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Ilham Kuncahyo, Ilham
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Journal : Science Midwifery

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Development and optimization of curcumin transfersomes in gel formulations as an antioxidant Mointi, Sella Septiyani; Kuncahyo, Ilham; Harmastuti, Nuraini
Science Midwifery Vol 13 No 4 (2025): October: Health Sciences and related fields
Publisher : Institute of Computer Science (IOCS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35335/midwifery.v13i4.2139

Abstract

Curcumin, a natural compound with potent antioxidant properties, faces challenges in pharmaceutical use due to its poor water solubility and low bioavailability. To overcome these limitations, curcumin was encapsulated in a transfersome drug delivery system and subsequently incorporated into a gel to enhance topical delivery and improve drug release efficiency. This study aimed to evaluate the influence of phospholipid, Tween 80, and cholesterol ratios on the physicochemical properties of curcumin-loaded transfersomes and to assess the antioxidant activity of the optimized transfersome gel. A Simplex Lattice Design (SLD) using Design Expert software generated 14 formulations varying in the three components. Transfersomes were produced via the thin layer hydration method and analyzed for particle size, zeta potential, and entrapment efficiency (%EE). The resulting gel was characterized for pH, viscosity, spreadability, adhesiveness, diffusion behavior using Franz cells, and antioxidant activity through the DPPH assay. Statistical analyses employed ANOVA, Wilcoxon, and T-tests. The optimized formulation containing 700 mg phospholipid, 200 mg Tween 80, and 50 mg cholesterol yielded particles of 134.627 nm, zeta potential –8.924 mV, and 93.656% EE. Antioxidant evaluation showed IC₅₀ values of 24±1.78 ppm (transfersome) and 42±2.5 ppm (gel), both indicating very strong antioxidant activity. The gel released 23.12 µg/cm² curcumin within 150 minutes.
Co-Authors Adam Ferdian Sigit Pratama Alfiana, Ina Ana Indrayati Anisa Devi Kharisma Wibowo Ayuk Armadani , Valentina Chaesti Setyo Hastuti Chatarina Umbul Wahyuni Dewi, Fitri Jaya Santi Utami Dian Marlina Dian Puspitasari Efrilia, Erin ELISABETH APRILIA Endang Diyah Ikasari Endang Dyah Ikasari Ghani Nurfiana Fadma Sari Gunawan, Lucia Sincu Hafizah, Dila Auli Hutami, Shabrina Nindya Ibnu Pratikto Ismi Rahmawati Iswandi Iswandi Kartikasari, Ayu Lifia Nur Kiki Puspitasary Kusumawati, Mulyaningtyas Ayu M Muchalal M. Andi Chandra M. Andi Chandra M. Henityo Agung As'adi Mahayana, Argoto Mamik Ponco Rahayu Mardiyono Mardiyono, . Mointi, Sella Septiyani Muhammad Dzakwan Noval Noval Nur Hidayati Nuraini Harmastuti Octavia Krisma O Opstaria saptarini Prasasti, Anin Pudiastuti RSP Putri, Hana Maylinda Putri, Sukma Oktafiani Rakhmi Hidayati Reslely Harjanti Resmi, Juniar Kalpika Rini Prastiwi Rizqi Fitria Yanuar Roosma Hatmayana Rudhi Pribadi Saifullah, T.N Septiawan Adi Nugroho Sesilia Putri Nandita Setyaningrum, Dewi Anggraheni setyawan, Ferdinta D Siti Aisiyah Siti Aisiyah Soebiyanto, Soebiyanto Sugiyarmasto Sugiyarmasto, Sugiyarmasto Suhartinah Suhartinah, Suhartinah Sukarno Sumardiyono Sumardiyono Sunardi Sunardi Supriyadi Supriyadi Supriyadi Supriyadi Syafira Nabillah Syaiful Choiri T. N. Saifullah Sulaiman T.N. Saifullah Sulaiman T.N. Saifullah Sulaiman Taena, Adriani Teuku Nanda Saifullah Sulaiman Titik Sunarni Titik Sunarni TN Saifullah Sulaiman, TN Saifullah Turdiyanto, Totok Valentina Ayuk Armadani Vivin Nopiyanti Waluyo Budi Atmoko, Waluyo Budi Wijayanti, Ifa Rizki Wiwin Herdwiani Wulandari, RR Sri Yudanti, Gendis Purno Yudi Rinanto Yuliana, Sinta Zahra, Iklila