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All Journal Juiperdo Jurnal Kesehatan Biomedical Journal of Indonesia Jurnal Panorama Hukum Jurnal Pengabdian Masyarakat AbdiMas Jurnal Kreativitas PKM International Journal of Nursing and Health Services (IJNHS) Health and Medical Journal J-Kesmas: Jurnal Kesehatan Masyarakat (Indonesian Journal of Public Health) Jurnal Ilmiah Edunomika (JIE) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Abdi Insani Jurnal Darma Agung Jurnal Pengabdian kepada Masyarakat Nusantara JPTE: Jurnal Pendidikan Teknik Elektro Jurnal Bisnis Mahasiswa Jurnal Ilmiah Kesehatan (JIKA) Jurnal Ilmiah Mahasiswa Fakultas Hukum Universitas Malikussaleh Edu Society: Jurnal Pendidikan, Ilmu Sosial dan Pengabdian Kepada Masyarakat JURNAL PENGABDIAN PENDIDIKAN MASYARAKAT (JPPM) Jurnal Keperawatan Soedirman (The Soedirman Journal of Nursing) EDUCATE : Journal of Education and Culture Majority Science Journal Medic Nutricia : Jurnal Ilmu Kesehatan TRANSFORMATIKA: Jurnal Bahasa, Sastra, dan Pengajarannya
Sari, Widia
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Vitamin D and Traumatic Brain Injury: A Systematic Review of Preclinical Evidence Jaslindo, Lieka Nugrahi; Sari, Widia; Dhuha, Alief; Handayani, Kurnia Maidarmi; Khudri, Ghaniyyatul Nugrahi; Maribeth, Annisa Lidra
Health and Medical Journal Vol. 8 No. 1 (2026): HEME January 2026
Publisher : Universitas Baiturrahmah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33854/heme.v8i1.2096

Abstract

Traumativ Brain Injury (TBI) triggers multiple secondary injury processes, such as inflammation, oxidative stress, apoptosis, BBB disruption, and impaired autophagy. These mechanisms contribute to progressive neuronal damage and functional decline. Vitamin D has emerged as a potential multi-target neuroprotective agent due to its regulatory roles in immune signaling, oxidative balance, neuronal survival, and autophagy pathways. This systematic review synthesized preclinical evidence evaluating the effects of Vitamin D supplementation in animal models of TBI. A comprehensive search of PubMed, OVID, and ProQuest identified six eligible studies. Across diverse dosing regimens and formulations, Vitamin D consistently improved key TBI outcomes. Reported benefits included reduced apoptosis, decreased neuroinflammation, attenuation of oxidative stress, preservation of BBB integrity, restoration of autophagy flux, and enhanced cognitive performance. Mechanistically, Vitamin D influenced several pathways, including Nrf2 activation, TLR4/MyD88/NF-κB suppression, mTOR and TRPM2 normalization, and improved microglial polarization. Although methodological quality varied, most studies demonstrated moderate rigor and supported the neuroprotective actions of Vitamin D. Heterogeneity in injury models, dosing strategies, and outcome measures limits direct comparison and highlights the need for standardized experimental approaches. Overall, current preclinical evidence indicates that Vitamin D confers robust neuroprotection following TBI. Further studies examining its mechanistic pathways, optimal therapeutic windows, and translational potential are warranted to inform future clinical applications.
Co-Authors Adi Pertiwi , Puji Adisty, Linda Anda, Juliet Medi Andrinatya, Dheavita Antoni Antoni Astari, Chitra Azteri, Veza Azzah, Fhasa Lifiansah Bagis, Fatmah Cahyani, Siti Meilinda Chamroonsawasdi, Kanittha Chaniago, Rudi Darmayanti, Andini Dhuha, Alief Eka Handayani Enny Yuliaswati Ety Nurhayati Fadhilah, Annisa Farida, Hana Fitriani, Herni Ghaniyyatul Khudri Gusti Ningsih, Wahidah Hadi Purnomo Hamda, Rialta Hansah, Rendri Bayu Haris Pauzan, Muhammad Hayuningtyas, Afwa Heni Fitriani Hidayatulloh, Rian Hurria, Hurria Imas Rosidawati Wiradirja Indah Pebrianti Irawan, Rizki Jailani Jailani Jaslindo, Lieka Nugrahi Kamaliah, Ulfah Karyanah, Yayah Khudri, Ghaniyyatul Nugrahi Krismadinata Krismadinata, Krismadinata Kurnia Maidarmi Handayani Maharani, Della Maribeth, Annisa Lidra Mayasari, Andi Melya Susanti Meutia, Nurma Mira Asmirajanti Muhammad Hatta Muhsin, Sri Wahyuni Neng Tine Kartinah Almuktabar Novardian, Novardian Novita Sari Nuribadah, Nuribadah Nursia, Lili Eky Pamungkas, Fhasa Lifiansah Azzah Permata, Sari Indah Pertiwi, Puji Adi Prisca, Cathrerine Andrea Putri, Suci Eka Ranggani, Nila Ratna Dewi Rian Adi Pamungkas Rifa'i Rifaat, Hafid Rinawati Rinawati Rosya, Ernalinda Salamiyah, Barokatus Sava, Zaskia Nada Sinaga, Irma Suryani Siti Hanifah Siti Maisyaroh Fitri Siregar Sukarno, Anita Triwid Syafarotun Najah, Triwid Syafarotun Veronika, Erna Wahyuni, Sarifah Wahyuni, Yulia Wati, Widya Sulistya Wijaya, Berlian Wiranda, Diki Yeyen, Siti Sari Yulfienti, Elfi Yulika, Villya Zahro, Lailatul Zeffira, Laura