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DURASI MENDERITA DM MEMENGARUHI KONTROL GLIKEMIK JANGKA PANJANG YANG DIUKUR MELALUI HbA1c PADA PASIEN DIABETES MELITUS TIPE 2 Nurgajayanti, Cendi; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 3 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i3.2085

Abstract

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia due to abnormalities in insulin secretion or action. In West Java, the prevalence of DM reached 1.9%, with a significant increase in Tasikmalaya City, which recorded 7,436 cases in 2022. This study aimed to explore the relationship between individual characteristics, nutritional status, comorbidities, and duration of DM with HbA1c levels in type 2 diabetes patients at one of the private hospitals in Tasikmalaya City.This study evaluated medical records of 210 patients with type 2 DM. The Spearman's rank correlation test was used to analyse the relationships between variables and a p<0.05 was considered as statistically significant. The research design used is cross sectional with purposive sampling technique.The result showed there was a statistically significant relationship between the duration of illness and HbA1c levels (p = 0.001 and r = 0,072). However, the relationship  between nutritional status or comorbidities and HbA1c levels were not statistically significant (p = 0.471 and 0.187, respectively), indicating no relationship between nutritional status and HbA1c levels. The study concluded there was no significant relationship between nutritional status and comorbidities with HbA1c levels. Namun, ada hubungan antara durasi penyakit dengan kadar HbA1c
EFEK EKSTRAK BAYAM MERAH VARIETAS MIRA TERHADAP GLUKOSA DARAH PUASA DAN MALONDIALDEHID TIKUS MODEL DMT2 Nilasari, Aprilina Citra Ayu; Wiboworini, Budiyanti; Listyawati, Shanti
Media Penelitian dan Pengembangan Kesehatan Vol. 34 No. 2 (2024): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v34i2.2003

Abstract

Persistent hyperglycemia in type 2 diabetes mellitus (T2DM) increases the risk of lipid peroxidation that produces malondialdehyde (MDA). Red spinach mira extract (RSME) contains anthocyanins and beta carotene, both of which have the potential as antioxidants in reducing fasting blood glucose (FBG) and MDA levels. The purpose of the study was to determine the effect of RSME administration on FBG and MDA levels in T2DM. The research method was true-experimental with pretest-posttest. The study used 30 male Wistar rats, and divided into 5 groups, namely the normal group and given  standard diet, K- T2DM rats and given a standard diet, K+ T2DM rats and given acarbose drug therapy 1.8 mg/200g/day, P1 T2DM rats and given a dose of RSME 688 mg/200g Body weight (BW) and P2 T2DM rats and given a dose of RSME 1376 mg/200g BW for 14 days. Statistical analysis of FBG and MDA using One Way Anova test and continued with Post Hoc test to determine the difference between groups, while to determine the effect using Paired t-test. The results of the study after intervention for 14 days, all groups given RSME experienced a decrease in FBG levels P1 by 158.60 mg/dl (p=0.000), KP2 by 180 mg/dl (p=0.000) and MDA KP1 decreased by 6.01 nmol/mL (p=0.000) and KP2 by 7.75 nmol/mL (p=0.000) and there was significant value (p<0.05). The study concluded that the best dose is KP2, which reduces FBG levels by 180.84 mg/dl and MDA by 7.75 nmol/ml, the highest decrease compared to the other doses.
EVALUATION OF THE IMPLEMENTATION OF THE LOCAL-BASED SUPPLEMENTARY FEEDING PROGRAM AND SPECIAL DIETARY PROCESSED FOODS FOR TODDLERS WITH WASTING WITH WASTING Ernawati, Erni; Wiboworini, Budiyanti; Andayani, Tri Rejeki
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 3 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i3.3124

Abstract

Wasting pada balita masih menjadi masalah gizi utama di Indonesia, termasuk di Kabupaten Bojonegoro Jawa Timur. Kabupaten Bojonegoro menerapkan kebijakan pemberian PMT jenis pangan olahan diet khusus (PDK) dan PMT lokal dalam penanganan wasting. Penelitian ini mengkaji lebih dalam pelaksanaan kombinasi dua jenis PMT di tingkat daerah. Tujuan penelitian untuk mengetahui tenaga pelaksana, daya terima, kepatuhan konsumsi, mekanisme distribusi dan monitoring, peningkatan berat badan dan status gizi, dan kendala pelaksanaan. Penelitian ini merupakan penelitian mix methode, melibatkan 17 informan. Data kualitatif didapatkan melalui wawancara dengan 1 pengelola gizi dinas kesehatan menggunakan 6 butir pertanyaan terbuka, pengisian kuesioner melalui google form untuk 4 petugas gizi dan 12 kader menggunakan 5 pertanyaan terbuka, yang selanjutnya dilakukan analisis tematik. Data kuantitatif daya terima, berat badan, status gizi didapatkan dengan studi dokumentasi pada laporan dinas kesehatan. Analisa data perbedaan berat badan setelah intervensi menggunakan paired t-test, perbedaan status gizi menggunakan McNemar. Secara umum pelaksanaan program PMT berjalan baik. Dilakukan pendampingan program oleh tenaga kesehatan dan kader. Kurangnya kesadaran ibu balita akan manfaat program PMT bagi balita menjadi kendala utama. Sebanyak 95% balita mempunyai daya terima baik terhadap konsumsi PMT jenis PDK. Sebanyak 69% balita mengalami kenaikan berat badan yang signifikan dengan rata-rata peningkatan berat badan 700 gram. Sebanyak 40% balita mengalami kenaikan status gizi walaupun tidak semua balita yang naik berat mengalami kenaikan status gizi namun secara statistik terdapat perbedaan yang signifikan setelah intervensi. Dukungan kebijakan daerah, pelibatan kader, serta strategi kombinatif dalam pelaksanaan PMT menjadi kunci keberhasilan program.
Study of Cholesterol Intake, Proportion of Fat in the Diet to Body Fat in Adolescents Lourena, Crysty; Tamtomo, Didik Gunawan; Wiboworini, Budiyanti
Indonesian Journal of Global Health Research Vol 6 No S5 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6iS5.4543

Abstract

The increase of body fat over students is caused by changes in lifestyle, especially diet, where adolescents often consume high-energy foods sourced from fat. High consumption of saturated fats can increase cholesterol and inflammation in the body, leading to fat storage disorders. To prevent this increase in excess, it is necessary to increase the intake unsaturated fat, like MUFA and PUFA which are known as one of the anti-inflammatory substances that can reduce fat in the body. Therefore, when consuming fats, a larger proportion of PUFA and MUFA is needed compared to the proportion of saturated fats. Objective: To analyze the relationship between cholesterol intake and the proportion of fat intake with percent body fat. Method: This study used a cross-sectional design with multistage random sampling involving 161 adolescents aged 15-18 years who attended high schools and vocational schools in Surakarta. Food intake data was collected using food frequency questionnaire (SQFFQ). Percent body fat was measured using Bioelectrical Impendence Analysis (BIA) Omron HBF -375 Karada scan. Bivariate data analysis using spearman rank. Results: The results of the analysis showed no relationship between cholesterol intake and percent body fat (p=0.531), proportion of saturated fat (p=0.332), proportion of MUFA (p=0.269), proportion of PUFA (p=0.213) Conclusions: It can be concluded that cholesterol intake and proportion of saturated fat, PUFA, and MUFA are not associated with percent body fat.
Faktor determinan risiko kardiometabolik pada remaja usia 15-18 tahun Wiboworini, Budiyanti; Shabrina, Amalina; Dewi, Yulia Lanti Retno; Sari, Amelya Augusthina Ayu; Handayani, Sutartinah Sri; Damayanti, Kusmadewi Eka; Azzahrah, Aisyah; Tjung, Vivienne
Jurnal Gizi Klinik Indonesia Vol 21, No 1 (2024): Juli
Publisher : Minat S2 Gizi dan Kesehatan, Prodi S2 IKM, FK-KMK UGM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijcn.90010

Abstract

Determinant factors of cardiometabolic risk in adolescents aged 15-18 yearsBackground: Cardiometabolic diseases are increasing worldwide, and the risk of developing them starts as early as adolescence. In the long term, they may lead to comorbidities. Evidence suggests the risk factors of cardiometabolic diseases among adolescents are obesity, excessive food intake, socioeconomic status, breakfast habits, and physical activity, among others. Objective: This study aimed to determine the determinants of cardiometabolic risk in adolescents aged 15-18. Methods: This was a cross-sectional study in Al-Abidin High School Surakarta with 146 study subjects. Cardiometabolic risks were classified using Cardiometabolic Disease Staging (CMDS), waist circumference was measured with Medline, physical activity was measured using a Physical Activity Questionnaire for Adolescents (PAQA), and blood pressure was measured with a sphygmomanometer. Socioeconomic, transportation, and breakfast habits were obtained from the general questionnaire. Chi-square, ANOVA, and logistic regression were then performed using SPSS 23. Results: Gender was significantly associated with cardiometabolic risk (p=0.001). A total of 41.3% of boys were at risk of cardiometabolic (OR=3.964). Socioeconomic, breakfast habits, transportation, and physical activity were not associated with cardiometabolic risk (p>0.05).Conclusion: Boys 15 – 18 years were at a higher risk of cardiometabolic, by 3.694 times greater than girls. Socioeconomic status, breakfast habits, transportation, and physical activity were not correlated with cardiometabolic risk among adolescents.
The Effect of Edamame Jelly on Lowering Blood Pressure in Primary Hypertension Patients Valensia, Yualeny; Wiboworini, Budiyanti; Hikmayani, Nur Hafidha
JURNAL INFO KESEHATAN Vol 22 No 2 (2024): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol22.Iss2.1538

Abstract

Hypertension is the cause of death in Indonesia, with 23.8% of the 1.7 million population. Management of primary hypertension is non-pharmacological therapy carried out by modifying lifestyle, namely increasing consumption of nuts that contain bioactive components that are beneficial for sufferers of primary hypertension, such as edamame (Glycine max (L.) Merrill). This study aims to determine how giving edamame jelly reduces blood pressure in primary hypertension patients. This research was quasi-experimental and used a pre-post-test control group design. The study population consisted of outpatients at the Sumbersari Jember Community Health Center who met the inclusion and exclusion criteria, totaling 42 subjects. Subjects were randomly divided into treatment and control groups. The intervention group was given amlodipine 5 mg/day and edamame jelly 150 grams/day. The control group was only assigned 5 mg of amlodipine. Statistical tests use the Paired t-test, Wilcoxon signed-rank test, and Mann-Whitney U-tests. The test results showed a significant difference in systolic and diastolic blood pressure between the control and treatment groups with a p-value <0.001. The median systolic blood pressure of the control group was 147.5 mmHg, and that of the treatment group was 130 mmHg. The median diastolic blood pressure in the control group was 90 mmHg, and the treatment group's was 80 mmHg. The reduction in systolic blood pressure in the treatment group was 17.5 mmHg greater than in the control group. The decrease in diastolic blood pressure in the treatment group was 10 mmHg greater than in the control group. Giving 150 grams of edamame jelly/day for 30 days effectively reduces blood pressure in sufferers of primary hypertension.               
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KEJADIAN STUNTING PADA ANAK USIA 12-59 BULAN Sinaga, Ruth Dearani; Sukamto, Ika Sumiyarsi; Wiboworini, Budiyanti; Wahidah, Nurul Jannatul; Sari, Atriany Nilam
Jurnal LINK Vol 18 No 2 (2022): NOVEMBER 2022
Publisher : Pusat Penelitian dan Pengabdian kepada Masyarakat, Poltekkes Kemenkes Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31983/link.v18i2.8931

Abstract

Stunting menggambarkan status gizi kurang yang bersifat kronik pada masa pertumbuhan dan perkembangan sejak awal kehidupan. Kejadian stunting terbesar di Kota Surakarta terdapat di wilayah Puskesmas Sangkrah yaitu 17,4% dan jumlah anak dengan stunting terbanyak terdapat di Kelurahan Semanggi yaitu 39,1%. Tujuan penelitian untuk mengetahui faktor-fakor yang berhubungan dengan kejadian stunting pada anak usia 12-59 bulan di Kelurahan Semanggi Kota Surakarta. Jenis penelitian ini analitik observasional dengan pendekatan cross sectional. Didapatkan sebanyak 82 ibu yang mempunyai anak usia 12-59 bulan dalam penelitian ini menggunakan teknik simple random sampling. Data dikumpulkan memakai lembar kuesioner, kemudian dianalisis dengan chi square. Hasil penelitian menunjukkan bahwa proporsi stunting sebesar 26,8% dan tidak stunting sebesar 73,2%. Faktor yang berhubungan dengan kejadian stunting adalah berat badan lahir dan riwayat ASI eksklusif (p<0,05). Faktor yang tidak berhubungan dengan kejadian stunting adalah tinggi badan ibu, pendidikan ibu, pekerjaan ibu, riwayat imunisasi, dan riwayat infeksi (p>0,05). Simpulan penelitian ini faktor yang berhubungan dengan kejadian stunting yaitu berat badan lahir dan riwayat ASI eksklusif.
ANALYSIS OF SECONDARY METABOLITE LEVELS AND ANTIOXIDANT ACTIVITY OF THE COMBINED EXTRACT OF RAJA BANANA PEEL AND PONTIANAK SWEET ORANGE PEEL Hasibuan, Wahyu Aulia; Wiboworini, Budiyanti; Susilawati, Tri Nugraha
Media Penelitian dan Pengembangan Kesehatan Vol. 35 No. 2 (2025): MEDIA PENELITIAN DAN PENGEMBANGAN KESEHATAN
Publisher : Poltekkes Kemenkes Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34011/jmp2k.v35i2.2684

Abstract

Ekstrak kulit pisang raja dan ekstrak kulit jeruk manis Pontianak mengandung senyawa bioaktif, seperti flavonoid dan antosianin, yang berpotensi sebagai sumber senyawa bioaktif dengan aktivitas antioksidan. Kombinasi ekstrak kedua bahan ini belum pernah dianalisis sebelumnya. Penelitian ini bertujuan untuk menganalisis kadar total flavonoid, antosianin, aktivitas antioksidan, fenol dan tanin pada ekstrak kombinasi kulit pisang raja dan kulit jeruk manis. Metode penelitian ini menggunakan pendekatan eksperimen, yang dilakukan di Laboratorium Setia Budi pada bulan Juli tahun 2024, dengan menggunakan pelarut etanol 80 % dengan perbandingan 1:10 melalui remaserasi sebanyak lima kali untuk meningkatkan rendemen dan kualitas senyawa yang dihasilkan. Formulasi ekstrak yang digunakan terdiri dari F1 (15:85%), F2 (25:75%), F3 (50:50%), F4 (75:25%). Kadar flavonoid dan tanin dianalisis dengan spektrofotometri, antosianin dengan metode pH diferensial, serta aktivitas antioksidan dan fenol dengan metode DPPH. Hasil penelitian menunjukkan bahwa formula F1 memiliki kadar flavonoid tertinggi (59,53 mgQE/g), F4 menunjukkan aktivitas antioksidan terbaik (91,47% inhibisi), dan F1 mengandung antosianin (361,45 ppm), fenol (1,80%), dan tanin (0,84%) tertinggi. Penambahan kulit jeruk manis meningkatkan kadar antosianin, fenol, dan tanin dalam ekstrak, sedangkan penambahan ekstrak kulit pisang raja meningkatkan aktivitas antioksidan. Penelitian lebih lanjut diperlukan untuk mengeksplorasi senyawa fitokimia lainnya dan potensi kesehatan dari kombinasi ekstrak ini.
The effects of raja banana (Musa acuminata) peel extract on body weight, body mass index, body fat percentage, and visceral fat mass in male rats with obesity Devina, Kezia Elian; Indarto, Dono; Susilawati, Tri Nugraha; Wiboworini, Budiyanti
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 2, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(2).115-125

Abstract

Background: Obesity is a risk factor for metabolic syndrome which can increase mortality. Obese sufferers often fail to lose body weight (BW) through non-pharmacological therapy. Obesity synthetic drugs can cause side effects, so natural ingredients are needed as alternative therapies.Objectives: This study aims to determine the effect of raja banana peel extract (RBPE) on BW, body mass index (BMI), body fat percentage (BFP), and visceral fat mass in obese male rats.Methods: The research subjects were 30 male Wistar rats weighing 125-200 g, aged eight weeks. Obesity was induced by being given high-fat high fructose (HFHFr) feed for 28 days. Rats were randomized and divided into five groups: the negative control group (C-) was given standard feed and distilled water, the positive control (C+) was given standard feed and orlistat, treatment 1 (T1), treatment 2 (T2), and treatment 3 (T3). Which were given standard feed and RBPE doses of 200 mg/kgBW/day, 400 mg/kgBW/day, and 800 mg/kgBW/day. Data before and after the induction of obesity were analyzed using paired t-tests. BW, BMI, and visceral fat mass were analyzed using the One-Way Analysis of Variance (ANOVA) and Repeated Measure ANOVA tests. BFP was analyzed using the Kruskal-Wallis test and the Friedman test.Results: RBPE can significantly reduce BW (p=0.026), BMI (p<0.001), and BFP (p<0.001). However, all groups had no significant difference in visceral fat mass (p=0.187). T3 was the group with the lowest average BW, BMI, BFP, and visceral fat mass although the highest weight loss during the intervention period occurred in C+.Conclusions: RBPE has the potential as an alternative therapy for obesity because it can reduce BW, BMI, and BFP. Future studies can investigate the effect of RBPE on other obesity parameters such as lipid profiles.
Analysis of stunting handling indicators based on SSGI 2022 data in Lampung Province: Multilevel analysis Betania, Sakha Ukta; Wiboworini, Budiyanti; Qadrijati, Isna
Jurnal Gizi dan Dietetik Indonesia (Indonesian Journal of Nutrition and Dietetics) VOLUME 12 ISSUE 5, 2024
Publisher : Alma Ata University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21927/ijnd.2024.12(5).372-386

Abstract

Background: The implementation of specific and sensitive nutrition interventions is an effort to prevent the increasing prevalence of stunting in Indonesia. However, not all target indicators performed optimally in their implementation, which could affect the increase in stunting prevalence.Objectives: Analyze the dominant factors of stunting incidence among toddlers aged 12-13 months from suboptimal handling of stunting in Lampung Province.Methods: This study utilized a cross-sectional design with secondary data from the 2022 Indonesian Nutrition Status Survey. The variables in this study were iron tablet consumption, exclusive breastfeeding, growth monitoring, primary immunization, access to drinking water, access to sanitation, and the incidence of stunting, and considering heterogeneity in subdisctrict and regencies/municipalities. The subjects were 1.929 toddlers aged 12-23 months, selected by purposive sampling. Data were analyzed with a frequency distribution table, a Chi-Square test, and a multilevel binary logistic regression test.Results: Chi-square test showed there was no relationship between iron tablet consumption (p=0.362; OR=1.14), exclusive breastfeeding (p=0.164; OR=0.85), growth monitoring (p=0.807; OR=1.08), and access to sanitation (p=0.431; OR=1.18) with incidence of stunting. However, there was a relationship between primary immunization (p=0.008; OR=1.39) and acces to drinking water (p=0.023; OR=1.35). Multilevel test results showed that there was no effect of non-exclusive breastfeeding (aOR=0,84; p>0,05) not routine growth monitoring (aOR=1,03;p>0,05), inappropriate iron tablet consumption (aOR=1,14; p>0,05), inadequate access to sanitation (aOR=1,10; p>0,05), rural domicile (aOR = 1,03; p>0,05), number of community health centers (aOR=1,00; p>0,05) contour of mountain territory (aOR=0,89; p>0,05), and contour of water territory (aOR=0,83; p>0,05) with incidence of stunting. Household-level variation had the largest effect on stunting incidence, with an ICC of 7,63%.Conclusions: Incomplete primary immunization and inadequate access to drinking water were the dominant factors affecting stunting in toddlers aged 12-23 months in Lampung Province.
Co-Authors AA Subiyanto, AA Adi Prayitno Agustina Indri Hapsari Ali Djamhuri Ari Natalia Probandari Ari Probandari Arum, Wuryan Dewi Miftahtyas Ayu Kusuma Dewi Ayusari, Amelya Aughustina Ayusari, Amelya Augusthina Azzahrah, Aisyah Bambang Purwanto Banun Rohimah, Banun Betania, Sakha Ukta Billah, Muhammad Muayyad Brian Wasita Budiastuti, Veronika Ika Dhoni Akbar Ghozali Didik Gunawan Tamtomo Diffah Hanim Dono Indarto Dwi Rahayu ernawati, ammik Ernawati, Erni Firnanda, Sani Widya Handayani, Sutartinah Sri Hanifah, Rosalinda Abir Hasibuan, Wahyu Aulia Jokomarsono, Elisabet Puspita Kezia Elian Devina khusnul khotimah Kristisanthy, Akwilina Dwi Kuntari Astriana, Kuntari Kusmadewi Eka Damayanti kusnandar kusnandar Kusumawati, Ratna Kusumawati, Ratna Lilik Retna Kartikasari Lourena, Crysty Mahyaningtyas, Fransisca Pradnya Majestika Septikasari, Majestika Mariestu, Farah Kurnia Maulidya, Rizki Mega Fatimah Rosana Muhammad Akhyar Muthmainah Muthmainah Nilasari, Aprilina Citra Ayu Nur Hafidha Hikmayani Nurgajayanti, Cendi Paramasari Dirgahayu Pasaribu, Sudana Fatahillah Putri, Mahendri Deayu Putri, Yulia Rahmawati Wibowo Qadrijati, Isna Retnowati, Sri Sanjaya, Evan Japutra SANTOSO SANTOSO Sapja Anantanyu, Sapja Sari, Amelya Augusthina Ayu Sari, Atriany Nilam Shabrina, Amalina Shanti Listyawati Sinaga, Ruth Dearani Sogen, Maria Dolorosa P. Sri Mulyani Sudarsono, Joko Sugiarto S Sugiarto, S Sukamto, Ika Sumiyarsi Suminah Suminah, Suminah Supriyadi Heri Respati, Supriyadi Heri Tjung, Vivienne Tri Nugraha Susilawati Tri Rejeki Andayani Valensia, Yualeny Veonika, Dea Anenta Wahidah, Nurul Jannatul widardo, Widardo Widyaningsih, Vitri Wijaya, Angellica Eliora Wrisnijati, Dita Wrisnijati, Dita Wulandari, Anggraini Yulia Lanti yulia lanti retno dewi Yuniarti, Windy