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All Journal HAYATI Journal of Biosciences Jurnal Pengolahan Hasil Perikanan Indonesia IPTEK Journal of Proceedings Series Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY The Indonesian Journal of Public Health Jurnal Kimia Riset Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Makara Journal of Science Frontiers in Community Service and Empowerment Borneo Journal of Pharmacy Journal of Bio-molecule Research And Engineering Jurnal Kesehatan Masyarakat
Teguh Hari Sucipto, Teguh Hari
Dengue Study Group, Institute Of Tropical Disease, Universitas Airlangga, Mulyorejo Street, Mulyorejo 60115, Surabaya, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Other

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Detection of Vgsc-L1014F Allele Knockdown-resistance Mutation in Male Culex quinquefasciatus Mahfudhah, Dzikra Nasyaya; Rahmafitria, Fistara Lesti; Hari Sucipto, Teguh; Fauziyah, Shifa; Anggarani, Mirwa Adiprahara; Herdyastuti, Nuniek; Naw, Sin War; Witaningrum, Adiana Mutamsari
HAYATI Journal of Biosciences Vol. 32 No. 6 (2025): November 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.6.1400-1406

Abstract

The distribution of Culex quinquefasciatus as a vector for several tropical diseases in Indonesia could affect the transmission of various pathogens, including filariasis, West Nile, encephalitis, and Rift Valley fever. The use of insecticides to control mosquito populations is carried out massively. However, this effort is threatened by an increase in mosquito resistance to insecticides, in this case, pyrethroids that target Voltage-gated sodium channel (VGSC) as a complex protein in mosquito nerve cells that plays a role in the movement of sodium ions, where these compounds can have a knockdown effect and lead to death. The existence of a single nucleotide mutation in this specific codon results in knockdown resistance (kdr) in mosquitoes. This study aims to determine whether there is a kdr mutation in the Vgsc-L1014F target using the latest molecular method ETAS-PCR to type tri-allelic variation at Vgsc-1014 in Cx. quinquefasciatus samples collected in three areas in the cities of Surabaya and Sidoarjo, namely Wonocolo, Sukodono, and Wonoayu. The result showed ten male pool samples (C1-C10) of Cx. quinquefasciatus did not carry mutations or present as homozygous wild type (TTT/TTT), with a DNA band size of 181 bp. Hence, this preliminary study could be extended for further research to build vector control monitoring programs.
Molecular Docking Analysis of Flavonoids from Syzygium cumini (L.) Skeels: Proapoptotic Potential as an Anticancer Mechanism Aini, Nur Sofiatul; Ansori, Arif Nur Muhammad; Widyananda, Muhammad Hermawan; Kharisma, Viol Dhea; Murtadlo, Ahmad Affan Ali; Herdiansyah, Mochammad Aqilah; Rebezov, Maksim; Burkov, Pavel; Gudz, Petr; Derkho, Marina; Bezhinar, Tatyana; Maksimiuk, Nikolai; Sazali, Munawir; Purnobasuki, Hery; Rollando, Rollando; Khairullah, Aswin Rafif; Sucipto, Teguh Hari
Borneo Journal of Pharmacy Vol. 8 No. 3 (2025): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v8i3.9843

Abstract

Non-small cell lung cancer (NSCLC) presents a significant global health challenge, with its prevalence and mortality rates rising steadily. In Indonesia, Syzygium cumini (L.) Skeels, known for its flavonoid richness, has a long history in traditional medicine. However, its specific mechanisms of action against cancer, particularly in inducing apoptosis in NSCLC, have not been fully elucidated. This study utilized an in silico approach to evaluate the pro-apoptotic potential of S. cumini flavonoids against NSCLC by targeting key proteins: Bcl-2, Bax, and Caspase-3. We retrieved flavonoid structures from PubChem and protein data from the Research Collaboratory for Structural Bioinformatics Protein Data Bank (RCSB PDB). The drug-likeness of these compounds was assessed using Swiss ADME, adhering to Lipinski's rule of five, while their anti-NSCLC probability was predicted using PASS Online. Molecular docking and screening were performed with PyRx, and the results were visualized using Discovery Studio. Our findings identified epigallocatechin 3-O-gallate and ellagic acid as the most promising anti-NSCLC candidates. Ellagic acid demonstrated the strongest binding affinity to Caspase-3, suggesting a potent pro-apoptotic effect. Epigallocatechin 3-O-gallate, on the other hand, exhibited the lowest binding energy across multiple target proteins, particularly Bcl-2 and Bax, indicating its broad pro-apoptotic potential. These results collectively suggest that flavonoids from S. cumini may hold significant promise as a source of novel anti-NSCLC agents, warranting further in vitro and in vivo investigations.
Synthesis and Characterization of Cu(II)-EDTA Complexes: Antibacterial Studies (Escherichia coli, Staphylococcus aureus) and Inhibition of Dengue Virus Serotype 2 in Vero Cell Kinetasari, Theresia Janice; Sucipto, Teguh Hari; Nugroho, Browi; Hariyono, Hariyono; Rehman, Saifur
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 2 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i2.69005

Abstract

The Cu(II)-EDTA complex is known to have antibacterial and antiviral potential, but its effectiveness against pathogenic bacteria and dengue virus serotype 2 (DENV-2) still needs to be studied. This study synthesized and characterized the Cu(II)-EDTA complex of CuSO4 precursors, and then tested the antibacterial activity against Escherichia coli and Staphylococcus aureus, as well as the antiviral activity against DENV-2 in Vero cells. This study successfully synthesized and characterized the Cu(II)-EDTA complex using CuSO4 as a precursor through the solvothermal method, producing blue crystals with a Cu ratio of 1:1. DSC analysis showed thermal stability up to 250°C with an endothermal peak at 270-300°C. The particles are 6.31 nm in size with a PDI of 0.076, indicating uniform distribution with nanoparticle size (<100 nm). FTIR confirms the formation of the complex through significant shifts in the O-H and C=O bands. SEM shows a layered morphology that can affect the solubility and release of substances. UV-Vis shows maximum absorbance peaks of EDTA at 244 nm and CuSO4 at 740 nm. Antibacterial tests of Cu(II)-EDTA against E. coli and S. aureus showed that Cu(II)-EDTA had less activity than pure CuSO4. For DENV-2, CuSO4 was more effective with an EC50 value of 77.86 μg/mL, lower than Cu(II)-EDTA 356.13 μg/mL, indicating that CuSO4 was better at inhibiting viral replication.
Telemonitoring-Based Cardiac Care to Reduce Readmissions in Coronary Heart Disease Patients Hariyono, Hariyono; Madyawati, Sri Pantja; Romli, Leo Yosdimyati; Tan, Chin Xuan; Fauziyah, Shifa; Sucipto, Teguh Hari
Jurnal Kesehatan Masyarakat Vol. 21 No. 2 (2025)
Publisher : Universitas Negeri Semarang in collaboration with Ikatan Ahli Kesehatan Masyarakat Indonesia (IAKMI Tingkat Pusat) and Jejaring Nasional Pendidikan Kesehatan (JNPK)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15294/kemas.v21i2.24553

Abstract

Coronary heart disease (CHD) continues to be a leading cause of hospital readmissions, especially among elderly individuals with low educational attainment and limited understanding of health information. This research aimed to evaluate how cardiac care management influences the frequency of hospital readmission in patients diagnosed with CHD. Employing a quasi-experimental method with a one-group pretest-posttest design, the study involved 100 participants at Jombang Hospital, chosen through purposive sampling. Information regarding readmission rates was gathered before and after the intervention using structured questionnaires and assessed through the Wilcoxon signed-rank test. Before receiving the intervention, 25% of patients had been readmitted more than twice, while none avoided readmission altogether. Following the management program, only 5% experienced multiple readmissions, and 25% reported none. The statistical outcome demonstrated a significant difference (p = 0.002), proving that cardiac care interventions consisting of educational support, family involvement, and consistent follow-up effectively decreased patient readmission. Most participants were aged between 61 and 75, male, and had only completed elementary school, all of which are factors associated with poor disease self-management. This trial confirms that integrated cardiac care management greatly improves the outcomes of recovery and decreases the risk of rehospitalization in CHD patients.
EMPOWERMENT OF ELDERLY POSYANDU VOLUNTERS IN EARLY DETECTION OF HYPERTENSION DISEASE Hariyono, Hariyono; Sri Pantja Madyawati; Syifa Fauziyah; Candra Panji Asmoro; Teguh Hari Sucipto; Leo Yosdimyati Romli; Risanti Handayani
Frontiers in Community Service and Empowerment Vol. 2 No. 4 (2023): December
Publisher : Forum Ilmiah Teknologi dan Ilmu Kesehatan (FORITIKES)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35882/ficse.v2i4.53

Abstract

The number of elderly populations in various countries continues to increase along with increasing life expectancy, so it is important to pay special attention to the health of the elderly, including early detection of hypertension. Posyandu volunters have good access to the elderly population because they are actively involved in community health activities. The aim of empowering elderly Posyandu volunters is to increase volunters' knowledge and skills in early detection of hypertension in the elderly. With adequate knowledge, volunters can provide better care and prevent more severe complications. The results of this research were that more than half had poor knowledge about early detection of hypertension before being given training (56%) and most of them had good knowledge about early detection of hypertension after being given training (63%). Empowering elderly Posyandu volunters has significant benefits. Skilled volunters can help increase elderly awareness of the importance of early detection of hypertension. Apart from that, volunters can provide assistance in regular health monitoring so that elderly people can take preventive measures in a timely manner..
Co-Authors Adi Sofyan Ansori, Muhammad Adiana Mutamsari Witaningrum Ahmad Rudi Setiawan Aini, Nur Sofiatul Aisyah, Nourmalasari Aksono HP., Eduardus Bimo Amaliah Labiqah, Amaliah Anika Rahma Putri Anisa Maharani Aquaresta, Febriana Arli Aditya Parikesit Aryati Aryati Azizia Kanya Fathiarachman Bezhinar, Tatyana Budi Utomo Budi Utomo BUDI UTOMO Burkov, Pavel Candra Panji Asmoro, Candra Panji Chan Chow Khuen DAMAYANTI, MAMIK Derkho, Marina Dian, Farida Aryani Eiji Konishi, Eiji Eryantika Cipta Dewi Fachry Abda El Rahman Fahimah Martak Farihah, Neni Isna Ganden Supriyanto Gudz, Petr Hapsari, Nafisah Nurul Hariyono Hariyono Hariyono Harsasi Setyawati Hebert Adrianto Herdiansyah, Mochammad Aqilah Hery Purnobasuki I Gede Widhiantara I Made Gde Sudyadnyana Sandhika I Wayan Rosiana Ihsan, Anaqi Syaddad Ilham Harlan Amarullah Jakhmola, Vikash Kautsar, Radinal Khairullah, Aswin Rafif Kharisma, Viol Dhea Khoirunnisa Suhandarini Kinetasari, Theresia Janice Kris Cahyo Mulyatno, Kris Cahyo Kurniawan, Muhammad Ridho Hafid Leo Yosdimyati Romli Maharani, Anisa Mahfudhah, Dzikra Nasyaya Maksimiuk, Nikolai Masanori Kameoka, Masanori Mirwa Adiprahara Anggarani Munawir Sazali Murtadlo, Ahmad Affan Ali Nastiti, Helena Putri Naw, Sin War NI KADEK YUNITA SARI Ni Njoman Juliasih Novia Faridatus Sholihah Nugroho, Browi Nuha, Zakiyathun Nuniek Herdyastuti Nur Ahwanah, Nur Nur Fadhilah Nur Syamsiatul Fajar, Nur Syamsiatul Nuryandari, Sufiandika Panjaitan, Novaria Sari Dewi Permatasari, Anak Agung Ayu Putri Permatasari, Anak Agung Ayu Putri Permatasari Prihartini Widiyanti PUJI LESTARI Puspa Wardhani Putri, Deva Permata Putu Angga Wiradana Rahadian Zainul Rahmafitria, Fistara Lesti Ramadhani, Aisyah Hadi Rebezov, Maksim Rehman, Saifur Reny Mareta Sari, Reny Mareta Risanti Handayani Rizqidhana Juliana Putri Rollando, Rollando Safira Madaniyah Saiku Rokhim Saputri, Ratih Dewi Sari Edi Cahyaningrum Scherbakov, Pavel Sepiashvili, Ekaterina Shifa Fauziyah Shifa Fauziyah Shifa Fauziyah Shifa Fauziyah Shifa Fauziyah Shuhai Ueda Sin War Naw Sin War Naw Siti Churrotin, Siti Soegeng Soegijanto Sri Pantja Madyawati Sri Pantja Madyawati, Sri Pantja Sri Subekti Sri Sumarsih Sulistiawati Syananda Zahra Fadila Tan, Chin Xuan Tasya Amalia Dwiyanti Tomohiro Kotaki, Tomohiro Tukiran Ueda, Shuhai Wardhani, Puspa Wibrianto, Aswandi Widati Fatmaningrum Widya, Alicia Margaretta Widyananda, Muhammad Hermawan Wijayanti, Alvia Rachma Yanuardi Raharjo, Yanuardi Yovilianda Maulitiva Untoro Yuanita Rachmawati