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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Multidiciplinary Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Edunomika (JIE) BERNAS: Jurnal Pengabdian Kepada Masyarakat Medfarm: Jurnal Farmasi dan Kesehatan Jurnal teknologi Kesehatan Borneo Eureka Herba Indonesia Natural Sciences Engineering and Technology Journal Jurnal EduHealth JOMPA ABDI: Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences. Journal of Economics and Public Health Journal of World Future Medicine, Health and Nursing Journal of Pharmacopoeia Dirya : Journal of Economic Management Sadewa: Jurnal Pengabdian Masyarakat Journal of Pharmacopoeia Indonesian Pharmacopeia Journal (IPJ)
Khrisna Agung Cendekiawan
Universitas Dr Soebandi, Jember, Indonesia
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Exploring the Potential of NIR Spectroscopy and Chemometrics to Verify the Flavonoid Content in Litsea cubeba Cendekiawan, Khrisna Agung; Susanti, Dhina Ayu; Isnawati, Nafisah; Mayasari, Shinta; Riswanto, Florentinus Dika Octa
Majalah Obat Tradisional Vol 30, No 2 (2025)
Publisher : Faculty of Pharmacy, Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/mot.99185

Abstract

The ancient records about herbal medicine show traditional healing practices are deeply rooted in Indonesian culture. The medical use of plants decreased because of inheritance customs combined with the lack of written documentation on medicinal plants but dependent on oral information transmission. Traditional research and preservation activities of local healing plants which belong to specific cultural communities become possible through this phenomenon. Researchers conducted ethnopharmacological research about antidiarrheal medicinal plant uses that included traditional knowledge about flavonoid-containing plants within the Osing ethnic group of West Java Indonesia. The goal of this research was to verify flavonoid compounds in Osing's medicinal plants through Near Infra-Red (NIR) spectroscopy combined with chemometric methods. The evaluation of antidiarrheal potential for these compounds relied on flavonoid standard reference substances because these compounds demonstrate strong antioxidant properties which stabilize intestinal functioning. Chemometric techniques together with Near Infra-Red spectroscopy (NIR) were applied to analyze krangean leaves (Litsea cubeba) in order to establish their flavonoid compound levels. The quality assessment of multivariate calibration models shows that PLS regression produces RMSEC of 2.870 and RMSEP of 0.0124 with R2cal = 0.9931 and R2val = 0.9919. The analysis using linear discriminant analysis (LDA) succeeded in its completion with recognition rates above 90% for each discriminating class.
Potential Secondary Metabolites in Guava (Psidium guajava) Assisted by Radar Chart Analysis (RCA) and Area Under Curve (AUC) Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci
MAGNA MEDIKA Berkala Ilmiah Kedokteran dan Kesehatan Vol 12, No 2 (2025): AUGUST
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/magnamed.12.2.2025.196-207

Abstract

Background:  Diarrhea is a common health problem worldwide, with causes ranging from microbial infections to gastrointestinal disorders. Conventional diarrhea treatments usually involve synthetic drugs, but medicinal plant-based therapies, such as those containing secondary metabolite compounds in guava leaves, show promising potential. In this systematic review, we aimed to identify potential metabolite compounds.Objective: In this systematic review, we aim to identify potential secondary metabolite compounds in medicinal plants with antidiarrheal effects and explore the biological mechanisms of action involved.Methods: Using a literature review, relevant articles were analyzed from reputable scientific databases.Results: The results of the review indicate that compounds such as flavonoids, polyphenols, tannins, and saponins in guava leaves possess antidiarrheal potential, contributing to the regulation of intestinal motility, inhibition of inflammation, and alteration of the gut microbiota composition.Conclusion: The results of this study indicate that medicinal plants and their secondary metabolites can be a promising alternative for safer and more efficient antidiarrheal therapy.
The effect of using antihypertensive drugs in hypertensive patients with kidney failure in hospital outpatients, Jember regency Savania Alifianty Hafzah, Savania; Mayasari, Shinta; Khrisna Agung Cendekiawan
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

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Abstract

Hypertension was a condition where systolic blood pressure was more than equal to 140 mmHg and diastolic was more than equal to 90 mmHg after two separate measurements and was one of the main risk factors for kidney failure because it can cause damage to blood vessels in the kidneys so that reduces the ability of the kidneys to filter blood properly. Hypertension was a disease with a high incidence rate worldwide and was a cause of death, around 1.13 billion people in the world have hypertension and its complications, therefore the aim of this study was to determine the effect of using antihypertensive drugs in hypertensive patients with kidney failure in hospital outpatients, jember regency. In a study using a cross-sectional design, the population in this study were all hypertensive patients with kidney failure who were outpatients in hospital outpatients, jember regency in the period December 2022-March 2023. The number of samples used probability sampling with the proportionate stratified random sampling technique as many as 100 patients in hospital outpatients, jember regency. The results of this study indicate that there was an effect of using antihypertensive drugs in hypertensive patients with kidney failure. Based on the output of "Test Stalistics", it is known that Alsymp.Sig. (2-tailed) has a value of 0.002. The calrenal value is 0.002 less than <0.05, malkal was concluded as "Hypothesis accepted". Alrtinyal aldal antihypertensive drug use paldal hypertensive patients with renal failure in hospital outpatients, jember regency. The blood pressure before the use of antihypertensive paldal antihypertensive medication with renal failure, that was, paldal paldal hypertension with gallstone saltu, while the blood pressure after the use of antihypertensive paldal pallid hypertensive patients with renal failure decreases in dual staging hypertension. From a statistical analysis using the Wilcoxon Maltch Palirs Test, it was discovered that Halsil might actually have an effect on the use of antihypertensive drugs in hypertensive patients with kidney failure in hospital outpatients, jember regency.
Changes in blood pressure in hypertension patients with kidney failure on drug valsartan administration in hospital Diana Kholifah; Mayasari, Shinta; Khrisna Agung Cendekiawan
Jurnal EduHealth Vol. 15 No. 01 (2024): Jurnal eduHealt, Edition January - March, 2024
Publisher : Sean Institute

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Abstract

Hypertension an increase in blood pressure, including systolic and diastolic blood pressure into two types, namely essential hypertension, the most common being essential and secondary hypertension. The prevalence of hypertension in Indonesia using measurement methods in samples aged ≥18 years 34.1%, while the prevalence of hypertension cases in East Java province 36.3%. In pharmacological therapy the administration of drugs includes thiazide diuretics, adrenergic blockers, Angiotensin Converting Enzyme Inhibitors (ACE-inhibitors), angiotensin - II - blockers, in non-pharmacological therapy, namely changes in diet and lifestyle by consuming balanced foods according to needs, avoiding saturated fat, maintaining body weight, limiting salt consumption, the aim of knowing changes in blood pressure in hypertensive patients with kidney failure when administering the drug valsartan at Hospital Citra Husada. This research used a numerical comparative analytical research type with a retrospective design, the research was conducted in March, April 2023 at Citra Husada Hospital, the source of research data was from medical records. The sample obtained was 32 hypertensive patients with kidney failure who met the inclusion criteria, namely all genders aged 18 years and over, and outpatients at Hospital on a single drug (valsartan). Sampling used a total sampling technique, using Wilcoxon test data analysis to analyze changes in blood pressure. The average value of systolic blood pressure before administering the drug valsartan was 165.87 mmHg with a standard deviation of 27.06. The average systolic value after administering the drug valsartan was 151.15 mmHg with a standard deviation of 26.06, with a difference value of 14.72 mmHg. The average value of diastolic blood pressure before administering the drug valsartan was found to be 92.81 mmHg with a standard deviation of 20.16. The average diastolic value after administering the drug valsartan was found to be 81.09 mmHg with a standard deviation of 18.8, with a difference value of 11.72 mmHg. Conclusion: There are marked changes in blood pressure after administering the drug valsartan, valsartan can be recommended as an antihypertensive with kidney failure according to the inclusion criteria in the study.
PENGARUH KEPUASAN KERJA, LINGKUNGAN KERJA DAN BEBAN KERJA TERHADAP KINERJA KARYAWAN Islami, Nurul Ariffaeni; Suryanti, Rensi; Cendekiawan, Khrisna Agung; Ardianto, Riski Eko; Tawil, Muhamad Risal
JURNAL ILMIAH EDUNOMIKA Vol. 8 No. 2 (2024): EDUNOMIKA
Publisher : ITB AAS Indonesia Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29040/jie.v8i2.13068

Abstract

Abstrak Dalam suatu instansi kinerja karyawan menentukan dalam keberhasilan instansi tersebut. Kinerja dapat diartikan sebagai hasil kerja yang dicapai seseorang dalam melaksanakan tugastugas yang diberikan untuk mencapai target kerja. Kinerja merupakan hasil kerja secara kualitas dan kualitas yang dicapai oleh seorang karyawan dalam melaksanakan tugasnya sesuai dengan tanggung jawab yang diberikan kepadanya. Penelitian ini bertujuan untuk mengetahui pengaruh kepuasan kerja, lingkungan kerja dan beban kerja berpengaruh terhadap kinerja karyawan. Tehnik pengumpulan data yang digunakan melibatkan pengiriman kuesioner yang telah menerima sekitar 165 tanggapan responden. Populasi dan sampel dalam penelitian ini adalah karyawan kantoran yang tersebar di Indonesia, dan metode analisisnya menggunakan software SPSS. Hasil penelitian telah menemukan bahwa kepuasan kerja, lingkungan kerja dan bahwa beban kerja berpengaruh terhadap kinerja karyawan. Kata Kunci: Kepuasan Kerja, Lingkungan Kerja Dan Beban Kerja, Kinerja Karyawan
An Studi Kepuasan Pengguna Layanan Farmasi di Klinik Kesehatan X di Jember Isnawati, Nafisah; Nuraini , April; Sholeh, Ayu Angger Putri M.; Cendekiawan, Khrisna Agung; Khairomatul L , Atmanita
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1142

Abstract

User satisfaction with pharmaceutical services in healthcare facilities is a critical indicator of service quality and plays an essential role in improving the overall healthcare experience. High satisfaction levels reflect the appropriateness, efficiency, and responsiveness of pharmacy services. This study aimed to evaluate the level of satisfaction among users of pharmaceutical services at the Pharmacy Installation of Clinic X in Jember. This study employed a prospective observational design conducted in August 2025. The study population consisted of outpatients receiving pharmaceutical services, and the sample included patients who met the inclusion criteria and agreed to participate. A total of 160 respondents were selected using consecutive sampling, a non-probability sampling technique. Data were collected using a structured questionnaire and tables documenting respondent characteristics and patient satisfaction outcomes. Satisfaction was assessed across five dimensions of pharmaceutical service quality: reliability, responsiveness, empathy, tangibles, and assurance. Descriptive analysis was used to summarize respondent characteristics and satisfaction scores. Of the 160 respondents, the majority were female (71.25%) and within the age group of 25–44 years (53.75%). Most respondents had a senior high school education or equivalent (50.00%), were self-employed (64.38%), and had visited the clinic twice (38.75%). Satisfaction scores across service dimensions were as follows: reliability 97.1%, responsiveness 65.5%, empathy 68.1%, tangibles 82.1%, and assurance 66.7%. The overall Customer Satisfaction Index (IKM) was 82.2%, categorizing the service quality as good. The results indicate that users were generally satisfied with the pharmaceutical services provided at Clinic X. The high score in the reliability dimension suggests consistent service performance and accuracy. However, the lower scores in responsiveness, assurance, and empathy highlight areas requiring improvement, particularly regarding timely service delivery, confidence-inspiring interactions, and patient-centered communication. Although the overall satisfaction level was good, targeted improvements in these dimensions are essential for enhancing the overall quality of pharmaceutical care. Overall, the level of user satisfaction with pharmaceutical services at Clinic X was categorized as good, with an IKM score of 82.2%. All five dimensions of service quality were rated positively, although responsiveness, assurance, and empathy showed room for improvement. These results highlight the importance of strengthening service quality components beyond technical accuracy to ensure a more holistic and patient-centered pharmaceutical care experience.
Ethnopharmacology, LC-MS profiling, and molecular docking of diarrheal-healing plants by the Osing tribe Cendekiawan, Khrisna Agung; Kintoko; Yuliani, Sapto; Wardhani, Firdha Aprillia
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.31315

Abstract

Indonesia has a long history of using medicinal plants, but much of this knowledge, especially among groups like the Osing people in East Java, is not well-documented. This study looks at the plants used by the Osing community to treat diarrhea. This research was conducted through interviews with residents of Banjar and Licin Villages in Banyuwangi Regency. The significance and perceived efficacy of each medicinal plant were evaluated using the ethnobotanical indices Use Value (UV) and Fidelity Level (FL). They also did tests to find the active chemicals in the plants. The most common plants for treating diarrhea were Psidium guajava (UV = 2.44) and Piper betle (UV = 1.11). Psidium guajava had the highest FL value (64.7%). Tests have shown that these plants contain essential chemicals. Further analysis confirmed the presence of quercetin and kaempferol, which are known to help alleviate stomach problems. To support these findings, computer-based tests were done, including Lipinski rule prediction, ADMET profiling, and molecular docking. The results showed quercetin binds well (ΔG = -9.72) and has a good RMSD value (1.83 Å). This suggests quercetin could be a good starting point for making antidiarrheal drugs. Overall, the study underscores the significance of traditional knowledge and recommends further research on plant-based treatments for stomach issues.
Antidiarrhoeal Potential of Secondary Metabolites in Betel Leaf (Piper betle): A Systematic Review with Radar Chart Analysis and AUC Evaluation. Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Wardhani, Firdha Aprillia; Poerwahyuningrum, Neny
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.594

Abstract

Diarrhoea is a widespread gastrointestinal disorder commonly caused by microbial infection, inflammation, or impaired intestinal function. While synthetic antidiarrhoeal drugs are available, their use is often limited by adverse effects and antimicrobial resistance, prompting increasing interest in medicinal plants such as Piper betle (betel leaf). This study systematically reviewed the literature to identify secondary metabolite compounds in Piper betle with antidiarrhoeal potential and to evaluate their biological activities using Radar Chart Analysis (RCA) and Area Under Curve (AUC) methods. A systematic search was performed across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords. Inclusion criteria comprised studies that investigated Piper betle or its secondary metabolites, reported antidiarrhoeal or related bioactivity, and provided quantitative data suitable for comparison. Studies were excluded if they focused solely on synthetic drugs, were not available in full text, or did not report measurable metabolite data. A total of 35 eligible studies were included after screening 176 records. The findings indicate that flavonoids, polyphenols, tannins, saponins, and catechins in Piper betle contribute to antidiarrhoeal effects through mechanisms that modulate intestinal motility, reduce fluid secretion, activate anti-inflammatory pathways, and exhibit antimicrobial activity. RCA and AUC analyses further demonstrated substantial variability in metabolite composition and antioxidant capacity across studies. Overall, Piper betle exhibits promising therapeutic potential as a natural antidiarrhoeal agent, although further mechanistic and clinical research is warranted.
In Silico Study of Compounds Bioactive Guava (Psidium guajava) as Antidiarrheal Assisted Liquid Chromatography-Mass Spectroscopy Cendekiawan, Khrisna Agung; Kintoko, Kintoko; Yuliani, Sapto; Anggraeni, Linda Suci; Ningrum, Lailatul Fitria; Hasana, Siti Nur; Wardhani, Firdha Aprillia
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.876

Abstract

Guava leaves seeds (Psidium guajava) are known contain various compound potential bioactives? as antidiarrheal, such as quercetin and tannins, which work with method hinder intestinal contractions and disrupts permeability membrane cell bacteria. Research This aim for explore potential antidiarrheal from compound in leaf guava seed through identification compound using LC-MS and simulation molecular docking to six human protein target receptors, namely Cytochrome P450 1A1, Ephrin Type-B Receptor 4, Multidrug Resistance Protein 1, Dihydrofolate Reductase, Extracellular Calcium-Sensing Receptor, and Rap Guanine Nucleotide Exchange Factor 4. Extraction done with method maceration use solvent methanol, then compound analyzed using Liquid Chromatography–Mass Spectrometry (LC-MS). A total of eleven compound main chosen foranalyzed in silico using device soft AutoDockTools, PyRx, and Discovery Studio. Validation was performed through redocking of native ligands with RMSD value ? 2 Å. The results show some ligands such as Kaempferol, Cathecin, and Quercetin own affinity strong bond, with? Kaempferol show lowest binding energy of -9.72 kcal /mol against BHF receptor. Drug-likeness test based on Lipinski's rule also shows that part big compound fullfil criteria compound drug analysis? interaction amino acids show existence bond hydrogen and hydrophobic support? stability bond. This result show that compound leaf guava seeds, especially Kaempferol and Cathecin, potentially as candidate agent antidiarrheal natural. Further studies in vitro and in vivo are recommended for support findings.
Pharmacological Effects of Curcumin in Chronic Inflammatory Therapy Muntasir Muntasir; Anggia Faradina; Tutik Wuryandari; Khrisna Agung Cendekiawan
Journal of Pharmacopoeia Vol. 2 No. 1 (2025): MARCH-JP
Publisher : Pt. Anagata Sembagi Education

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62872/r1y2wm33

Abstract

Herbal plants Herbal plants in Indonesia have an important role in traditional medicine and public health. The study aims to evaluate the effectiveness and mechanism of action of curcumin in chronic inflammatory therapy. This study employs the Systematic Literature Review (SLR) methodology.. This study uses a database from Scopus of 9 Scopus articles from the range of 2020 to 2025. There are three stages carried out in mapping the effectiveness and mechanism of action of curcumin in chronic inflammatory therapy, namely data harvesting, screening data and Data Analysis and Visualization. The results obtained are that curcumin is effective in chronic inflammatory therapy by inhibiting the main inflammatory pathways (NF-ƙB and JAK/STAT), has antioxidant effects, accelerates tissue regeneration, and functions as an immunomodulator. However, the limited bioavailability of curcumin presents a significant challenge in its application. Nanoformulation technology and its combination with compounds like CMPs can enhance its effectiveness in clinical therapy.The implications of this research are directed to researchers, the community and the government
Co-Authors Agus Mukholid Alfiansyah, Andika Aliyah Purwanti Amalia Wardatul Firdaus Ancah Caesarina Novi Marchianti Andika Alfiansyah Anggia Faradina Anggraeni, Linda Suci Anggraeni, Lutvi Anggraeni, Lutvi Anggraeni Ardianto, Riski Eko Arnes Yuli Vandika Avrillana Dewangi Gea Ayunda Diarso Bambang Kuswandi Dhina Ayu Susanti Diah Yuli Pangesti Diana Kholifah Dina Trianggaluh Fauziah Dyan Wigati Elisa wardatul awaliya Fadli Fadli Fadli Fadli Fadli Fadli Faradina, Anggia Fitria Hariati Florentinus Dika Octa Riswanto Hariati , Fitria Hasana, Siti Nur Heru Sulistijono Iski Weni Pebriarti Islami, Nurul Ariffaeni Khairomatul L , Atmanita Kintoko Kintoko Kintoko Lia Fitriyaningrum Linda Suci Anggraeni lindawati setyaningrum Lutvi Anggraeni M. Rofik Usman Minarti Minarti Muhamad Risal Tawil Muntasir Muntasir Muntasir, Muntasir Nafisah Isnawati nafisah isnawati Nia Kristiningrum Ningrum, Lailatul Fitria Nuraini , April Nurul Ariffaeni Islami Pangesti, Yuli Poerwahyuningrum, Neny Putra, Dewa Ngakan Gde Wahyu Mahatma Rasmita, Dina Rensi Suryanti Rina Fitriana Riski Eko Ardianto Runtu, Andro Ruben Sapto Yuliani Sapto Yuliani Savania Alifianty Hafzah, Savania Setyorini, Dhiana Shinta Mayasari Shinta Mayasari Sholeh, Ayu Angger Putri M. Sholihatil Hidayati Sugeng Winarso Sugiah Sugiah Sugiah, Sugiah Suryanti, Rensi Susanti, Dhina Ayu Tutik Wuryandari Wardhani, Firdha Aprillia Wulandari, Hilwiyah Septi Wuryandari, Tutik Zani, Benny Novico Zulkarnain Permana