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All Journal JURNAL PHARMASCIENCE Jurnal Riset Industri Hasil Hutan Jurnal Kesehatan Gigi MPI (Media Pharmaceutica Indonesiana) Vidya Karya Pharmascience Berkala Kedokteran Medical Laboratory Technology Journal Jurnal Surya Medika Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Farmasains : Jurnal Ilmiah Ilmu Kefarmasian JOPS (Journal Of Pharmacy and Science) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat JCPS (Journal of Current Pharmaceutical Sciences) Jurnal Jamu Indonesia JURNAL FARMASIMED (JFM) Jurnal Pengabdian Kepada Masyarakat (Mediteg) An-Nadaa: Jurnal Kesehatan Masyarakat Borneo Journal Of Pharmascientech Jurnal Insan Farmasi Indonesia Tropical Health and Medical Research Journal Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Bakti Untuk Negeri Safari : Jurnal Pengabdian Masyarakat Indonesia Benzena Pharmaceutical Scientific Journal Jurnal Pengabdian Masyarakat Panacea Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Indonesian Journal of Jamu
Muhammad Ikhwan Rizki
Prodi Farmasi FMIPA Universitas Lambung Mangkurat
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Journal : MPI (Media Pharmaceutica Indonesiana)

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Penetapan Kadar Fenolik Total dan Uji Aktivitas Antioksidan Fraksi dari Ekstrak Etanol Daun Cempedak (Artocarpus integer) dengan Metode DPPH Rizki, Muhammad Ikhwan; Sari, Anna Khumaira; Kartika, Dewi; Khairunnisa, Amalia; Normaidah
MPI (Media Pharmaceutica Indonesiana) Vol. 4 No. 2 (2022): DECEMBER
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v4i2.4937

Abstract

Daun cempedak (Artocarpus integer) dimanfaatkan secara tradisional oleh masyarakat Kalimantan Selatan dalam pengobatan. Golongan fenolik terkandung dalam ekstrak daun cempedak dan memiliki kemampuan sebagai antioksidan. Fraksi dari ekstrak daun cempedak belum pernah ditetapkan kadar fenolik total dan akivitas antioksidannya. Penelitian ini bertujuan untuk mengetahui fraksi dari ekstrak daun cempedak yang mengandung kadar fenolik dan aktivitas antioksidan tertinggi. Penelitian dimulai dengan pengeringan daun segar menggunakan lemari pengering, pembuatan serbuk simplisia, proses ekstraksi secara maserasi, pengeringan ekstrak dengan lemari pengering, dan proses fraksinasi dengan pelarut n-heksan, etil asetat dan aquadest. Penetapan kadar fenolik total dapat dilakukan dengan reagen Folin-Ciocalteu dan menggunakan baku pembanding asam galat. Aktivitas antioksidan dilakukan menggunakan metode DPPH berdasarkan nilai IC50 dan dengan pembanding kuersetin. Kadar fenolik total pada fraksi n-heksan 9,352 ± 0,113% b/b, fraksi etil asetat 12,595 ± 0,415% b/b, dan fraksi aquadest 9,992 ± 0,485% b/b ekivalen asam galat. Fraksi n-heksan, etil asetat, dan aquadest masing-masing memiliki nilai IC50 sebesar 89,192 ± 2,91 bpj (kuat), 64,754 ± 2,803 bpj (kuat), dan 82,247 ± 23,034 bpj (kuat). Kesimpulan dari penelitian ini bahwa fraksi etil asetat memiliki kadar fenolik total tertinggi dan aktivitas antioksidan paling kuat dibandingkan fraksi n-heksan dan fraksi aquadest dari ekstrak daun cempedak. Cempedak (Artocarpus integer) leaves are traditionally used by people in South Kalimantan as medicine. The phenolic group contained in cempedak leaf extract has known as an antioxidant. The fraction of cempedak leaf extract has never been determined for total phenolic content and antioxidant activity. This study aimed to determine the fraction of cempedak leaf extract that contains the highest levels of phenolic and antioxidant activity. The study started with drying of fresh leaves using a drying cabinet, simplicia powder preparation, maceration extraction, extract drying, and fractionation with n-hexane, ethyl acetate and aquadest as solvents. Determination of total phenolic content was obtained with Folin-Ciocalteu reagent and gallic acid as a standard for comparison. Antioxidant activity was measured using the DPPH method based on the IC50 value and comparison with quercetin. The total phenolic content of the n-hexane, ethyl acetate and aquadest fraction were 9.352 ± 0.113% w/w, ethyl acetate fraction 12.595 ± 0.415% w/w, and aquadest fraction 9.992 ± 0.485% w/w equivalent gallic acid, respectively. The n-hexane, ethyl acetate, and aquadest fractions showed IC50 values of 89.192 ± 2.91 ppm (strong), 64.754 ± 2.803 ppm (strong), and 82.247 ± 23.034 ppm (strong), respectively. The conclusion of this study was that the ethyl acetate fraction had highest total phenolic content and strongest antioxidant activity compared to n-hexane and aquadest fraction from cempedak leaf extract.
Co-Authors Aghna Mafruha Zahrah, Aghna Mafruha Agung Nugroho Agustina, Ni Kadek Ayu Akbar, Nabila Hadiah Akhmad Nabil Akhmad Nabil, Akhmad Akhsanul Rahmatullah Alfandani, Gina Alifni Adha Bakti Amalia Khairunnisa Amalia Khairunnisa Amalia Khairunnisa, Amalia Amalia Khirunnisa Ana Ulfah Anna Humaira Anna Khumaira Sari Anna Khumaira Sari Aprianto . Arnida Arnida Arnida Arnida Aulea Rahmawati Azhara, Desiya Damayanti Baharuddin Yusuf Baharudin Yusuf Barkinah, Tut Beny Rahmanto Beny Rahmanto Beny Rahmanto Buih, Putri Helena Junjung Devi Eka Pratama Dewi Kartika Dewi Sari Mulia Dewi, Anita Ratna Dewi, Vonny Khresna Difa Intannia Dyah Anggraeni Effendi, Ibrahim Rully Evi Mintowati Evi Mintowati, Evi Evi Mulyani Fadlilaturrahmah Fadlilaturrahmah, Fadlilaturrahmah Fadlillaturahmah Fadlillaturahmah Fajar Lestari Fajar Lestari Fajar Lestari Fariz, Abshar Fauzi, Rakhmat Gina Alfandani Hayatun Izma Helmina Wati Heri Budi Santoso Herningtyas Nautika Lingga Hilneser Simamora Izma, Hayatun Khalifah, Sefa Nur Khoerul Anwar Khoerul Anwar Khoerul Anwar Khumaira Sari, Anna Kirana, Rita Laura Sarwo Liling Triyasmono Lutfi Chabib, Lutfi Madani, Al Malahayati, Siti Maman Turjaman Maman Turjaman Ma’shumah Ma’shumah Metty Amperawati Mia Fitriana Mohammad Rizki Fadhil Pratama Muhammad Rusydi Taufik Mutia Mawaddah Naning Kisworo Utami Naning Kisworo Utami Nashrul Wathan Nazhipah Isnani Normaidah, Normaidah Nugroho, Agung Nur Mahdi Nurlely, Nurlely Okta Muthia Sari Oktavia Indrati, Oktavia Putra, Aditya Maulana Perdana Rabiatul Adawiyah Rahma, Salsabila Fadiya Rahmanto, Beny Rahmatullah, Satrio Wibowo Rahmawati, Aulea Ramadhan, Fery Ramadhani , Syahrizal Ratnapuri, Prima Happy Rorry Adivrio Rizky Salamiah . Salamiah Salamiah Samsul Hadi Sandi, Dita Ayulia Dwi Saragih, Triando Hamonangan Sari , Anna Khumaira Sari, Fitri Novita Sholihin, Muhammad Aditya Silviana, Mega Siswadi Siswadi Sofia Suratno Suratno Surya Wahyudi Susiani, Eka Fitri Susy Andriani Sutomo Sutomo Sutomo Sutomo Syifa Auliani Syifa Auliani Titin Nor Tjitradi, Sukhito Yohanes Totok Wianto Valentina Meta Srikartika Wawan Halwany Wawan Halwany Wawan Halwany Wawan Halwany, Wawan Yuni Kartika