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All Journal International Journal of Electrical and Computer Engineering Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Medula Juke Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Kesmas Indonesia: Jurnal Ilmiah Kesehatan Masyarakat Jurnal Dunia Kesmas Jambura Journal of Health Sciences and Research Jurnal Kesehatan JURNAL PENELITIAN PERAWAT PROFESIONAL JK Unila (Jurnal Kedokteran Universitas Lampung) Poltekita: Jurnal Pengabdian Masyarakat Jurnal Abdimas ADPI Sains dan Teknologi Majority JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Dwi Indria Anggraini
Universitas Lampung
Agriculture, Biological Sciences & Forestry Astronomy Biochemistry, Genetics & Molecular Biology Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Energy Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Terapi Imunologi Pada Melanoma Muhamad Addin Syakir; Dwi Indria Anggraini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.118

Abstract

Introductions: Immunotherapy for cancer is used based on the principle of the disease that the immune system is able to produce an immune response to tumor cells. Treatment is currently available for selective melanoma patients based on the response rate of the disease. Objectives: To determine the management of melanoma using immunology. Methods: This article was compiled using the literature review method, using 32 sources derived from journals and books. Results: Interferon-? was approved for the treatment of adjuvant stage III melanoma with increased survival rate. New and more innovative approaches are needed with increasing therapeutic effects. The prognosis of patients with metastatic melanoma in the world has changed dramatically since the presence of an immune checkpoint inhibitor. Discussions: Ipilimumab, which targets the cytotoxic T lymphocyte-associated protein 4 (CTLA-4) protein is the first agent that exists. Furthermore, nivolumab and pembrolizumab that bind to programmed death protein 1 (PD-1) proteins have been shown to be more effective and lower in toxicity than ipilimumab. The combination of nivolumab or pembrolizumab with ipilimumab has resulted in increased response rates and patient survival rate results. This literature review will explore important clinical trial data that have led to the use of this immunotherapy agent in the world and some clinical trial results currently reported for new combination therapies. Conclusions: At present immunology therapy for melanoma management can be applied. Keywords: Chemotherapy, immunotherapy, management, melanoma
Penggunaan Ester Asam Fumarat Oral Dalam Pengobatan Kasus Dermatologi Elina Rahma; Dwi Indria Anggraini
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 8 No 2 (2020): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 8.2 Edisi Maret - Agus
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v8i2.138

Abstract

Introduction: Oral fumaric esters acid (FAE) are interesting compounds in the field of dermatology. FAE works on skin cells and cytokine tissue. So far only a mixture of dimethylfumarate (DMF) and monoethylfumarate (MEF) has been approved for oral treatment of moderate to severe plaque psoriasis. Objective: To determine the use of oral fumaric acid esters (FAE) in the treatment of dermatology Method: The article was prepared using the literature review method, involving 34 literature sourced from books and journals. Results: DMF appears to be a major active component. It is important to emphasize the difference between fumaric acid and fumaric acid esters. Fumaric acid formulations are available as health supplements and are often marketed as natural alternative medicines for treating psoriasis. However, it is poorly absorbed by the intestine and excreted through urine without having any therapeutic effect. Discussion: Although the mode of action of FAE and its mechanism of action in psoriasis therapy is still unclear, the evidence shows that it has nothing to do with the Krebs cycle and the main active compound DMF. There is evidence that FAE is not only effective and safe in psoriasis but also non-granulomatous infectious diseases like annulare granulomas, necrobiosis lipoidica, and sarcoidosis. In vitro and animal studies show some activity in malignant melanoma as well. Conclusion: Oral fumaric acid (FAE) esters are widely used in some dermatology cases. Keywords: Dermatology, fumaric acid, psoriasis, sarcoidosis
Faktor yang Mempengaruhi Kejadian Dermatitis Kontak Akibat Kerja pada Pengrajin Tahu di Keluarahan Gunung Sulah Justiani, Andinni Aurellia; Kurniawaty, Evi; Rahmayani, Fidha; Anggraini, Dwi Indria
Jurnal Dunia Kesmas Vol 13, No 3 (2024): Volume 13 Nomor 3
Publisher : Persatuan Dosen Kesehatan Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jdk.v13i3.15715

Abstract

Occupational health and safety risks can arise in workers, the most common is contact dermatitis. Occupational Contact Dermatitis (OCD) is an inflammatory response of the skin that can be acute or chronic due to exposure with irritants or allergens at work. Tofu craftsmen are always exposed to tofu coagulation substances and water that can induce skin irritation reactions. Therefore, this study aims to determine the factors that influence the incidence of OCD in tofu craftsmen in Gunung Sulah Village, Way Halim District, Bandar Lampung. This research is analytical observational study with cross sectional. The sample of this research was 65 tofu craftsmen who were selected by the total sampling method. Data was collected by filling out questionnaires and diagnosed by a doctor. The data was analyzed by univariate and bivariate. The result was 56,9% has contact dermatitis. There is significant association between OCD with the exposure of personal protective equipment (p-value = 0,001), personal hygiene (p-value = 0,015), work periode (p-value = 0,043), and length of contact (p-value = 0,028). There is a significant association between personal protective equipment, personal hygiene, work periode, and length of contact with the incidence contact dermatitis in tofu craftsmen in Gunung Sulah Village.
Uji Daya Hambat Ekstrak Andaliman (Zanthoxylum Acanthopodium) terhadap Pertumbuhan Escherichia Coli Silitonga, Yona Arisena Magdalena; Apriliana, Ety; Anggraini, Dwi Indria
Jurnal Penelitian Perawat Profesional Vol 6 No 4 (2024): Agustus 2024, Jurnal Penelitian Perawat Profesional
Publisher : Global Health Science Group

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/jppp.v6i4.2703

Abstract

Penyakit infeksi merupakan salah satu penyakit yang banyak menyebabkan kematian di seluruh dunia, terutama pada negara berkembang yang banyak mempunyai angka kematian yang tinggi, termasuk Indonesia. Escherichia coli merupakan bakteri yang normalnya hidup di dalam usus manusia dan hewan. Kebanyakan Escherichia coli tidak berbahaya, tetapi beberapa Escherichia coli merupakan patogen, yang mana dapat menyebabkan penyakit, diare atau penyakit di luar saluran usus. Infeksi oleh Escherichia coli adalah penyebab diare terbanyak kedua setelah rotavirus. Resistensi bakteri terhadap antibiotik telah menjadi masalah serius dalam kesehatan masyarakat. Derivat tanaman antibakteri selalu menjadi terapi baru. Terdapat adanya aktivitas antimikroba dari minyak atsiri andaliman (Zanthoxylum acanthopodium) serta komponen aktif penyusunnya. Penelitian ini bertujuan untuk mengetahui hasil daya hambat ekstrak buah andaliman dibandingkan kontrol positif serta menentukan diameter zona hambat ekstrak buah andaliman (Zanthoxylum acanthopodium) terhadap Escherichia coli. Desain penelitian ini adalah penelitian eksperimental murni, dengan rancangan post-test control group. Penelitian ini menggunakan bakteri Escherichia coli yang diberikan ekstrak buah andaliman dengan 6 kelompok. Konsentrasi 25% (K1), konsentrasi 50% (K2), konsentrasi 75% (K3), konsentrasi 100% (K4), kontrol negatif dengan akuades (K5), dan kontrol positif dengan gentamicin (K6), kemudian dilihat daya hambatnya dengan mengukur diameter zona hambat dengan metode difusi sumuran. Hasil rerata diameter zona hambat yaitu K1 0 mm, K2 0 mm, K3 0 mm, K4 7,25 mm, K5 0 mm, dan K6 30 mm. Hasil analisis menunjukkan p: 0,000. Analisis dilanjutkan dengan uji post hoc dan ditemukan kelompok yang memiliki perbedaan bermakna yaitu K1, K2, K3, K4 dengan K6. Efek antibakteri ekstrak buah andaliman (Zanthoxylum acanthopodium) terhadap Escherichia coli kurang signifikan.
Co-Authors Agustyas Tjiptaningrum Ahmad Fauzi Ahmad Fauzi Ahmad Sirajudin Alfi Yasmina Alwiyah, Fadilah Amira Zhafira Anggraeni Janar Wulan, Anggraeni Janar Annisa Adietya Pratama Annisa Cahyani AYU WULANDARI Ayu Wulandari Dian Isti Angraini Dian Isti Angraini Efrida Warganegara Elina Rahma Elina Rahma Emantis Rosa Erna Kristin Ety Apriliana Fauziani, Andra Nabila Febe Sintia Kristiani Fitria Saftarina Graceciela, Yohana Eva Hakim, Lukmanul Hasril Mulya Budiman Hendra Tarigan Sibero Hendra Tarigan Sibero Hendra Tarigan Sibero Hendra Tarigan Subero Hery Dian Septama Indri Windarti Isti Angraini, Dian iwan Dwiprahasto Jarir At Thobari Justiani, Andinni Aurellia Karimah, Nisa Kurniawaty, Evi Lania, Siska Mahala Ramah Sari Mayasari Diana Mayasari, Diana Muhamad Addin Syakir Muhamad Addin Syakir Muhammad Rafi Eka Putra Muhammad Syafei Hamzah Muhammad Yusran Muhammad, Meizano Ardhi Nisa Karima Nisa Karimah Novita Carolia Pairulsyah Pairulsyah Piesta Prima Beta Pairul Putra, I Wayan Ardana Rahmatika, Achisna Rahmayani, Fidha Rani Himayani Rasmi Zakiah Oktarlina Rizki Hanriko Robert Bestak Roro Rukmi Windi Perdani, Roro Rukmi Rudiyanto, Waluyo Sagia, Nabilla Alsa Silitonga, Yona Arisena Magdalena Suharmanto Suharmanto Syahrul Hamidi Nasution Syazili Mustofa Tri Umiana Soleha Tri Umiana Soleha Umniya Umniya Yulisna Yulisna Yustisya Khoirunnisa Zetira, Zihan