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All Journal Health Notions Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Kesehatan Prima Jurnal Analis Medika Biosains (JAMBS) Hydrogen: Jurnal Kependidikan Kimia Jurnal Ilmiah Wahana Pendidikan Jurnal Borneo Cendekia Gemakes: Jurnal Pengabdian Kepada Masyarakat Indonesian Health Issue Lambda: Jurnal Ilmiah Pendidikan MIPA dan Aplikasinya Jurnal Teknologi Laboratorium Medik Borneo Journal of Indonesia Laboratory Students (JILTS) Thrive Health Science Journal
Iswari Pauzi
Poltekkes Kemenkes Mataram
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Effect of Aloe vera Gel Formulation and Jatropha multifida L Leaf on the Growth of Staphylococcus aureus Bacteria Dektra, I Made Putra Pramaditya; Pauzi, Iswari; Srigede, Lalu; Jiwintarum, Yunan
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 4 (2025): August 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i4.17104

Abstract

Staphylococcus aureus bacteria is one of the agents of health problems that require special attention. Inappropriate use of antibiotics can cause resistance, so a more effective and safe alternative treatment is needed, one of which is by giving aloe vera gel formulations and tintir castor leaves that can help overcome bacterial infections, such as Staphylococcus aureus. Knowing the effect of aloe vera gel formulation (Aloe vera) and tintir castor leaf (Jatropha multifida) on the growth of Staphylococcus aureus bacteria. The study was pre-experimental with a cross sectional design. Gel formulations were made with various comparisons between aloe vera gel and tintir castor leaf, then tested against Staphylococcus aureus bacteria by observing the inhibition zone as an indicator of antibacterial activity. The results of testing the Aloe vera gel formulation and castor leaf filtrate showed that there was no inhibition zone in each of the tested formulation ratios. In the testing using Aloe vera gel formulations and Jatropha multifida leaf extract, no inhibition zones were observed in the 1:1 and 1:3 ratios, but an inhibition zone was present in the 3:1 ratio, measuring 4–6 mm with an average inhibition zone of 5 mm. This result can be considered sensitive but at a low level for inhibiting bacterial growth. There is an effect of Aloe vera gel and jarak tintir leaf formulation on the growth of Staphylococcus aureus bacteria.
Long Suffering Type 1 Diabetes Mellitus During Metabolic Acidosis on Positiveness of Ketones in Urine Patients Mahayani, I Gusti Ayu Putu Sachita; Urip, Urip; Khusuma, Ari; Pauzi, Iswari
THRIVE Health Science Journal Vol. 1 No. 1 (2024): March
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v1i1.89

Abstract

Examination of ketones in the patient's urine and measuring the patient's blood sugar level will determine whether there will be metabolic acidosis in patients with type 1 diabetes mellitus, which is a metabolic disorder that can be caused by various etiologies, such as chronic hyperglycemia due to impaired insulin secretion or impaired insulin action. alone. Diabetes Mellitus type 1 itself is more caused by reduced insulin secretion due to damage to pancreatic -cells. This study was conducted to examine ketones in urine on the duration of suffering from type 1 diabetes mellitus when metabolic acidosis occurs Data collection in this study was carried out by accidental sampling method by researchers to collect secondary and primary data on urine ketones in patients with metabolic acidosis. Based on research that has been done, data obtained from 34 patients with type 1 diabetes mellitus at the Sigerongan Health Center, as many as 8 patients with positive results of urine ketones with a prevalence of +2 totaling 3 people and +3 totaling 5 people. Judging from the high level of glucose (hyperglycemia) that is > 200 mg/dl and the positivity of ketone bodies in the patient's urine as a sign of metabolic acidosis. With a long-susceptibility to suffer from diabetes mellitus 1-5 years and above. The results of measuring ketone levels in the patient's urine show that there is no relationship with the duration of suffering from diabetes mellitus in the urine but blood sugar levels.
Comparison of Fast and Time Blood Glucose Levels in Chronic Disease Management Program Patients (Proalnic) and Non-Prolanic with Diabetes Mellitus in Praya Health Center Aini, Miftahul; Tatontos, Erlin Yustin; Inayati, Nurul; Pauzi, Iswari
THRIVE Health Science Journal Vol. 1 No. 1 (2024): March
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v1i1.92

Abstract

Glucose is the most important carbohydrate which is mostly absorbed into the bloodstream as glucose and other sugars are converted into glucose in the liver. Blood glucose levels are closely related to DM. Prolanic (Chronic Disease Management Program) is a health service system that involves participants from Health Facilities and BPJS health in the context of health care for participants suffering from chronic diseases including diabetes mellitus to achieve optimal quality of life with cost-effective and efficient health services. To determine the comparison of fasting and intermittent blood glucose levels in prolanic and non-prolanic patients suffering from DM at Praya Health Center. : This type of research is Analytical Observation, the sample is taken purposively. A sample of 30 respondents, in this study were 15 respondents who took prolanis and 15 respondents who did not follow prolanis who had a history of diabetes mellitus and underwent blood glucose level checks at the UPTD BLUD Laboratory of Praya Health Center. Based on research that has been done, the average fasting blood glucose level in prolanis is 158 mg/dl and fasting glucose is 204 mg/dl. Meanwhile, non-prolanic fasting glucose levels are 156 mg/dl and fasting glucose levels are 204 mg/dl.
The Effect of Long Suffering Diabetes Mellitus on Blood Ureum Levels Tasya, Rabaika Monica; Fihiruddin, Fihiruddin; Pauzi, Iswari
THRIVE Health Science Journal Vol. 1 No. 1 (2024): March
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v1i1.94

Abstract

Diabetes mellitus is a disease characterized by increasing blood sugar levels caused by defective insulin secretion or action. Increased levels of sugar in the blood have a direct impact on the blood vessels in the kidneys. Such as decreasing the function of the kidney, the disturbing kidney function will increase the level of urea in the blood.To find out whether there is an effect of long-suffering from Diabetes mellitus on blood urea levels. This research is analytical observational research with a cross-sectional approach. The samples used Diabetes mellitus patients with variations in length suffering of 1-3 years, 4-6 years, and > 6 years. Data were collected and analyzed using Kruskal Wallis non-parametric statistical test. The average blood urea level of Diabetes mellitus patients who suffer 1-3 years, 4-6 years, and > 6 years is 29.17 mg/dL, 53.25 mg/dL, and 118.11 mg/dL. The Kruskal Wallis test showed a significant value = 0.000 < 0.05 (Pα) which indicated that the duration of suffering from Diabetes mellitus affected increasing blood urea levels
The Effect of Carbohydrate Diet Program on Urine Ketone Positivity with A Long Time on A Diet of One until Three Years Maya, Kadek; Pauzi, Iswari; Zaetun, Siti
THRIVE Health Science Journal Vol. 1 No. 1 (2024): March
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v1i1.165

Abstract

Carbohydrate diet is a diet pattern that reduces carbohydrate consumption. Therefore, the body will use fat as an alternative energy source. The continuous use of fat causes the accumulation of fatty acids so it is often the cause of ketone positivity in the urine. Objective: Find out the effect of a carbohydrate diet program on the positivity of urine ketones. Method this research is an analytic observational study with a cross-sectional approach. The sample used was urine from respondents who had been on a carbohydrate diet for 1 year, 2 years, and 3 years, then urine ketones were examined using the dipstick method. Data analysis was carried out using the Chi-Square test with a confidence value (α = 0.05). Result: The sample in this study amounted to 45 samples, with a total of 23 samples of positive ketones and 22 samples of negative ketones. The results of the Chi-Square test obtained an Asymp.sig value of 0.009 <0.05 (α) which indicates that the carbohydrate diet program has a significant effect on the positivity of urine ketones. The carbohydrate diet program affects urine ketone levels.
Korelasi antara Titer Antigen H dengan Kadar SGPT pada Pasien Demam Tifoid Helenia Ananda Feriska Felanis; Ida Bagus Rai Wiadnya; Thomas Tandi Manu; Rohmi; Pauzi, Iswari
Journal of Indonesia Laboratory Students (JILTS) Vol. 3 No. 1 (2024): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v3i1.79

Abstract

Latar Belakang: Demam tifoid merupakan penyakit demam akut yang disebabkan oleh infeksi bakteri Salmonella enterica serotipe typhi atau lebih dikenal dengan nama Salmonella Typhi. Berdasarkan hasil penelitian Marselina dkk 2022, mengungkapkan bahwa bakteri Salmonella typhi masuk kedalam organ hati dan menginfeksi organ tersebut sehingga terjadi peningkatan pada kadar SGPT. Tujuan Penelitian: Mengetahui korelasi antara titer antigen H dengan kadar SGPT pada pasien demam tifoid. Metode Peneltian: Obeservasional Analitik dengan pendekatan cross sectional. Teknik Pengambilan sampel yang digunakan dalam penelitian ini adalah Non Random Purposive Sampling. Jumlah sampel yang digunakan sebanyak 34 sampel. Penelitian ini menggunakan uji statistik Korelasi Pearson. Hasil Penelitian: Sampel penderita demam typhoid sebanyak 34 sampel meliputi titer widal antigen H 1/80 berjumlah 16 orang dengan kadar SGPT tertinggi sebesar 42 µ/L. Pada titer widal antigen H 1/160 didapatkan sampel berjumlah 10 orang dengan kadar SGPT tertinggi sebesar 34 µ/L. Sedangkan titer widal antigen H 1/320 didapatkan sampel berjumlah 8 orang dengan kadar SGPT tertinggi sebesar 34 µ/L. Hasil uji normalitas terdistribusi normal masing-masing variabel memiliki nilai signifikansi > 0,05 dan hasil uji korelasi pearson diperoleh nilai signfikansi yaitu 0,7 > 0,5 artinya tidak ada koreasi. Kesimpulan: Tidak ada korelasi antara titer antigen H dengan kadar SGPT pada pasien demam tifoid Kata kunci: Titer Antigen, SGPT, Demam Tifoid
The Effect of Long-Term Addiction to Online Games on Hemoglobin Levels and Urine Sediment Crystals in Adolescents in Mataram City Farhataini, Annisa; Pauzi, Iswari; Urip, Urip; Diarti, Maruni Wiwin
THRIVE Health Science Journal Vol. 1 No. 2 (2024): September
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v1i2.219

Abstract

Online gaming addiction has a negative impact on health, such as reduced sleep hours and changes in sleep patterns can lead to a decrease in hemoglobin levels in the blood. This decrease in hemoglobin has an impact, namely anemia. Besides that, it can also cause kidney disease, especially the formation of urine sediment crystals caused by sitting too much, not drinking enough water and moving little. Objective: To determine the effect of long-term addiction to online games on hemoglobin and urine sediment crystal levels in adolescents in Mataram City.  Method: This study is an analytical observational research with a cross sectional approach of 24 samples.  Using data in the form of blood hemoglobin and urine levels. Sampling techniques with purposive sampling methods and descriptive data analysis. Results: The results of the study of 7 respondents who were not addicted to online games had normal hemoglobin levels (29.16%), 9 respondents who were addicted to online games with mild anemia (37.5%) and 8 respondents with moderate anemia (33.3%). Negative (-) crystals were found in the urine sediments of 24 respondents. Conclusion: There is an effect on the hemoglobin levels of adolescents who are addicted to online games and negative crystals on urine sediments
Analysis of Circadian Rhytme Variations on Glucose Examination Results Rahmani, Putri Ziddanur; Jiwintarum, Yunan; Tatontos, Erlin Yustin; Pauzi, Iswari
THRIVE Health Science Journal Vol. 1 No. 2 (2024): September
Publisher : Balai Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56566/thrive.v1i2.234

Abstract

Background: Circadian rhythm is a term used to describe the 24-hour physiological rhythm of organisms. According to Minister of Health Regulation no. 43 of 2013 concerning How to Organize a Good Clinical Laboratory, the Circadian rhythm variation is explained in the body as levels of certain substances change from time to time. Changes in substance levels that are influenced by time can be cyclical, such as daily cycles (diurnal variations), monthly cycles (menstruation), or linear/straight lines, such as age. Classic experiments using a 72-hour glucose clamp methodology, demonstrated that humans exhibit a robust Circadian rhythm in insulin secretion, independent of food and glycemia. Additionally, a cell-autonomous Circadian clock appears to oversee the diurnal rhythm in glucose-induced insulin secretion.Research Objectives: Knowing the analysis of Circadian rhythm variations on glucose examination results. Research Methods: Analytical observational analysis using cross sectional methods and purposive sampling techniques. The sample population of applied TLM undergraduate students class of 2020 had blood serum taken and using the Slovin formula to determine the sample size, 36 samples were obtained with respondents without a history of diabetes mellitus. Data analysis used the Paired t-test statistical test. Research Result: The results obtained from the examination of the average glucose level at the time of sampling in the morning were 80.25 mg/dl, in the afternoon 96.5 mg/dl, and in the evening 85.91 mg/dl. The results of the paired t-test statistical analysis obtained Sig. (2-tailed) or p 0.010 means p < 0.05 there is a difference in the average glucose results at the time of sampling in the morning and afternoon and Sig. (2-tailed) or p 0.115 means p > 0.05 there is no difference in the average glucose test results at the time of sampling in the morning and evening. Conclusion:  Blood glucose levels taken in the morning have lower average levels than during the day and evening.
Relationship between Cholesterol Levels and Ca 15-3 Tumor Markers in Patients with Carcinoma Mammae Faylori, Adelia Yusnita; Pauzi, Iswari; Fihiruddin
Hydrogen: Jurnal Kependidikan Kimia Vol. 13 No. 5 (2025): October 2025
Publisher : Universitas Pendidikan Mandalika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33394/hjkk.v13i5.17460

Abstract

Breast cancer is the most common malignancy among women worldwide and remains a major cause of cancer-related mortality in Indonesia. Various risk factors, including hormonal, genetic, lifestyle, and metabolic factors, such as elevated cholesterol levels, have been associated with the development and progression of breast cancer. Cholesterol plays a crucial role in cell membrane formation and hormone synthesis, and recent studies have suggested its potential role in tumor growth and metastasis, particularly through the modulation of estrogen receptors and inflammatory pathways. CA 15-3 is a tumor marker widely used for monitoring breast cancer progression and recurrence. However, the correlation between cholesterol levels and CA 15-3 remains underexplored. The research objective is to determine the correlation between total cholesterol levels and the breast cancer tumor marker CA 15-3 in patients diagnosed with breast carcinoma at the Regional General Hospital of West Nusa Tenggara Province (RSUDP NTB). A cross-sectional analytic observational study was conducted using secondary data from the medical records of 33 breast carcinoma patients collected between January to November 2024. Cholesterol and CA 15-3 levels were analyzed using standard laboratory procedures. Data distribution was tested using the Kolmogorov-Smirnov test, and Pearson correlation analysis was applied to evaluate the relationship between cholesterol levels and CA 15-3. Showed that the mean cholesterol level was 214.24 mg/dL, and the mean CA 15-3 level was 41.55 U/mL, both exceeding normal reference values. Pearson correlation analysis demonstrated a very strong and statistically significant positive correlation between total cholesterol and CA 15-3 levels (r = 0.940, p < 0.001), indicating that higher cholesterol levels are associated with increased CA 15-3 concentrations. The study found a significant correlation between cholesterol levels and CA 15-3 in breast carcinoma patients, suggesting that cholesterol may influence tumor activity. Routine monitoring of cholesterol levels may be valuable in the clinical management of breast cancer, especially in assessing disease progression.
Perbedaan Kadar Kolesterol Berdasarkan Lama Mengkonsumsi Obat Golongan Statin pada Lansia di Wilayah Kerja Puskesmas Wanasaba Ayu Rosita; Erlin Yustin Tatontos; Iswari Pauzi; Yunan Jiwintarum
Journal of Indonesia Laboratory Students (JILTS) Vol. 4 No. 2 (2025): Journal of Indonesia Laboratory Students
Publisher : Poltekkes Kemenkes Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32807/jilts.v4i2.171

Abstract

Latar Belakang: Kolesterol adalah hasil metabolisme lemak sterol membran sel yang ditemukan dalam plasma darah. Pada usia lanjut, kadar kolesterol total lebih tinggi daripada pada usia muda. Ini disebabkan oleh fakta bahwa aktivitas reseptor berkurang seiring bertambahnya usia. Obat tradisional yang digunakan oleh orang tua (manula) yang mungkin mengurangi. kadar kolesterol adalah obat golongan statin. Tujuan Penelitian: Mengetahui perbedaan kadar kolesterol pada lansia berdasarkan lama mengkonsumsi obat golongan statin di wilayah kerja Puskesmas Wanasaba. Metode Penelitian: Penelitian ini merupakan penelitian Pre-Eksperiment rancangan One grup pretest-postest. Populasi penelitian ini adalah lansia dengan kadar kolesterol tinggi di <200 mg/dl. Sampel penelitian ini adalah populasi sebanyak 24 orang yang dibagi menjadi dua kelompok. Kelompok pertama berjumlah 12 responden satu tahun sebelum mengonsumsi statin, dan kelompok kedua berjumlah 12 responden satu tahun setelah mengonsumsi statin. Teknik pengambilan sampel Non-probability Purposive Sampling, analisis data menggunakan One Way Anova. Hasil Penelitian: Rerata kadar kolesterol pada kelompok lansia sebelum satu tahun mengonsumsi obat golongan statin adalah 271,9 mg/dl dan rerata kadar kolesterol pada kelompok lansia sesudah satu tahun mengonsumsi obat golongan statin adalah 224,8 mg/dl. Hasil uji statistic dengan one way anova 0,001 yang berarti rata rata kadar kolesterol sebelum dan sesudah mengonsumsi obat golongan statin yang berbeda secara signifikan atau secara nyata. Kesimpulan: Berdasarkan pemeriksaan yang telah dilakukan kadar kolesterol lansia sebelum satu tahun mengkonsumsi obat golongan statin lebih tinggi dibandingkan sesudah satu tahun mengkonsumsi obat golongan statin.
Co-Authors A.A Sukarso Agus Muliadi Agus Muliadi Aliefmam Hakim Anam, Haerul Anaz, Haerul Aprilla, Annisa Suci Ari Khusuma Aris Doyan Aris Doyan Asrorul Makmur Azizi Ayu Rosita Bachtiar Ardiansyah Bachtiar Ardiansyah Baiq Eliya Yusrina Eliya Dektra, I Made Putra Pramaditya Dera Suci Elmaria Dewi, Lale Budi Kusuma Dewi, Ni Made Uci Pramesthy Dyah Astining Maya Erlin Yustin Tatontos Erna Kristinawati Ersandhi Resnhaleksmana Ershandi Resnhaleksmana Faiza Waziran Mulyadi Farhataini, Annisa Faylori, Adelia Yusnita Fihiruddin, Fihiruddin Fitriyani Fitriyani Fitriyani Fitriyani Gito Hadiprayitno Gito Hadiprayitno Hadi, Aprilia Khairunnisa Hakim, Aliefmam Hamidi Hamidi Haryanti, Alya Helenia Ananda Feriska Felanis I Gusti Ayu Nyoman Danuyanti I Ketut Swirya Jaya I Ketut Swiryajaya I Komang Agusjaya Mataram, I Komang Agusjaya IGAN Danuyanti Intan Mustika Nila Jiwantarum, Yunan Joni Rokhmat Joni Rokhmat Laelin Hijriyani Lalu Srigede, Lalu Mahayani, I Gusti Ayu Putu Sachita Maruni wiwin Danuarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maruni Wiwin Diarti Maya, Dyah Astining Maya, Kadek Melyana Nurul Widiawati Miftahul Aini, Miftahul Mira Pramesty Cahyaningtyas Muh. Zaini Hasanul Muttaqin Muhammad Sarjan Muhammad Sarjan Muhammad Yamin Muhammad Yamin MULIA RASYIDI Naning Fitri Yuliatrik Ni Putu Agustini Ni Putu Karunia Ekayani Nila, Intan Mustika Nurul Inayati Nurul Inayati Pusaka, Semerdanta Rahmani, Putri Ziddanur RAI WIADNYA, IDA BAGUS Resnhaleksmana, Ersandhi Rindu Rahmatiah Rindu Rahmatiah Rohmi Sahputri, Maulidia Rohmiati Septiawan, Dandi Shohifatul Wahyuni Siti Malika Amini Siti Rif’ah Sabariah Siti Zaetun Siti Zaetun, Siti Sitiana, Nining St. Halimatussya’diah Suda Adnyana Yoga, I Gede Sudarmi Sudarmi Sudirman Sudirman Sudirman Sudirman Sukarso, A.A Tasya, Rabaika Monica Thomas Tandi Manu Urip Urip Urip Urip Urip Urip Urip, Urip Wahyuni, Shohifatul Yudha Anggit Yudha Anggit Jiwantoro Yuli Laraeni Yunan Jiwintarum Yunan Jiwintarum Yunan Jiwintarum Yunita Wardani Yusran Khery Yusran Khery Zaena Safitri, Trysia