Article Per Year (5 Year)
p-Index From 2021 - 2026
4.177
P-Index
This Author published in this journals
All Journal JURNAL GIZI INDONESIA Jurnal Ilmu Kedokteran (Journal of Medical Science) Majalah Kedokteran Bandung Medical Journal of Indonesia Jurnal Kesehatan Andalas Jurnal Penelitian Sains Jurnal Kesehatan Manarang Jurnal Hilirisasi IPTEKS (JHI) Buletin Ilmiah Nagari Membangun Journal of Midwifery Jurnal Respirologi Indonesia Majalah Kedokteran Andalas International Islamic Medical Journal Narra J Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Riset Ilmiah Jurnal Sains, Teknologi dan Kesehatan
Aisyah Elliyanti
1) Nuclear Medicine Division Of Radiology Department, Faculty Of Medicine, Universitas Andalas, Padang, Indonesia 2) Dr. M. Djamil Hospital, Padang, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

Published : 43 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search
Journal : Narra J

 1 
A comparative analysis between next-generation sequencing and conventional culture method to detect empyema-associated microorganisms: A systematic review Yovi, Indra; Syah, Nur A.; Anggraini, Dewi; Simanjuntak, Arya M.; Hanifah, Zulfa N.; Elliyanti, Aisyah
Narra J Vol. 4 No. 1 (2024): April 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i1.650

Abstract

Empyema poses a significant global health concern, yet identifying responsible bacteria remains elusive. Recent studies question the efficacy of conventional pleural fluid culture in accurately identifying empyema-causing bacteria. The aim of this study was to compare diagnostic capabilities of next-generation sequencing (NGS) with conventional pleural fluid culture in identifying empyema-causing bacteria. Five databases (Google Scholar, Science Direct, Cochrane, Research Gate, and PubMed) were used to search studies comparing conventional pleural fluid culture with NGS for identifying empyema-causing bacteria using keywords. Positive results identified through conventional pleural fluid culture and NGS were extracted. In addition, bacterial profiles identified by NGS were also documented. Joanna-Briggs Institute (JBI) critical appraisal tool was employed to assess quality of included studies. Descriptive analysis was employed to present outcome of interests. From five databases, three studies, with 354 patients, were included. Findings from three studies showed that NGS outperformed conventional pleural fluid culture in detecting empyema-causing bacteria even in culture-negative samples. Moreover, dominant bacterial profiles identified through NGS included Streptococcus pneumoniae, Staphylococcus aureus, and anaerobic bacteria. In conclusion, NGS outperforms conventional pleural fluid culture in detection empyema-causing bacteria, yet further studies with larger samples and broader bacterial profiles are needed to increase confidence and urgency in its adoption over conventional pleural fluid culture.
Transcriptomic analysis of profibrinolytic and fibrinolytic inhibitor genes in COVID-19 patients Febrianti, Ika K.; Putra, Andani E.; Raveinal, Raveinal; Elliyanti, Aisyah
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.843

Abstract

The immunopathogenesis of COVID-19 infection is initiated by the entry of the SARS-CoV-2 virus into the human body through droplets, entering the lungs and binding to the ACE-2 receptor. Activated macrophages stimulate an immune and inflammatory response, leading to the activation of the coagulation cascade, including profibrinolytic and fibrinolytic inhibitor processes. One of the proteins involved in profibrinolytic is encoded by the PLAUR gene, while fibrinolytic inhibitor proteins are encoded by the A2M and SERPINE1 genes. This research aims to assess the transcriptomic analysis of genetic expression data of profibrinolytic genes, fibrinolytic inhibitor genes and their correlation with serum D-dimer levels, which describe the clinical condition of coagulation in COVID-19 patients. This cross-sectional study included 25 patients each for mild and moderate-to-severe COVID-19 at Dr. M. Djamil Padang General Hospital, Padang, Indonesia. Inter-group gene expression comparisons will be analyzed using log2 folds change, and bivariate tests will be analyzed using correlation. The results show that the PLAUR gene has higher expression in moderate-to-severe compared to mild cases. Similarly, the SERPINE1 and A2M genes expressions are higher in moderate-to-severe compared to mild cases. Furthermore, there is a significant correlation between serum D-dimer levels and profibrinolytic factor (PLAUR gene) expression in COVID-19 patients. The correlation between serum D-dimer levels with fibrinolytic inhibitor factor (SERPINE1 and A2M genes) expression was found. These conclude that there is a significant difference in the expression of the profibrinolytic and fibrinolytic inhibitor genes between mild and moderate-to-severe cases in COVID-19, demonstrating COVID-19 infection affects coagulation activities.
Exploring the promising therapeutic benefits of iodine and radioiodine in breast cancer cell lines Elliyanti, Aisyah; Hafizhah, Nurul; Salsabila, Dhianisa; Susilo, Veronica Y.; Setiyowati, Sri; Tofrizal, Alimuddin; Kurniawati, Yulia; Irrahmah, Miftah
Narra J Vol. 4 No. 3 (2024): December 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i3.1078

Abstract

Iodine has an anti-proliferative effect on cancer cells; however, its effects have not been explored adequately. The aim of this study was to evaluate the therapeutic potential of iodine and radioiodine by assessing their effects on the viability of various breast cancer cell lines: MCF7, SKBR3, and MDA-MB231. The viability of cells was measured in treated cells exposed to six doses of iodine (5, 10, 20, 40, 60, 80 µM) and two doses of radioiodine (3.7×104 and 3.7×105 Bq). A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and modified clonogenic assays were used to assess cell viability. Exposure to 80 µM of iodine significantly reduced the viability of all cell types. The cells were then exposed to a 50% inhibitory concentration (IC50) dose. When the cells were exposed to the IC50 dose of iodine, the MCF7 cell viability was reduced by 42.6±0.14% (IC50 dose 12.88 µM), 40.2±0.08% for SKBR3 (IC50 dose 11.03 µM) and 47.0±0.02% for MDA-MB231 (IC50 dose 14.09 µM). All cells were also exposed to 3.7×104 Bq and 3.7×105 Bq radioiodine. Both doses significantly reduced the cell viability of MCF7 and SKBR3 cells compared to the unexposed control cells (all had p<0.05), while MDA-MB231 cell viability only reduced significantly after 3.7×105 Bq of radioiodine exposure compared to the unexposed control cells (p<0.05). This study highlighted that iodine had a toxic effect on breast cancer cells, and radioiodine enhanced the toxicity to breast cancer cells. The types of cancer cells and doses of iodine and radioiodine influenced the effect. These findings suggest that iodine and radioiodine hold promise as therapeutic agents for breast cancer, similar to their established use in thyroid disease treatment. However, further in vivo studies are important to provide more evidence.
Exploring the potential effects of Lactococcus lactis D4 on the proliferation, apoptosis, and inflammatory responses in colorectal cancer cells Rivai, Muhammad I.; Lusikooy, Ronald E.; Putra, Andani E.; Elliyanti, Aisyah; Sukma, Ade
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1596

Abstract

Lactococcus lactis D4 is a probiotic produced through the fermentation of buffalo milk in bamboo, namely "dadih", a traditional food from West Sumatera, Indonesia. To the best of our knowledge, no specific research has investigated the effects of L. lactis D4, derived from dadih extraction, on colorectal cancer or its potential clinical applications. Therefore, the aim of this study was to evaluate the potential of L. lactis D4 from dadih to inhibit colorectal cancer growth in rat models, with a focus on its effects on cell proliferation, apoptosis, and inflammatory responses. An in vivo study was conducted using 37 male Sprague-Dawley rats, allocated into five groups: (1) control (no treatment), (2) dysplasia (induced with 1,2-dimethylhydrazine until dysplasia developed), (3) dysplasia + L. lactis D4 (induced with 1,2-dimethylhydrazine, then treated with L. lactis D4 after dysplasia confirmation), (4) cancer (induced with 1,2-dimethylhydrazine until cancer was confirmed), and (5) cancer + L. lactis D4 (induced with 1,2-dimethylhydrazine until cancer was confirmed, then treated with L. lactis D4 for 15 days). The effects of L. lactis D4 on cancer progression were assessed through immunohistochemical analysis of cell proliferation (cyclin D1, Bcl-2), apoptosis (p53, caspase-3), and inflammation (nuclear factor-κB (NF-κB) and cyclooxygenase-2 (COX-2)). This study found that L. lactis D4 treatment reduced adenocarcinoma and dysplasia severity in colorectal cancer models through significant reduction in cyclin D1, Bcl-2, NF-κB, and COX-2 expression observed across all groups (p<0.01), although changes in dysplasia and cancer subgroups were not statistically significant (p>0.05). No statistically significant change was noted in p53 expression (p=0.518), whereas caspase-3 expression varied significantly across groups (p=0.010). In conclusion, L. lactis D4 reduces the expression of cyclin D1, Bcl-2, NF-κB, and COX-2 proteins, offering insights into its potential to modulating proliferation and inflammation in colorectal cancer growth.
Mortality and associated factors among community-acquired pneumonia patients: A cross-sectional study in a provincial referral hospital in Indonesia Rosdiana, Dani; Siregar, Fajri M.; Ediwi, Nabila C.; Putri, Rahmi T.; Nurrahma, Zuyyina ER.; Elisabet, Adinda; Sarassari, Rosantia; Safari, Dodi; Ilmiawati, Cimi; Elliyanti, Aisyah
Narra J Vol. 5 No. 2 (2025): August 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i2.1649

Abstract

Community-acquired pneumonia (CAP) poses a significant impact on the healthcare system due to rehospitalization and mortality. About one-third of hospitalized CAP patients died within one year. In addition to advanced age, vulnerable groups with comorbidities such as cancer, diabetes, and cerebrovascular disease (CVD) are more likely to suffer from severe CAP. The aim of this study was to investigate the factors linked to mortality in adult hospitalized CAP patients. The study extracted the medical records of patients aged ≥18 years, admitted to a referral hospital in Riau Province, who were diagnosed with CAP between January and December 2023. Multiple logistic regression step-wise analysis was employed to determine the factors associated with mortality in CAP patients. The study involved 334 patients with a median age of 58 years. Based on the confusion, urea, respiratory rate, blood pressure, and age ≥65 years (CURB-65) score, 11.9% of patients had severe CAP (CURB-65 scores 3 and 4). Age was a significant predictor of severe CAP (p≤0.001). The most prevalent comorbidities were malignancy (33.2%), CVD (30.2%), and diabetes (28.4%). Mortality incidence during hospitalization reached 35.9%. Significant factors associated with mortality in hospitalized CAP patients included renal dysfunction/elevated serum urea levels (p=0.031), CURB-65 score (p=0.023), vasopressor use (p≤0.001), mechanical ventilator use (p≤0.01) and steroid use (p=0.029). However, CVD was associated with a decreased risk of mortality (p=0.019). Gram-negative bacteria predominated, accounting for 50.6% of all positive isolates.  Several significant factors were associated with mortality in adult patients hospitalized with CAP at referral Hospital in Riau, including renal dysfunction, CURB-65 score, vasopressor use, mechanical ventilator use, and steroid use. This finding underscored the importance of early identification factors in CAP patients.
Co-Authors Ade Sukma Afriwardi Afriwardi Andani Eka Putra Angriani, Winda Ariani, Novita Arina Widya Murni Arnelis Arnelis Arni Amir Ashal, Taufik Aswiyanti Asri Aziza, Zulva Cimi Ilmiawati, Cimi Daan Khambri Dani Rosdiana Desmawati Desmawati Dewi Anggraini Dewi Anggraini Dia Rofinda, Zelly Dia Dian Pertiwi Dian Pertiwi Ediwi, Nabila C. Elisabet, Adinda Elizabeth Bahar Elmatris Sy Eryati Darwin Esha, Indi Eti Yerizel Faiz Chalidzar Fasril , Thira Febrianti, Ika K. Febrianti, Ika Kurnia Fika Anggraini Fika Anggraini Fitri Wahyu Febriwani Genia, Dara Indah Hafizhah, Nurul Hanifah, Zulfa N. hanifah, zulfa nur Harahap, Sari Hendriati, Hendriati Herlambang Herlambang Husna Yetti Husna, Annisaul Husnil Wardiyah Ibrahim, Raihan Syah Ika Kurnia Febrianti Ilmiati Ilmiati INDRA YOVI Intan, Shinta Ayu Irrahmah, Miftah Iskandar Iskandar Johan S. Masjhur, Johan S. Julizar Julizar Julizar Julizar Julizar Julizar Katrin Monika Lili Irawati Lili Irawati Lusikooy, Ronald E. Mardhatilah, Ashifa Meidrin Joni Miftah Irrahmah Miftah Irrahmah Miftah Irramah Mohamad Reza Monika, Katrin Netti Suharti, Netti Noormartany Nora Harminarti Noza Hilbertina, Noza Nur Afrainin Syah Nurhajjah, Sitti Nurrahma, Zuyyina ER. Putra, Andani E. Putri, Nabila Putri, Rahmi T. Raden Mohamad Herdian Bhakti Rahmad Syawqi Rahmad Syawqi Rahman, Fikri Rahmat Syawqi Rahmat Syawqi Raihan Syah Ibrahim Ramacos Fardela Rasya, Salsabila Faiha Wiendra Rasyada, Latifah Aulia RAVEINAL RAVEINAL Rina Gustia Rivai, Muhammad I. S Setiyowati Sabar Hutabarat Safari, Dodi Safitri, Nuridha Audinia Salsabila, Dhianisa Sarassari, Rosantia Shapira, Vanesya Zahrani Simanjuntak, Arya M. Siregar, Fajri M. Siregar, Muhammad Abi Ghoffari Siti Nurhajjah Sorayya A'dilah Putri Sri Setiyowati Suminta RS, Teresia Susilo, Veronica Y. Syah, Nur A. Syaiful Azmi Syamel, Muhammad Tenny Putri Wikayani, Tenny Putri Tofrizal, Alimuddin Tri Hanggono Achmad Veronica, R. Merlinda VY Susilo Wulandari Wulandari Yose Ramda Ilhami Yose Ramda Ilhsmi Yulia Iriani, Yulia Yulia Kurniawati Yulia Kurniawati Yulistini, Yulistini Yusticia Katar, Yusticia Zelly Dia Rofinda