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All Journal Phi : Jurnal Pendidikan Fisika dan Terapan Indonesian Journal of Pharmaceutical Science and Technology Biology, Medicine, & Natural Product Chemistry Jurnal Ilmiah Teknik Industri Pharmascience Artika Sistem : Jurnal Ilmu-Ilmu Teknik CIRCUIT: Jurnal Ilmiah Pendidikan Teknik Elektro JURNAL PENGABDI SELAPARANG: Jurnal Pengabdian Masyarakat Berkemajuan Jurnal Ilmu Fisika PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JENIUS (Jurnal Ilmiah Manajemen Sumber Daya Manusia) TIN: TERAPAN INFORMATIKA NUSANTARA Atrat: Jurnal Seni Rupa Jurnal Ilmiah Wahana Pendidikan Sasambo Journal of Pharmacy Practice of Fashion and Textile Education Journal J.Pelastek Style : Journal of Fashion Design Jurnal Salingka Abdimas Riset Informasi Kesehatan Sinteza Jurnal Pendidikan Kesehatan (e-Journal) Blantika : Multidisciplinary Journal Jurnal Akademika Kimia Jurnal Sains dan Kesehatan Jurnal Laboratorium Sains Terapan Journal Pharmacy of Tanjungpura JPBD (Jurnal Penelitian Busana dan Desain) Dinamika Kerajinan dan Batik: Majalah Ilmiah Berita Biologi
Hadi Kurniawan, Hadi
Program Studi Teknik Industri Universitas Diponegoro
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POTENTIAL ANTIBACTERIAL ACTIVITY OF Sapindus rarak DC FRUIT AGAINST ESBL (EXTENDED SPECTRUM BETA LACTAMASE) PRODUCING Escherichia coli: IN SILICO AND IN VITRO STUDIES Nugraha, Fajar; Kurniawan, Hadi; IH, Hariyanto; Fajriaty, Inarah; Nurbaeti, Siti Nani
Berita Biologi Vol 24 No 3 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.13496

Abstract

The increasing Antimicrobial Resistance (AMR) drives the need of new antibacteria as drug candidate to eradicate resistant bacteria such as ESBL (Extended Spectrum Beta-Lactamase) producing Escherichia coli. Extract and fraction of Sapindus rarak fruit contains numerous saponin compounds, which exert potential antibacterial effect by binding to the bacterial cell membrane. The purpose of this research is to analyze and evaluate Sapindus rarak fruit extract and fraction antibacterial effects through in silico and in vitro approach. Molecular docking is conducted to identified compounds contained in Sapindus rarak fruit against Penicillin Binding Protein (PDB ID: 6NTZ) using Autodock Tools. Antibacterial testing of Sapindus rarak fruit extract and fraction is also conducted with disc diffusion and microdilution. In silico docking study resulted in potential activity from raraoside A and rarasaponin V, which showed affinity tinggi through their binding energy whilst interacting with the active site of the receptor protein. No inhibition zone was detected on extract and fraction, yet lowest minimum inhibition concentration (MIC) was detected at 2.5×104μg/mL on water and n-hexane fraction Sapindus rarak fruit ethanol extract. This weak antibacterial effect tends to happen to crude extract than to compound isolates. Hence, Sapindus rarak fruit fraction exhibits weak antibacterial effect on ESBL producing E. coli, but certain isolates might be potential to be further researched. Sapindus rarak fruit isolates such as raraoside A and rarasaponin V is potential to solve antimicrobial resistance by acting as a plant based antibiotic.
Analysis of Sodium Content and Estimated Daily Intake from Shellfish Consumption: Case Study in Banda Aceh Ardila, Mutia; Kurniawan, Rizky; Kurniawan, Hadi; Harahap, Muhammad R.
Jurnal Akademika Kimia Vol. 14 No. 3 (2025)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24775185.2025.v14.i3.pp163-168

Abstract

This study aims to analyze sodium (Na) levels and estimate the daily intake (EDI) from the consumption of three shellfish species: blood mussels (Anadara granosa), kepah (Polymesoda erosa), and nipah (Geloina coaxans) obtained from Al Mahira Market and the Alue Naga area in Banda Aceh. Sodium concentrations were determined using Atomic Absorption Spectrophotometry (AAS). The results showed that sodium levels ranged from 1186 to 4656 mg/kg (wet weight). The highest EDI was found in blood mussels from Al Mahira Market at 0.997 mg/kg body weight/day (3.489% of the recommended daily sodium intake). In comparison, the lowest was observed in nipah clams from the exact location at 0.247 mg/kg body weight/day (0.866%). Overall, sodium intake from shellfish in both locations contributed less than 5% of the daily sodium limit. These findings indicate that shellfish consumption poses a low sodium-related health risk, although frequent or high intake may still contribute to long-term hypertension risk.
Pengaruh Motivasi dan Lingkungan Kerja Terhadap Kinerja Karyawan Arianto, Nurmin; Kurniawan, Hadi
Jurnal Ilmiah Sumber Daya Manusia Vol 3 No 3 (2020): JENIUS (Jurnal Ilmiah Manajemen Sumber Daya Manusia)
Publisher : Universitas Pamulang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32493/JJSDM.v3i3.4869

Abstract

Tujuan pada penelitian ini adalah untuk mengetahui pengaruh motivasi dan lingkungan kerja terhadap kinerja karyawan baik secara parsial ataupun simultan.Metode yang digunakan adalah metode deskriptif dengan pendekatan asosiatif. Teknik sampling yang digunakan adalah non probability sampling menggunakan metode teknik sampling jenuh dengan sampel sebanyak 65 responden. Analisis data menggunakan analisis regresi, analisis koefisien korelasi, analisis koefisien determinasi dan uji hipotesis.Hasil penelitian bahwa motivasi dan lingkungan kerja memiliki pengaruh baik secara parsial ataupun simultan, sedangakan dari hasil korelasi maka motivasi dan lingkungan kerja memiliki hubungan yang Sangat Kuat terhadap Kinerja. Kata Kunci : Komunikasi Dan Kinerja Karyawan.
Co-Authors Abbassyyah, Abbassyyah Ade, Putut Afani, Selly Alfisyahrin, Nur Alilatulbariza, Nailah Amalia, rizqika Amelia, Nanda Ananda, Ersa Andang Firmansyah Andriayani Anjani, Ayu Paramitha Anshar, Teuku Apsanita, Wulan Ardila, Mutia Azra, Irfan Yumardi Badaria, Lailatul Dana Kurnia Syabana, Dana Kurnia Dianova, Dahlia Djuniwarti Djuniwarti, Djuniwarti Edwin Mirzachaerulsyah Eka Kartika Untari Erdatama, Fiqry Fajar Nugraha Fajjeri, Zul Fajriaty, Inarah Fauzan Romadlon Fauzi, Masyithah Fauzy, Rizal Nur Fitra, Annis Fortuna, Dhea Geraldin, Shely Jesica Goh, Sri Wahyuni Gunawan, Alvin Hakimulfaiq, Mohammad Aziz Haq, Hutama Abdillah Harahap, Muhammad R. Hari Anna Lastya Hariyanto IH Hasni, Ali Almurtadho Helmi, T. Ahmad Ilham, Nur Arifin Indri Kusharyanti Irhamni Irianti, Putriana Shalum Isnindar Isnindar Izzati, Alvi Julian, The Hezkiel David Karamigi, Iota Rias Karisa, Silvy Kartika, Dharsono Sony Khairunisa, Vera Khoerul Umam, Khoerul Kirom, Ikhwanul Kurniawati, Eka Lubis, Muhammad Taufan Rizka Luliana, Sri Luthfiyyah, Nabila Made Suandika MAHMUDI Masluh, Said Agil Al Maulana, Aditya Indra Mauliza, Nizar Mayesa, Sabila Minto Basuki Mutiadiva, Utin Najini, Robby Nihayaturrofingah, Umi Nuraini, Nabila Nurmainah Nurmainah Nurmin Arianto, Nurmin Nursapni, Salma Olvi, Tea Gilda Dara Mula Pasaman, Ima Kristo Miatus Perkasa, Muhammad Rifki Podo Yuwono Puji Astuti Putri, Syilvi K Rahim, Mutia Ramadhani, Wasiila Ratnasari, Della Rico Saputra Ridho Ananda Rindiawaty, Sri Nenden Rizky Kurniawan Ropiqa, Meri RR. Ella Evrita Hestiandari Safitri, Siti Alya Saharman Gea Saifulloh, Khafiz Salam, Naufal Firdaus Abdus Sianjung, Mayesa Helena Nangdara Siti Aisyah siti hanisah Siti Nani Nurbaeti Sollehudin, Khosim Muhammad Stevia, Tessa Suptya, Irzha Putra Susanto, Amin Sutantio, Erian Suwaryo, Putra Agina Widyaswara Syamsa, Layla Tanu, Yoga The, Michelle Thoyyiba, Azwa Tamara Varera, Reski Agus Venturini, Fernanda Aisya Wibowo, Farras Husna Widianto, Putri Anastacia Willy, Yosefa Winatha, Muhammad Dede Yoga Matin Albar Yuswar, Muhammad Akib Zahriah, Zahriah Zalianti, Alya Zaskia, Nayla