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Journal : Open Access Health Scientific Journal

Potential of Propolis for Diabetic Wound Healing: A Literature Review Sukmana, Mayusef; Rasyid, Muhammad; Paramita, Swandari; Yasir, Yadi; Wahyuningsih, Sri
Open Access Health Scientific Journal Vol. 6 No. 2 (2025): August 2025
Publisher : Griya Eka Sejahtera

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55700/oahsj.v6i2.96

Abstract

Background: Diabetes mellitus, a chronic metabolic disorder often leads to impaired wound healing, a serious complication resulting in diabetic ulcers, infections and even amputations. Conventional treatments for diabetic wounds can be costly and have side effects. Propolis, a natural resinous substance collected by honeybees from various plants, has long been recognized for including antibacterial, anti-inflammatory, antioxidant, and immunomodulatory properties. This literature review aims to summarize and analysed the scientific evidence regarding the potential of propolis in accelerating wound healing in diabetic conditions.Methods: Google Scholar, PubMed, Science Direct, EBSCO, Watase UAKE and Proquest using relevant keywords including "propolis," "wound," "diabetic ulcer,". The selected articles included original research studies only that discussed the potential of propolis in diabetic wound healing. Inclusion criteria were articles published in English and specifically addressing the effects of propolis on wound healing in diabetic patients, randomised clinical trial sampling technique and the article published in 2015-2025.Results: The article search process found in Google Scholar are 184 articles, PubMed are 10 articles, Science Direct are 185 articles, EBSCO are one article, and Watase UAKE is one article and ProQuest are 721 articles. There were 2 articles that met the inclusion criteria. The article discussed the potential and relationship of propolis with Erythema and Exudates, White Blood Cell (WBC) Count and ESR, Ulcer Discharge, Surrounding Erythema, Wound healing, connective tissue formation, oxidative stress markers, inflammatory markers, HbA1c level.Conclusion: Propolis, as a natural product, offers a potential alternative or complementary treatment to conventional therapies. affects wound healing through a complex process erythema and exudates, White Blood Cell (WBC) Count and ESR, ulcer discharge, surrounding erythema, wound healing, connective tissue formation, oxidative stress markers, inflammatory markers, HbA1c level. This is a new strategy for managing diabetic foot ulcers.
Co-Authors Abda Abda Abu Umayah Afkarina, Naffa Ahmad Izzuddin Ainun Sajidah Akh. Fauzi Aseri Alfaiz, Salahuddin Algaus, Icong Anas, Brian Arianti, Mega Arsi, Arsi Aseri, Akh. Fauzi Aseri, Mukhsin Azzahra, Meilinda Putri Bambang Gunawan Bisepta Prayogi, Bisepta Bog, Kim Jung Butarbutar, Abdul Hakin Daniel, Irwan Devi Anggraini dompak, timbul Fadillah, Luthfi Nur Fahira, Dini Farida, Hana Dhiya Fathammubin, Fauzan Fedorchenko, Oleh Gumelar, Angga Hakim, Beny Rahman Hammad, Hammad Handayani, Sri Haq, Yusdi Harahap, Sahrul Henny Pagoray, Henny Heru Kuswanto Ika Chandriyanti Insih Wilujeng Izma, Hayatun Jiki Romadoni Jumadi Jumadi Kaila, Wafa Khairir Rizani, Khairir Krispinus Duma Laifa Rahmawati, Laifa Lathief, Muhammad Lestari, Hasanah Dewi Marwa, Neneng Widya Sopa Minwal, Minwal Monalisah, Monalisah Muhammad Syazwan Faid Muhsin Aseri Muhsin Aseri, Muhsin Mustapha, Ahmad Sharifuddin bin Nengsih, Ratika Nofirda, Fitri Noviani, Noviani Nur Rizki Nurbaiti Amir Nurhaliza, Fahzalika Siti Nurrahmah, Ika Maulida Nuruddaroini, M. Ahim Sulthan Otib Satibi Hidayat Panjaitan, Saut Parulian Parellangi, Parellangi Pari, H. Fauzie Permadi Iskandar, Budi Prasetia, Aditia Pudjiati, Indri PUTRI WULANDARI Putri, Nafisa Yasara Rahmadi, Agus Rahman, Adam Aulia Rahman, Arief 4 Rahman, Fatih Junius Rahman, Imas Kania Rahman, Muhammad Arief Rahmana, Muhamad Syeikha Rambe, Muhammad Rahman Rizky, Ihza Rosyadi, A. Rahmat Sabar Nurohman Safitri, Nur Haifa Sampoerno, M. Rizki Sandi, Dita Ayulia Dwi Satriani, Desi Setiawan, Muhammad Irwan Setiawati, Tiyas Silviano, Haykal Sugeng Riyadi Sukarni Sukarni Sukarni Sulistiyawati Sulistiyawati Suyanta Suyanta Swandari Paramita Syafi’i, Ahmad Syahid, Akhmad Tamam, Abas Mansur Tien Aminatun tono, Nasrullah Wilu Unayah, Habibatul Waode, Hamdi Wilutono, Nasrullah Winedar, Ihza Rizky Yadi Yasir Yanuarief, Cecilia