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Sri Wulan, Sri
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Journal : The Indonesian Biomedical Journal

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Butterfly Pea and Roselle Combination Extracts Reduce V-CAM, ICAM, and IL-6 Levels in High Fat Atherogenic Diet Rats Harefa, Karnirius; Ritonga, Ahmad Hafizullah; Safitri, Riri; Aritonang, Barita; Gurusinga, Rahmad; Irmayani, Irmayani; Wulan, Sri
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3361

Abstract

BACKGROUND: Atherosclerosis, driven by inflammation and oxidative stress, increases the risk of coronary heart disease (CHD). Flavonoids in butterfly pea and roselle are known for their potent antioxidant and anti-inflammatory properties. While their individual effects on cardiovascular health have been studied, no studies have explored the combined impact on atherosclerosis biomarkers, including vascular cell adhesion molecules (VCAM)-1, intercellular adhesion molecule (ICAM)-1, and interleukin (IL)-6. Therefore, this study was performed to evaluate the synergistic effects of butterfly pea and roselle combination extracts (BPRCE) on these biomarkers.METHODS: A study with a post-test control group design using 36 male white rats was performed. The rats were randomly assigned to 6 groups; 1 group was fed with standard feed, while 5 groups were fed with a high-fat atherogenic diet (HFAD) to create atherosclerosis rat models. The HFAD rats were given either no treatment, sodium carboxymethylcellulose (Na-CMC), 300, 400, or 500 mg/kgBW BPRCE. Serum levels of VCAM-1, ICAM-1, and IL-6 of rats were measured using enzyme-linked immunosorbent assay (ELISA) methods.RESULTS: Increasing doses of BPRCE resulted in a significant reduction in VCAM-1, ICAM-1, and IL-6 compared to the other groups. The group with the highest dose, 500 mg/kgBW BPRCE, showed the greatest reduction of VCAM-1 level (32.73±3.57 pg/mL), ICAM-1 level (5.68±1.17 ng/mL), and IL-6 levels (21.49±4.62 pg/mL).CONCLUSION: Administration of BPRCE in atherosclerosis rats model reduces VCAM-1, ICAM-1, and IL-6 in a dose-dependent manner. This study showed that using BPRCE as a traditional remedy for preventing and treating CHD at an optimal dose of 500 mg/kgBW might be a potential future application in reducing atherosclerosis biomarkers.KEYWORDS: VCAM-1, ICAM-1, IL-6, butterfly pea, rosella, atherosclerosis
Co-Authors A Difinubun, Balqis Adindi, Satria Ahmad Hafizullah Ritonga Ainun Jariyah Anisah Arisaputra, Muh Ilham Aritonang, Barita Arsil N. , R. Sibyan Asep Munajat Auliyani, Siti Azka, Haula Millati Badrudin Berutu, Achmanudin Br. Girsang, Desri Meriahta Cahyani Kusuma, Tesya Christy, Naulita Dea Febriani Dede, Dede Hikmah Desyanti - Desyanti Dewi Fatmasari DEWI SARTIKA Dewi, Meidiana Sonya Rachma Dewi, Suci Mulia Ekalestari, Susi Elindra Yetti Fakhrimantho, Agus Fince Tinus Waruwu Firda Aprilia, Elsa Frastiyono, Arjun Fridani, Lara Gunarti, Winda Halim, Muliha Hapidin, Hapidin Harahap, Cindy Artika Harmonika, Sri Haryono Haryono Hasrul, Muh Haula, Haula Millati Azka Hikmah Hikmah Hilmi Najamudin, Muhammad I Gusti Agung Gede Widnyana, I Gusti Agung Gede Irmayani Irmayani Irsan Bertinus Tondowala Istanti, Jannah Triska Tri Iva Sarifah Jamaris, Martini Jayani, Rina Junia, Rita Karnirius Harefa Kesya Dia Ramadani Khairiyah, Umi Kristian, Wemni Kurniahu, Hesti Kurniati, Nina Siti Labesani, Cirtye Lisda Yuni Mardiah Livina, Meri M. Manugeren, M. Machmud Yunus Maha, Rahmadani Ningsih Mahid, Perveen Sonia Mahmudah, Zuhrotul Manugeren, M Mardiah, Lisda Yuni Maringan Sianturi Masril Aguswandi Tudjuka Mesran, Mesran Mochammad Imron Awalludin Mohamad Syarif Sumantri Muhammad Irham Mursidah, Nailul Nasution, Amanda Maulida Nasution, Cherry Adistya Nazwa, Nazwa Nirwana, Nirwana Nurbiana Dhieni Nurjannah Nurjannah Nurnaningsih Nurnaningsih, Nurnaningsih Nurulhikmah Pardede, Desika Wali Pardi Pardi Pardi Pratiwi, Elsa Pudjiastuti, Sri Indah Purwarno, Purwarno Putri, Dea Febriana Putri, Lusianawati Eka Putri, Nada Febriansyah Rahmad Gurusinga Rahmat Rahmat Rahmat, Dadan Risa Rahmawati, Risa Riska Andriani Riskawati Riskawati, Riskawati Rita Junia Rita Suirlan Rivalri Kristianto Hondro Rohima, Yulia Kuraesin Ila Rohminatin, Rohminatin Rosa Dwi Wahyuni RR. Ella Evrita Hestiandari Sabarudin, Mohammad Safitri, Riri Saprudin, Asep Sarifah , Iva Shalwa Fatona Siti Mutiara Zam Zam Siwi, Purwanto Sofia Hartati Solehudin, Didin Sri Rosyidatul B, Eulis Sri Susanti Suci Wardani, Anggieta Suginam Sumadi, Tjipto Supriyadi, Deni Susanti, Plistiana Syahida, Ridha Syifauzakia, Syifauzakia Tabasi, Yosafat Tri Setyawati Vera Diana Towidjojo Wahyu Dewantoro, Gema Widjayatri, Rr. Deni Yohan Yohan Yuliani Nurani Yuliati, Chariroh Yunus Sading Yuyun Alfasius Tobondo Zainal Zainal Zara, Mutiara Zarina Akbar