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All Journal Jambi Medical Journal : Jurnal Kedokteran dan Kesehatan Jurnal Kedokteran Brawijaya Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Jurnal Sains dan Teknologi Farmasi Indonesian Journal of Pharmaceutical Science and Technology EduChemia: Jurnal Kimia dan Pendidikan Acta Pharmaceutica Indonesia Pharmascience Jurnal Farmasi Sains dan Komunitas Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Majalah Farmasi dan Farmakologi (Trends in Pharmacy and Pharmaceutical Sciences) Abditani : Jurnal Pengabdian Masyarakat Jurnal Ilmu Kefarmasian Indonesia JURNAL FARMASIMED (JFM) Dharma Raflesia : Jurnal Ilmiah Pengembangan dan Penerapan IPTEKS Jurnal Peduli Masyarakat Borneo Journal Of Pharmascientech Poltekita: Jurnal Pengabdian Masyarakat Jurnal Ilmiah Pharmacy MEDIC MEdical Dedication SCIENCE : Jurnal Inovasi Pendidikan Matematika dan IPA Indonesian Journal of Pharmaceutical Education Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Pharmaceutical Care and Sciences Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Panthera : Jurnal Ilmiah Pendidikan Sains dan Terapan Jurnal Katalisator Riset Informasi Kesehatan Jurnal Pengabdian Harapan Ibu (JPHI) Journal of Pharmaceutical and Sciences. Jurnal Kedokteran Meditek Prosiding Seminar Nasional Unimus Borneo Journal of Pharmacy Bencoolen Journal of Pharmacy Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Abdimas Kesehatan Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan Jurnal Kesehatan Farmasi Nusantara Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice)

Sani K, Fathnur

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Author-ID : 1565059

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Economics, Econometrics & Finance Education Energy Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Uji Preklinik: Aktivitas Penyembuhan Luka Bakar Ekstrak Air Daun Singkong (Manihot esculenta) Havizur Rahman; Raudhatul Jannah; Elisma Elisma; Fathnur Sani
Jurnal Pharmascience Vol 9, No 2 (2022): Jurnal Pharmascience
Publisher : Program Studi Farmasi FMIPA Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v9i2.13707

Daun singkong (Manihot esculenta) merupakan tanaman yang sering digunakan masyarakat untuk mengobati luka bakar, luka bernanah, atau luka baru. Daun singkong mengandung metabolit sekunder yang beraktivitas sebagai antiinflamasi, antioksidan dan antibakteri. Kuersetin merupakan salah satu senyawa golongan flavonoid yang banyak terkandung pada daun singkong yang memiliki kemampuan menghambat radikal bebas. Antioksidan dari senyawa kuersetin mampu memicu kolagen dan peningkatan vaskular endothelia growth factor (VEGF), sebagai parameter kesembuhan luka bakar. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas penyembuhan luka bakar dari ekstrak daun singkong. Penelitian ini merupakan penelitian eksperimental menggunakan metode rancangan acak lengkap (RAL) yang terdiri dari 5 kelompok perlakuan: kontrol positif (Bioplacenton®), kontrol negatif (vaselin flavum), dan ekstrak air daun singkong dengan konsentrasi 2,5%, 5% serta 7,5%. Hasil pengukuran diameter kesembuhan luka bakar menunjukkan adanya aktivitas penyembuhan luka dengan perbedaan yang nyata (p < 0,05) pada tiap perlakuan terhadap kontrol negatif. Konsentrasi terbaik terdapat pada konsentrasi 7,5% dengan presentase kesembuhan 82,18% dan diikuti dengan konsentrasi 5% serta 2,5%. Berdasarkan hal tersebut dapat disimpulkan bahwa ekstrak daun singkong telah menunjukan aktivitas penyembuhan luka bakar pada konsentrasi terendah yaitu 2,5%. Kata Kunci: Ekstrak Air, Daun Singkong, AUC, Penyembuhan Luka Bakar Cassava leaf (Manihot esculenta) is a plant that is often used by the community to treat burns, festering wounds or new wounds. Cassava leaves contain compounds of alkaloids, flavonoids, tannins, phenolics and saponins which act as anti-inflammatory, antioxidant and antibacterial. Quercetin is one of the flavonoid groups contained in cassava leaves which has the ability to inhibit free radicals. Antioxidants from quercetin compounds are able to trigger collagen and increase vascularity endothelia growth factor as a burn wound healing parameter. The purpose of this study was to determine the burn healing activity of cassava leaf extract. This study was an experimental study using a completely randomized design (CRD) method consisting of 5 treatment groups: positive control (Bioplacenton), negative control (vaseline flavum) and water extract of cassava leaves with a concentration of 2.5%, 5%, 7.5 %. Based on the results of measuring the diameter of the burn wound healing showed a significant difference in each treatment given to the negative control, which indicated the presence of wound healing activity in each treatment. The best concentration is 7.5% with a cure percentage of 82.18%. Followed by a concentration of 5% and 2.5%. It can be concluded that cassava leaf extract has shown burn healing activity at the lowest concentration of 2.5%.

Antidiabetic and antihyperlipidemic activity of ethanol extract of Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott ) in alloxan-induced male white rats Fathnur Sani K; Yuliasati Yuliawati; Havizur Rahman; Agung Giri Samudra
Pharmaciana Vol 12, No 3 (2022): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Antidiabetic and antihyperlipidemic have a very close relationship for Mellitus Diabetics. In previous research, Ekor Naga leaves (Rhaphidophora pinnata (L.f) Schott) had an antihyperglycemic effect. The effect was obtained from the presence of secondary metabolites, namely alkaloids, flavonoids, tannins, saponins, and steroids. This research is expected to be a further test of the antidiabetic and antihyperlipidemic effects of alloxan-induced male white rats. This research used an experimental method. The treatment group was divided into four groups, namely negative control (Na CMC 0,5%), positive control (10 mg/kg BW of glibenclamide), group one (250 mg/kg BW of Ekor Naga leaves extract), and group two (500 mg/kg BW of Ekor Naga leaves extract). Data were taken from blood sugar levels on the days 0th, 7th, 10th, and 14th. Total cholesterol, triglyceride, LDL, and HDL levels were observed on the 14th day. Results were analyzed by one-way ANOVA test. The followed by Duncan’s test. The result of ethanol extract from Ekor Naga leaves showed antidiabetic and antihyperlipidemic activity in alloxan-induced rats, which had a statistically significant difference relative the negative control (p<0,05) decreased the levels of blood glucose, total cholesterol, HDL, LDL, triglycerides. Where the best group is two (500 mg/kg BW of Extract) and followed by group one (250 mg/kg BW of Extract). We concluded that Ekor Naga leaves extract provides activity in the treatment option for patients with diabetes and hyperlipidemia.

Antioxidant Activities of Scrub Body Lotion Extract of Surian Leaves (Toona sinensis) with Powder Scrub Date Seeds (Phoenix dactylifera) Uce Lestari; Yuliawati Yuliawati; Fathnur Sani; Yuliana Yuliana; Muhaimin Muhaimin
Indonesian Journal of Pharmaceutical Science and Technology Suppl. 4, No. 1 (2022)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v1i1.42828

Free radicals from exposure to ultraviolet radiation (UVB) cause dull, rough, dry, cracked skin andpremature aging so that they can damage skin tissue and result in fatal skin cancer. To prevent this,antioxidants are needed. Plants that have potential as antioxidants are Surian leaves and date seedswhich contain lots of flavonoids and phenolics. To make it easier to use, it is processed into a scrubbody lotion using a date seed powder scrub (Phoenix dactylifera). This study aimed to find a scrubbody lotion formula that has the best physical properties and is stable during storage and the bestformula has the strongest antioxidant activity. Each formula contains ethanol extract of Surian leaves(Toona sinensis) with a concentration of 0.1%; 0.3%; 0.5%; 0.7%; 0.9%. After that, an evaluationof the physical properties of scrub body lotion preparation was carried out. From the results of theevaluation of the physical properties of the best scrub body lotion preparations, stable in storage andhedonic tests and safe for irritation tests, formula 5 contains ethanol extract of surian leaves with aconcentration of 0.9% and has an antioxidant activity of IC50 28,554 ppm with a very strong category.

Efektivitas Khasiat Penyembuhan Luka Sayat Gel Ekstrak Etanol Daun Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Berdasarkan Analisis Hidroksiprolin Fathnur Sani K; Agung Giri Samudra; Havizur Rahman; Ave Olivia Rahman
Jurnal Farmasi Sains dan Terapan Vol 9, No 2 (2022): October
Publisher : Jurnal Farmasi Sains dan Terapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jfst.v9i2.4084

Ekstrak daun ekor naga (Rhaphidophora pinnata (L.f) Schott) merupakan ekstrak yang telah teruji dari penelitian sebelumnya memiliki efek sebagai penyembuh luka sayat, luka bakar dan inflamasi. Efek ini didukung dengan adanya kandungan metabolit skeunder alkaloid, flavonoid, steroid, saponin dan tannin. Efek gel sebagai penyembuh luka sayat juga telah di publish. Tujuan penelitian ini adalah untuk mengetahui kadar hidroksiproline kulit yang mengalami luka sayat setelah pemberian gel ekstrak daun ekor naga selama 14 hari. Metode penelitian yang digunakan merupakan experimental design. Hewan uji yang digunakan masing-masing perlakuan sebanyak 5 ekor hewan uji. Kontrol Positif (Bioplacenton®), Formula 0 (Basis Gel), Formula 1 (Konsentrasi ekstrak daun ekor naga 10%), Formula 2 (Konsentrasi ekstrak daun ekor naga 15%), dan Formula 3 (Konsentrasi ekstrak daun ekor naga 20%). Pengamatan yang dilakukan adalah skrining fitokimia, dan kadar hidroksiproline. Hasil penelitian menunjukkan bahwa formula 2 merupakan formula yang memiliki efektivitas terbaik dalam pembentukan kolagen yaitu sebesar 35,251±4,16 µg/mL. Dimana secara statistik memiliki perbedaan yang bermakna (p<0,05) antar kelompok perlakuan. Kesimpulan bahwa gel ekstrak daun ekor naga memiliki pengaruh terhadap kadar hidroksiprolin pada kasus luka sayat hewan uji.

Acute Toxicity Test of Ekor Naga (Rhaphidophora pinnata (L.f) Schott) Leaf Extract in Mice and Kidney Histological Examination Fathnur Sani K.; Dian Magfirah; Yuliawati Yuliawati; Elisma Elisma; Uce Lestari
Indonesian Journal of Cancer Chemoprevention Vol 13, No 3 (2022)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev13iss3pp152-158

Ekor Naga (Rhaphidophora pinnata (L.f) Schott) is a traditional plant used by the community. Previous studies have shown that this plant has pharmacological effects, including as anthelmintics, antioxidant, and anti-inflammatory agent as well as promotes wound healing. Thus, it is necessary to do a toxicity test. The study aimed to determine the effect of the extract on histopathology of the kidney through a toxicity test. The research used an experimental design. The test animals were divided into 5 groups, each of which consisted of 5 test animals: negative control (0.5% Na. CMC), Treatment 1 (Extract of ekor naga leaves at a dose of 200 mg/Kg BW), Treatment 2 (Extract of ekor naga leaves at a dose of 600 mg/Kg BW), Treatment 3 (Extract of ekor naga leaves at a dose of 1800 mg/Kg BW), and Treatment 4 (Extract of Ekor Naga Leaves at a dose of 5400 mg/Kg BW). The parameters observed were the Letal Dose (LD50) and the histophatology of the kidney. Data were analyzed using One Way ANOVA test, followed with Duncan’s test. The results showed no significant difference in the weight of the kidney (p>0.05), and the histophatology of the kidney after 14 days of acute administration of ekor naga leaf extract in all the treatment was normal. The administration of ekor naga leaf extract at therapeutic doses and larger doses of single administration did not have a bad effect on the histology of the kidney.Keywords: Ekor Naga Leaves, Kidney, Histopathology, Acute Toxicity.

Anti-Inflammatory Effects of Ripe Areca Nut Ethyl Acetate Fraction in Wistar Rats with Knee Joints Osteoarthritis Daffa Akrama Yuda; Ave Olivia Rahman; Fathnur Sani Kasmadi; Humaryanto Humaryanto
Jurnal Kedokteran Brawijaya Vol. 32 No. 3 (2023)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2022.032.03.1

Osteoarthritis (OA) is the most common form of arthritis. Meloxicam are one of NSAIDs commonly used that have many side effects. Areca nut (Areca catechu L), which contains flavonoids, can provide anti-inflammatory effects. This study aimed to determine the potential anti-inflammatory effect of ethyl acetate fraction from ripe areca nut in OA rat model. Twenty five of adults, male Rattus novergicus strain Wistar were induced to OA with Monosodium Iodoacetate (MIA), then divided into five groups that each group were given ethyl acetate fraction of ripe areca nut doses of 15mg/kgBW, 30mg/kgBW, and 60mg/kgBW, meloxicam 1.35mg/kgBW and aquadest as negative control for 14 days. Diameter of the knee joint is measured by digital metric kaliper to assess joint edema. The Histopathological examination with Haematoxyllin-Eosin stain to assess degree of inflammation on synovial. Among the areca groups, dose 30mg/kgBW had knee joint diameter reduced better and lower synovitis score. In conclusion, ethyl acetate fraction of the ripe areca nut group has anti inflammation effect in OA model but not dose-dependent.

INOVASI DAN KREASI PRODUK HERBAL BERBASIS TOGA DI RT 02, KELURAHAN MENDALO INDAH, KECAMATAN JAMBI LUAR KOTA Elisma Elisma; Fathnur Sani K; Syamsurizal; Yuliawati
Prosiding Seminar Nasional Pengabdian Kepada Masyarakat Vol 3 (2022): PROSIDING SEMINAR NASIONAL PENGABDIAN KEPADA MASYARAKAT - SNPPM2022
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat Universitas Negeri Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract Herbal medicine is in great demand by the public, especially in the current pandemic conditions. This herbal medicine can be made from herbal plants that are in the home environment. One of them is TOGA. Every RT in mendalo indah area has TOGA which is planted with a variety of herbal plants that have benefits in treating diseases and restoring health. This TOGA was created in an effort to improve the degree of public health by utilizing local wisdom.However, public knowledge about the properties and processing of herbal plants is still very minimal. As a result, the plants in TOGA are rarely used by the community. Innovation and creation of TOGA-based herbal products can increase the added value of herbal plants and have business opportunities. Product creations from herbal plants can be in the form of herbal candies, herbal snacks, and herbal teas. For this reason, activities are needed that can provide knowledge and skills to the community in processing herbal plants into products that have added value. The community service program is a forum for lecturers to provide information and solutions to every problem that occurs in the community. In this program, the targeted communities are communities in RT.02, Mendalo Indah Village, Jambi Outer City District, Muaro Jambi Regency. The community will be equipped with knowledge and skills in processing herbal plants from toga community into innovative herbal medicinal products and provide knowledge to the community of business opportunities from these products through promotional means. The service was held on Saturday, October 2022 with 34 service participants. The service process begins with the coordination of time and place with the chairman of Yasinan Annisa in RT 02 and its surroundings. The service activity began with an extension of the efficacy and how to make herbal medicine from herbal plants grown at TOGA, the mendalo Indah community, then a demo was carried out on how to process herbal innovation products until they became products that had been packaged and were ready to be marketed. The public's understanding of the material presented was measured using instruments and obtained results 88.24% of the community understood the material that had been delivered. Abstrak Obat herbal sangat diminati oleh masyarakat terlebih dalam kondisi pandemic saat ini. Obat herbal ini dapat dibuat dari tanaman-tanaman herbal yang berada dilingkungan rumah. Salah satunya adalah TOGA. Setiap RT dikelurahan Mendalo Indah memiliki TOGA yang ditanami berbagai macam tanaman herbal yang memiliki manfaat dalam mengobati penyakit dan memulihkan kesehatan. TOGA ini dibuat dalam upaya meningkatkan derajat kesehatan masyarakat dengan memanfaatkan kearifan local. Namun pengetahuan masyarakat tentang khasiat dan cara pengolahan tanaman herbal masih sangat minim. Akibatnya tanaman yang ada di TOGA jarang dimanfaatkan oleh masyarakat. Inovasi dan kreasi produk herbal berbasis TOGA dapat meningkatkan nilai tambah dari tanaman herbal dan mempunyai peluang usaha. Kreasi produk dari tanaman herbal dapat berupa permen herbal, cemilan herbal, dan teh herbal. Untuk itu diperlukan kegiatan yang dapat memberikan pengetahuan dan keterampilan kepada masyarakat dalam mengolah tanaman herbal menjadi produk yang memiliki nilai tambah. Program pengabdian pada masyarakat merupakan wadah bagi dosen untuk memberikan informasi dan solusi dari setiap masalah yang terjadi di masyarakat. Pada program ini masyarakat yang menjadi sasaran adalah masyarakat di RT.02, Desa Mendalo Indah, Kec. Jambi Luar Kota, Kabupaten Muaro Jambi. Masyarakat akan dibekali dengan pengetahuan dan keterampilan pengolahan tanaman herbal dari TOGA masyarakat menjadi produk obat herbal yang inovatif serta memberikan pengetahuan kepada masyarakat peluang usaha dari produk tersebut melalui cara-cara promosi.Pengabdian dilaksanakan pada hari Sabtu tanggal Oktober 2022 dengan peserta pengabdian berjumlah 34 orang. Proses pengabdian diawali dengan koordinasi waktu dan tempat dengan ketua yasinan Annisa di RT 02 dan sekitarnya. Kegiatan pengabdian di awali dengan peyuluhan tentang khasiat dan cara pembuatan jamu dari tanaman herbal yang ditanam di TOGA masyarakat mendalo Indah kemudian selanjutnya dilakukan demo cara pengolahan produk inovasi herbal sampai menjadi produk yang telah dipacking dan siap dipasarkan. Pamahaman masyarakat tentang materi yang disampaikan diukur menggunakan instrument dan diperoleh hasil 88,24 % masyarakat mengerti dengan materi yang telah disampaikan.

Uji efek tonikum ekstrak daun sawo manila (Manilkara zapota) pada mencit putih jantan (Mus musculus) dengan metode ketahanan renang Fathnur Sani K; Yuliawati Yuliawati; Herlina Herlina; Reza Yolandini
Riset Informasi Kesehatan Vol 9 No 1 (2020): Riset Informasi Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Harapan Ibu Jambi

ABSTRAK Penggunaan obat penambah stamina tubuh sangat dibutuhkan dalam kegiatan sehari-hari, pola aktifitas kerja masyarakat yang semakin meningkat membutuhkan tenaga yang lebih banyak sehingga dalam mengcukupinya perlu adanya suplemen penambah. Daun Sawo Manila merupakan salah satu tanaman yang sering digunakan untuk masyarakat sebagai penambah stamina. Pengujian ini bertujuan untuk mengetahui efek tonikum dari ekstrak daun sawo manila (Manilkara zapota). Metode yang digunakan pada penelitian ini adalah metode uji renang. Dimana dosis perlakuannya adalah kontrol positif (Kafein 0,52mg/20gram BB), control negative (Na CMC), Dosis I (6mg/20gramBB), Dosis II (12 mg/20 gramBB), dan Dosis III (18mg/20gramBB). Berdasarakan hasil Anova 1 arah menunjukkan adanya perbedaan yang bermakna pada tiap kelompok (p<0,05). Dimana berdasarkan uji lanjutan Duncan menunjukkan dosis terbaik adalah dosis III (18mg/20gramBB). Kemudian diikuti dosis II (12mg/20 gramBB) dan dosis I (6mg/20gramBB).

Pelatihan Pembuatan Sabun Lembaran Berbahan Aktif Kulit Buah Naga di Panti Asuhan Izzati Jannah Fathnur Sani K.; Yuliawati Yuliawati; Elisma Elisma; Syamsurizal Syamsurizal; Muhammad Syukri
Poltekita: Jurnal Pengabdian Masyarakat Vol. 4 No. 2 (2023): April-Juni
Publisher : Pusat Penelitian & Pengabdian Masyarakat Poltekkes Kemenkes Palu

In recent years, the world has been shocked by the emergence of a disease caused by a virus, namely the corona virus or better known as COVID-19. The rapid spread of Covid-19 requires precautions to prevent transmission to break the chain of the COVID-19 pandemic and be able to face the new normal era. One of the preventive measures is to carry out the movement of washing hands with soap. Sheet soap is used as disposable hand soap and is perfect for use when traveling or doing activities outside the home. Currently, the community has started to carry out offline school and lecture activities. This activity aims to demand awareness to increase activities that are able to prevent the spread of Covid-19. So bringing antiseptic products, both in the form of liquids and sheet soap, is highly recommended to provide comfort in dealing with the new normal conditions after the Covid-19 pandemic. Activity method: This activity is planned to be carried out at the izzati jannah orphanage where the orphanage students have carried out learning activities offline. Activities are carried out following strict health protocols. The counseling activity was attended by 30 orphanage children. Based on the results of the post test, it was obtained a value of 92% of students being able to understand the training material provided. So that the results of the activity show that there is an increase in the knowledge of the orphans about processing dragon fruit peel powder into sheet soap that is easy to use and carry.

FORMULATION AND CHARACTERIZATION OF 50% ETHANOL EXTRACT OF ARECA NUT (Areca catechu) NANOPARTICLES USING THE IONIC GELATION METHOD Humaryanto; Fathnur Sani Sani K; Yuliawati; Ave Olivia Rahman; Muhaimin; Alfi Khatib
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 3 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i3.826

The extract of areca nuts (Areca catechu) contains secondary metabolites, such as flavonoids, alkaloids, saponins, tannins, and steroids. These compounds possess pharmacological effects and can be developed into herbal medicine products. The objective of this study is to determine the optimal nanoparticle formulation by varying the concentrations of chitosan and sodium tripolyphosphate. The 50% ethanol extract of areca nuts was obtained through the maceration method. The extract obtained calculation the yield value. Then tested for phytochemical screening. Subsequently, the extract was formulated into nanoparticle colloids with different ratios of extract concentration: chitosan: sodium tripolyphosphate: Tween 80. The resulting nanoparticles were characterized by their particle size, zeta potential, and polydispersity index. The research findings demonstrated that Formula 3 exhibited the best results, with a particle size of 254.2 Â± 0,00, zeta potential of 12.7 Â± 0,71, and polydispersity index of 0.436 Â± 0,03. Keywords: Formulation, Nanoparticles, 50% Ethanol, Areca Nuts, Ionic Gelation.

Co-Authors Adisty, Aura Rasyanda Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Agung Giri Samudra Aina Fatkhil Haque Alfi Khatib Amalia Nasution, Riska Andriani, Annisa Anggia, Sonia Anggraini, Dewi Febrina Annisa Luthfiyyah Apriza Hongko Putra Asima Widyawaty Sinurat Ave Olivia Rahman Ave Olivia Rahman Ave Olivia Rahman Ave Olivia Rahman Bambang Hernawan Nugroho Bella Pascila Bernike Anatasya Cassa de Floris Cathelya, Bunga Cyntia Dwi Utami Daffa Akrama Yuda Danuartha, Dhimas Dara Permata Sari Diah Riski Gusti Diah Tri Utami Diah Tri Utami DIAN LESTARI Dian Magfirah Dinofitri, Hanifah Dominica, Dwi Dwikanti Prindani Putri Dyah Fitriani Efendi, M. Rifki Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Elisma Enda Oktri Mayora Eva Melisa Evi Maryanti Fazariana, Anjaly Rizkya Febriyani, Ulfa Fitrianingsih Fitrianingsih Fitrianingsih Fitrianingsih Gatot Prasetya Gina Lestari Gina Lestari, Gina Haque, Aina Fatkhil Hasnaul Maritsa Havizur Rahman Havizur Rahman Havizur Rahman Herlina Herlina herlina herlina Humaryanto Humaryanto Humaryanto Humaryanto Humaryanto Humaryanto, Humaryanto Huntari Harahap Idamanda, Rahma Intan Lestari Iskandar, Mirna Marhami Jannah, Miptakul Jannah, Zahratul Joevanda, Salsabila Kristin Simamora Kusdiyah, Erni M. Rifqi Efendi Maharini, Indri Maimum Maulida, Dafa Riska Mayora, Enda Oktri Mesa Sukmadani Rusdi Monic Sri Cahnia Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhaimin Muhammad Farhan Muhammad Syukri Nada Afrilia Naurah Nazifah Nazar, Armenia Neldi, Vina Nori Wirahmi Novia Tri Astuti Nurfadilah Nurfadilah Nurfijrin Ramadhani Nurfijrin Ramadhani, Nurfijrin nurwani purnama aji Oktarina, Widiawati Pondawinata, Marizki Puspa Dwi Pertiwi Puspa Dwi Pratiwi Putri Aulia, Bilqis Putri, Andinni Putri, Fadilla Aliyah Putri, Kresentia Qiftiah, Mariatul Rahayu, Stepania Dwimulia Rahman , Ave Olivia Rahman, Havizur Rahman, Havizur Rahmila Yuni Astika Raudhatul Jannah Revis Asra Revis Asra Reza Pertiwi Reza Pertiwi Reza Yolandini Rizamevia, Fhidila Sadli, Nurul Kamilah Salsabilla, Navira Santi Perawati, Santi Sari, Dara Permata Sari, Indah Syamsul Arifin Syamsurizal Syamsurizal Syamsurizal - - Syamsurizal Syamsurizal Tia Wida Eka Putri Uce Lestari Uce Lestari Uce Lestari Uce Lestari Uce Lestari 1 Ulfa Febriyani Usna, Rozatul Vanika, Niken Widiawati Oktarina Yesi Nursofia Yolandini, Reza Yudha Putra, Diky Okta Yuliana Yuliana Yuliandani, Yuliandani Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati Yuliawati, Yuliwati

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