Article Per Year (5 Year)
p-Index From 2021 - 2026
9.211
P-Index
This Author published in this journals
All Journal Gorga : Jurnal Seni Rupa DiE: Jurnal Ilmu Ekonomi dan Manajemen Tanra : Jurnal Desain Komunikasi Visual Fakultas Seni dan Desain Universitas Negeri Makassar Journal of Visual Art and Design Indonesian Journal of Tropical and Infectious Disease Jurnal Ilmiah Pendidikan Pancasila dan Kewarganegaraan Jurnal Ilmiah Universitas Batanghari Jambi Journal of Accounting Science Jurnal Teknik Industri : Jurnal Hasil Penelitian dan Karya Ilmiah dalam Bidang Teknik Industri PRODUCTUM : Jurnal Desain Produk (Pengetahuan dan Perancangan Produk) Indonesian Journal of Cardiology Majalah Ekonomi Equilibrium: Jurnal Ekonomi-Manajemen-Akuntansi Care : Jurnal Ilmiah Ilmu Kesehatan Waca Cipta Ruang: Jurnal Ilmiah Desain Interior Jurnal Abdimas PHB : Jurnal Pengabdian Masyarakat Progresif Humanis Brainstorming Jurnal Fundadikdas (Fundamental Pendidikan Dasar) Building of Informatics, Technology and Science JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Industri Kreatif (JIK) INCARE Jurnal Tarbiyatuna : Kajian Pendidikan Islam Darul Ilmi: Jurnal Ilmu Kependidikan dan Keislaman Jurnal Kajian dan Pengembangan Umat Fitrah: Journal of Islamic Education Narra J Dharmas Education Journal (DE_Journal) Ikhtisar: Jurnal Pengetahuan Islam Sulawesi Tenggara Educational Journal Journal of Social Research Journal of Innovation Research and Knowledge eProceedings of Art & Design Jurnal Tahsinia Bali-Dwipantara Waskita: Seminar Nasional Republik Seni Nusantara Neraca Manajemen, Akuntansi, dan Ekonomi Journal Education And Islamic Studies Journal Of Humanity Dedication Indonesian Journal of Electronics, Electromedical Engineering, and Medical Informatics J-CEKI Computer & Science Industrial Engineering Journal Insight: Indonesian Journal of Social, Humanity, and Education Journal of Applied Informatics Science Folia Medica Indonesiana
Andrianto Andrianto
Telkom University
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

Published : 93 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search
Journal : Narra J

 1 
Perindopril and losartan affect ACE-2 and IL-6 expression in obese rat model Andrianto, Andrianto; Hermawan, Hanestya O.; Harsoyo, Primasitha M.; Zaini, Bagas SI.; Muhammad, Akbar R.
Narra J Vol. 4 No. 2 (2024): August 2024
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v4i2.681

Abstract

Obesity has emerged as a worldwide health concern due to its increasing prevalence. Adipocytes have the ability to express angiotensin-converting enzyme 2 receptors (ACE2) and several adipocytokines. These expressions could lead to the activation of a cytokine storm, which in turn promotes the development of cardiovascular diseases. The aim of this study was to investigate the impact of perindopril and losartan exposure on the ACE2 and interleukin 6 (IL-6) levels in adipocyte cells. This study used an in vivo true experimental design utilizing a post-test-only control group. A total of 24 adult male albino rats were divided into four groups, one group served as the non-obese (negative control), while the other three groups were obese: (1) the positive control (untreated obese rats); (2) perindopril group (2 mg/kg BW/day orally for 4 weeks); and (3) losartan group (20 mg/kg BW/day for 4 weeks). Afterwards, the rats were euthanized, and the visceral fat tissue were obtained during dissection. The levels of ACE2 and IL-6 were measured using the enzyme-linked immunosorbent assay (ELISA). Losartan administration in obese rats resulted in a notable elevation in ACE2 levels compared to both the perindopril group (losartan vs perindopril, p=0.011) and the positive control (p=0.004). In addition, the treatment of perindopril and losartan in obese rats resulted in a significant reduction in IL-6 levels when compared to the positive control (perindopril vs positive control, p=0.020; losartan vs positive control, p=0.002, respectively). This study provides insight into the administration of perindopril and losartan, which could suppress the pro-inflammatory (IL-6) but increase the ACE2 levels in adipose tissue.
Co-Authors A, Ford Ance Abdulloh, Muchammad Raafi Achmad Reza Adnan, Syaiful Afnita, Nora Akmal Nur Arifin Akram, Muhammad Rafiul Alam, Citi Hasanah Nur Alamsyah, Nanang Alvian Fajar Setiawan Amanah, Fisa Amin, Aminul Amris, Firda Khairati Andi Dwi Riyanto Andita Putri, Sheila Anggraeni Putri, Sukmawati Annanda, Yefri Anugrah Siregar, Wira Aqil, Sultan Arifin, Akmal Nur Arindanie, Amelia Asep Sufyan Muhakik Atamtajani Ayunda, Salsabila Azamel Fata Badriyatul Muniroh, Badriyatul Cahyo Sasmito Chris Chalik Christian Hutasoit, Roby Dandi Yunidar Dani Arifudin Diana Artamevia Khoirunnisa Dona Saphiranti Dudik Djaja Sidarta Duski Samad Edwin Buyung Syarif Efendi, Syafrizal Elisa, Erlin Enggar Budi Pratama Enny Istanti Fajar Astuti Hermawati Fajar Sadika Fajri, Muhammad Afhandry Farida Ariani FATHUR ROHMAN Fitri Nuraini, Fitri Giat Karyono Gusnita, Fitri hardiansyah, bagus Hardy Adiluhung Harsoyo, Primasitha M. Harsoyo, Primasitha Maharany Hermawan, Hanestya O. Hidayah, Teguh Ibadurrahman, Pejagote Ica Ramawisari Idris, Saufi Zahra Ihsan, Naufal Fadlan Ikbal, Ahmad Imam Tahyudin Imam, Muhammad Fadhil Imtihan Hanom Indragunawan, Cakti Iskandar, Muh Faldi Julhadi, Julhadi Khoirunnisa, Diana Artamevia Kusuma, Gabrielle Mahanaim Lahmi, Ahmad Lestari, Sella Rizkita Lutvia Ebd, Adinda Nadya Mawarni, Wulan Eka Msitam, Zainulfikar Putera Wardana Mufid, Abiyyu Rozan Muhakik Atamtajani, Asep Sufyan Muhakik, Asep Sufyan Muhammad Ramadhan Muhammad, Akbar R. Muhammad, Raafi Nur Mukhtar, Salsabila Nindya Kartika Kusumayati Ningsih, Sri Wahyuni Nisrina, Nabila Ratu Nofitayanti, Nofitayanti Noviyani, Rafiqa Nugroho, J Nur Handayati Nuruddin Hady Nuvus, Alviyatul Ainin Oky Setiawan Pardosi, Pardomuan Pikir, Budi S Prabu Wardono Prasetya, Bima Pregustama, Moch Refqi Prinata, Fadhil Surya PUTRA, AHMAD Putri, Ardella Anindya Rahmansyah, Farhan Rahmiyati Rahmiyati, Rahmiyati Rais, Zaim Ramadhan, Rizki Aulia Ratri, Anudya Kartika Refdilzon Yasra, Refdilzon Rehani rehani Revanza Vialdi, Mohammad Rieska Maharani, Rieska Rizka Rachmawati Rizkiawan, Ronaldi Robbany, Fadly Rohmah, Nadhifa Ainur Rozak, Rofiq 'Abdul Rozak, Rofiq ‘Abdul Rully Hidayatullah Sabaniah, Nofetriani Safitri, Winda Saputra, Edriagus Saputra, Syahnan Sayuti, M. Sheila Andita Putri Solly Aryza Sony Wibisono Sri Untari Sumiarti Sumiarti Sundari Indah Wiyasihati Supriani, Bella SURYANINGRUM, EVI Suyitno Suyitno Syafruddin Syafruddin Syahputri, Marwah Annie Syamsurizal Syamsurizal - - Tahyudin, Imam Zaheen Terbit Setya Pambudi Tikaningsih, Ades Triana, Yeni Wahyu Prawesthi Wahyuni, Yosi Sri Wandi, Joni Indra willy.masrur@gmail.com Yahdi, Putri Octavia Regina Yani, Putri Andri Yanti, Novita Yanuar Herlambang Yoga Pujiraharjo Yulia Fitria Zaini, Bagas SI.