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Journal : AKSONA

Clinical Improvement in Autism Spectrum Disorder Symptoms Following Hyperbaric Oxygen as Adjuvant Therapy in a 12-Year-Old Boy Untari, Ni Komang Sri Dewi; Nugraheni, Pramita Anindya; Agustin, Renny; Oktavia, Reza Mardiana Ayu; Rantika, Rheina Hasna; Hadi, Rifqi Athaya Vinanta; Utami, Rina Mega; Adiwinoto, Ronald Pratama
AKSONA Vol. 6 No. 1 (2026): JANUARY 2026
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v6i1.70643

Abstract

Highlight: The potential role of hyperbaric oxygen therapy (HBO) as an adjunctive treatment for autism spectrum disorder (ASD), demonstrating significant improvements in clinical symptoms. By exploring the plausible mechanisms of HBO, the manuscript underscores the importance of further research and clinical trials to validate its efficacy and safety in the ASD population. This study adds to the literature advocating for innovative therapeutic strategies that address the complex interplay of oxidative stress, neuroinflammation, and mitochondrial dysfunction, inviting a personalized treatment approach.   ABSTRACT Introduction:  Autism spectrum disorder (ASD) is a multifaceted neurodevelopmental condition influenced by both genetic predispositions and environmental factors. Its underlying pathophysiology commonly involves oxidative stress, impaired cerebral perfusion, neuroinflammation, immune dysregulation, and mitochondrial dysfunction. Although conventional interventions, such as applied behavior analysis (ABA), are commonly employed, they may yield limited progress for some individuals. Consequently, emerging interventions, such as hyperbaric oxygen therapy (HBO), show promise for enhancing neurological outcomes and warrant further exploration. HBO, a well-established treatment for decompression sickness, is currently being investigated for its potential benefits in various neurological disorders, including ASD. Case: We present a case of ASD in a 12-year-old boy characterized by minimal eye contact, limited expressive language, and restricted, repetitive behaviors. On neurological examination, the patient was alert and capable of spontaneous eye opening, vocalizing incomprehensible words, and, at times, responding to simple commands. Despite undergoing ABA therapy, the patient exhibited limited developmental progress. The patient was subsequently undergoing hyperbaric oxygen therapy (HBO) at 1.3 ATA for 60 minutes for 10 days. Following the completion of HBO therapy, there was a decline in the CARS score from 41.5 (severe) to 29 (mild), the ATEC score from 115 to 68, the platelet count (51,000 / μL), and interleukin-1β levels (181.4 pg/mL). Conclusion: This case highlights the potential of HBO therapy as an adjunctive treatment modality for ASD, offering significant symptomatic improvements in a patient for whom traditional therapies were insufficient. The presumed mechanisms underlying these effects include anti-inflammatory effects and enhanced cerebral oxygen delivery, which may facilitate neuronal recovery and function. Given these findings, further research and clinical trials are warranted to confirm the therapeutic efficacy, long-term benefits, and safety profile of HBO therapy.
Co-Authors Abdul Azis, Bima ADAM, OLIVIA MAHARDANI Adisyahputra, Vega Adnyana , I Made Dwi Mertha Agung Dwi Wahyu Widodo Agung Pranoto Agustin, Renny Al Hasan, Hafidz Ramadhan Alpha Fardah Athiyyah Amin, M. Shadiqul Angelica Kresnamurti Ariewibawa, Fariz Atiqi Arifin, Alief Qobidh Al Bashor Artha Budi Susila Duarsa Astrid Kusuma Avelline, Kendraadine Dheayu Baita, Etina Noor Biutifasari, Verna Brilliandinda Ichsasqia Sidqi Auliayahya Brilliant , Fahridho Ramadhana Cahya Yudha Laksmana Putra Cempakasari, Aulia da Cruz , Zito Viegas Devanda, Kasilda Pasha Dewi, I Gusti Ayu Ajeng Widia Kencana Dewindra Candra Puspita, Amalia Diah Utami, Prawesty Diana, Adawiyah Putri Diarnasa Zihara Safira, Lavenda Dinda Umardy, Fairuziah Distyvanya, Shakira Azzahra Dwinka Syafira Eljatin Dwitama Adiwinoto, Robert E.J.T, SIHNING Effendi, Muchiddin Andri Setyo Eka Fitriani Hafel Erina Yatmasari Ersanda Nurma Fathir Fadhilah, Yahdiyan Febri Endra Budi Setyawan Florentina Sustini Graciela, Anne Maria Hadi, Janto Poernomo Hadi, Rifqi Athaya Vinanta Hamdy, Irza Hasanal Hardiono Hardiono, Hardiono Hardjono, Ellen Angelique Haris, Ivana Angelica Hayati, Khofifah Bela Rachmanu Helda Dwiana Sari HENDRATA ERRY ANDISARI2 Herdiyantini, Mita Heru Nurdianto Hibatullah, Faiz Nur Hidajat, Boerhan Hutami, Firdha Yekti Izzah Al Nabilah Jongky Hendro Prajitno Kalada, Elisabeth Chelsea Uma Ketut Edy Sudiarta Kharizmatika Kurnia Cahya, Sekar Larassanti, Levina Lauwis, Keziah Queency Liliawanti Liza Yudistira Yusan Lutfian, Lutfian Made Ayu Mira Cyntia Dewi Made Peni Juliana Maliku Nurrochman Widandi Manata Wijaya Sasmita Martono, Alicia Stevina Maulana Muchammad Aunun Najib Maulana, Sidik Maylisca Theresia Mulya Diprasta, Made Medina, Nadra Odifa Meiriyanti Dhita Mentari Nata Kusuma Michael Bramantya Michelle Madeline Maydavania Miranda, Stefani MOCHAMAD ALVIRIO NEDYA RIZKA Muhammad Kalaznykov MUHAMMAD RIZAL Nadya Aisyah Sasqia Putri Nahdah, Jaudah NANDA ABIGAIL Nelya Rindayu, Dinnara Ni Luh Gede Sudaryati Norholila Nugraheni, Pramita Anindya Oki Nugraha Putra Oktavia, Reza Mardiana Ayu Peppy Nawangsasi Peter Gunawan Tandean Pikir, Rizqi Rokhmadhoni Poerwanto, Eka Pramita Anindya Nugraheni Pramudita Riwanti Prasasti, Vincentia Prasetya, Hanung Prasetyadi , Frans O.H. Prima Arundani Purmata, Andrew Theo William Chris Putra, Fabianus Yvan Marino Cahaya Putra, Oki Nugraha Putri, Fernita Naomi Putri, Ida Ayu Govinda Lazenobia De Sanjaya Putri, Jeanaya Hedya Alfara Putri, Jenniefer Clarissa Raharja, Febrila Tarisa Rahmadita, Annisa Putri Rahmawati, Tiara Rantika, Rheina Hasna Rasyida, Annisa Ullya Raza, Syed Meesam Renata Prameswari Retno Budiarti Retno Budiarti Riami Ristanti, Safira Roanna Gabrielle, Vania Robert Dwitama Adiwinoto Rokhmadhoni Pikir, Rizqi Rr. MUTIARA DEVANIA SAMARA QALBA Rusli, Christina S. Soedarsono Sadya Wendra SAES, JOVITASARI ELVIANA PUTRI Safira, Vita Sandy, Emy Noviana Santoso, Clara Cindy Ateng Saptono Putro Setyawan, Yuswanto Sianipar, Habel Ryan Annerico Soedarsono Soedarsono Soelistijo, Soebagijo Adi Sri Umijati STEFANUS DJONI HUSODO Sudiarta, Ketut Edy Sulistiawati Sulistiawati Sulistiawati Sulistiawati Sulistio, Timothy Sunur, Vincentius William Syahputri, Dewi Sylvia Rizki Tamam Jauhar Tasalina Yohana Parameswari Gustam Titong Sugihartono Ubaid, Angling Febriani Ariqoh Ulwani, Qulistan Balqis UNTARI, NI KOMANG SRI DEWI Usman Hadi Utami , Prawesty Diah Utami, Rina Mega Vivien Earlyanti, Callista Wahyu Prasasti Mutiadesi Wahyu Prasasti Mutiadesi Widati Fatmaningrum Widjajanto , Hendra Wijaya, Jennifer Wijaya, Rike Andy Wijayaningrum, Lena Zeeva, Evane Jovanie Zenjaya, Kellyn Trycia Zunnahri, Salsabila Qurrotul Aini