Claim Missing Document
Check
Articles

KARAKTERISTIK KLINIKOPATOLOGI KARSINOMA SERVIKS DI RUMAH SAKIT DR. M. DJAMIL PADANG  PERIODE 2018 – 2021 Fedrivia, Rannia; Asri, Aswiyanti; Elfi, Eka Fithra; Muhammad, Syamel; Mulyani, Henny; Nofita, Eka
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1206

Abstract

Cervical carcinoma is a malignant tumor of cervical epithelial cells which is more than 90% caused by the human papillomavirus. Clinicopathology factors in cervical carcinoma such as age, history of parity, history of sexual intercourse, history of clinical manifestations, histopathology type and degree of differentiation are known to affect the prognosis. This study aims to determine the clinicopathological characteristics of cervical carcinoma at Dr. M. Djamil Hospital Padang in 2018-2021. This research is a descriptive research with the number of samples, 108 patients with confirmed cervical carcinoma. Research was conducted from March 2022 to March 2023 at the Laboratory of Anatomical Pathology, Dr. M. Djamil Padang. The results found that majority of cervical carcinoma patients is ≥45 years old (74,1%) with all patients are married (100%). The clinical manifestation that most patients complained about was vaginal bleeding 99.1% and 91,7% patients of cervical carcinoma were multiparity. The most common histopathological type of cervical carcinoma is squamous cell carcinoma (77.8%) and the highest degree of differentiation is moderate (47.2%). The cervical carcinoma patients at the Laboratory of Anatomical Pathology Dr. M. Djamil Hospital in 2018-2021 were found in the early elderly age group and are in advanced stage so it is necessary to carry out early detection and prevention of cervical carcinoma.
The Correlation of P16 Expression with Degree of Differentiation and Tumor Stage in Cervical Squamous Cell Carcinoma (CSCC) Sari, Nova Fenita; Nizar, RZ; Asri, Aswiyanti
Majalah Patologi Indonesia Vol. 32 No. 3, September 2023
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v32i3.653

Abstract

Background Cervical squamous cell carcinoma (CSCC) represents 70-80% of all cervical cancer cases. This cancer ranks 4th most common death cause due to malignancy in women. Cervical SCC patients were found at an older age and were detected at an advanced stage. High risk human papillomavirus (HPV) infection is main cause of SCC. Protein cyclin-dependent kinase inhibitor 2A also called p16 is a well-known tumor suppressor protein involved in cell cycle regulation, senescence, apoptosis, cell invasion and angiogenesis. This p16 protein can be used as surrogate marker for HPV infection. From several previous studies, there were differences between p16 expression relationship with differentiation degree and cervical SCC tumor stage results. Relationship research between p16 expression and differentiation degree and tumor stage of cervical SCC patients has never been conducted in West Sumatra. Methods This research was retrospective observational cross-sectional study with 35 cervical SCC cases that have been diagnosed at Anatomical Pathology Laboratory, RSUP Dr. M. Djamil Padang period January 2018-December 2019. Samples were obtained by simple random sampling from paraffin blocks derived from tumor tissue. The histopathological slide was reassessed to assess differentiation degree and tumor stage data were obtained from the patient's medical record. p16 expression in tumor cells was seen by immunohistochemical examination. To determine the correlation, bivariate statistical analysis was performed using the chi-square test with significance p<0.05 level. Results p16 high expression was found in 22 cases, tended to be higher in degree of well differentiation (40.9%) and moderate differentiation (50.0%) and was higher at an advanced stage (90.9%). Statistically, there is no correlation between p16 expression and differentiation degree with p value=0.138. There was no correlation between p16 expression and tumor stage with p value=0.337. Conclusions This study concluded that p16 expression was not associated with differentiation degree and tumor stage in cervical SCC.
Penggunaan Sitologi Imprint Intraoperatif Pada Lesi Ganas Payudara: Suatu Mucinous Carcinoma yang Dikonfirmasi dengan Pemeriksaan Histopatologi Dwi Yanti Fioni Putri; Aswiyanti Asri; Rony Rustam; Meta Zulyati Oktora
Scientific Journal Vol. 4 No. 4 (2025): SCIENA Volume IV No 4, July 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i4.247

Abstract

Pendahuluan: Mucinous carcinoma (MC) merupakan jenis karsinoma payudara yang langka dan khusus, ditandai oleh kelompokan sel tumor epitel yang berada dalam kumpulan musin ekstraseluler. Diagnosis MC dapat diperoleh pada sampel sitologi imprint yang memberikan gambaran berupa kelompok epitel tiga dimensi dan sel tunggal berukuran kecil hingga sedang, atipia inti ringan hingga sedang, dan vakuola intrasitoplasma, yang tersuspensi dalam musin ekstraseluler yang melimpah. Penting untuk menentukan fitur sitologi dari karsinoma ini karena keberadaan musin ekstraseluler saja tidak patognomonik untuk MC. Laporan kasus: Seorang pasien perempuan usia 62 tahun datang ke poliklinik Bedah RS UNAND dengan keluhan utama benjolan pada payudara kanan sejak 2 tahun yang lalu. Pasien dilakukan tindakan MRM berdasarkan hasil pemeriksaan potong beku berupa lesi ganas. Pemeriksaan sitologi imprint intraoperatif dilakukan bersamaan dengan potong beku dan didapatkan gambaran berupa kelompokan sel-sel dengan peningkatan N/C ratio dan inti hiperkromatik dengan latar belakang musin ekstraseluler. Kesimpulan gambaran sitologi adalah mencurigakan untuk keganasan. Diagnosis histopatologi dari sediaan blok paraffin mengkonfirmasi suatu Mucinous Carcinoma Tipe A. Kesimpulan: Penggunaan sitologi imprint intraoperatif dapat menjadi pilihan dalam diagnostik sitologi dengan spesifisitas dan sensitivitas tinggi dalam mendiagnosis lesi jinak dan ganas. Sitologi imprint memiliki tingkat akurasi yang sama dengan FNA dengan pemeliharaan detail sel yang sangat baik, sehingga dapat digunakan sebagai alat bantu diagnosis introperatif pada lesi payudara di negara-negara berkembang.
Diffuse Sclerosing Papillary Thyroid Carcinoma (Ds-Ptc): Kasus Jarang Dengan Perilaku Agresif: Kasus Jarang Dengan Perilaku Agresif Yuliza Ariani; Yessy Setiawatu; Aswiyanti Asri; Tofrizal; Hera Novianti; Meta Zulyati Oktora
Scientific Journal Vol. 4 No. 6 (2025): SCIENA Volume IV No 6, November 2025
Publisher : CV. AKBAR PUTRA MANDIRI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56260/sciena.v4i6.284

Abstract

Pendahuluan: Diffuse sclerosing Papillary Thyroid Carcinoma (DS-PTC) adalah subtipe PTC yang jarang terjadi dengan perilaku klinis yang agresif. Adanya ciri-ciri papiler membuat ahli patologi salah mendiagnosis tumor ini sebagai PTC konvensional. Namun, adanya keterlibatan kelenjar getah bening yang menyebar di kelenjar getah bening harus diwaspadai oleh ahli patologi. Laporan Kasus: dilaporkan kasus seorang pria berusia 35 tahun dengan benjolan di lehernya yang semakin membesar dalam 3 tahun, mengeluh sesak napas dan suara serak. Benjolan tersebut memiliki konsistensi padat, berukuran 12x7x5 cm dan 10x6x4 cm, dan mengikuti gerakan menelan. Nilai FSH dan T4 berada dalam batas normal. CT scan leher menunjukkan tumor tiroid kistik (sugestif ganas) dengan limfadenopati koli bilateral. Tiroidektomi bilateral dilakukan. Kelenjar getah bening (KGB) dan jaringan dikirim ke laboratorium anatomi patologis untuk diperiksa. Jaringan tiroid tampak berwarna putih kecoklatan pada penampang melintang dengan beberapa kista. Secara mikroskopis, terdapat proliferasi sel tumor yang membentuk struktur papiler dengan inti yang besar dalam mode tumpang tindih dengan gambaran groove dan ground glass. Ditemukan juga sklerosis stroma, psamoma bodies, dan metaplasia skuamosa, serta infiltrasi limfovaskular dan penyebaran sel tumor ke 26 kelenjar getah bening. Temuan ini konsisten dengan diagnosa DS-PTC stadium minimal pT3aN1bMx. Pasien ditangani dengan radioterapi setelah operasi. Kesimpulan: DS-PTC memiliki insiden metastasis kelenjar getah bening dan metastasis jauh yang lebih tinggi dibandingkan dengan classic PTC.Temuan ini harus diperhatikan oleh ahli patologi saat mendiagnosis tumor.
Hubungan Ekspresi E-cadherin dengan Derajat Histopatologik dan Tumor Budding pada Karsinoma Endometrium Jenis Endometrioid Pemuda, Haris; Asri, Aswiyanti; Zuryati Nizar, Rachmadijah; Yetti, Husna
Majalah Patologi Indonesia Vol 31. No. 3, September 2022
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55816/mpi.v31i3.515

Abstract

BackgroundEndometrial carcinoma is the fourth most common malignancy among women worldwide with increasing incidence and death rate every year. One of the types of endometrial carcinoma is endometrioid carcinoma, originated from atypical hyperplasia and develop into carcinoma. Lack of intercellular cohesiveness in the epithelial tumors such as endometrioid carcinoma occur due to lack of expression of E-cadherin. It can also causetumor invasion and metastatic through the epithelial-mesenchymal transition (EMT) process. Tumor differentiation and tumor budding are presumed to be histopathologic representations due to lack of cohesiveness and the occurrence of the EMT process so that these two things need to be related with the expression of E-cadherin on tumor cells.MethodsAn observational study was conducted using a cross-sectional approach with 46 cases of endometrioid endometrial carcinoma.Samples were obtained from 4 Anatomical Pathology Laboratories in West Sumatra during 2016-2019 in the form of paraffin blocks and HE slides that obtained from hysterectomy surgery. Reevaluation of tumor grade and tumor budding in HE slides was performed. E-cadherin expression in tumor cells was seen by immunohistochemical staining. Bivariate statistical analysis was performed using Fisher's Exact test and the results were considered significant if the p value was <0.05.ResultsSpecimens with negative E-cadherin expression were more common in grade 2 tumors (41.7%) and grade 3 tumors (50.0%) and in specimes with positive tumor budding (91.7%). Statistical analysis revealed a significant correlation between E-cadherin expression with tumor grade (p=0.000) and tumor budding (p=0.000).ConclusionExpression of E-cadherin has a significant correlation with the tumor grade and tumor budding in endometrioid endometrial carcinoma.
Tumor Budding Grade Based on the ITBCC 2016 Criteria is Associated with Lymphovascular Invasion and Lymph Node Involvement in Invasive Breast Carcinoma Nelzima, Maisyah; Asri, Aswiyanti; Tofrizal, Alimuddin; Hilbertina, Noza; Mulyani, Henny; Devianti, Loli; Fadila, Zurayya
Jurnal Penelitian Kesehatan SUARA FORIKES 2026
Publisher : FORIKES

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33846/sf17a03

Abstract

Invasive breast carcinoma is a malignant neoplasm with metastatic potential influenced by various histopathological parameters, including tumor budding (TB). TB has emerged as a potential indicator of tumor aggressiveness; however, differences in assessment criteria may affect its clinical relevance. This study aimed to evaluate the association between TB grade and lymphovascular invasion (LVI) as well as lymph node involvement in invasive breast carcinoma using three different assessment criteria. A cross-sectional study was conducted on 44 cases of invasive breast carcinoma that met the inclusion criteria. TB was assessed at the invasive front using the International Tumor Budding Consensus Conference (ITBCC) 2016 criteria, as well as the criteria proposed by Usta et al. and Manimaran et al. LVI and lymph node status were determined through histopathological examination. The associations between variables were analyzed using the chi-square test or Fisher’s exact test, as appropriate. Tumor budding grade based on one standardized assessment system demonstrated a significant association with both LVI and lymph node involvement. In contrast, the other two grading approaches did not show statistically significant associations. As conclusion, within the context of this study, the ITBCC 2016 criteria appear to be more representative in reflecting tumor invasive activity in invasive breast carcinoma. These findings support the potential role of tumor budding as an additional indicator of tumor aggressiveness and highlight the importance of standardizing its assessment method in invasive breast carcinoma.Keywords: invasive breast carcinoma; tumor budding; lymphovascular invasion; lymph node involvement
Hubungan Overekspresi HER2 dengan Status Reseptor Hormonal Kanker Payudara Di RSUP Dr. M. Djamil Padang Tahun 2017-2021 Aldestra, Yudha; Yenita; Khambri , Daan; Asri, Aswiyanti; Rustam, Rony; Anggraini, Fika Tri
Jurnal Ilmu Kesehatan Indonesia Vol. 7 No. 1 (2026): Maret 2026
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v7i1.1519

Abstract

Latar Belakang: Overekspresi HER2 terjadi pada sekitar 10-15% kanker payudara dan cenderung mempunyai prognosis yang buruk. Reseptor hormonal terdiri dari reseptor estrogen dan reseptor progesteron. Hubungan overekspresi dari HER2 dan reseptor hormonal digunakan untuk menilai prognostik dan prediktif pada kanker payudara. Objektif: Penelitian ini bertujuan untuk mengetahui hubunngan overekspresi HER2 dengan status reseptor hormonal kanker payudara di RSUP Dr. M. Djamil Padang tahun 2017 – 2021 Metode: Penelitian ini adalah studi analitik retrospektif dengan pendekatan cross-sectional untuk mengetahui hubungan antara overekspresi HER2 dengan reseptor hormonal di RSUP Dr. M Djamil tahun 2017 – 2021. Hasil: Berdasarkan uji Chi-Square menunjukkan terdapat hubungan antara overekspresi HER2 dengan reseptor hormonal kanker payudara (p<0,05). Kesimpulan: Terdapat hubungan antara overekspresi HER2 dengan reseptor hormonal kanker payudara.
Loss of E-cadherin Expression Stratifies Aggressive versus Non-Aggressive Papillary Thyroid Carcinoma Dwi Yanti Fioni Putri; Yenita; Aswiyanti Asri; Tofrizal; Rony Rustam; Husna Yetti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 2 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i2.1498

Abstract

Background: Papillary thyroid carcinoma (PTC) is generally indolent, yet specific histological subtypes defined by the World Health Organization (WHO) are linked to aggressive behavior and poor prognosis. The loss of the cell-adhesion protein E-cadherin is a hallmark of the epithelial-to-mesenchymal transition (EMT), a process implicated in tumor aggression. However, its role in stratifying PTC subtypes versus its correlation with tumor stage remains a significant controversy in the literature. This study aimed to disentangle these two parameters by clarifying the relationship between E-cadherin expression and both histological phenotype and tumor stage. Methods: This was an observational, cross-sectional pilot study on 40 randomly selected, formalin-fixed, paraffin-embedded (FFPE) PTC cases from a 2024 cohort (N=74) at a tertiary hospital in Indonesia. All cases were re-evaluated and classified according to the WHO 5th Edition (2022) criteria as non-aggressive (n=34) or aggressive (n=6). E-cadherin expression was assessed by immunohistochemistry (IHC) using a standardized semi-quantitative scoring system (product of intensity and proportion) adapted from previous studies, with inter-rater reliability assessed (Cohen’s Kappa = 0.88). Scores were dichotomized as 'High' (n=25) or 'Low' (n=15). The association between E-cadherin expression and both histological subtype and AJCC 8th Edition tumor stage (Early: I/II [n=32] vs. Advanced: III/IV [n=8]) was analyzed using Fisher's Exact Test, with Odds Ratios (OR) and 95% Confidence Intervals (CI) calculated. Results: High E-cadherin expression was observed in 62.5% of cases. A statistically significant and strong association was found between E-cadherin expression and histological subtype (p=0.021; OR 12.0; 95% CI 1.2–118.9). Low E-cadherin expression was present in 83.3% (5 of 6) of aggressive-subtype tumors, versus only 29.4% (10 of 34) of non-aggressive subtypes. In contrast, no significant correlation was found between E-cadherin expression and advanced tumor stage (p=0.126; OR 3.67; 95% CI 0.7–18.6). Conclusion: Loss of E-cadherin expression is a significant biomarker associated with high-risk, aggressive histological phenotypes in PTC. Its lack of correlation with tumor stage, confirmed by an uncertain OR, suggests E-cadherin's role is indicative of an inherent tumor biological phenotype (aggressiveness) rather than a linear marker of tumor progression (stage). This dichotomy, likely reflecting EMT/MET plasticity, positions E-cadherin IHC as a powerful ancillary tool for pathological risk stratification.
The Large-Mass Phenotype of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential (STUMP): A Clinicopathological Analysis of 37 Cases in Indonesia Using WHO 2021 and Modified Stanford Criteria Yuliza Ariani; Henny Mulyani; Noza Hilbertina; Yenita; Aswiyanti Asri; Tofrizal; Loli Devianti; Hera Novianti
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 10 No. 4 (2026): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v10i4.1565

Abstract

Background: Uterine smooth muscle tumor of uncertain malignant potential (STUMP) presents a diagnostic dilemma, especially in Southeast Asian populations, where delayed presentation often leads to advanced tumor burden. This study aimed to characterize the clinicopathological profile of STUMP in Indonesia using the 2021 WHO Classification and modified Stanford parameters. Methods: A descriptive study analyzed 37 STUMP cases diagnosed between 2023 and 2025 at a tertiary referral center in West Sumatra. A panel of pathologists re-evaluated archival slides for atypia, mitotic activity, necrosis, and growth patterns, establishing inter-observer reliability. Fisher’s Exact Test was employed to correlate tumor size with morphological markers of aggression. Results: The cohort demonstrated a distinct large-mass phenotype, with 54.1% of tumors exceeding 10 cm and a median diameter of 14.5 cm. Pathological review classified 56.8% of cases into WHO Group 4 (atypia with ambiguous mitosis). A statistically significant correlation was identified between tumor size >10 cm and the presence of infiltrative growth margins (81.1%; p=0.034). Conclusion: Indonesian STUMP cases are distinctively characterized by massive size and high rates of infiltrative growth, likely driven by prolonged natural history. The prevalence of ambiguous mitotic figures underscores the utility of the WHO Group 4 category in resource-limited settings. These findings advocate for aggressive surgical management and wider resection margins in large-mass variants to mitigate local recurrence risk.
Lack of Significant Association between Stromal Tumor-Infiltrating Lymphocytes and 2014 FIGO Stage in Epithelial Ovarian Cancer: A Cross-Sectional Study Amanda Putri; Aswiyanti Asri; Puja Agung Antonius
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 17 No. 1 (2026): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V17I12026.81-86

Abstract

Highlights: Understanding the relationship between TIL infiltration and tumor stage could refine prognostic models and guide targeted therapies. Tumor-infiltrating lymphocytes density is considered an essential immune marker in ovarian cancer, but this study did not demonstrate a significant association with FIGO staging.   Abstract Introduction: Ovarian cancer is the fifth most common cancer among females. Prognostic factors such as stage and tumor-infiltrating lymphocytes (TILs) may influence outcomes. This study aimed to analyze the relationship between stromal TIL density and 2014 International Federation of Gynecology and Obstetrics (FIGO) staging in epithelial ovarian cancer. Methods: This cross-sectional analytical study included 44 cases (n=44) of epithelial ovarian cancer diagnosed at the Laboratory of Anatomical Pathology, Dr. M. Djamil General Hospital, Padang, Indonesia, in 2021-2022, selected using consecutive sampling. Stromal TIL density was evaluated on hematoxylin and eosin (HE) slides according to the International TILs Working Group guidelines and categorized as low (≤10%) or high (>10%). 2014 FIGO staging was obtained from medical records. Statistical analysis was performed using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 26.0, with Chi-square or Fisher’s exact test, and p<0.05 was considered significant. Results: Early-stage disease (stage I-II) comprised 25 cases (56.8%), of which 12 cases (48%) had low TIL density, and 13 cases (52%) had high TIL density. Advanced-stage disease (stage III-IV) comprised 19 cases (43.2%), of which 13 (68.4%) had low TIL density and 6 (31.6%) had high TIL density. Chi-square analysis showed no significant association between TIL density and FIGO stage (p=0.295). Conclusion: No significant relationship was found between stromal TIL density and 2014 FIGO staging in epithelial ovarian cancer. Further research with larger cohorts and detailed TIL subtypes may clarify their prognostic relevance.
Co-Authors Adrial Adrial Adrial Adrial Afriani Sandra Afriani, Nita Aisyah Elliyanti Alan Mustaqim Aldestra, Yudha Alimuddin Tofrizal Almurdi Almurdi Amanda Putri Andi Friadi Anggrainy, Fenty Antonius, Puja Agung Anum, Qaira Arifuddin Arifuddin Aristya Rahadiyan Budi Arni Amir Arnofyan, Budi Pratama Asril Zahari Asril Zahari Bestari Jaka Budiman Bobby Indra Utama Daan Khambri Deddy Saputra Desi Aliefia Dessy Arisanti Devianti, Loli Dia Rofinda, Zelly Dia Dian Pertiwi Dini Andri Utami Dutia Gestin Dutia Gestin Dwi Yanti Fioni Putri Dwi Yanti Fioni Putri Edison Eka Fithra Elfi, Eka Fithra Eka Nofita Elmatris Sy Elmatris Sy Endrinaldi Etriyel Myh Febriyanti, Rizka Fedrivia, Rannia Fika Tri Anggraini Ginting, Desi Scorpinasari Hafni Bachtiar Hardian, Sonny Hardisman Hasmiwati Hasnaini Hasnaini Hendra Permana henny Mulyani Henny Mulyani Henny Mulyani Hera Novianti Hera Novianti Hera Novianti Hera Novianti Hera Novianti Hera Novianti Hera Novianti, Hermafasya, Ayu Octarin Hirowati Ali Histawara Subroto Husna Yetti Husnil Kadri iftahillah - iftahillah Iwani Rahmah Rambe Julizar Julizar Kamelia, Muthia Karmia, Hudila Rifa Khambri , Daan Kusumardani, Dini Laila Isra Laila Isrona liana, nana Lismawati Rasyd Loli Devianti Malinda Meinapuri Mayorita, Pamelia Meta Zulyati Oktora Meta Zulyati Oktora Miftah Irramah Mohamad Reza Muflikal Hamdi Muhamad Febry Mulyani, Henny Muthia Kamelia Nabilla Mahyenda Nadhira Isza Qushoyyi Nadia Oktarina Nana Liana Nana Liana Nelzima, Maisyah Nita Afriani Nizar, RZ Nova Fenita Sari Noverial Noverial Novianti, Hera Noza Hilbertina Noza Hilbertina, Noza Nuzulia Irawati Oktora, Meta Zulyati Pamelia Mayorita Pemuda, Haris Putri, Rizqy Nurfathonah R Zuryati Nizar R. Zuryati Nizar Rachmadijah Zuryati Nizar Rahmani Welan Rahmi Ramadhani Randi Septiah Hendri Rauza Sukma Rita Resti Aulia Fitri Rizka Fitria Husni Rony Rustam Rony Rustam Rosfita Rasyid Rum Affida Rasfa Rustam, Rony RZ Nizar RZ Nizar Sabrina Herfika Putri Salmiah Agus Salmiah Agus Salmiah Agus Salsabila Aulia Kasbina Salsabila Muslim Salsabilla Firdaus Sari, Nova Fenita Sari, Rini Purnama Satya Wydya Yenny Selly Alinta Syukri Shofi Faiza sondang - nora Sorayya A'dilah Putri Suci Rahmadhani Sukri Rahman Susanto Winarko Syamel Muhammad Syandrez Prima Putra Teddy Kurniawan Tofrizal Tofrizal Tofrizal Tofrizal, Alimuddin Tuti Lismayarni Utami, Dini Andri Valencia Valencia Valencia Valencia Valencia, Valencia Vashti Resti Putri Firdaus Wirsma Arif Harahap Yanwirasti . Yenita Yenita Yenita - Yenita . Yenita Afriyeni Yessy Setiawati Yessy Setiawati Yessy Setiawatu Yuastika Puspita Sari Yulistini, Yulistini Yuliza Ariani Yuliza Ariani Zurayya Fadila Zuryati Nizar, Rachmadijah