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All Journal Indonesian Journal of Pharmaceutical Science and Technology Unnes Science Education Journal JURNAL GALUNG TROPIKA Jurnal Penelitian Pendidikan IPA (JPPIPA) Al-Kimia Biosfer: Jurnal Pendidikan Biologi Indonesian Journal of Chemistry Journal of Education and Instruction (JOEAI) BIOEDUSAINS: Jurnal Pendidikan Biologi dan Sains Alignment: Journal of Administration and Educational Management Jurnal Kartika Kimia Seminar Nasional Pengabdian Kepada Masyarakat Jurnal Pengabdian Kepada Masyarakat Sosiosaintifik Tamaddun Venn: Journal of Sustainable Innovation on Education, Mathematics and Natural Sciences JIPI (Jurnal IPA dan Pembelajaran IPA) Abdi Kimia : Jurnal Pengabdian Masyarakat SMART: Jurnal Pengabdian Kepada Masyarakat Hayyan Journal Mammiri: Jurnal Pengabdian Masyarakat Illea
Irfandi, Rizal
Department Of Chemistry, Faculty Of Mathematics And Natural Science, Universitas Negeri Makassar, Makassar, Jalan Daeng Tata Raya Makassar, 90244, Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Physics Social Sciences Other

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Journal : Hayyan Journal

 1 
Literature Review: Network Pharmacology as a New Approach and Trend in Medicine ihya, Zahratul; Irfandi, Rizal; Rijal, Syamsu; Yani, Ahmad; Arafah, Muhammad; Badli Rompegading, Andi
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1130

Abstract

Network pharmacology is a new approach to medicine that aims to understand drug interactions with body tissues more specifically. This concept involves a deep understanding of the mechanisms of drug action, drug metabolism, and the influence of drugs on tissue function. In recent years, network pharmacology has become a significant trend in drug development. This approach allows researchers to design drugs that are more effective and have fewer side effects. By understanding in detail how drugs interact with specific tissues, specific and targeted drug development can be undertaken. Network pharmacology also opens the door to the development of more particular and existent therapies. By taking into account individual differences in response to drugs, this approach allows for more effective and safer treatment. This article presents a literature review of network pharmacology as a new approach and trend in medicine. This literature review also explores the latest research and current trends in the world of medicine using a network pharmacology approach.This article shows that tissue pharmacology has great potential in more effective and safer treatments. With a better understanding of drug - tissue interactions, we can develop more targeted therapies and reduce the risk of undesirable side effects.
Review of Transition Metal Dithiocarbamate Complexes: Novel Fluorescent Materials for Biosensor Applications Irfandi, Rizal
Hayyan Journal Vol. 2 No. 2 (2025): June
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i2.3149

Abstract

Transition metal complexes with dithiocarbamate ligands have attracted significant attention in recent decades due to their unique electronic and optical properties. This article presents a comprehensive review of transition metal-dithiocarbamate complexes as fluorescent materials and their potential in biosensor development. Focus is given on their chemical structure, fluorescence mechanism, as well as their application in detecting important biomolecules. With the increasing need for sensitive, selective, and low-cost biosensors, these materials offer promising prospects in various biomedical and environmental applications.
Literature Review: Network Pharmacology as a New Approach and Trend in Medicine ihya, Zahratul; Irfandi, Rizal; Rijal, Syamsu; Yani, Ahmad; Arafah, Muhammad; Badli Rompegading, Andi
Hayyan Journal Vol. 1 No. 1 (2024): February
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v1i1.1130

Abstract

Network pharmacology is a new approach to medicine that aims to understand drug interactions with body tissues more specifically. This concept involves a deep understanding of the mechanisms of drug action, drug metabolism, and the influence of drugs on tissue function. In recent years, network pharmacology has become a significant trend in drug development. This approach allows researchers to design drugs that are more effective and have fewer side effects. By understanding in detail how drugs interact with specific tissues, specific and targeted drug development can be undertaken. Network pharmacology also opens the door to the development of more particular and existent therapies. By taking into account individual differences in response to drugs, this approach allows for more effective and safer treatment. This article presents a literature review of network pharmacology as a new approach and trend in medicine. This literature review also explores the latest research and current trends in the world of medicine using a network pharmacology approach.This article shows that tissue pharmacology has great potential in more effective and safer treatments. With a better understanding of drug - tissue interactions, we can develop more targeted therapies and reduce the risk of undesirable side effects.
Molecular Docking of Quercetin for Inhibition of Enoyl-Acyl Carrier Protein Reductase in Mycobacterium tuberculosis Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4345

Abstract

Tuberculosis remains a global health issue, with treatment hindered by drug resistance. This study aims to identify the potential of Quercetin as an inhibitor of Enoyl-Acyl Carrier Protein Reductase (M. tuberculosis), a key enzyme in the fatty acid biosynthesis of the bacteria. Using molecular docking, Quercetin is evaluated based on its binding affinity and stability with the target protein. The docking results show that Quercetin binds to the active site of Enoyl-Acyl Carrier Protein Reductase through hydrogen bonds, π-alkyl, and π-sigma interactions, with an RMSD value of 1.6466 Å, indicating valid results. Comparison with the control compound, 5-hexyl-2-(2-methylphenoxy)phenol, reveals that Quercetin has a stronger binding affinity, supporting its potential as a more effective enzyme inhibitor. These findings open new opportunities for the development of natural compound-based anti-Tuberculosis therapies that can address the growing problem of drug resistance. Further research is needed for experimental validation in biological models and the development of more efficient Quercetin formulations.
Transition Metal Layered Double Hydroxide Nanosheets for Breast Cancer Drug Delivery Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4375

Abstract

This review synthesizes research on transition metal layered double hydroxide nanosheets in breast cancerdrug encapsulation to address challenges in targeted delivery, drug resistance, and controlled release. Thereview aimed to evaluate synthesis and functionalization strategies, benchmark drug loading and releaseprofiles, elucidate metal doping effects on targeting and uptake, compare therapeutic outcomes, and identifyclinical translation barriers. Literature selection focused on experimental in vitro and in vivo studies publishedup to mid-2024, emphasizing physicochemical characterization, cellular internalization, and therapeuticefficacy. Findings reveal that transition metal doping and surface modifications enable ultrahigh drug loadingcapacities with pH-responsive, tumor-specific release, enhancing intracellular delivery via receptor-mediatedand endocytic pathways. Multifunctional nanosheets demonstrate synergistic anticancer effects throughcombined chemo-, photothermal, and immunotherapies, with favorable biocompatibility and low systemictoxicity in preclinical models. However, variability in synthesis reproducibility, incomplete mechanisticunderstanding of metal ion interactions, and limited long-term safety data impede clinical translation.Integrating these findings underscores the potential of transition metal-doped LDH nanosheets as versatileplatforms for breast cancer nanotherapy while highlighting the need for standardized evaluation andcomprehensive in vivo assessments. These insights inform future research directions toward optimizingnanosheet design and advancing clinical applications in precision oncology.
Visual Detection of Lead Ions (Pb²⁺) Using a Colorimetric Sensor for Fishery Products Fudhail, Ahmad; Irfandi, Rizal
Hayyan Journal Vol. 2 No. 3 (2025): October
Publisher : Education and Talent Development Center of Indonesia (ETDC Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51574/hayyan.v2i3.4498

Abstract

The presence of lead ions (Pb²⁺) in fishery products poses potential risks to human health. Therefore, simple, rapid, and easily applicable detection methods are highly required. This study aimed to develop a simple colorimetric sensor for the visual detection of Pb²⁺ based on color change as an analytical signal. The sensor was prepared through the interaction of a complexing indicator with the target metal ion, resulting in a distinct and visually observable color response. The novelty of this work lies in the application of a simple colorimetric sensor with a low visual detection limit and high selectivity toward Pb²⁺, as well as its direct applicability to simulated fishery product samples without the need for complex analytical instruments. The results demonstrate that the developed sensor is capable of selectively detecting Pb²⁺ with a clear visual response, indicating its potential use as a low-cost and practical method for preliminary screening of lead contamination.
Co-Authors Abd Rahman Abd Rahman Abdul Kadir Ade Sucitra Putri Ahmad Fudholi Ahmad Ghazali Samad Ahmad Rinaldy Ahmad Yani ahmad yani Ahmad Yani Ahmad Yani Ahyar Ahmad Ahyar Ahmad Ahyar Ahmad Aisyah Gusfira Ambo Upe Ambo Upe Andi Alwa Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Badli Rompegading Andi Muh. Fathul Andi Pitung Andi Wilda Resky Angga Andriana Anita Anita Arifuddin, Arman Arini Rajab Arisa, Arisa Arman Arifuddin Asriana Asriana Audya Syahra Ayu Lestari Ayu Muliana Badli Rompegading, Andi Baso Bambang Juni Edi Baso Muhammad Reski Bima Sardina Bunyamin, Andi Bulqiah Nur Cindy Agustina Cindy Agustina Dahlan, Darsal Darsal Dahlan Darwis Desy Kartina Devi Wulandari Ramli Dewi Sartika Dian Ramadhani Dian Ramadhani Diana Eka Pratiwi Dingse Pandiangan Erna Sulastri P Erwing Erwing Esti Arni Fandi Ahmad Fatimah Fatimah Febriani Danur, Riny Firdaus Zenta Fudhail Majid, Ahmad Fudhail, Ahmad Hadarmawandi Hadarmawandi Hadarmawandi, Hadarmawandi Harningsih Karim Harningsih Karim Hasnah Natsir Hasnah Natsir Herlina, Besse ihya, Zahratul Ilyas, Nita Magfirah Indah Raya Indah Raya Indah Raya Jasri Djangi, Muhammad Jayawarsa, A.A. Ketut Lili Suryani Luthfi Siraj, Muhammad Mazaya, Maulida Mirjawanda Mirjawanda Mitha Febriani Muh. Damriansyah Muh. Faqhi S. Muh. Fathir Rahmat Muh. Ilham Muhammad Afdal Muhammad Akbar Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Arafah Muhammad Fadryansah Muhammad Fathir Rahmat Muhammad Nasir Muhammad Nasir Muhammad Nasir Muhammad Nur Muhammad Nur Muhammad Nur Muhammad Resky Muhammad Taufiq Muhlis, Nur Fadhillah Muriyati Murniati Safitri Mutmainnah Gani Nasser P, Muh Kemal Nasser P, Muhammad Kemal Negara, Satria Putra Jaya Netti Herawati Nia Febrianti Nirmawati Hamka Nirmayanti Syamsuddin Nur Aulia Hazzah Nur Fadhillah Muhlis Nur Fisabilianti, Nur Nur Indah Sari Nur Insani Amir Nur Nur Fisabilianti Nur Rahmi Nurcaya Nurcaya Nurcaya Nurcaya Nurul Hikma Fajar Paulina Taba Pitung, Andi Putri Dewi Suci Ramadhani Rachmat Triandi Tjahjanto Rahma, Besse Nuramalia Rahmawati Rahmawati Ramadani, Ananda Ramadhani, Andi Amaliyah Rani Sengka Renaldi Reski Hamdiah Riki Rusanda Ririn Eka Riska Febrianti Riska Ramayana Rismawati Rismawati Rizky Arfadilla Rompeggading, Andi Badli Rony, Zahara Tussoleha Rosdiana Rosdiana Rugaiyah Arfah Ruslang, Ruslang Sahriah Rahim Santi Santi Sarlan, Sarlan Sasmita, Reski Aggun Sengka, Rani Sir, Panessai Siti Fauziah SITI HALIMAH LAREKENG, SITI HALIMAH Sitti Aminah Subakir Salnus Subakir Salnus Sudarmianti, Sudarmianti Sugiarti Sugiarti Suharni Sudirman Sulistiani Jarre Sumarni Sumarni Sumiati Side Suriati Eka Putri Suriati Eka Putri Suriya Satar Susan Marlein Mambu Susilo Sudarman Desa Syah, Uswah Trywulan Syamsu Rijal Syamsu Rijal Syamsu Rijal Syamsu Rijal Tantu, Zakiah Vitrani Vitrani Wahid Wahab Yanti, Reski Yetti Anita Yuliana S Zakiah Tantu Zulfian Armah