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All Journal e-Journal Pustaka Kesehatan Pharmaciana: Jurnal Kefarmasian Majalah Obat Tradisional Multidiciplinary Journal MAGNA MEDICA: Berkala Ilmiah Kedokteran dan Kesehatan Jurnal Mandala Pharmacon Indonesia Jurnal Farmamedika (Pharmamedica Journal) Jurnal Ilmiah Edunomika (JIE) Jurnal Ilmiah Farmako Bahari BERNAS: Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Pamenang (JIP) Medfarm: Jurnal Farmasi dan Kesehatan Eureka Herba Indonesia Natural Sciences Engineering and Technology Journal Jurnal Pengabdian Masyarakat Madani Jurnal EduHealth INDRA: Jurnal Pengabdian kepada Masyarakat Jurnal Pengabdian Masyarakat Bidang Sains dan Teknologi JOMPA ABDI: Jurnal Pengabdian Masyarakat Journal of Pharmaceutical and Sciences. Journal of Economics and Public Health Jurnal Kesehatan dr. Soebandi Journal of Pharmacopoeia Dirya : Journal of Economic Management Sadewa: Jurnal Pengabdian Masyarakat Journal of Pharmacopoeia Indonesian Pharmacopeia Journal (IPJ) Halal Science Jurnal Farmasi Islam Kalimantan Jurnal teknologi Kesehatan Borneo Biodiversitas Journal of Biological Diversity Journal of World Future Medicine, Health and Nursing
Khrisna Agung Cendekiawan
Bachelor’s Degree Program In Pharmacy, Faculty Of Health Sciences., Universitas Dr. Soebandi, Indonesia
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Antibacterial Activity of Endophytic Fungi Isolated from Betel Leaf (Piper betle) Against Pseudomonas aeruginosa and Staphylococcus aureus Kintoko Kintoko; Khrisna Agung Cendekiawan; Sapto Yuliani; Siti Nur Hasana; Firdha Aprilia Wardhani
Jurnal Ilmiah Farmako Bahari Vol 17 No 2 (2026): Jurnal Ilmiah Farmako Bahari
Publisher : Faculty of Mathematic and Natural Science, Garut University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jifb.v17i2.43506

Abstract

Betel leaf (Piper betle) contains antibacterial compounds such as flavonoids, saponins, and alkaloids. Endophytic fungi within plant tissues can produce similar bioactive metabolites. This study aimed to isolate, identify, and evaluate the antibacterial activity of endophytic fungi from young betel leaves against Pseudomonas aeruginosa and Staphylococcus aureus. This was experimental research. Endophytic fungi were isolated from young betel leaves on Potato Dextrose Agar (PDA) and identified macroscopically and microscopically. Antibacterial activity was tested using the paper disk agar diffusion method. Three endophytic fungal isolates were obtained: Isolate 1 (Trichoderma sp.), Isolate 2 (Rhizoctonia sp.), and Isolate 3 (Fusarium sp.). Against P. aeruginosa, Isolate 2 produced an average inhibition zone of 7.33 mm, and Isolate 3 produced 8.00 mm. Against S. aureus, Isolate 1 produced 7.33 mm and Isolate 3 produced 7.33 mm. No inhibition was observed for the negative control (DMSO). Endophytic fungi from betel leaves, particularly isolates resembling Rhizoctonia sp., Fusarium sp., and Trichoderma sp., show weak to moderate antibacterial activity against P. aeruginosa and S. aureus under the tested conditions. Further studies using molecular identification and purified extracts are recommended.
Ethnopharmacology and scientific validation of antidiarrheal plants used by the Osing Tribe in Banyuwangi, Indonesia KHRISNA AGUNG CENDEKIAWAN; KINTOKO KINTOKO; SAPTO YULIANI; FIRDHA APRILLIA WARDHANI
Biodiversitas Journal of Biological Diversity Vol. 27 No. 2 (2026)
Publisher : Society for Indonesian Biodiversity

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/biodiv/d270229

Abstract

Abstract. Cendekiawan KA, Kintoko, Yuliani S, Wardhani FA. 2026. Ethnopharmacology and scientific validation of antidiarrheal plants used by the Osing Tribe in Banyuwangi, Indonesia. Biodiversitas 27 (2): d270229. https://doi.org/10.13057/biodiv/d270229. Indonesia has a rich heritage of medicinal plant use; however, much of this traditional knowledge, especially among indigenous communities such as the Osing people in East Java, remains undocumented. This study aimed to explore the antidiarrheal plants used by the Osing community through an ethnopharmacological survey and scientific validation. Data were collected through structured interviews with local informants in Banjar and Licin Villages, Licin Sub-district, and Banyuwangi District. Use value (UV) and fidelity level (FL) indices were calculated to assess the cultural significance and therapeutic relevance of each species. Phytochemical screening and liquid chromatography-mass spectrometry (LC-MS) were conducted to identify bioactive compounds. The most frequently reported species were Psidium guajava (UV = 2.44; FL = 64.7%) and Piper betle (UV = 1.11). LC-MS analysis confirmed the presence of major secondary metabolites, including quercetin and kaempferol, which are known for their pharmacological activity in the treatment of gastrointestinal disorders. Scientific validation in this study also incorporated in silico approaches, including Lipinski’s Rule of five evaluation to assess drug-likeness, ADMET profiling to predict pharmacokinetic and toxicity parameters, and molecular docking to explore the binding interactions of identified phytoconstituents with antidiarrheal target proteins. Quercetin demonstrated strong binding affinity (ΔG = -9.72) and an acceptable RMSD value (1.83 Å). A TPC value of 0.2357 was obtained from a mixture containing 0.84 g of P. guajava and 0.18 g of P. betle. The antioxidant activity, measured as IC50, was 7.51 µg/mL. These findings suggest that quercetin holds strong potential as a lead compound for antidiarrheal drug development. Overall, this study highlights the scientific value of traditional knowledge and encourages further investigation into plant-based treatments for gastrointestinal disorders.
Antidiarrhoeal Potential of Secondary Metabolites in Betel Leaf (Piper betle): A Systematic Review with Radar Chart Analysis and AUC Evaluation. Khrisna Agung Cendekiawan; Kintoko Kintoko; Sapto Yuliani; Linda Suci Anggraeni; Firdha Aprillia Wardhani; Neny Poerwahyuningrum
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 2 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i2.594

Abstract

Diarrhoea is a widespread gastrointestinal disorder commonly caused by microbial infection, inflammation, or impaired intestinal function. While synthetic antidiarrhoeal drugs are available, their use is often limited by adverse effects and antimicrobial resistance, prompting increasing interest in medicinal plants such as Piper betle (betel leaf). This study systematically reviewed the literature to identify secondary metabolite compounds in Piper betle with antidiarrhoeal potential and to evaluate their biological activities using Radar Chart Analysis (RCA) and Area Under Curve (AUC) methods. A systematic search was performed across PubMed, Scopus, Web of Science, and Google Scholar using predefined keywords. Inclusion criteria comprised studies that investigated Piper betle or its secondary metabolites, reported antidiarrhoeal or related bioactivity, and provided quantitative data suitable for comparison. Studies were excluded if they focused solely on synthetic drugs, were not available in full text, or did not report measurable metabolite data. A total of 35 eligible studies were included after screening 176 records. The findings indicate that flavonoids, polyphenols, tannins, saponins, and catechins in Piper betle contribute to antidiarrhoeal effects through mechanisms that modulate intestinal motility, reduce fluid secretion, activate anti-inflammatory pathways, and exhibit antimicrobial activity. RCA and AUC analyses further demonstrated substantial variability in metabolite composition and antioxidant capacity across studies. Overall, Piper betle exhibits promising therapeutic potential as a natural antidiarrhoeal agent, although further mechanistic and clinical research is warranted.
Mycotoxicological Profiling and Chromatographic Characterization of Retail Spices: A Mechanistic Evaluation of Microclimatic Packaging Dynamics on Aflatoxin Biosynthesis in Tropical Environments Khrisna Agung Cendekiawan; Linda Suci Anggraeni; Firdha Aprillia Wardhani; Rina Fitriana
Natural Sciences Engineering and Technology Journal Vol. 6 No. 1 (2026): Natural Sciences Engineering and Technology Journal
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/nasetjournal.v6i1.75

Abstract

Spices produced in equatorial tropical climates are highly susceptible to mycotoxin contamination. Aflatoxin, a carcinogenic secondary metabolite synthesized by Aspergillus flavus and Aspergillus parasiticus, poses a severe global public health threat by inducing hepatotoxicity and transversion mutations. This study investigates the prevalence of toxigenic fungi and quantifies aflatoxin analogues in retail culinary spices across varying microclimatic environments. An observational surveillance study was conducted using purposive sampling of onion, turmeric, and pepper matrices from traditional markets and modern supermarkets. Fungal characterization utilized Potato Dextrose Agar and Nash-Snyder media. Precise quantification of Aflatoxins B1, B2, G1, and G2 was executed via high-performance liquid chromatography coupled with fluorescence detection (HPLC-FLD) and post-column derivatization. Mycological isolation confirmed pervasive colonization by Aspergillus flavus, A. niger, Penicillium spp., and Fusarium oxysporum. Method validation yielded excellent recovery (greater than 85%) and precision. Supermarket-sourced pepper (Sample C4) exhibited catastrophic hyper-contamination, with Aflatoxin B1 at 45.35 ppb and total aflatoxins at 99.35 ppb. Turmeric demonstrated intrinsic resistance, with maximum Aflatoxin B1 at 1.41 ppb. Non-parametric Spearman rank analysis revealed a significant positive correlation between trapped packaging micro-humidity and aflatoxin synthesis. In conclusion, modern non-vacuum packaging methodologies drastically elevate trapped micro-humidity, heavily driving the logarithmic growth and toxicological output of Aspergillus. Strict regulatory enforcement of storage humidity and water activity monitoring is urgently required in commercial retail sectors.
Application of Voice Recognition Technology for Early Detection of Respiratory Disorders in Premature Babies Dhiana Setyorini; Benny Novico Zani; Dina Rasmita; Khrisna Agung Cendekiawan; Arnes Yuli Vandika
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 2 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i2.758

Abstract

Bayi prematur memiliki risiko tinggi mengalami gangguan pernafasan yang berpotensi mengancam nyawa yang dapat berujung pada komplikasi atau permasalahan yang serius atau bahkan kematian jika tidak dideteksi secara tepat waktu. Untuk itu diterapkanlah sebuah teknologi pengenalan suara dagar dapat mengidentifikasi gangguan pernapsan yang terjadi pada bayi premature. Tujuan dari penelitian ini adalah untuk mengembangkan sistem yang dapat mengenali pola suara khas yang terkait dengan gangguan pernafasan pada bayi prematur. Dengan memanfaatkan teknologi ini, diharapkan dapat meningkatkan kemampuan deteksi dini gangguan pernafasan pada bayi prematur, sehingga memungkinkan intervensi medis yang lebih cepat dan tepat. Metode penelitian melibatkan pengumpulan data suara respirasi dari bayi prematur menggunakan mikrofon yang dipasang di sekitar inkubator mereka, diikuti oleh analisis menggunakan teknik pengolahan sinyal digital dan algoritma pembelajaran mesin. Hasil penelitian menunjukkan bahwa sistem yang dikembangkan mampu mengidentifikasi pola suara yang menunjukkan tanda-tanda gangguan pernafasan dengan tingkat akurasi yang tinggi yang di alami oleh bayi permatur. Hal ini didukung oleh data validasi yang menunjukkan bahwa sistem berhasil mendeteksi sebagian besar kasus gangguan pernafasan pada bayi permatur.Kesimpulan dari penelitian ini adalah bahwa teknologi pengenalan suara memiliki potensi besar sebagai alat deteksi dini gangguan pernafasan pada bayi prematur, yang dapat membantu tenaga medis dalam memberikan perawatan yang tepat waktu dan mengurangi risiko komplikasi serius. Dengan demikian, penerapan teknologi ini di lingkungan klinis dapat meningkatkan prognosis dan kelangsungan hidup bayi prematur yang rentan.
The Effect of Structured Physical Exercise on the Quality of Life of Patients with Multiple Sclerosis Minarti Minarti; Heru Sulistijono; Agus Mukholid; Khrisna Agung Cendekiawan; Andro Ruben Runtu
Journal of World Future Medicine, Health and Nursing Vol. 2 No. 2 (2024)
Publisher : Yayasan Adra Karima Hubbi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.70177/health.v2i2.759

Abstract

neurologis kronis yang seringkali menimbulkan penurunan fungsi fisik dan psikologis. Multiple Sclerosis (MS) adalah penyakit autoimun yang memengaruhi sistem saraf pusat, sering menyebabkan penurunan fungsi fisik dan psikologis. Gejala seperti kelemahan otot, kelelahan, dan gangguan kognitif dapat mengganggu aktivitas sehari-hari dan kualitas hidup pasien secara signifikan. Tujuan penelitian ini adalah untuk mengevaluasi apakah latihan fisik terstruktur dapat memperbaiki QoL pada pasien dengan MS. Metode penelitian yang digunakan adalah sebuah studi klinis acak terkontrol. Sejumlah pasien dengan Multiple Sclerosis dibagi secara acak menjadi dua kelompok: kelompok intervensi yang menjalani program latihan fisik terstruktur dan kelompok kontrol yang tidak menjalani program tersebut. Intervensi dilakukan dengan mengawasi dan menyesuaikan latihan fisik sesuai dengan kebutuhan individu pasien, dengan fokus pada peningkatan kekuatan, keseimbangan, dan mobilitas. Hasil penelitian menunjukkan bahwa pasien yang menjalani latihan fisik terstruktur mengalami peningkatan dalam QoL mereka dibandingkan dengan kelompok kontrol. Para peserta menunjukkan peningkatan dalam aspek-aspek seperti kemandirian, mobilitas, kualitas tidur, dan kesejahteraan psikologis. Selain itu, mereka melaporkan pengurangan dalam gejala kelelahan dan depresi. Kesimpulan dari penelitian ini yaitu latihan fisik terstruktur memiliki dampak positif pada QoL pasien dengan Multiple Sclerosis. Intervensi ini tidak hanya meningkatkan fungsi fisik, tetapi juga memberikan manfaat psikologis yang signifikan, meningkatkan rasa percaya diri dan kesejahteraan emosional. Implikasi dari temuan ini adalah pentingnya memasukkan latihan fisik terstruktur sebagai bagian integral dari manajemen MS, membantu pasien untuk mengelola gejala mereka secara efektif dan meningkatkan kualitas hidup mereka secara keseluruhan.
An Studi Kepuasan Pengguna Layanan Farmasi di Klinik Kesehatan X di Jember Nafisah Isnawati; April Nuraini; Ayu Angger Putri M. Sholeh; Khrisna Agung Cendekiawan; Atmanita Khairomatul L
Journal of Pharmaceutical and Sciences JPS Volume 8 Nomor 4 (2025)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v8i4.1142

Abstract

User satisfaction with pharmaceutical services in healthcare facilities is a critical indicator of service quality and plays an essential role in improving the overall healthcare experience. High satisfaction levels reflect the appropriateness, efficiency, and responsiveness of pharmacy services. This study aimed to evaluate the level of satisfaction among users of pharmaceutical services at the Pharmacy Installation of Clinic X in Jember. This study employed a prospective observational design conducted in August 2025. The study population consisted of outpatients receiving pharmaceutical services, and the sample included patients who met the inclusion criteria and agreed to participate. A total of 160 respondents were selected using consecutive sampling, a non-probability sampling technique. Data were collected using a structured questionnaire and tables documenting respondent characteristics and patient satisfaction outcomes. Satisfaction was assessed across five dimensions of pharmaceutical service quality: reliability, responsiveness, empathy, tangibles, and assurance. Descriptive analysis was used to summarize respondent characteristics and satisfaction scores. Of the 160 respondents, the majority were female (71.25%) and within the age group of 25–44 years (53.75%). Most respondents had a senior high school education or equivalent (50.00%), were self-employed (64.38%), and had visited the clinic twice (38.75%). Satisfaction scores across service dimensions were as follows: reliability 97.1%, responsiveness 65.5%, empathy 68.1%, tangibles 82.1%, and assurance 66.7%. The overall Customer Satisfaction Index (IKM) was 82.2%, categorizing the service quality as good. The results indicate that users were generally satisfied with the pharmaceutical services provided at Clinic X. The high score in the reliability dimension suggests consistent service performance and accuracy. However, the lower scores in responsiveness, assurance, and empathy highlight areas requiring improvement, particularly regarding timely service delivery, confidence-inspiring interactions, and patient-centered communication. Although the overall satisfaction level was good, targeted improvements in these dimensions are essential for enhancing the overall quality of pharmaceutical care. Overall, the level of user satisfaction with pharmaceutical services at Clinic X was categorized as good, with an IKM score of 82.2%. All five dimensions of service quality were rated positively, although responsiveness, assurance, and empathy showed room for improvement. These results highlight the importance of strengthening service quality components beyond technical accuracy to ensure a more holistic and patient-centered pharmaceutical care experience.
Co-Authors Agus Mukholid Ahmad Robittah Alfiansyah, Andika Aliyah Purwanti Alvia Putri Priyono, Rosyidatul Amalia Wardatul Firdaus Ancah Caesarina Novi Marchianti Andika Alfiansyah Andro Ruben Runtu Anggia Faradina Anggraeni, Linda Suci Anggraeni, Lutvi Anggraeni, Lutvi Anggraeni April Nuraini Arnes Yuli Vandika Atmanita Khairomatul L Avrillana Dewangi Gea Ayunda Diarso Ayu Angger Putri M. Sholeh Bambang Kuswandi Benny Novico Zani Dea Maulidi Saputri Dewa Ngakan Gde Wahyu Mahatma Putra Dhina Ayu Susanti Diah Yuli Pangesti Diana Kholifah Dina Rasmita Dina Trianggaluh Fauziah Dwi, Jacinta Dyan Wigati Elisa wardatul awaliya Endang Lifchatullaillah Fadli Fadli Fadli Fadli Fadli Fadli Faradina, Anggia Fitria Hariati Florentinus Dika Octa Riswanto Hariati , Fitria Hasana, Siti Nur HELMALIA HELMALIA, HELMALIA Heru Sulistijono Heru Sulistijono Iski Weni Pebriarti Islami, Nurul Ariffaeni Khoirun N., Hilda Kintoko Kintoko Kintoko Kintoko Kintoko KINTOKO KINTOKO Kintoko Kintoko Kintoko, Kintoko Lia Fitriyaningrum Linda Suci Anggraeni Linda Suci Anggraeni lindawati setyaningrum Lutvi Anggraeni Lutvi Anggraeni Anggraeni M. Rofik Usman Minarti Minarti Minarti Minarti Muhamad Risal Tawil Muntasir, Muntasir Nafisah Isnawati Neny Poerwahyuningrum Neny Poerwahyuningrum Nia Kristiningrum Ningrum, Lailatul Fitria Nufus, Galuh Maulidatun Nuraini, April Nurul Ariffaeni Islami Pangesti, Yuli Putra, Dewa Ngakan Gde Wahyu Mahatma Rasmita, Dina Rensi Suryanti Rina Fitriana Riski Eko Ardianto Runtu, Andro Ruben Santoso, Blegoh Iwan Sapto Yuliani SAPTO YULIANI Sapto Yuliani Sapto Yuliani Savania Alifianty Hafzah, Savania Setyorini, Dhiana Shinta Mayasari Shinta Mayasari Sholihatil Hidayati Siti Nur Hasana Siti Nur Hikmah Sugeng Winarso Sugiah Sugiah Sugiah, Sugiah Suryanti, Rensi Susanti, Dhina Ayu Tutik Wuryandari Wardhani, Firdha Aprillia Wulandari, Hilwiyah Septi Wuryandari, Tutik Zani, Benny Novico Zulkarnain Permana