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All Journal HAYATI Journal of Biosciences Jurnal Pengolahan Hasil Perikanan Indonesia IPTEK Journal of Proceedings Series Indonesian Journal of Tropical and Infectious Disease Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY The Indonesian Journal of Public Health Jurnal Kimia Riset Qanun Medika - Medical Journal Faculty of Medicine Muhammadiyah Surabaya Makara Journal of Science Frontiers in Community Service and Empowerment Borneo Journal of Pharmacy Journal of Bio-molecule Research And Engineering Jurnal Kesehatan Masyarakat Folia Medica Indonesiana
Teguh Hari Sucipto, Teguh Hari
Dengue Study Group, Institute Of Tropical Disease, Universitas Airlangga, Mulyorejo Street, Mulyorejo 60115, Surabaya, East Java, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Earth & Planetary Sciences Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Epidemiology Study of Dengue Virus In Surabaya, Bogor, and Bangkalan, Indonesia 2008-2018 Soegijanto, Soegeng; Sucipto, Teguh Hari; Mulyatno, Kris Cahyo; Churrotin, Siti
Folia Medica Indonesiana Vol. 56, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Dengue virus (DENV) is mosquito-borne viral diseases, transmitted by the vector mosquitoes such as Aedes sp. Infection with four serotypes of DENV-1 to 4. Indonesia, dengue haemorrhagic fever (DHF) was first recognized in 1968 in the cities of Jakarta and Surabaya. In 2007, we started DENV surveillance in Surabaya supported by the joined program of the Japan Initiative for Global Research Network on Infectious Disease (J-GRID) established the Indonesia-Kobe University Collaborative Research Center for Emerging and Reemerging Infectious Diseases (CRC-ERID). The results of serotype and genotype, in Surabaya and Bangkalan are similar with previous result in Indonesia, but especially in Bogor similar with Japan 2014. This study showed the importance of continuous virus surveillance in dengue endemic areas, in order to understand the dynamic of dengue infection disease in Indonesia.
DETECTION OF SEROTYPES AND KNOCKDOWN-RESISTANCE MUTATIONS IN DENGUE AND OTHER FLAVIVIRUS SAMPLES COLLECTED FROM MENGARE ISLAND, INDONESIA Dwiyanti, Tasya Amalia; Sucipto, Teguh Hari; Suhandarini, Khoirunnisa; Fathiarachman, Azizia Kanya; Nastiti, Helena Putri; Putri, Anika Rahma; Fauziyah, Shifa; Widiyanti, Prihartini; Hariyono, Hariyono; Rehman, Saifur
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

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Dengue fever, caused by the dengue virus (DENV), poses a significant public health challenge, particularly in tropical regions. This study aimed to detect flavivirus presence, DENV serotypes, and knockdown-resistance (kdr) mutations in mosquito samples collected from Mengare Island, Gresik, Indonesia. A cross-sectional experimental design was employed, utilizing reverse transcription polymerase chain reaction (RT-PCR) for flavivirus detection and serotyping, as well as for identifying kdr mutations. Ribonucleic acid (RNA) extraction was performed using the Quick-RNA™ Miniprep Plus Kit (Zymo Research, Irvine, CA, USA), followed by RT-PCR with specific primers for DENV serotypes 1–4 and kdr mutations (V1016G and F1534C). Six adult female Aedes albopictus mosquitoes were analyzed in this study. The results revealed no evidence of flavivirus infection or DENV serotypes in the mosquito samples, as no complementary deoxyribonucleic acid (cDNA) bands corresponding to expected base pair sizes were observed on the agarose gels. Similarly, the analysis of kdr mutations showed that all samples were homozygous wildtype, with no mutations detected at the V1016G or F1534C loci. In conclusion, these findings suggest the absence of active dengue virus transmission or notable insecticide resistance in the studied mosquito population from Mengare Island. This study highlights the importance of continuous monitoring of flavivirus presence and resistance mutations. The variability in kdr mutation frequencies across regions underscores the need for sustained surveillance and effective control measures to mitigate potential outbreaks in high-risk areas such as Mengare Island.
Screening of Tuberculosis Infection through Acid-Fast Bacilli Tests among Waste Workers in Gresik, Indonesia Utomo, Budi; Fatmaningrum, Widati; , Sulistiawati; Fauziyah, Shifa; Khuen, Chan Chow; Fadhilah, Nur; Sucipto, Teguh Hari
Folia Medica Indonesiana Vol. 60, No. 2
Publisher : Folia Medica Indonesiana

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Highlights: 1. This study was the first in Gresik, Indonesia, to conduct mass screening of tuberculosis among waste workers, comprising various demographic profiles. 2. Although the tuberculosis screening of the waste workers showed negative results, mass examination using an acid-fast bacilli smear remains crucial to detect latent infections and prevent transmissions. Abstract Tuberculosis is a major source of illness and mortality worldwide. Therefore, tuberculosis screening is important to increase the number of active case-finding in a community. Bacteriological examinations can be used to initiate community-based active case-finding. Waste workers face a high risk of contracting Mycobacterium tuberculosis due to their constant exposure to waste. This study aimed to conduct bacteriological examinations to identify tuberculosis infections among waste workers in Gresik, Indonesia, who were considered a high-risk group. An analytical observational study was carried out throughout September 2023 in the Ngipik subdistrict, Gresik, East Java, Indonesia. The primary study was conducted using a cross-sectional design using interviews, measurements, and sputum examinations for all samples. The screening involved a total of 72 waste workers who had daily contact with various types of sewage and waste, including medical waste. The data were analyzed descriptively because of the constant variable. Following the analysis, the data were presented using a table and a figure. According to the acid-fast bacilli examinations, all of the samples yielded negative results. Nevertheless, this study concludes that it is imperative to carry out mass tuberculosis screening in various settings, specifically among those with a high risk. Mass screening can uncover the potential of latent tuberculosis and, thus, reduce its transmission.
Detection of Knockdown-Resistance Homozygous Mutant C1534C using Allele-Specific Polymerase Chain Reaction in Aedes Albopictus and Aedes Aegypti Fadila, Syananda Zahra; Setiawan, Ahmad Rudi; Fauziyah, Shifa; Madaniyah, Safira; Dewi, Eryantika Cipta; Naw, Sin War; Cahyaningrum, Sari Edi; , Tukiran; Sucipto, Teguh Hari
Folia Medica Indonesiana Vol. 59, No. 2
Publisher : Folia Medica Indonesiana

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Highlights: • This research analyzed a previously understudied subject in Surabaya, Indonesia, and discovered knockdown resistance (kdr) mutations in Aedes albopictus. • The findings of this study can prompt further research, including bioassay testing and the development of more potent insecticides. Abstarct : Dengue hemorrhagic fever (DHF) has been endemic in Indonesia for decades. Insecticides are necessary to manage the transmission of the dengue virus. However, prolonged use of insecticides can lead to insecticide resistance. This study aimed to examine the genotype of mosquitoes using the allele-specific polymerase chain reaction (ASPCR) method. The ASPCR method was chosen for genotype detection due to its high sensitivity, affordability, and ease of design. Five mosquitoes were collected from human habitation in four different areas of Surabaya, Indonesia, namely Kranggan, Ulul Azmi Mosque, Ploso, and Kalijudan. Among them, three samples were identified as Aedes albopictus (A1, A2, and A5) and two samples were identified as Aedes aegypti (A3 and A4). The frequency of resistant alleles was analyzed using the Hardy-Weinberg package in RStudio version 2023.03.1. This study revealed that two mosquitoes carried homozygous mutant alleles with a band of 113 bp and three mosquitoes carried homozygous wild-type alleles with a band of 93 bp. Cysteine-to-cysteine (C/C) mutations and phenylalanine-to-phenylalanine (F/F) mutations at codon 1534 were observed in Aedes aegypti and Aedes albopictus mosquitoes. The homozygous mutant alleles were found in Kranggan, Surabaya, Indonesia. Further research is required to assess insecticide resistance and knockdown resistance (kdr)-like mutation by collecting more representative samples from larger areas within the region of Surabaya. Nevertheless, this study can be used as a reference for vector control and early prevention of dengue fever.
The Use of Comics as a Tuberculosis Learning Medium for Junior High School Students Utomo, Budi; Fatmaningrum, Widati; , Sulistiawati; Fauziyah, Shifa; Sucipto, Teguh Hari; Khuen, Chan Chow
Folia Medica Indonesiana Vol. 60, No. 1
Publisher : Folia Medica Indonesiana

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Highlights: 1. Comics centered around tuberculosis offer a novel method tailored for specific audiences, specifically children or those of school age, to learn about the disease. 2. The tuberculosis comics feature the etiology, prevention, and treatment of tuberculosis conveyed through their unique design. 3. Comics can be an innovative promotional method to support the preventive campaign against tuberculosis. Abstract As a tropical country, Indonesia continues to grapple with the prevalence of tuberculosis. This study conducted by the Department of Public Health and Preventive Medicine at Universitas Airlangga, Surabaya, Indonesia, presented a novel approach to prevent tuberculosis through measures tailored to the socio-cultural context of the population. Specifically, this study assessed how effective the use of tuberculosis comics is as an educational tool to inform junior high school students about tuberculosis. This research was quasi-experimental, with a one-group pre-test-post-test design. Seventy junior high school students in Dukun District, Gresik, Indonesia participated in this study. Each participant received a questionnaire consisting of ten questions about tuberculosis. Afterward, tuberculosis education was shared through comics. The post-test was carried out using the same questions as the pre-test. The data were analyzed using the R Program for Windows, version 4.1.3 (Auckland University, New Zealand). The analysis revealed a significant difference between the pre-test and post-test results (p < 0.0001). As indicated by the data, comics proved to be an effective method of educating people about infectious diseases, specifically tuberculosis. Here, we introduce an educational tool designed to revitalize the educational method for disseminating knowledge about infectious diseases. Ultimately, comics can increase students' interest in learning about tuberculosis, including its etiology, prevention, and treatment strategies.
Evaluation of Mangrove, Acanthus ilicifolius Aqueous Extract on Inhibition of Dengue Virus Replication: In Vitro and Molecular Docking Approach Wiradana, Putu Angga; Wiartini, Ni Wayan Ayu Wiartini; Sucipto, Teguh Hari; Herdiansyah, Mochammad Aqilah; Permatasari, Anak Agung Ayu Putri; Widhiantara, I Gede; Sari, Ni Kadek Yunita Sari; Darmanto, Win; Panjaitan, Novaria Sari Dewi Panjaitan; Kusala, Muhammad Khaliim Jati Kusala
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.71217

Abstract

Dengue virus (DENV) infection is a worldwide health risk, presenting severe symptoms with possibly lethal consequences. The search for effective antiviral drugs against DENV has largely focused on natural products. Mangrove, Acanthus ilicifolius, has been empirically shown to exhibit various biological activities and good safety profiles.  The purpose of this investigation was to examine the antiviral activity of A. ilicifolius aqueous extract against DENV, and the way it functions of action of its bioactive components function was explored utilizing an in vitro and molecular docking method. Aqueous extract of A. ilicifolius leaves was made, and its therapeutic potential was examined using half cytotoxic concentration (CC50) and effective concentration (EC50) on Vero cells using the MTT method. The selectivity index (SI) value was determined from the ratio of CC50 and EC50. A total of 12 ligand compounds reported to be contained in the extract were prepared for molecular docking using AutoDock Vina, followed by in silico drug-like potential.  A. ilicifolius water extract achieved the greatest Vero cell viability rate of 159.80% at a concentration of 31.25 μg/mL. A. ilicifolius extract at 100 μg/mL demonstrated the greatest DENV-3 inhibitory rate of 79.69%. The CC50 value was 78.55 μg/ml, and the EC50 value was 64.37 μg/mL.  The SI value calculated from the ratio of CC50 to EC50 was 1.22. Molecular docking identified stigmasterol, stigmasterol-3-O-β-d-glucopyranoside, and quercetin as the primary compounds with the greatest docking values (-7.9 kcal/mol, -7.6 kcal/mol, and -7.7 kcal/mol, respectively).  The findings of this study demonstrate the anti-DENV capability of the A. ilicifolius extract compound, which can limit viral multiplication via biological agents that interact with virus attachment within host cells, with an SI value of 1.22.
Correlation Between Platelet and Hematocrite Values with Duration Fever in Dengue Hemorrhagic Fever (DHF) Patients at Dr. Soedomo General Hospital, Trenggalek Alelo, Richardo Reynaldi Sakka; Sucipto, Teguh Hari; Soegijanto, Soegeng; Wardhani, Puspa
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 3 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i3.73388

Abstract

Dengue Hemorrhagic Fever (DHF) is an endemic disease in Indonesia with laboratory manifestations such as thrombocytopenia and hemoconcentration. The duration of fever in DHF can be an indicator of disease severity, but its relationship to laboratory parameters such as platelets and hematocrit requires further study. The purpose of this research is to determine the relationship between platelet and hematocrit values and the duration of fever in DHF patients at Dr. Soedomo Trenggalek Regional General Hospital. This study used a cross-sectional design with secondary data from the medical records of 71 dengue fever patients. Statistical analysis used the Spearman correlation test to assess the relationship between platelets and hematocrit with fever duration. 54.93 % of patients were male, with the largest age group being young adults (26–45 years, 39.44%). The maximum duration of fever was 5 days (54.93 %). There was a weakly significant relationship between decreased platelets and increased duration of fever (p = 0.025; r = 0.266). However, there was no significant relationship between hematocrit and duration of fever (p = 0.359; r = -0.111). Platelets can be used as an indicator to estimate the duration of fever in dengue fever patients, while hematocrit did not show a significant relationship. These findings support the importance of platelet monitoring for the clinical management of dengue fever, although factors such as fluid therapy and disease phase need to be considered in hematocrit interpretation.
Co-Authors , Sulistiawati Adi Sofyan Ansori, Muhammad Adiana Mutamsari Witaningrum Ahmad Rudi Setiawan Aini, Nur Sofiatul Aisyah, Nourmalasari Aksono HP., Eduardus Bimo Alelo, Richardo Reynaldi Sakka Amaliah Labiqah, Amaliah Anika Rahma Putri Anisa Maharani Aquaresta, Febriana Arli Aditya Parikesit Aryati Aryati Azizia Kanya Fathiarachman Bezhinar, Tatyana Budi Utomo Budi Utomo BUDI UTOMO Burkov, Pavel Candra Panji Asmoro, Candra Panji Chan Chow Khuen DAMAYANTI, MAMIK Derkho, Marina Dewi, Eryantika Cipta Dian, Farida Aryani Dwiyanti, Tasya Amalia Eiji Konishi, Eiji Eryantika Cipta Dewi Fachry Abda El Rahman Fadila, Syananda Zahra Fahimah Martak Farihah, Neni Isna Fathiarachman, Azizia Kanya Ganden Supriyanto Gudz, Petr Hapsari, Nafisah Nurul Hariyono Hariyono Hariyono Harsasi Setyawati Hebert Adrianto Herdiansyah, Mochammad Aqilah Hery Purnobasuki I Gede Widhiantara I Made Gde Sudyadnyana Sandhika I Wayan Rosiana Ihsan, Anaqi Syaddad Ilham Harlan Amarullah Jakhmola, Vikash Kautsar, Radinal Khairullah, Aswin Rafif Kharisma, Viol Dhea Khoirunnisa Suhandarini Khuen, Chan Chow Kinetasari, Theresia Janice Kris Cahyo Mulyatno, Kris Cahyo Kurniawan, Muhammad Ridho Hafid Kusala, Muhammad Khaliim Jati Kusala Leo Yosdimyati Romli Madaniyah, Safira Maharani, Anisa Mahfudhah, Dzikra Nasyaya Maksimiuk, Nikolai Masanori Kameoka, Masanori Mirwa Adiprahara Anggarani Munawir Sazali Murtadlo, Ahmad Affan Ali Nastiti, Helena Putri Naw, Sin War NI KADEK YUNITA SARI Ni Njoman Juliasih Novia Faridatus Sholihah Nugroho, Browi Nuha, Zakiyathun Nuniek Herdyastuti Nur Ahwanah, Nur Nur Fadhilah Nur Fadhilah Nur Syamsiatul Fajar, Nur Syamsiatul Nuryandari, Sufiandika Panjaitan, Novaria Sari Dewi Panjaitan, Novaria Sari Dewi Panjaitan Permatasari, Anak Agung Ayu Putri Permatasari, Anak Agung Ayu Putri Permatasari Prihartini Widiyanti PUJI LESTARI Puspa Wardhani Putri, Anika Rahma Putri, Deva Permata Putu Angga Wiradana Rahadian Zainul Rahmafitria, Fistara Lesti Ramadhani, Aisyah Hadi Rebezov, Maksim Rehman, Saifur Reny Mareta Sari, Reny Mareta Risanti Handayani Rizqidhana Juliana Putri Rollando, Rollando Safira Madaniyah Saiku Rokhim Saputri, Ratih Dewi Sari Edi Cahyaningrum Sari, Ni Kadek Yunita Sari Scherbakov, Pavel Sepiashvili, Ekaterina Setiawan, Ahmad Rudi Shifa Fauziyah Shifa Fauziyah Shifa Fauziyah Shifa Fauziyah Shifa Fauziyah Shuhai Ueda Sin War Naw Sin War Naw Siti Churrotin, Siti Soegeng Soegijanto Sri Pantja Madyawati Sri Pantja Madyawati, Sri Pantja Sri Subekti Sri Sumarsih Suhandarini, Khoirunnisa Sulistiawati Syananda Zahra Fadila Tan, Chin Xuan Tasya Amalia Dwiyanti Tomohiro Kotaki, Tomohiro Tukiran TUKIRAN Ueda, Shuhai Wardhani, Puspa Wiartini, Ni Wayan Ayu Wiartini Wibrianto, Aswandi Widati Fatmaningrum Widya, Alicia Margaretta Widyananda, Muhammad Hermawan Wijayanti, Alvia Rachma Win Darmanto Yanuardi Raharjo, Yanuardi Yovilianda Maulitiva Untoro Yuanita Rachmawati