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All Journal Jurnal Kesehatan Andalas Logista: Jurnal Ilmiah Pengabdian Kepada Masyarakat Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education Majalah Kedokteran Andalas Pelita Eksakta Warta Pengabdian Andalas: Jurnal Ilmiah Pengembangan Dan Penerapan Ipteks MAHESA : Malahayati Health Student Journal Jurnal Ilmu Kesehatan Indonesia (JIKSI) Pharmaceutical Sciences and Research (PSR) Mandala of Health : A Scientific Journal Innovative: Journal Of Social Science Research The International Science of Health Journal Medic Nutricia : Jurnal Ilmu Kesehatan Jurnal Kesehatan Masyarakat Indonesia (JKMI) Jurnal Riset Ilmiah Frontiers on Healthcare Research
Putri, Biomechy Oktomalio
Bagian Histologi Fakultas Kedokteran Universitas Andalas
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Pengaruh Pemberian Ekstrak Akar Kayu Kuning (Arcangelisia Flava Merr.) terhadap Aktivitas Enzim Katalase pada Mencit (Mus Musculus) yang Diinduksi D-Galaktosa Cesar, Afifah Raudhati; Putri, Biomechy Oktomalio; Irramah, Miftah; Rita, Rauza Sukma; Rahmatini, Rahmatini; Hanum, Fathiya Juwita
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19551

Abstract

Abstrak Studi ini merupakan studi eksperimental sejati (true experimental) dengan rancangan post-test only control group design. Objek studi ini menggunakan 25 ekor mencit dan dibagi secara acak ke dalam lima kelompok perlakuan. Kelompok kontrol negatif (K−) hanya diberikan pakan standar, sedangkan kelompok kontrol  positif (K+)  diinduksi  dengan D-galaktosa dosis 150 mg/kgBB. Tiga kelompok perlakuan  lainnya, yaitu P1, P2, dan P3, masing-masing diinduksi dengan D-galaktosa dosis 150 mg/kgBB serta diberikan ekstrak akar kayu kuning dengan dosis berturut-turut 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB. Hasil studi menyatakan rerata aktivitas enzim katalase pada kelompok K- sebesar 5,75 ± 0,27 Unit/mg, K+ sebesar 3,28 ± 0,21 Unit/mg, P1 sebesar 3,87 ± 0,96 Unit/mg, P2 sebesar 4,86 ± 0,68 Unit/mg, dan P3 sebesar 4,87 ± 0,87 Unit/mg. Dapat disimpulkan terdapat pengaruh pemberian ekstrak akar kayu kuning dosis 250 mg/kgBB, 500 mg/kgBB, 750 mg/kgBB terhadap aktivitas enzim katalase.   Kata Kunci : Antioksidan; D-galaktosa; Ekstrak Akar Kayu Kuning; Katalase
Pengaruh Ekstrak Akar Kayu Kuning (Arcangelisia flava Merr.) terhadap Kadar MDA Mencit (Mus musculus) Model Penuaan yang Diinduksi D-Galaktosa Tafdil, Zhafirah Khairunnisa; Putri, Biomechy Oktomalio; Alioes, Yustini; Irramah, Miftah; Asterina, Asterina; Mahata, Liganda Endo
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19575

Abstract

Ekstrak akar kayu kuning (Arcangelisia flava Merr.) diketahui bisa memperlambat stres oksidatif dan menurunkan kadar MDA serum. Jenis studi ini yakni true experimental research dengan desain post test only control group dengan 25 ekor mencit yang dibagi menjadi 5 kelompok. Hasil studi menunjukkan rerata kadar MDA serum mencit pada kelompok K- sebesar 2,73 ± 0,33 nmol/ml, K+ sebesar 4,12 ± 0,26 nmol/ml, P1 sebesar 3,47 ± 0,26 nmol/ml, P2 sebesar 3,22 ± 0,29 nmol/ml dan P3 sebesar 3,05 ± 0,28 nmol/ml. Uji One Way ANOVA menghasilkan nilai p sebesar 0,000 (p kurang dari 0,05), hal ini dapat diartikan bahwa terdapat pengaruh pemberian ekstrak akar kayu kuning terhadap kadar MDA serum. Hasil studi ini menunjukkan bahwa ekstrak akar kayu kuning pada dosis 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB mampu menurunkan kadar MDA dalam serum.
Pengaruh Pemberian Mesenchymal Stem Cell Wharton's Jelly Terhadap Aktivitas Enzim Katalase pada Tikus Wistar Model Hiperglikemia Ramadhani, Dhea Amaliya; Endrinaldi; Putri, Biomechy Oktomalio; Rita, Rauza Sukma; Mahata, Liganda Endo; Dian Pertiwi
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i2.p117-124.2025

Abstract

Objective: To determine the effect of Wharton's Jelly (MSC-WJ) mesenchymal stem cells on the activity of the catalase enzyme in hyperglycemic Wistar rats. Methods: This study used 21 male Wistar rats aged 2-3 months with a body weight of 200-300 grams according to the inclusion and exclusion criteria. Mice were divided into 3 groups: negative control (K-), positive control (K+), and treatment (P). Group K- was only given food and drink without being given treatment. The K+ group was injected intraperitoneally with alloxan at a dose of 100 mg/kg BW so that the rats became hyperglycemic. Group P was given an alloxan injection and left for a week, then given MSC-WJ 3x106 cells through the tail vein and left for four weeks. After four weeks, all groups had their blood taken to examine the catalase enzyme. Result: Mean of catalase activity enzyme in the K-, K+, and P groups were 4.22 ± 0.27 units/mg, 2.39 ± 0.19 units/mg, and 3.93 ± 0.45 units /mg, respectively. Conclusion: This shows that the administration of mesenchymal stem cells Wharton's Jelly (MSC-WJ) has an effect on increasing the serum catalase enzyme activity of Wistar rats with hyperglycemia models.
Gambaran Kematian di RSUP Dr M Djamil Padang Rahmadiyani, Rahmadiyani; Susanti, Rika; Putri, Biomechy Oktomalio; Manela, Citra; Lestari, Tuti; Rustini, Rini
MAHESA : Malahayati Health Student Journal Vol 4, No 9 (2024): Volume 4 Nomor 9 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i9.14854

Abstract

ABSTRACT The definition of death is stated in the Law of the Republic of Indonesia, this law explains the diagnostic criteria for clinical death and brain stem death. In forensic medicine, we study death, changes after death, and what is behind these changes. Forensic and Medicolegal Department of RSUP Dr. M. Djamil has a body register book which contains data on the deaths of incoming bodies containing name, gender, age, registration number, diagnosis, actions taken and so on. However, there has been no research regarding the alleged cause and manner of death at Dr. M. Djamil Padang. The aim of this study was to determine the description of deaths at RSUP Dr. M. Djamil Padang in 2018-2022. This research is a descriptive study which takes data from the body register book which is entered into the Forensic and Medicolegal Department of RSUP Dr. M. Djamil Padang 2018-2022. The number of bodies entered into the Forensic and Medicolegal Department of RSUP Dr. M. Djamil Padang from 2018 to 2022 is 16,765 bodies. Every year more than 50% of deaths occur in men with the largest age group being the late elderly at 24.2%-25.6% per year and 46.1%-53.1% per year of deaths from West Sumatra outside Padang. The largest group of causes of death based on ICD-10 is the group of symptoms, signs and other disorders at 33%-45% per year with the most frequent diagnoses being septic shock and MODS. Deaths occurring outside hospitals are less than 2% per year. The percentage of unnatural deaths is below 7% per year, of which as many as 40.5%-78.1% per year are not examined because of refusal from the family. Description of death at RSUP Dr. M. Djamil Padang is relatively same every year. Keywords: Forensics, Cause of Death, Description of Death  ABSTRAK Definisi kematian tercantum dalam Undang-Undang Republik Indonesia, yang menjelaskan tentang kriteria diagnosis mati klinis dan mati batang otak. Dalam kedokteran forensik dipelajari tentang kematian, perubahan setelah kematian, dan apa yang melatarbelakangi perubahan tersebut. Departemen Forensik dan Medikolegal RSUP Dr. M. Djamil memiliki buku register jenazah yang berisi data kematian jenazah yang masuk berisi nama, jenis kelamin, usia, nomor registrasi, diagnosis, tindakan yang dilakukan dan sebagainya. Namun, belum ada penelitian terkait dugaan sebab dan cara kematian di RSUP Dr. M. Djamil Padang. Tujuan penelitian ini adalah untuk mengetahui gambaran kematian di RSUP Dr. M. Djamil Padang pada tahun 2018-2022. Penelitian ini adalah penelitian deskriptif dimana mengambil data dari buku register jenazah yang masuk ke Departemen Forensik dan Medikolegal RSUP Dr. M. Djamil Padang tahun 2018-2022. Jumlah jenazah yang masuk ke Departemen Forensik dan Medikolegal RSUP Dr. M. Djamil Padang tahun 2018 hingga 2022 adalah 16.765 jenazah. Setiap tahunnya lebih dari 50% kematian pada laki-laki dengan kelompok usia terbanyak masa lansia akhir sebesar 24,2%-25,6% pertahun dan 46,1%-53,1% pertahun jenazah dari Sumatera Barat diluar Padang. Kelompok penyebab kematian berdasarkan ICD-10 yang terbanyak adalah kelompok gejala, tanda, dan kelainan lainnya sebesar 33%-45% pertahun dengan diagnosis terbanyak syok sepsis dan MODS. Kematian yang terjadi diluar rumah sakit kurang dari 2% pertahun. Persentase mati tidak wajar berada dibawah 7% pertahun, dimana sebanyak 40,5%-78,1% pertahun tidak dilakukan pemeriksaan karena penolakan dari pihak keluarga. Gambaran kematian di RSUP Dr. M. Djamil Padang relatif sama setiap tahunnya. Kata Kunci: Forensik, Penyebab Kematian, Gambaran Kematian
GAMBARAN FUNGSI PARU PADA MAHASISWA DAN RELAWAN LABORATORIUM DENGAN DAN TANPA RIWAYAT COVID-19 DI FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS TAHUN 2021 Dhiaulhaq, Zalva Indira; Afriwardi, Afriwardi; Ermayanti, Sabrina; Irawati, Lili; Russilawati, Russilawati; Putri, Biomechy Oktomalio
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1232

Abstract

Over the past two years, the COVID-19 pandemic has infected many individuals worldwide. Indonesia is one of the countries affected. This virus primarily infects the respiratory system. Some survivors have reported experiencing persistent symptoms after recovering from COVID-19, with some experiencing such symptoms for months. These persistent symptoms can also be referred to as long COVID-19. The purpose of this study is to determine the pulmonary function profile in medical students and laboratory volunteers with and without a history of COVID- 19 at the Faculty of Medicine, Andalas University. This is an observational study with a cross-sectional approach using a total sampling technique. The sample size is 43 COVID-19 survivors and 53 without history of COVID-19 from medical students and laboratory volunteers at the Faculty of Medicine, Andalas University. It is concluded and recommended that the respondents in this study have an average pulmonary function (FEV1, FVC, and FEV1/FVC ratio) in the normal category, with males being the majority among COVID-19 survivors and females among non-COVID-19 survivors.
Characteristics of Type 2 Diabetes Mellitus Patients With Diabetic Ketoacidosis: A Study in A National Referral Hospital in Indonesia Fuada, Afifah Annis; Aprilia, Dinda; Putri, Biomechy Oktomalio
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p17-23.2024

Abstract

Background: Diabetic ketoacidosis (DKA) is one of the acute complication of diabetes mellitus (DM) with high mortality and morbidity rates. Research data regarding the characteristics of patients with type 2 diabetes mellitus (T2DM) with and without DKA are not yet widely available. Therefore, further research is needed to minimize the annual morbidity and mortality rate and prevent complications at the earliest possible moment. This study was carried out to determine the differences in the characteristics of T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang period 1st January 2018 to 31stDecember 2020. Methods: This study used a comparative analytic study with a cross-sectional approach using the medical records of T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang period 1st January to 31st December 2020 with total sampling. Data analysis calculated by chi-square test, unpaired T-test, and Mann-Whitney test. Results: Most of T2DM patients with DKA were aged ≥ 40 years (62.1%), female (65.5%), secondary level of education (72.4%), DM diagnosis duration was ≤ 5 years (75.9%), had infection precipitating factors (65.5%), on insulin (58.6%), Body Mass Index (BMI) in overweight-obese criteria (55%), fasting blood glucose (FBG) < 250 mg/dl (62.1%), and post-prandial glucose (PPG) 250-600 mg/dl (51.7%). This study found that the association of age, DM diagnosis duration, precipitating factors, medication use, and PPG with DKA in T2DM patients (p<0.05). Conclusion: This study confirmed significant differences in age, DM diagnosis duration, precipitation factors, type of antidiabetic therapy, and PPG between T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang.
Co-Authors Afriwardi Afriwardi Almahdy A Almahdy A Antonius, Puja Agung Aprilia, Dinda Ari Yanto Wijaya Asterina, Asterina Cesar, Afifah Raudhati Citra Manela Daan Khambri Desnita Dhiaulhaq, Zalva Indira Dia Rofinda, Zelly Dia Dian Pertiwi Dina Arfiani Dina Arfiani Rusjdi Dwi Sari Dillasamola Dwisari Dillasamola Elfira Yusri Elizabeth Bahar Endrinaldi Ermayanti, Sabrina Eryati Darwin Eryati Darwin Eryati Darwin Eva Decroli Fathiyyatul Khaira, Fathiyyatul Fathur Rahman Firdawati Firdawati Firdawati, Firdawati Fortuna, Fory Fuada, Afifah Annis Hanum, Fathiya Juwita Hendra, Gabriel Septian Hirowati Ali, Hirowati Husnil Kadri Isna Annisatuzzakiyah Lestari, Tuti Lili Irawati Mahata, Liganda Endo Malinda Meinapuri Mazara, Fitria Miftah Irramah Mohamad Reza Netti Suharti, Netti Nita Afriani Nita Afriani Noverial Noverial Noverial, Noverial Novita Ariani Novita Ariani Novita Purnama Sari Pritasa Muthia Ulfa Rahmadiyani, Rahmadiyani Rahmat Syaifullah Rahmatini . Ramadhani, Dhea Amaliya Rauza Sukma Rita Rika Susanti Rini Rustini Roza Silvia Russilawati, Russilawati Salsabila Dhiyaa Syifa Sari, Novita Purnama Sheila Diana Skunda Diliarosta SM Rezvi Syandana, Firjatul Tafdil, Zhafirah Khairunnisa Tegar Abdillah Tofrizal Tuti Handayani Wirsma Arif Harahap YN Zuhal Chaisart Chaniago Yulia Kurniawati Yulistini, Yulistini Yusticia Katar Yustini Alioes Zawata Afnan Zehan Afifa Yusran