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All Journal HAYATI Journal of Biosciences Natural Science: Journal of Science and Technology Media Eksakta Indonesian Journal of Pharmaceutical Science and Technology Biocelebes Jurnal Farmasi Sains dan Komunitas Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Penelitian Pendidikan IPA (JPPIPA) Indonesian Journal of Chemistry JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Ilmu Kefarmasian Indonesia Jurnal Health Sains Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks Narra J Proceeding of Mulawarman Pharmaceuticals Conferences Jurnal DiMas (Jurnal Pengabdian Kepada Masyarakat) Journal of Noncommunicable Diseases (JOND) Dedication : Jurnal Pengabdian Masyarakat Journal of Public Health and Pharmacy Jurnal Pengabdian Masyarakat dan Riset Pendidikan Jurnal Medika: Medika Jurnal Pengabdian Farmasi dan Sains Journal of Tropical Pharmacy and Chemistry Jurnal Dedikatif Kesehatan Masyarakat Poltekita: Jurnal Pengabdian Masyarakat
Yuliet Yuliet
Department Of Pharmacy, Faculty Of Mathematics And Natural Sciences, Tadulako University, Jl. Sukarno-Hatta Km 9, Palu 94148, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Journal of Public Health and Pharmacy

 1 
Acute and Lethal Dose Toxicity Test of Pure Eel Fish (Anguilla marmorata [Q.] Gaimard) Oil in Mice (Mus musculus) Jamaluddin, Jamaluddin; Ihwan, Ihwan; Khaerati, Khildah; Hasanuddin, Asriani; Serdiati, Novalina; Nilawati, Jusri; Wijaya, Berniawan; Yuliet, Yuliet; Ahmad, Iftitah
Journal of Public Health and Pharmacy Vol. 5 No. 3: NOVEMBER 2025
Publisher : Pusat Pengembangan Teknologi Informasi dan Jurnal Universitas Muhammadiyah Palu

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56338/jphp.v5i3.5987

Abstract

Introduction: Eel fish oil (Anguilla marmorata (Q.) Gaimard) highlighted its nutritional advantages, especially vitamin A, EPA (eicosapentaenoic acid), DHA (docosahexaenoic acid), and omega-3. Unsaturated fats in fish oil are known to have positive effects in the treatment of various diseases, although the potential negative impacts also need to be considered. Methods: This research aims to focus on the cytotoxic activity of eel fish oil and carry out extraction using the soxhlation method, Thomson and Weil, and Metode fixed dose. To evaluate the toxicity of the extract, the acute toxicity test was carried out by measuring the middle lethal dose (LD50), which is often used as a benchmark. Apart from that, the research also aims to determine the lethal dose 50 (LD??) value of eel fish oil, namely the dose that can cause the death of 50% of the test animal population. The extraction process uses diethyl ether solvent at 60°C, followed by purification using a 3% bentonite adsorbent. The test was carried out twice with female mice and rats as test animals, divided into groups with oral doses of 5, 50, 300, 2000, and 5000 mg/kg. Result: The results showed no deaths in the test animals, and the LD50 of eel fish oil extract was greater than the dose used. Clinical symptoms in mice include decreased motor activity and increased grooming frequency as the dose increases, as well as increased muscle tone and tension responses. Conclusion: Based on the research results, it can be concluded that eel fish oil extracts up to a dose of 5000 mg/kg are still classified as "safe" for use because they do not cause death in test animals.
Co-Authors -, Khildah Abd. Rahman Razak Adisaputra, Arya Dibyo Agus Ritna Agustinus Widodo Agustinus Widodo Ahmad, Iftitah Akhmad Khumaidi Al-Amri, Siti B. Alfia, Dhara Ali Djamhuri Alkaff, Firas F. Alkaff, Sylmina D. Amelia Rumi Amelia Rumi Amelia Rumi Amelia, Sinta Andi Athira Masyta Andi Atirah Masyita Andi Atirah Masyita Andi Fadya Andrya B Andrya B Apriyanti Anastasia Arisca, Windhy Nur Ariza Abu Bakar Putri Armini Syamsidi Arta, Putri A. Arwinda Alitsia Hasyim Asriani Hasanuddin Atirah Atirah Auliana, Rhizky S Bustanul Arifin Cahyani, Rezki Cornelia Ayu Putri Daniel Happy Putra Darmayanti Dermiati T Dermiati T Devi Saputri Bahman Devyayu Prabaningsih DEWI RISMAYANTI Djaleha, Helena Fransisca Dwicahya, Bambang Dwinthasari Meilinda Azhari Elin Yulinah Sukandar Elin Yulinah Sukandar Ersamukti Rahmatullah Achmad Evi Sulastri Fahrul Hardani, Muhammad Firman, Nurul Awwaliyah P. FIRMANITA DWIMURTI Fitri Anggun Solehah Hamdani, Silviana Haq, Muhammad F. Hardani, Muhammad Fakhrul Heni Purwitasari I Ketut Adnyana Ihwam Ihwan Ihwan Ihwan Ihwan Ihwan Iklima Indriani, Meri Feki Inggrid Yuliana Ingrid Faustine Ismail, Ihwan Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Jamaluddin Joni Tandi Joni Tandi, Joni Jusri Nilawati Karmini Karmini khaerati Khildah Khaerati Khildah Khaerati Khildah Khaerati Khusnul Diana Khusnul Diana Kurniawan, Muh D. Lakahoro, Syamsul Lokong, Gladies Melinda Lutfiana Kusumawati Malasugi, S. Mariyani Maryani, Adetya Masyita, Andi Atirah Meike Rachmawati Mia Audina Miranti Moh. Roem Mohamad Ikram Muhamad Rinaldhi Tandah Muhammad Anggriawan Muhammad Fahrul Hardani Muhammad Sulaiman Zubair Musnina, Wa Ode S. Muthi’ah H Z Nasrah Said Nela Sharon Ni Made Susilawati Ni Wayan Swintari Nifien Mokuna Niluh Puspita Dewi, Niluh Puspita Novalina Serdiati Nur Hikmah Nur Ramadhani Nurihardiyanti Nurihardiyanti Oryza Sativa Padmawati, Retna S. Perwitasari, Dyah A. Postma, Maarten J. Putri, Gina N. R. Rokhman, Muhammad Ramadhanil Ramadhanil Rasuane Noor Rauf, Saidah Recky Patala Revina Triani Rindiani, Ni Luh Rini Saputri Ririen Hardani Ririen Hardani Ririen Ririen Ririn Hardani Ritha Pratiwi Salamah, Sovia Shaldan, Syahna Shella Desiana Sitti Kholidah Sombolinggi, Marzelany M Sri Indrawati Steffi Liem Sugeng, Santoso Sukmawati, Sukmawati Syaputra, Gunawan Syariful Anam Tirza Retno Kinasih Baginda Triana Riandani Djamhuri Tricia Andini Tunreng, Muh. Fadil Usman Wijaya, Berniawan Yonelian Yuyun Yusriadi Yusriadi Zulkarnain Zulkarnain