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All Journal Farmaka Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Jurnal Riset Kimia Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia IDJP (Indonesian Journal of Pharmaceutics) As-syifaa Jurnal Farmasi Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Indonesian Food Science and TechnologyJournal Pharmacology and Clinical Pharmacy Research JSFK (Jurnal Sains Farmasi & Klinis) Pharmaceutical Journal of Indonesia JURNAL FARMASI GALENIKA Majalah Farmasetika Jurnal Ilmiah Farmasi Farmasyifa ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal Sabdariffarma: Jurnal Ilmiah Farmasi Hubungan Tingkat Pengetahuan Petugas Pengelola Obat dengan Tingkat Ketersediaan Obat Di Puskesmas Kota Malang MAHESA : Malahayati Health Student Journal Jurnal Abdimas Indonesia : Jurnal Abdimas Indonesia Indonesian Journal of Biological Pharmacy Journal of Pharmaceutical and Sciences. Medical Laboratory Journal Media Kesehatan Politeknik Kesehatan Makassar Journal of The Indonesian Society of Integrated Chemistry Vitalitas Medis : Jurnal Kesehatan Dan Kedokteran Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Journal of Agropharmacy Jurnal Farmasi Galenika
Patihul Husni
Departemen Farmasetika Dan Teknologi Farmasi, Fakultas Farmasi, Universitas Padjadjaran, Indonesia
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Other

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Formulasi Dan Evaluasi Fisik Lipstik Dari Ekstrak Kulit Umbi Bit (Beta vulgaris L.) Eryani, Mikhania Christiningtyas; Aditama, Agnis Pondineka Ria; Husni, Patihul; Permatasari, Lina Putri
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.417

Abstract

Lipstick is a cosmetic used to add color to the lips. Natural dyes that can be used as a lipstick component are beet (Beta vulgaris L.) skin extract. The skin of beet contains betacyanin which can give color to the lips. This study aims to determine the effect of varying concentrations of beet skin extract on the physical properties of lipstick. There are 3 lipstick formulas used with a 1% (F1), 2% (F2), and 3% (F3) concentration of beet skin extract. The research results show that F1 is pink, F2 is red, and F3 is dark red. The entire formula has even spreadability. The pH values of F1, F2, and F3 are 4.9±0.173, 5±0.3, and 5.3±0, respectively. The melting points of F1, F2, and F3 are 50.66±1.15°C, 52.66±1.15°C, and 53.66±0.58°C, respectively. The conclusion of this study is that variations in the concentration of beet extract affect the color, pH, and melting point of lipstick but do not affect the spreadability of lipstick.
Pengembangan Sediaan Losio Ekstrak Buah Naga Putih Husni, Patihul; Budianto, Muhamad Oke; Baitariza, Ardian; Eryani, Mikhania Christiningtyas; Febryanto, Hery Diar; Januarti, Melinda
JURNAL FARMASI GALENIKA Vol 12 No 3 (2025): Jurnal Farmasi Galenika Volume 12 No 3
Publisher : Universitas Bhakti Kencana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70410/jfg.v12i3.419

Abstract

White dragon fruit (Hylocereus undatus) is a tropical fruit from a type of cactus plant that contains various powerful antioxidants. The purpose of this study was to obtain the best lotion formula containing extract of white dragon fruit based on physical evaluation. Three lotion formulas (F1, F2, F3) containing 7,5% white dragon fruit extract were prepared in this study. Physical assessment of the lotion preparation included organoleptic tests, homogeneity, pH determination, and viscosity evaluation. The results showed that the preparation was in the form of a liquid and homogeneous lotion with a white color and a rose odor. The pH of the preparation was around 5.2-6.5 with a viscosity between 1200-1800 cps. F3 is the best lotion formula based on physical evaluation during four weeks of storage with a composition of 7.5% white dragon fruit extract, 1% glycerin, 0.05% triethanolamine, 3% liquid paraffin, 0,3% methyl paraben, 2% dimethicone, 2% stearyl alcohol, 1.5% glycerol monostearate, 3% virgin coconut oil, 0.1% disodium edetate, 3% cetyl alcohol, 0.2% titanium dioxide, parfum qs, and aquadest ad 100%.
Strategi Komunikasi dan Peran BPOM dalam Menghadapi Produk Bahan Alam Ilegal Yusuf, Marsha Afifah; Husni, Patihul; Ratnawati, Aini
Indonesian Journal of Biological Pharmacy Vol 5, No 3 (2025): IJBP
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i3.68556

Abstract

Peredaran produk bahan alam ilegal, terutama Obat Tradisional (OT) yang mengandung Bahan Kimia Obat (BKO) terus meningkat di Indonesia, dari 31 kasus pada tahun 2020 menjadi 61 kasus pada tahun 2022. Fenomena ini merupakan tanggung jawab Badan Pengawas Obat dan Makanan (BPOM). Artikel ulasan ini bertujuan untuk menganalisis strategi komunikasi dan peran BPOM dalam menghadapi isu produk bahan alam ilegal. Penelitian ini menggunakan metode tinjauan pustaka (literature review) dengan mengidentifikasi, mengevalusi, dan mensintesis studi dan publikasi resmi BPOM/pemerintah dalam rentang waktu 2015-2025. Hasil analisis menunjukan bahwa peran BPOM sudah komprehensif, mencakup regulasi, pengawasan, dan penindakan. Namun, peningkatan tren kasus produk ilegal yang berulang mengindikasikan bahwa regulasi yang ketat dan upaya penindakan seperti penarikan produk yang rutin dilakukan BPOM pada Juli, Agustus, dan September 2025 belum sepenuhnya efektif. Keberhasilan pengawasan juga bergantung pada kerjasama antar lembaga dan penagak hukum untuk meningkatkan efek jera. Strategi komunikasi BPOM dan BBPOM berfokus pada Komunikasi, Informasi, dan Edukasi (KIE) melalui media daring dan luring. Diperlukan optimalisasi platform regional BBPOM agar informasi resmi dapat bersaing dengan berita palsu. 
Dampak Minor Stoppage terhadap Overall Equipment Effectiveness pada Lini Produksi Sediaan Steril : Tinjauan Literatur Aziz, Calista Sasikirana Finola; Husni, Patihul; Sigalingging, Asima Rohana
Majalah Farmasetika Vol 11, No 3 (2026)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/mfarmasetika.v11i3.70346

Abstract

Industri farmasi, khususnya pada lini produksi sediaan steril, menuntut tingkat mutu dan efisiensi yang tinggi untuk menjamin keselamatan pasien serta memenuhi persyaratan regulasi. Salah satu faktor yang memengaruhi efektivitas produksi adalah penghentian singkat (minor stoppage), yaitu gangguan singkat pada mesin atau lini produksi yang cenderung dapat diatasi dengan intervensi ringan operator. Tinjauan literatur ini bertujuan untuk mengkaji dampak penghentian singkat (minor stoppage) terhadap Efektivitas Keseluruhan Peralatan (Overall Equipment Effectiveness / OEE) pada lini produksi sediaan farmasi steril. Metode yang digunakan adalah tinjauan literatur melalui database Google Scholar, PubMed, dan ScienceDirect. Hasil menunjukkan bahwa minor stoppage termasuk kategori kerugian akibat penurunan kecepatan (speed losses) yang dominan menurunkan komponen kinerja (performance) pada OEE. Meskipun berdurasi singkat, frekuensi kejadian minor stoppage yang tinggi menyebabkan akumulasi kehilangan waktu operasional yang signifikan. Dampak tersebut semakin kompleks pada produksi sediaan farmasi steril karena keterbatasan intervensi operator dan persyaratan lingkungan aseptik. Faktor penyebab minor stoppage dapat berasal dari mesin, manusia, material, dan lingkungan. Pengendalian melalui Pemeliharaan Produktif Total (Total Productive Maintenance / TPM) terbukti efektif menekan gangguan dan meningkatkan OEE. Kesimpulannya, minor stoppage merupakan salah satu penyebab utama penurunan OEE sehingga perlu dikendalikan secara sistematis. 
Implemetasi Regulasi BPOM pada Industri Obat Bahan Alam di Jawa Barat: Upaya Menjamin Mutu, Kemanan, dan Efikasi Produk Herbal Ratnadani Amalia Safitri; Patihul Husni
Jurnal Abdimas Indonesia Vol. 5 No. 4 (2025)
Publisher : Perkumpulan Dosen Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34697/jai.v5i4.2676

Abstract

Penelitian ini bertujuan mengevaluasi implementasi regulasi BPOM, khususnya penerapan Cara Pembuatan Obat Tradisional yang Baik (CPOTB), pada industri obat bahan alam di Jawa Barat selama periode 2022–2024. Metode yang digunakan adalah kualitatif deskriptif melalui analisis data pemeriksaan sarana produksi (IOT, IEBA, UKOT, UMOT), hasil uji mutu fisika–kimia, dan penilaian kepatuhan pelabelan. Hasil menunjukkan bahwa tingkat kepatuhan sarana berfluktuasi, dengan IOT konsisten berada pada kategori tinggi, sementara UKOT dan UMOT masih menghadapi kendala pada aspek sanitasi, fasilitas, dan dokumentasi. Evaluasi mutu menunjukkan tingkat kelulusan produk sangat tinggi, berkisar 98–99,8%, yang menandakan bahwa industri cukup berhasil dalam menjaga kualitas produk herbal. Kepatuhan pelabelan meningkat signifikan dari 84,2% pada 2022 menjadi ±99% pada 2023–2024, mengindikasikan keberhasilan pembinaan dan kemudahan penyesuaian industri pada aspek informasi produk. Secara keseluruhan, regulasi BPOM terbukti efektif dalam meningkatkan mutu dan kepatuhan label, namun implementasi pada sarana produksi masih memerlukan penguatan terutama bagi industri kecil dan mikro. Penelitian ini menekankan pentingnya strategi pengawasan adaptif dan pembinaan berkelanjutan untuk memastikan keamanan, mutu, dan efikasi obat bahan alam secara menyeluruh. Kata Kunci: BPOM, obat bahan alam, CPOTB, kepatuhan, mutu produk
Analisis Aktivitas Antioksidan Nanoemulsi Berbaris Tanaman dalam Aplikasi Farmasi dan Kosmetik : Kajian Literatur Nur Aisyah; Sriwidodo Sriwidodo; Patihul Husni; Santi Sinala
Media Kesehatan Politeknik Kesehatan Makassar Vol 20 No 1 (2025): Media Kesehatan
Publisher : Direktorat Politeknik Kesehatan Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32382/medkes.v20i1.1458

Abstract

Plant-based nanoemulsions are increasingly attracting attention in pharmaceutical and cosmetic applications due to their ability to enhance the stability, solubility, and bioavailability of natural active compounds, such as flavonoids, terpenoids, and polyphenols, which possess antioxidant activity. However, the challenge lies in optimizing the nanoemulsion formulation to enhance the efficacy of these compounds. This study aims to explore the potential of plant-based nanoemulsions in enhancing the effectiveness of antioxidant compounds and to provide recommendations for developing more stable and efficient nanoemulsion formulations for pharmaceutical and cosmetic applications. A literature review was conducted by analyzing relevant scientific articles on the use of plant-based nanoemulsions in enhancing antioxidant activity. This study includes various studies that describe the methods of preparation, physicochemical characteristics, and applications of nanoemulsions in the biomedical and cosmetic fields. Plant-based nanoemulsions, such as those using Cordyceps mushroom extract and Mucuna seeds, exhibit stronger antioxidant activity and good stability. Formulations with small particle sizes and uniform particle distribution exhibit higher bioavailability and efficacy, making them promising for application in medical therapy and skin care. Plant-based nanoemulsions offer significant potential for enhancing the efficacy of antioxidant compounds in the pharmaceutical and cosmetic fields. Further development is needed through laboratory and clinical testing to ensure the efficacy and stability of nanoemulsion formulations in real-world applications. Keywords: nanoemulsion, medicinal plants, bioavailability, drug delivery system
Comparative Study of HPLC Detectors in PT. FIP : A Review Annisa Luthfiyah Handini; Patihul Husni; Indriana Agustin Claradila Frinda
Calory Journal Medical Laboratory Journal Vol. 3 No. 2 (2025): June : Medical Laboratory Journal
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/caloryjournal.v3i2.648

Abstract

High Performance Liquid Chromatography (HPLC) is a vital analytical technique used for separation, identification, and quantification of compounds in complex mixtures. This review explores the comparative performance of four detectors employed in the Chemical Laboratory of PT FIP: UV-Visible, Refractive Index (RI), Conductivity, and Evaporative Light Scattering Detector (ELSD). Each detector operates on distinct principles and is selected based on analyte characteristics such as the presence of chromophores, ionic nature, or volatility. The UV-Vis detector remains the most widely used due to its precision and compatibility with chromophoric compounds. However RI, Conductivity, and ELSD detectors serve as essential alternatives for analytes that lack UV absorption, non-ionizing, or exhibit low volatility. This review summarizes the key principles, advantages, limitations, and applications of each detector. The comparative evaluation highlights the strengths and constraints of each system, facilitating method optimization in pharmaceutical analysis.
Formulation of Serum Sunflower (Helianthus annuus L.) Seed Oil as Antiacne Preparation Soraya Ratnawulan Mita Mita; Sri Agung Fitri Kusuma; Devani Olivia Winardi; Patihul Husni; Yoshihito Shiono
JSFK (Jurnal Sains Farmasi & Klinis) Vol 11 No 3 (2024): J Sains Farm Klin 11(3), December 2024
Publisher : Fakultas Farmasi Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jsfk.11.3.197-207.2024

Abstract

Acne is caused by a microbial imbalance due to the overgrowth of Propionibacterium acnes in the skin microbiome. Sunflower seed oil (Helianthus annuus L.), which contains linoleic acid and terpenoids, has an antibacterial activity against P. acnes. This study aimed to increase the availability of anti-acne compounds from natural resources by formulating an anti-acne serum containing sunflower seed oil. The research methods included antibacterial activity testing of sunflower seed oil, serum formulation, product evaluation, and serum effectiveness testing. The results of the antibacterial activity test of sunflower seed oil against P. acnes ATCC 6919 showed a minimum inhibitory concentration (MIC) of 100 mg/mL and a minimum bactericidal concentration (MBC) of 200 mg/mL. The result of serum evaluation and stability testing during the freeze-thaw cycling test depicted stable formulation for all formulas based on organoleptic parameters, homogeneity, pH, viscosity, and spreadability. The effectiveness test results of the serum preparation showed that formula 3, containing 200 mg/L of sunflower seed oil, was the best formula with an inhibition zone diameter of 12.76 ± 0.03 mm. In conclusion, sunflower seed oil demonstrates the ability to prevent and treat acne-prone skin, making it a suitable alternative anti-acne compound.
POTENSI KITOSAN DARI CANGKANG RAJUNGAN (Portunus pelagicus) SEBAGAI ZAT ANTIBAKTERI Patihul Husni; Junaedi Junaedi; Dolih Gozali
Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Vol. 11 No. 1 (2024)
Publisher : Universitas Muhammadiyah Prof. DR. HAMKA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/farmasains.v11i1.14588

Abstract

Plak gigi merupakan suatu lapisan biofilm yang tersusun atas sel-sel dari koloni mikroorganisme pada permukaan gigi yang berperan sangat dominan dalam pembentukan karies gigi. Salah satu penyebab timbulnya plak adalah bakteri Staphylococcus aureus. Kitosan dari cangkang rajungan (Portunus pelagicus) diketahui memiliki aktivitas antibakteri. Tujuan penelitian ini adalah menguji potensi kitosan dari cangkang rajungan yang diperoleh dari pantai Pasir Putih, Cilamaya, Karawang sebagai zat antibakteri. Uji aktivitas antibakteri kitosan dilakukan terhadap bakteri S. aureus dengan nilai konsentrasi hambat tumbuh minimum (KHTM) pada konsentrasi 0,05–0,1% dan konsentrasi bunuh minimum (KBM) pada konsentrasi 0,1%. Hasil penelitian menunjukkan bahwa aktivitas antibakteri terhadap S. aureus terjadi pada konsentrasi 0,4% dan 0,8% berdasarkan zona hambat. Kesimpulan studi ini adalah kitosan dari cangkang rajungan menunjukkan potensinya sebagai agen antibakteri.
Encapsulation Natural Oils Plant Based Using Freeze-Drying Alyanis Mufid SWM; Soraya Ratnawulan Mita; Patihul Husni
MAHESA : Malahayati Health Student Journal Vol 6, No 3 (2026): Volume 6 Nomor 3 (2026)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v6i3.21306

Abstract

ABSTRACT Natural oils, such as essential oils and oils with high unsaturated fatty acids, can be derived and extracted from plant sources. Essential oils contain aromatic compounds commonly used in the food industry, while oils rich in unsaturated fatty acids, such as omega-3, -6, and -9, along with vitamin E, are highly beneficial in industrial sectors. Furthermore, natural oils possess antimicrobial and antioxidant properties that are valuable in daily life. However, degradation of natural oils is inevitable due to various external factors such as temperature, humidity, and light. Therefore, an effective technique is required to enhance the stability of natural oils, with one of the methods being freeze drying, using wall materials made from various polymers depending on the intended application. This review aims to summarize the development of natural oils encapsulated by freeze dryingThe literature search in this review was conducted using the search engines Google Scholar and ScienceDirect. The selected papers used for this review consist of original research articles published between 2021 and 2025, focusing on natural oils unsaturated fatty acids or essential oils as the primary subject of study. Stability can be improved by examining thermal analysis parameters in various natural oils, such as walnut, sacha inchi, rose damascena, mandarin, and boswellia sacra. Storage at low temperatures helps enhance the chemical stability of natural oils. In natural oils, both essential oils and oils with high unsaturated fatty acids, stability improvement can be achieved through freeze drying using polymers as wall materials such as polysaccharides, proteins, gums, lignin, or other polymers. The use of proper machine freeze drying parameter settings is also necessary to obtain the best results with high encapsulation efficiency Keywords: Encapsulation, Essential Oils, Freeze Drying, Natural Product, Unsaturated fatty Acids.
Co-Authors Adi Prayitno Aditama, Agnis Agita, Kiva Agnis Pondineka Ria Aditama Ahmad Muhtadi Ahmad Muhtadi Alicia Ima Dara Alika Nuansa Pratiwi Alyanis Mufid SWM Ami Tjitraresmi Ami Tjitraresmi, Ami Anggia Diani Amalia Anggun Putri Perwira Anis Yohana Chaerunisaa, Anis Yohana Annisa Luthfiyah Handini ANUGRAHANI YUNIAR EKAWATI Apriyani, Mila Ardian Baitariza Ardian Baitariza Ardian Baitariza, Ardian Aryani, Annisa Fitri Asa Falahi Astri Sherly Inggriani Astri Sherly Inggriani ASTRI SULASTRI Ayuning Trias, Diah Aziz, Calista Sasikirana Finola Azizul Hakim Billa Nidia Hikmatiana Budianto, Muhamad Oke Cahya Lestari, Riska Carolina, Theresia Denok Risky Ayu Paramita Devani Olivia Winardi Dewi Rashati Dolih Gozali Dolih Gozali Dwi Puji Astuti Een herliani Eka Yulia Agustin Ella Masliana Dewi Erika Herawati, Irma Eryani, Mikhania Christiningtyas Fairuzati Anisah Murthadiah Fakhirah, Maitsa Alya Fakhri Rabbani FARIANTI EKO NUR KHASANAH Fauziah, Neneng Alifia Nur FIKAMILIA HUSNA Firmansyah Firmansyah Ghifari, M Alvien Hadisoebroto, Ginayanti Hazrina, Aghnia Henny Lucida Hery Diar Febryanto Hosiana, Vinny Ida Musfiroh Ida Musfiroh -, Ida Musfiroh Imam Adi Wicaksono Indriana Agustin Claradila Frinda IRMA RAHAYU LATARISSA Januarti, Melinda Judy Handojo, Kukuh Junaedi Junaedi Junaedi Junaedi Kartika Puspitaningrum Khanifah Hidayati Puspa Negara Khoirunnisa, Arina Kurniati, Bunga Dian Kurniawan Syah, Insan Sunan Kusdi Hartono, Kusdi La Ode Zahid Al Hajri Nur Salam Layyareza, Rania Talinta Luluk Luqyana Mahdiyah Luthfiah, Annisa Mala Fitriani Mayang K. Dewi Mayang Kusuma Dewi MEGA HIJRIAWATI Melinda Januarti Melinda Januarti Muchamad Luthfi Fadhiilah Muhaimin Muhaimin Muhammad Dimas Mulyani, Tuti Sri Muthia Izati Mutia Dwi Lestari Nadya Indah Dewanti NADYA INDAH DEWANTI, NADYA INDAH Nafisa Nurfatia Hidayat Nina Wijiani Norisca A. Putriana Norisca A. Putriana Norisca Aliza Putriana Nur Aisyah NUR DIANA HADAD Nurulita Dina Ulfah Nuryani, Tri Winarsih Permatasari, Lina Putri Perwira, Anggun Putri perwita, tista Puspitaningrum, Kartika Putri, Refitha Nurul Rashati, Dewi Ratnadani Amalia Safitri Ratnawati, Aini Regina Liviandari RESTIKA ERIA PUTRI Rina Haryani Rini Hendriani Rini Silviya Riska Cahya Lestari Safitri, Manzil Salsabila, Annisa Siti Santi Sinala SHEILA PRATIWI Sigalingging, Asima Rohana Silvia, Nurfianti Siti Nur Azizah, Siti Nur Sitinjak, Bernap Dwi Putra Soewahju, Renata Bella Soraya Ratnawulan Mita Soraya Ratnawulan Mita Mita SORAYA RATNAWULAN MITA, SORAYA RATNAWULAN Sri Agung Fitri Kusuma Sriwidodo Sriwidodo Syuhuriah, Ainin Taofik Rusdiana Tryani Sutisna Putri, Sussy Uswatul Hasanah Uswatul Hasanah Uvita Kafilatul Ikhrom Vinny Hosiana Vista Kamilania Widayanti Supraba Wirna Grace Tua Sihombing Yasarah Hisprastin Yoga Windhu Wardhana Yoshihito Shiono Yosita Aulia Mustofa Yuli Agung Prasetyo Yuni Ruspriyani YUNIKE KARUNIA PUTRI Yusuf, Marsha Afifah Zelika Mega Ramadhania, Zelika Mega