5i2.1530

Abstract

Abstrak Dengan adanya perkembangan teknologi yang sangat pesat lifestyle pun lambat laun berubah. Salah satunya adalah berbelanja secara online melalui E – commerce. Shopee merupakan salah satu E – commerce dengan tingkat pengunjug tertinngi di Asia Tenggara pada tahun 2019. Hal itu disebabkan karena kemudahan penggunaan pada aplikasi E – commerce Shopee dan promosi yang dilakukan oleh E – Commerce ShopeePenelitian ini digunakan untuk mengetahui bagaimana kemudahan penggunaan aplikasi dan promosi pada E – Commerce Shopee. Tujuan dilakukan penelitian ini adalah untuk mengetahui pengaruh kemudahan penggunaan aplikasi dan promosi terhadap keputusan pembelian pada E – Commerce Shopee baik secara parsial mapun secara simultanHasil penelitian menunjukan pada analisis deskriptif variabel kemudahan penggunaan aplikasi mendapatkan hasil sebesar 91,58% berada pada kategori sangat mudah, variabel promosi mendapatkan hasil sebesar 85,61% berada pada kategori sangat baik, variabel keputusan mendapatkan hasil 85,77% berada pada kategori sangat baik. Secara parsial kemudahan penggunaan aplikasi tidak berprngaruh secara signifikan terhadap keputusan pembelian sedangkan promosi berpengaruh secara signifikan terhadap keputusan pembelian. Secara simultan kemudahan penggunaan aplikasi dan promosi berpengaruh secara signifikan terhadap keputusan pembelian. Kata Kunci : Kemudahan Penggunaan Aplikas, Promosi, Keputusan Pembelian AbstractWith the rapid development of technology, lifestyle is slowly changing. One of them is shopping online through E-commerce. Shopee is one of the E-commerce sites with the highest visitor rates in Southeast Asia in 2019. This is due to the ease of use of the Shopee E-commerce application and the promotions carried out by Shopee E-CommerceThis research is used to find out how easy it is to use applications and promotions on E-Commerce Shopee. The purpose of this study was to determine the effect of ease of use of applications and promotions on purchasing decisions at E-Commerce Shopee either partially or simultaneously.The results showed that in the descriptive analysis of the application ease of use variables, 91,58% were in the verry easy category, the promotion variable 85,61% was in the verry good category, and the decision variable was 85,77% in the verry good category. Partially, the ease of use of the application does not have a significant effect on purchasing decisions, while promotions have a significant effect on purchasing decisions. Simultaneously the ease of use of applications and promotions significantly influence purchasing decisions. Keywords: Ease of Use of Applications, Promotion, Purchase Decision
Analisis Peran Service Quality dan Brand Awareness dalam Meningkatkan Consumer Satisfaction pada Industri Ritel Food & Beverage (Studi Kasus Foodpedia) Tannady, Hendy; Wardhana, Aditya; Nuryana, Arief; Sesario, Revi; Arief, Ilham; Suryawan, Ryan Firdiansyah; Bando, Nurjannah; Hernawan, Moch Arif
Jurnal Kewarganegaraan Vol 6 No 3 (2022): October 2022
Publisher : UNIVERSITAS PGRI YOGYAKARTA

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (259.756 KB) | DOI: 10.31316/jk.v6i3.3929

Abstract

AbstrakTujuan dari penelitian ini adalah untuk mengetahui adakah pengaruh Brand Awareness dan Kualitas Pelayanan Terhadap Kepuasan Konsumen. Penelitian menggunakan pendekatan kuantitatif dengan metode teknik purposive sampling dan sampel penelitian konsumen foodpedia sebanyak 155 responden. Hasil penelitian menunjukkan bahwa terdapat pengaruh kualitas pelayanan terhadap Kepuasan konsumen dan tidak terdapat pengaruh Brand Awareness terhadap kepuasan konsumen.Kata Kunci: Brand Awareness, Kualitas Pelayanan, Kepuasan Konsumen AbstractThe purpose of this study is to determine whether there is an effect of Brand Awareness and Service Quality on Consumer Satisfaction. This research uses a quantitative approach with purposive sampling technique method and sample of this study is 155 respondents of consumer Foodpedia. The result of this approach that the service quality partially can influenced customer satisfaction and Brand Awareness partially can not influenced customer satisfaction.Keywords: Brand Awareness, Service Quality, Consumer Satisfaction
Co-Authors Adzani, Shofi Raihan Agnelia, Revina Anisa Agusman Aris, Affandy Al Hazmi, Nadhil Alief Maulana Aldi Akbar Amalina Fitria, Nur Anisa Agnelia, Revina Arief Ramadhan Arief, Ilham Arif Kuswanto Aris, Affandy Agusman Augiani, A. S Augiani, Amani S. Awaliyah, Nadila Rabiatul Azhari, Nadya Dewi Bando, Nurjannah Budi Harto Budi Rustandi Kartawinata Cakranegara, Pandu Adi Christabella, Rininta Citra, Khansa Fairuz Cleopas Martin Rumende Dadang Sudrajat Daya, Mulianah desi kristanti, desi Dien, Siphora Dwikawardhana, Galih Santika Dyah Maharani E. Mudjaddid A. Siswanto Deddy N.W.Achadiono Hamzah Shatri Efendi Efendi Em Yunir, Em Erni Juwita Nelwan, Erni Juwita Faizah, Ana Farhana, Nadya Feroniasanti, Lauda Hafifah, Ariqah Nur Haidar, Zeffan Daffa Fitra Halim, Jessica Hartini Hartini Hartini Hartini Hartini, Hartini - Hendy Tannady Hermawan, Saskia Apriliana Hernawan, Moch Arif Insani, Al Fajrin Irmia Kusumadewi Irzan Soepriyadi Joko Ariawan Kaltha, Karina Kameswari, Varra Awaliah Pinus Karimah, Benati Kautsar, Raisya Ayu Khalida, Nurma Kispa, Tera Kumalawati, July Kurniasari, Dhita Leonard Nainggolan Liem, Isabella Kurnia Lis Lesmini Listiya, Marcella Tirta Mahendra Fakhri Mahir Pradana Mapata, Dg. Marcellus Simadibrata Marcevianto, Kevin Varian Maya Kasmita Melati Putri , Nandita Melvani, Belvana Putri Miranda, Eliza Mohamad Rachadian Ramadan Mujadid, Fajar Muzhaffar, Muhammad Azhar Farrell N, Kristanty Marina Natalia N, NORMIYATI Nabilah , Agne Natasha, Bella Nisrina Kamila Normiyati Normiyati Novialdi . Noviandi Syarif , Akhmad Nuryana, Arief Octovia, Lily Indriani Oklia, Sheila Pelitahati, Puguh Piprim B. Yanuarso, Piprim B. Pratama, Aulya Rahman Putri Pratiwi, Intan Pudjiti, Dyah Juliana Pusponegoro, Erdina Hardiono D Putri, Nandita Melati Rachmawaty Rachmawaty Rachmawaty, Rachmawaty Raharjanti, Natalia Widiasih Rahmah Kusuma, Tyas Rahmawati, Nosita Rahmawati, Rahmawati Ramadhania, Dian Araminta Rasyid, Nurhayati M Revi Sesario Revina Anisa Agnelia Ricky Aditya Rismala Dewi Rizal S, Muh. Rustam, Musfardi Salma Nurhaliza Sandhi, Afriyanti Sandora, Normalina Santosa, Arby Mauliddan Sapinah, Sapinah Sari, Ade Risna Sari, Ayu Diandra Satyani, Metta Sesario, Revi Setiawan, Evania Setyowati, Tri Mulyani Soegeng Wahyoedi Sugiarto, Adhrie Sulaiman, Syarifuddin Suryaningsih, Lilik suryawan, ryan firdiansyah Suyuti, Rizal Syah Putra, Syah Syahputra Syahputra Syahputra, Syahputra Syarif, Akhmad Noviandi Syarifuddin Syarifuddin Tanjunga, Sanjaya F. Tanjunga, Sanjaya Faisal Tedjaatmadja, Chintya Tenriulan, Andi Tienni Mariana Simanjorang Tjhin Wiguna Trisnianti, Rika Valeria, Michelle Veronica, Raja Merlinda Wina Sinaga Winanda, Rizki Aniza Winarno, Gammaditya A. Winarno, Gammaditya Adhibarata Wulandari, Yohannessa Yahya, Muh. Zainuddin Iba Zakaria, Meutia Zidna, An’umillah Arini