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All Journal Medula Science and Technology Indonesia Jurnal Ilmu Kedokteran dan Kesehatan Community Development Journal JURNAL PENELITIAN PERAWAT PROFESIONAL Journal of Language and Health Jurnal Pengabdian Fakultas Pertanian Universitas Lampung Jurnal Pengabdian Masyarakat JPM (Jurnal Pengabdian Masyarakat) Ruwa Jurai
Ety Apriliana
Bagian Mikrobiologi, Fakultas Kedokteran, Universitas Lampung
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Computer Science & IT Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Journal : Medula

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Diare adalah kondisi yang ditand Ecoli Penyabab Diare Akut : Ecoli Penyabab Diare Akut: Patogenesis, Diagnosis dan Tatalaksana Shinta Dewi, Brigitta; Soleha, Tri Umiana; Septiani, Linda; Apriliana, Ety
Medula Vol 14 No 5 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i5.903

Abstract

The presence of Escherichia coli bacteria or what is often called E.coli is an indicator of contaminated food and water which shows that there is contamination in human feces. 16 Research results show that consuming food contaminated with Escherichia coli bacteria can cause symptoms of diarrhea, pain, fever, and vomiting6. Escherichia coli bacteria can be transmitted through contact with infected food handlers when processing food16. Escherichia coli can be transmitted from feces through contact with human fingers, flies, soil and water that comes into direct contact with food and eating utensils19. Diarrhea in Indonesia is an endemic disease and a potential disease that is associated with a significant mortality rate. In that year, there were 21 extraordinary events (KLB) which spread across 12 provinces and 17 districts/cities. 12. An increase in diarrhea occurred in 2018 with the number of cases reaching 4,504,524 people. In 2019, diarrhea cases decreased slightly to 4,485,513 people. The national incidence rate of diarrhea is 270 per 1,000 population12. In 2020, diarrhea in Bandar Lampung City reached 16,989, in 2021 there was an increase with the number of cases 22,371 (Central Statistics Agency for Bandar Lampung City, 2023) 4. Knowledge and updates regarding E. Coli as a cause of diarrhea are important for medical personnel.
Faktor-Faktor yang Mempengaruhi Keparahan Derajat Infeksi Dengue pada Pasien Anak Rahel, Clara Arta Uli; Apriliana, Ety; Septiani, Linda; Soleha, Tri Umiana
Medula Vol 14 No 1 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i1.954

Abstract

Dengue infection is an infectious disease transmitted by mosquitoes, especially Aedes species which have been infected to humans. Dengue virus (DENV) consists of four serotypes, namely DEN-1, DEN-2, DEN-3, and DEN-4. Dengue virus infection in humans, especially in pediatric patients, can cause different symptoms from one patient to another. To make it easier to classify the patient's condition, WHO has classified the clinical severity of dengue infection, namely dengue fever, dengue hemorrhagic fever which consists of four levels, and dengue shock syndrome. The varying progression of dengue infection is the basis for knowing the factors that can influence the severity of the degree of dengue infection in terms of the patient's characteristics, clinical symptoms and laboratory results.
Retinopati Diabetik yang Mengancam Penglihatan Oktaryona Trisera; Himayani, Rani; Apriliana, Ety; Yusran, M
Medula Vol 14 No 4 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i4.1070

Abstract

Diabetic retinopathy is a progressive microangiopathy characterized by retinal vascular damage and blockage. The global prevalence of diabetic retinopathy is 34.6%. Clinical manifestations in patients with diabetic retinopathy include aneurysms, vein dilation, vitreous hemorrhage, and hard exudates which can affect visual acuity. Progression of diabetic retinopathy can potentially threaten vision and even blindness even though initially there are no severe clinical manifestations. Visual-threatening diabetic retinopathy is classified into severe NPDR, PDR, and all DR with diabetic macular edema. The global prevalence of VTDR is 7.26% and according to research by Sasongko et al (2017) states that 1 in 4 DM patients has a vision-threatening DR condition (VTDR). The best management of DR is prevention in the form of early screening, education, and counseling, especially in DM patients. For patients who have been diagnosed with DR, follow-up treatment, laser, injection, or even surgery, depending on the severity.
Sepsis neonatal atau biasa dikenal dengan sepsis neonatorum merupakan infeksi yang melibatkan seluruh aliran darah dan semua organ-organ pada bayi baru lahir yang berusia kurang dari 28 hari. Penyakit ini masih menjadi penyebab utama morbiditas dan mort Sabila, Ghina; Apriliana, Ety; Islamy, Suryadi; Sari, Ratna Dewi Puspita
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1258

Abstract

Neonatal sepsis is a systemic infection that involves the entire bloodstream and organs of newborns, making it one of the leading causes of neonatal morbidity and mortality, particularly in low- and middle-income countries. Neonatal sepsis is classified into early-onset sepsis (EOS) and late-onset sepsis (LOS), with varying etiologies involving gram-positive bacteria, gram-negative bacteria, and fungi. This article aims to provide a comprehensive review of the etiology, risk factors, diagnosis, and management of neonatal sepsis using an evidence-based approach. This article is based on an analysis of current literature relevant to the epidemiology, pathogenesis, and treatment of neonatal sepsis. EOS is primarily caused by vertical transmission of infection during delivery, with Group B Streptococcus (GBS) as the leading cause, while LOS is often associated with nosocomial infections caused by Staphylococcus epidermidis. Risk factors include prematurity, low birth weight, invasive procedures, and poor infection control. Management involves the administration of broad-spectrum empirical antibiotics within one hour of suspected sepsis, tailored to culture results. A holistic approach, including NICU care, family education, and optimization of infection prevention, has been shown to effectively reduce morbidity and mortality. Neonatal sepsis remains a significant challenge in perinatology, necessitating comprehensive management with an evidence-based approach encompassing timely antibiotic therapy, nosocomial infection control, and family education to improve neonatal outcomes. Preventive efforts, such as enhancing perinatal hygiene and neonatal care, must be optimized to reduce the incidence of neonatal sepsis.
Pengaruh Waktu Inkubasi Terhadap Daya Hambat Ekstrak Daun Binahong Pada Cutibacterium Acnes Alvista, Valentina Nancy; Sibero, Hendra Tarigan; Aditya, Muhammad; Apriliana, Ety
Medula Vol 14 No 7 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i7.1272

Abstract

Acne (Acne vulgaris) is a common skin disorder often caused by the bacterium Cutibacterium acnes. Bacterial resistance to antibiotics used in acne treatment has become a significant concern. This study evaluated the effect of incubation time on the diameter of the inhibition zone produced by binahong (Anredera cordifolia) leaf extract in inhibiting the growth of C. acnes. The well diffusion method was employed using extract concentrations of 25%, 50%, 75%, and 100%. Data analysis was conducted using a paired t-test. The results showed a significant difference (p < 0.001) in the inhibition zones formed based on variations in incubation time. The findings indicated that longer incubation times resulted in larger inhibition zones. Binahong leaf extract was found to be effective in inhibiting the growth of C. acnes, particularly at higher concentrations and with longer incubation durations. These results demonstrate the potential of binahong leaf extract as an effective acne treatment to address antibiotic resistance.
RISK FACTORS FOR PULMONARY TUBERCULOSIS COINFECTION IN HIV/AIDS PATIENTS Ildha Rosendy Kurnianda; Apriliana, Ety; Putri, Giska Tri; Wardani, Dyah Wulan Sumekar Rengganis
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1318

Abstract

Tuberculosis and HIV co-infection is a major public health problem in many parts of the world. In Indonesia, tuberculosis (TB) is an opportunistic infection that most often occurs in people living with HIV/AIDS (PLWHA). HIV infection increases susceptibility to Mycobacterium tuberculosis, thereby increasing the risk of developing TB. The World Health Organization (WHO) estimates that TB causes 13% of deaths in AIDS sufferers. Tuberculosis (TB) and HIV co-infection occurs when a person is infected with Mycobacterium tuberculosis and HIV at the same time. People with HIV have a 30 times greater risk of suffering from TB than people who are not infected with HIV. There is a significant relationship between these two infections, where each infection accelerates the development of the other infection. HIV infection can trigger reactivation of latent TB into active TB, while TB infection can worsen the clinical condition of patients who have been infected with HIV. The aim of this study was to determine various risk factors for pulmonary tuberculosis co-infection in HIV/AIDS patients. The method used is qualitative with literature study as a data collection technique. The results obtained were alcohol consumption and extra-pulmonary TB, education level, monthly income, occupation, family history of PTB, lack of appetite, balanced diet, maintaining healthy nutrition, smoking, and stopping taking medication if you felt the condition was under control and the incidence of PTB were factors associated with an increase in pulmonary tuberculosis co-infection..
Potensi Ekstrak Kulit Nanas (Ananas comosus) Sebagai Antimikroba Sinaga, Herman Fransiskus; Apriliana, Ety; Septiani, Linda; Kurniati, Intanri
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1427

Abstract

Pineapple is one of the traditional plants that may be used as an alternative treatment to reduce pathogenic microbes. Its content is rich in chlorine, iodine, phenol and the enzyme bromelain which functions to stop microbial growth. This research aims to determine the potential of pineapple peel extract (Ananas comosus) as antimicrobe agents. This research uses a literature review study method, namely by using research articles obtained through a literature search process related to the potential use of pineapple peel extract on microbe from 2015 to 2025. Pineapple peel extract contains the main compounds, namely flavonoids, polyphenols, bromelain and saponins. This content causes pineapple skin extract (Ananas comosus) to have an effect on microbes.
UJI DAYA HAMBAT EKSTRAK DAUN LIDAH MERTUA (Sansevieria trifasciata laurentii) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus Saputra, Kurnia Hadi; Apriliana, Ety; Rodiani, Rodiani; Oktarlina, Rasmi Zakiah
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1579

Abstract

Infectious and communicable diseases remain one of the leading causes of mortality in Indonesia and worldwide. Several pathogenic bacteria can cause infections, one of which is Staphylococcus aureus. This bacterium can lead to a variety of conditions, including mastitis, dermatitis (skin inflammation), respiratory tract infections, impetigo, abscesses, toxic shock syndrome, and food poisoning. With the advent of antibiotics, an increasing number of bacterial strains have developed antibiotic resistance. The primary cause of this resistance is the widespread and irrational use of antibiotics, which allows some bacteria to survive and become resistant. The snake plant (Sansevieria trifasciata laurentii) contains compounds with antibacterial properties, such as tannins, saponins, and flavonoids. This study aimed to investigate the antibacterial activity of snake plant extract against Staphylococcus aureus. The research design used was a laboratory-based observational study. The antibacterial activity of the snake plant leaf extract was tested at concentrations of 20%, 40%, 60%, 80%, and 100% against Staphylococcus aureus using the dilution method to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC). The results showed that the snake plant extract exhibited antibacterial activity against Staphylococcus aureus at all tested concentrations (20% to 100%). The MIC was observed at a concentration of 20%, while the MBC was found at 40%. These findings confirm that the extract of Sansevieria trifasciata laurentii has inhibitory effects on the growth of Staphylococcus aureus.
Faktor Risiko Personal dan Lingkungan dalam Kejadian Demam Tifoid Kurniawan, Diva Ardhana; Apriliana, Ety; Sutarto, Sutarto; Himayani, Rani
Medula Vol 14 No 11 (2024): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i11.1328

Abstract

Typhoid fever is one of the infectious diseases that has a fairly high morbidity and mortality rate, especially in developing countries, especially in Indonesia. Typhoid fever is an infectious disease caused by the bacteria Salmonella typhi. This disease can be transmitted through consuming water or food contaminated with urine and feces from typhoid fever sufferers, for example, water that will be used for drinking, cooking, or washing food ingredients. There are more serious clinical symptoms, such as high fever or hyperthermia, remittent fever, and decreased level of consciousness that can lead to coma or delirium. Further complications such as dehydration and acidosis can also occur, which have negative impacts in cases of typhoid fever. The purpose of this review article is to determine what personal and environmental risk factors are present in the occurrence of typhoid fever. The method used in this study is a review article with specific research of various articles found, then combined and a summary conclusion is drawn. The journals used have been published for the past 5 years (2019-2024). The results and conclusions show that several personal and environmental risk factors in the occurrence of typhoid fever include age, gender, personal hygiene, and clean water sources.
Manuver Epley dan Brandt-Daroff Dalam Penatalaksanaan Benign Paroxysmal Positional Vertigo (BPPV) Hafidah, Hazima Hasna; Marcellia, Selvi; Apriliana, Ety
Medula Vol 14 No 10 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v14i10.1383

Abstract

Benign Paroxysmal Positional Vertigo (BPPV) is the most common cause of vertigo with a case prevalence of 1.6% globally. It is characterized by recurrent episodes of vertigo due to changes in head position. BPPV disease is caused by the transfer of otoconia to the semicircular canal, stimulating the vestibulocochlear nerve resulting in symptoms of vertigo, nystagmus, and becoming more sensitive to head movement. The impact is significant on the physical, psychological, and quality of life aspects of the patient. This literature review discusses the mechanism, effectiveness, and success rate of Epley and Brandt-Daroff maneuvers. Data were obtained from relevant literature with data sources coming from Pubmed, NCBI, and Google Scholar.  The results of the literature review showed that the Epley maneuver has high effectiveness with a cure rate of up to 92% within one week and a significant reduction in sequelae, especially in the modified Epley maneuver. In addition, the Brandt-Daroff maneuver proved to be effective for self-treatment at home with gradual improvement of vertigo symptoms. Both methods have advantages, such as the flexibility of the Brandt-Daroff maneuver and quick results in the Epley maneuver, but have certain limitations in patients with comorbid conditions. The conclusion of this literature review shows that the Epley maneuver is the first choice in the treatment of BPPV due to its higher effectiveness, while the Brandt-Daroff maneuver can be used as an alternative.
Co-Authors Adisti, Fransiska Afifah, Syafira Hasna Agustin, Nur Aini Ahmadi, Peni Alvinasyrah, Alvinasyrah Alvista, Valentina Nancy Ambarwati, Yuli Andi Setiawan Arafah, Aisyah Putri Arai, Masayoshi Ari Wahyuni Aspita Laila Bayu Anggileo Pramesona Betta Kurniawan, Betta Carolia, Imelda Dian Isti Angraini Dian Septinova Dwi Indria Anggraini Dyah Wulan Sumekar Rengganis Wardani Efrida Warganegara Efriyan Imantika Fitria Saftarina Frauprades, Kaltihennah Oktavia Giska Tri Putri Hafidah, Hazima Hasna Hanna Mutiara, Hanna Helmi Ismunandar Hendra Tarigan Sibero Hermawan, Alan Ildha Rosendy Kurnianda Indri Windarti Intanri Kurniati Irawati, Nur Ayu Virginia Islamy, Suryadi Janar Wulan, Anggraini Jausal, Anisa Nuraisa Jhons Fatriyadi Suwandi John Hendri Juliasih, Ni Luh Gede Ratna Karima, Nisa Kartika, Juspeni Khairun Nisa Kurniawan, Diva Ardhana Kurniawaty, Evi Legowo, Ahmad Bambang Madi Hartono Marcellia, Selvi Mayasari, Diana Muatiara, Hanna Muhammad Aditya, Muhammad Muhammad Ricky Ramadhian Muhammad Yusran Novi Nurhayati, Novi Novita Carolia Nugraha, Ega Nurul Utami Oktafany, Oktafany Oktaryona Trisera Puspita, Ratna Dewi Putra, Muhammad Ferdiansyah Qonita, Adzrok Rahel, Clara Arta Uli Rahmadian, M. Ricky Ramadhana Komala Rani Himayani Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Ratna, Maya Ganda Reni Zuraida Rika Lisiswanti Rito, Hardiansyah Faisal Rodiani, Rodiani Sabila, Ghina Salsabila, Nafila Khansa Saputra, Kurnia Hadi Saputra, Wahyu Agung Dwi Sari, Merry Indah Selawati, Diyah Septia Eva Lusina Septiani, Linda Setiawan, Gigih Shinta Dewi, Brigitta Shinta Nareswari, Shinta Sihaloho, San Maulina Silitonga, Yona Arisena Magdalena Sinaga, Herman Fransiskus Sofyan Musyabiq Wijaya Suharmanto Suryadi Islami Susianti, Susianti Sutarto Sutarto Suwandi, Jhosn Fatriyadi SYAIFUL BAHRI Tengku Riza Zarzani N Tri Umiana Soleha Tugiyono Tugiyono Utari Gita Mutiara WAWAN ABDULLAH SETIAWAN, WAWAN ABDULLAH Widyastuti Widyastuti Yusran, M