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All Journal Journal of Food and Pharmaceutical Science Jurnal Sain Veteriner Jurnal Pendidikan Indonesia Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Sains dan Teknologi Farmasi JURNAL ILMIAH PENDIDIKAN FISIKA AL BIRUNI Pharmacon Majalah Obat Tradisional Acta Pharmaciae Indonesia : Acta Pharm Indo Farmasains : Jurnal Ilmiah Ilmu Kefarmasian WIDYA LAKSANA PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) FITOFARMAKA: Jurnal Ilmiah Farmasi Jurnal Komunikasi Pendidikan Optika : Jurnal Pendidikan Fisika Jurnal Insan Farmasi Indonesia AL-KHAZINI: JURNAL PENDIDIKAN FISIKA Jurnal Pengabdian Kolaborasi dan Inovasi IPTEKS Journal of Food and Pharmaceutical Sciences Borneo Journal of Pharmacy
Wahyu Widyaningsih
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Physics Public Health Social Sciences Veterinary Other

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Efek Antioksidan Ekstrak Etanol Ganggang Hijau (Ulva Lactuca L.) Terhadap Kadar Malondialdehid (MDA) Dan Aktivitas Enzim Superoksida Dismutase (SOD) Hepar Tikus Yang Diinduksi CCL4 Widyaningsih, Wahyu; Sativa, Riza; Primardiana, Indra
Media Farmasi: Jurnal Ilmu Farmasi Vol. 12 No. 2: September 2015
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v12i2.3756

Abstract

Kerusakan hepar sering disebabkan karena stress oksidatif yang berkaitan erat dengan radikal bebas. Karbon tetraklorida merupakan senyawa toksik sumber radikal bebas penyebab timbulnya stress oksidatif. Adanya kerusakan jaringan tersebut dapat ditandai dengan meningkatnya kadar malonildialdehid (MDA) dan kenaikan kadar enzim superoksid dismutase (SOD). Ganggang hijau (Ulva lactuca L.) mengandung senyawa melatonin yang berfungsi sebagai antioksidan. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol ganggang hijau (Ulva lactuca L.) sebagai antioksidan dengan parameter kadar MDA dan aktivitas enzim SOD hepar tikus yang diinduksi CCl4. Penelitian ini bersifat eksperimental menggunakan post-test only control group design dilakukan pada 25 hewan uji yang dibagi menjadi lima kelompok, terdiri dari kelompok I (normal) hanya diberi makan dan minum, kelompok II diberi CMC-Na 1%, kelompok III (kontrol pembanding) diberi tablet curcuma 200 mg/KgBB, kelompok IV dan V diberi ekstrak etanol ganggang hijau dosis 100 dan 200 mg/KgBB. Perlakuan dilakukan selama 21 hari dan pada hari ke-22 diinduksi CCl4 1,0 ml/KgBB intraperitoneal(i.p) kecuali kelompok I. Setelah 24 jam, hepar tikus diambil dan diukur kadar MDA hepar dengan metode TBARs. Aktivitas enzim superoksida dismutase (SOD) menggunakan metode spektrofotometri. Analisis data menggunakan One way ANOVA dengan taraf kepercayaan 95% dan dilanjutkan dengan uji LSD. Hasil penelitian menunjukkan bahwa kadar MDA hepar meningkat dan aktivitas enzim SOD menurun secara signifikan akibat induksi CCl4 (p<0,05). Tablet curcuma dosis 200 mg/kgBB, ekstrak etanol ganggang hijau dosis 100 dan 200 mg/KgBB dapat menurunkan kadar MDA dan meningkatkan aktivitas SOD hepar tikus yang diinduksi CCl4 secara signifikan (p<0,05). Kesimpulan penelitian ini adalah ekstrak etanol ganggang hijau (Ulva lactuca L.) mempunyai aktivitas antioksidan dengan menurunkan kadar MDA dan meningkatkan aktivitas enzim SOD hepar tikus yang diinduksi CCl4.
SKRINING FITOKIMIA EKSTRAK ETANOL Ulva lactuca L. DENGAN METODE KROMATOGRAFI LAPIS TIPIS Widyaningsih, Wahyu; Pramono, Suwidjiyo; Widyarini, Sitarina; Sugiyanto, Sugiyanto
Media Farmasi: Jurnal Ilmu Farmasi Vol. 13 No. 2: September 2016
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v13i2.7772

Abstract

Ganggang hijau (Ulva lactuca L.) merupakan spesies ganggang laut yang berpotensi sebagai obat kardiovaskuler. Untuk mendukung pemanfaatannya perlu dilakukan skrining fitokimia kandungan ganggang hijau yang berasal dari pantai Drini, Daerah Istimewa Yogyakarta. Tujuan penelitian ini adalah melakukan skrining fitokimia Ulva lactuca yang berasal dari pantai Drini dengan Kromatografi Lapis Tipis (KLT). Ulva lactuca diekstraksi dengan metode maserasi dengan etanol 96%. Ekstrak yang diperoleh ditetapkan randemen,  kadar air, kadar abu dan kadar logam berat (Pb dan Cd). Penetapan kadar air dengan alat Hydrogen Moisturizer Analyzer (HMA), kadar abu dengan metode gravimetri dan penetapan logam berat Pb dan Cd dengan Spektrofotometer Serapan Atom (SSA). Skrining fitokimia dilakukan untuk mengindentifikasi golongan senyawa alkaloid, flavonoid, saponin, antrakuinon dan terpenoid dengan KLT. Identifikasi klorofil dilakukan dengan metode Nollet (2004). Hasil penelitian menunjukkan ekstrak etanol Ulva lactuca  mempunyai randemen 14,52%, kadar air 9,67±0,07%, kadar abu 34,05% , kadar logam Pb<0,07 mg/kg dan kadar logam Cd<0,01 mg/kg. Terdapat golongan senyawa flavonoid, alkaloid dan klorofil dalam  ekstrak etanol Ulva lactuca L. yang diperoleh dari pantai Drini.
AKTIFITAS HEPATOPROTEKTIF EKSTRAK ETANOL DAUN SIDAGURI (Sida rhombifolia L.) DILIHAT DARI RASIO BERAT HEPAR, NILAI SGPT-SGOT, DAN HISTOPATOLOGI HEPAR PADA TIKUS SPRAGUE DAWLEY YANG DIINDUKSI CCL4 Irham, Lalu Muhammad; Widyaningsih, Wahyu
Media Farmasi: Jurnal Ilmu Farmasi Vol. 14 No. 1: Maret 2017
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v14i1.9826

Abstract

Hepar merupakan organ yang berperan dalam pengaturan homeostasis tubuh meliputi metabolisme, biotransformasi, sintesis dan imunologi. Penyebab penyakit hepar bervariasi, diantaranya adalah virus, obat-obatan, alkohol dan stress oksidatif yang merupakan faktor utama. Jumlah radikal bebas yang melebihi antioksidan menyebabkan terjadinya stres oksidatif. Sidaguri (Sida rhombifolia L.) mengandung senyawa fenol dan flavonoid yang berkhasiat sebagai antioksidan. Penelitian ini bertujuan untuk menguji efek hepatoprotektif ekstrak etanol daun sidaguri (EEDS) terhadap nilai SGPT-SGOT, gambaran histopatologi hepar tikus dan rasio berat hepar yang diinduksi carbon tetrachloride (CCl4). Dua puluh lima tikus dibagi menjadi 5 kelompok. Kelompok I merupakan kelompok normal yang hanya diberi makan dan minum, kelompok II merupakan kelompok kontrol yang diinjeksi CCl4 secara intraperitoneal dengan dosis 1 mL/KgBBdan kelompok (III, IV dan V merupakan kelompok perlakuan yang diberi EEDS peroral dengan dosis: 25, 50 dan 100 mg/KgBB) berturut-turut selama 21 hari. Pada hari ke 21 kelompok ini diinjeksi CCl4 1 mL/KgBB secara intraperitoneal 1 jam setelah perlakuan. Data rasio berat organ hepar dari masing masing kelompok dianalisis secara statistik menggunakan analisis varian (ANOVA), LSD post hoc test P<0,05 untuk menentukan perbedaan signifikan. Hasil penelitian menunjukkan bahwa rasio berat hepar pada kelompok II (kontrol) 216,52±15,04 berbeda signifikan dibandingkan dengan kelompok III, IV dan V berturut turut dengan nilai 436,56± 46,78; 438,86±44,79; dan 534,46±45,49. Hal ini menunjukkan bahwa pemberian EEDS dapat menaikkan rasio berat hepar. Data ini didukung dengan nilai SGPT dan SGOT yang berbeda bermakna dengan kelompok kontrol (p<0,05). Dilihat dari gambaran histopatologi hepar, pada  kelompok  II (kontrol), III, IV dan V berturut-turut tidak  menunjukkan adanya nekrosis karena CCl4. Kesimpulan dari penelitian ini bahwa EEDS dapat melindungi hepar berdasarkan rasio berat hepar dan nilai SGPT-SGOT, namun belum dapat disimpulkan bahwa EEDS memiliki efek hepatoprotektif dilihat dari gambaran histopatologi.
EFEK EKSTRAK ETANOL GANGGANG HIJAU (Ulva lactuca , L) TERHADAP EKSPRESI COX-2 MIOKARDIUM TIKUS YANG DIINDUKSI ISOPROTERENOL Widyaningsih, Wahyu; Salamah, Nina; Pramono, Suwidjiyo; Sugiyanto, Sugiyanto; Widyarini, Sitarina
Media Farmasi: Jurnal Ilmu Farmasi Vol. 16 No. 2: September 2019
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v16i2.12822

Abstract

Penyakit kardiovaskuler masih merupakan masalah di Indonesia salah satunya adalah Infark Miokardial Akut (IMA). Patofisiologis AMI karena rective oxigen spesies  (ROS) melibatkan stimulasi sitokin pro inflamasi salah satunya adalah  interleukin-1 yang berakibat peningkatan ekspresi COX-2. Penelitian ini bertujuan mengetahui efek ekstrak etanol ganggang hijau dalam menurunkan ekspresi COX-2 pada tikus IMA yang diinduksi isoproterenol (ISO). Ekstraksi ganggang hijau dengan maserasi menggunakan etanol 96%. Tikus berat 200-250 g dibagi menjadi 6 kelompok masing-masing 6 ekor. Kelompok I kontrol, tikus tidak diberi ISO hanya diberi CMC Na, kelompok II kelompok ISO, tikus diberi CMC Na dan ISO, kelompok III, IV dan V tikus diberi ekstrak etanol ganggang hijau dosis 250, 500 dan 750 mg/KgBB peroral dan kelompok VI diberi melatonin 10 mg/KgBB. Perlakuan ekstrak selama 28 hari. Pada hari ke 29 dan 30 tikus diberi isoproterenol dosis 85 mg/KgBB selama 2 kali pemberian secara subkutan kecuali kelompok I. Pada hari ke 31 tikus diambil organ jantung kemudian dibuat preparat histologis dan dilakukan analisis ekspresi COX-2 dengan metode imunohistokimia dengan antibodi anti COX-2. Hasil penelitian menunjukkan bahwa pemberian ekstrak etanol ganggang hijau dosis 250, 500 dan 750 mg/KgBB dapat menurunkan ekspresi COX-2 pada tikus yang diinduksi isoproterenol.
Formulation of self-nano emulsifying drug delivery system (SNEDDS) Red Ginger extract (Zingiber Officinale var. rubrum) Erliyana, Mila; Widyaningsih, Wahyu; Wumu, Dea Anggrainy; Wulansari, Widyanari Febriyana
Media Farmasi: Jurnal Ilmu Farmasi Vol. 19 No. 2: September 2022
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v19i2.21655

Abstract

Red ginger extract is one of the new medicinal discoveries made from natural substances that has pharmacological benefits in the treatment of diabetes. Many gingerol components in red ginger can aid in the treatment of diabetes mellitus. However, the administration of red ginger extract is not so effective, a delivery system such as SNEDDS (Self-Nano Emulsifying Drug Delivery System) must be developed. When compared to standard formulations, SNEDDS can boost the oral bioavailability of lipophilic medicines by up to 2.4 times. The oil phase of SNEDDS red ginger extract was virgin coconut oil, with tween 80 as a surfactant and PEG 400 as a co-surfactant. The fourth formula of the SNEDSS preparation of red ginger rhizome extract satisfied the requirements for a good nanoemulsion particle size in this study, with a percent T value of 99.7% and PSA test data showing that this formulation met the requirements for a good nanoemulsion particle size
Standardization of Paku Lindung extract (Pneumatopteris callosa (Blume)) Fauzi, Muh Fajar; Widyaningsih, Wahyu
Media Farmasi: Jurnal Ilmu Farmasi Vol. 21 No. 1: March 2024
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v21i1.23941

Abstract

The standardization of the paku lindung extract was carried out to obtain new data regarding the standardization of the hedgehog extract which had not previously been established. In addition, this determination is carried out to obtain quality preparations in the form of a guarantee process, that the extract obtained has certain parameter values that are constant after the data has been determined. Extract standardization test includes specific parameters including organoleptic, soluble compounds in certain solvents. Non-specific parameter tests include drying shrinkage, moisture content, ash content, heavy metal contamination, microbial contamination. Chemical content test includes chromatogram pattern, determination of total flavonoid content. The yield of the resulting extract was 13.88±3.19% g. The test results of non-specific parameters include drying shrinkage 0.47±0.01%, moisture content 8.28±0.16%, total ash content 18.97±3.53%, acid insoluble ash content 1.69± 0.02%, total plate number 7.8x104±12.91 colonies/gram, yeast mold number 1x102±0.24 colonies/gram, heavy metal contamination of Cd, Cr and Pb negative and Fe of 73.88 ppm. The results of the specific parameter test include 85.55±4.29% water soluble compounds, 31.27±5.06% ethanol soluble compounds. The results of the chemical content test included the total flavonoid content of 16.6±17.60 mgEQ/g, the Rf value of the extract was the same as the Rf of quercetin with 5 variations of the mobile phase. The test results were carried out to meet the predetermined determination and provide new data on the standardization of the paku lindung extract.
Effects of Fermented Red Rice Bran on Gut Microbiota Modulation and Colorectal Cancer Prevention in a DMBA-Induced Mouse Model Anasyua, Fairuz Khairunnisa; Cahya, Sella Nur; Hanifah, Azka Khansa; Kusuma, Rio Jati; Rahmawati, Dini; Widyaningsih, Wahyu
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.20690

Abstract

Colorectal cancer prevention is closely linked to gut microbiota modulation, particularly by increasing lactic acid bacteria (LAB) and short-chain fatty acids (SCFA). This study investigates the effect of fermented red rice bran on colon microbiota improvement. Fermented bran was produced by mixing red rice bran with water and yeast, followed by an analysis of the proximate composition, dietary fiber, resistant starch, antioxidants, and phenols. A quasi-experimental study was conducted on 30 mice, assigned to normal, negative control, 10% bran, 20% bran, 10% fermented bran, and 20% fermented bran groups. Colorectal cancer was induced using DMBA (20 mg/kgBW) intraperitoneally four times over two weeks. Treatment groups received bran or fermented bran ad libitum for 14 days. Cecal analysis showed that 20% red rice bran and 10% fermented bran significantly increased SCFA levels (p < 0.05), suggesting improved microbiota function, but did not significantly alter pH or LAB counts. These findings highlight the potential of fermented red rice bran in modulating gut microbiota, though further studies are needed to elucidate its long-term effects and mechanisms in colorectal cancer prevention.
Quantitative Determination of Flavanone Content in Teki Grass Tuber (Cyperus rotundus L) using Ultraviolet-Visible Spectrophotometry Fitriyati, Laeli; Nurani, Laela Hayu; Utami, Dwi; Widyaningsih, Wahyu
Journal of Food and Pharmaceutical Sciences Vol 13, No 3 (2025): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.21526

Abstract

Teki grass (Cyperus rotundus L.) tubers are medicinal plants that have been widely utilized for their anti-inflammatory, antioxidant, antibacterial, and anticancer properties. These pharmacological activities are attributed to the presence of polyphenolic compounds, particularly flavanones. This study aims to determine the flavanone content in teki grass tubers using UV-Vis spectrophotometry. The research was conducted as a laboratory-based experimental study, involving several steps: sample preparation, simplisia processing, extraction, and quantitative analysis of flavanone content by comparison with a flavanone standard. The UV-Vis spectrophotometric analysis revealed the presence of flavanones in the extract of teki grass tubers. Quantitative results showed that the flavanone concentration in the extract was 128.29 µg/mL. These findings confirm that teki grass tubers are a potential natural source of flavanones, supporting their traditional herbal medicine use.
In-vivo study of oleic acid and tween-80 on patch transdermal A.paniculata as anti-diabetic Wahyuningsih, Iis; Fadilah, Nur Aini; Widyaningsih, Wahyu
Pharmaciana Vol. 14 No. 2 (2024): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v14i2.27851

Abstract

Sambiloto (Andrographis paniculata) has been known empirically as a plant that has benefits as a traditional antidiabetic Javanese medicine to treat diabetes mellitus (DM). The main compound contained in sambiloto is andrographolide which has a hypoglycemia effect. Andrographolide has low solubility in water and poor bioavailability due to biotransformation by P-glycoprotein in the intestinal tract which causes andrographolide to metabolize more quickly in the duodenum and jejunum. To overcome this extract ethanol of sambiloto (EES) formulated to patch transdermal. Enhancers can affect the characteristics of transdermal patch preparations which affect the pharmacological activity of transdermal patch preparations. The critical point of transdermal patch preparation is the selection of enhancers which is one of the compounds to increase the penetration of active substances in the skin by disrupting the permeability of the stratum corneum. The aim of this research is to determine the effect of variations in the combination of oleic acid and tween 80 as an enhancer on the physical characteristics of EES patches.The methods of extraction sambiloto use soxhetation with ethanol 96% as solvent. The formulation of EES patch transdermal using solvent casting technique with various concentration enhancer tween-80 and oleic acid. This research was conducted by making 3 formulas, where F1  (1:1), F2 (1:3) and F3 (1:3). The evaluations include weight uniformity, thickness, water content, pH and folding endurance of the patch. The result of visual appearance the patch EES has a dark green with aroma specific of EES. The characteristics of EES transdermal patches were affected by the ratio of tween-80 and oleic acid as the enhancers. The combination of oleic acid and tween 80 as a permeation enhancer has an influence on physical characteristics (weight and thickness) of EES patches.
Analisis Efektifitas Dan Kemampuan Berfikir Kreatif Peserta Didik Melalui Pembelajaran Daring Dimasa Covid-19 Pada Pelajaran Fisika Riska, Riska; Widyaningsih, Sri Wahyu; Sebayang, Sri Rosepda
Al-Khazini Vol 2 No 2 (2022): OKTOBER
Publisher : UIN Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (348.699 KB) | DOI: 10.24252/al-khazini.v2i2.31991

Abstract

This study aims to analyze the effectiveness and creative thinking of student’s learning throught online learning during the Covid-19 era in physics lessons at SMA Advent Manokwari. The research method used is the survey method using a questionnaire. The sampling technique is using purposive sampling with a sample 79 studens. The instrument used is an effectiveness questionnaire as many as 15 statements and a creative thinking questionnaire as many as 15 statements with data analysis technique using the Rasch Model with the help of the Winstep Application. The results of the analysis show that for learning effectiveness the Crombach Alpha value 0,82, while using Wright map the distribution of respondents generally gathers between logit SD (+0,00) to logit SD (+2,00) and above logit SD (-0,20) this means that many students are interested in taking physics lessons online and consider it good or effective. Meanwhile, for creative thinking, the Crombach Alpha value is 0,76, also using the Wright map the distribution of respondents generally gathers berween the logit SD (+0,00) the logit SD (+3,00) and above the logit SD (-0,30). This means that many students have a high enough creative way of thinking. This shows that online physics lessons at the SMA Advent Manokwari can be said to be good and the student’s creative thinking level is high.
Co-Authors Aditya Prabowo Aditya Prabowo Ainiyah, Nadia Putri Aldri Frinaldi Anasyua, Fairuz Khairunnisa Astutik, Novita Santi Ayu Wulandari Azis Ikhsanudin Bachri, Mochammad Saiful Bahagia, Tasya Br. Sebayang, Sri Rosepda Cahya, Sella Nur Danang Prasetyaning Amukti Dara Pranidya Tilarso Daru Estiningsih Dedi Kuswandi Desi Iswahyuni Desyandri Desyandri Dini Rahmawati Dwi Fitriani Dwi Utami Erliyana, Mila Eti Nurwening Sholikhah Fadilah, Nur Aini fatima, fatma Fauzi, Muh Fajar Fitriyati, Laeli Galang Pergiawan Ramadhan Hanifah, Azka Khansa Hari Susanti Iin Narwanti Iis Wahyuningsih Indra Primardiana, Indra Irfan Yusuf Iriwi L.S Sinon, Iriwi L.S Iriwi L.S. Sinon, Iriwi L.S. Istyarini Istyarini, Istyarini Jumina Jumina Jumina Jumina Kaffah, Silmi Kusuma, Rio Jati Laela Hayu Nurani Laela Hayu Nurani Lalu Muhammad Irham M. Paden, Thereziana Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Ma'ruf Muhammad Yusron Maulana El-Yunusi Mujasam Mujasam Nina Salamah Nisa Isneni Hanifa Nur Asih, Nur Nurliawaty, Lilis Pramono, Suwidjiyo Primardiana, Indra Puteriragil Atma Pertiwi, Puteriragil Atma Radjab Sutrisno, Radjab Rerung, Nensy Rezza Wahyudi Rifka Salsabila Riska Riska Riza Sativa, Riza Rumansara, Tamariska Herlindo Ryan Syahputra Sapto Yuliani Sapto Yuliani Sativa, Riza Septianingsih, Ulfah Silmi Kaffah Siswanti Siswanti Sitarina Widyarini Siti Fatmawati Fatimah, Siti Fatmawati Sri Rosepda Sebayang, Sri Rosepda Suci Kurniati Sugiyanto - Sugiyanto, Sugiyanto Sumiasih Sumiasih Sundari, Trias Kania Suwidjiyo Pramono Tirza Pangkali, Tirza Ulfah Septianingsih Vivi Sofia Wiki Yuli Anita Wulandari, Silviana Wulandari, Silviana Wulansari, Widyanari Febriyana Wumu, Dea Anggrainy Y.T. Allo, Alberto Yenusi, Kaleb Amaghi Yoga Yuniadi Yuliawanti, Risma