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Pengaruh Pemberian Ekstrak Akar Kayu Kuning (Arcangelisia Flava Merr.) terhadap Aktivitas Enzim Katalase pada Mencit (Mus Musculus) yang Diinduksi D-Galaktosa Cesar, Afifah Raudhati; Putri, Biomechy Oktomalio; Irramah, Miftah; Rita, Rauza Sukma; Rahmatini, Rahmatini; Hanum, Fathiya Juwita
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19551

Abstract

Abstrak Studi ini merupakan studi eksperimental sejati (true experimental) dengan rancangan post-test only control group design. Objek studi ini menggunakan 25 ekor mencit dan dibagi secara acak ke dalam lima kelompok perlakuan. Kelompok kontrol negatif (K−) hanya diberikan pakan standar, sedangkan kelompok kontrol  positif (K+)  diinduksi  dengan D-galaktosa dosis 150 mg/kgBB. Tiga kelompok perlakuan  lainnya, yaitu P1, P2, dan P3, masing-masing diinduksi dengan D-galaktosa dosis 150 mg/kgBB serta diberikan ekstrak akar kayu kuning dengan dosis berturut-turut 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB. Hasil studi menyatakan rerata aktivitas enzim katalase pada kelompok K- sebesar 5,75 ± 0,27 Unit/mg, K+ sebesar 3,28 ± 0,21 Unit/mg, P1 sebesar 3,87 ± 0,96 Unit/mg, P2 sebesar 4,86 ± 0,68 Unit/mg, dan P3 sebesar 4,87 ± 0,87 Unit/mg. Dapat disimpulkan terdapat pengaruh pemberian ekstrak akar kayu kuning dosis 250 mg/kgBB, 500 mg/kgBB, 750 mg/kgBB terhadap aktivitas enzim katalase.   Kata Kunci : Antioksidan; D-galaktosa; Ekstrak Akar Kayu Kuning; Katalase
Pengaruh Ekstrak Akar Kayu Kuning (Arcangelisia flava Merr.) terhadap Kadar MDA Mencit (Mus musculus) Model Penuaan yang Diinduksi D-Galaktosa Tafdil, Zhafirah Khairunnisa; Putri, Biomechy Oktomalio; Alioes, Yustini; Irramah, Miftah; Asterina, Asterina; Mahata, Liganda Endo
Innovative: Journal Of Social Science Research Vol. 5 No. 3 (2025): Innovative: Journal Of Social Science Research
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/innovative.v5i3.19575

Abstract

Ekstrak akar kayu kuning (Arcangelisia flava Merr.) diketahui bisa memperlambat stres oksidatif dan menurunkan kadar MDA serum. Jenis studi ini yakni true experimental research dengan desain post test only control group dengan 25 ekor mencit yang dibagi menjadi 5 kelompok. Hasil studi menunjukkan rerata kadar MDA serum mencit pada kelompok K- sebesar 2,73 ± 0,33 nmol/ml, K+ sebesar 4,12 ± 0,26 nmol/ml, P1 sebesar 3,47 ± 0,26 nmol/ml, P2 sebesar 3,22 ± 0,29 nmol/ml dan P3 sebesar 3,05 ± 0,28 nmol/ml. Uji One Way ANOVA menghasilkan nilai p sebesar 0,000 (p kurang dari 0,05), hal ini dapat diartikan bahwa terdapat pengaruh pemberian ekstrak akar kayu kuning terhadap kadar MDA serum. Hasil studi ini menunjukkan bahwa ekstrak akar kayu kuning pada dosis 250 mg/kgBB, 500 mg/kgBB, dan 750 mg/kgBB mampu menurunkan kadar MDA dalam serum.
Pengaruh Pemberian Mesenchymal Stem Cell Wharton's Jelly Terhadap Aktivitas Enzim Katalase pada Tikus Wistar Model Hiperglikemia Ramadhani, Dhea Amaliya; Endrinaldi; Putri, Biomechy Oktomalio; Rita, Rauza Sukma; Mahata, Liganda Endo; Dian Pertiwi
Majalah Kedokteran Andalas Vol. 48 No. 2 (2025): MKA April 2025
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v48.i2.p117-124.2025

Abstract

Objective: To determine the effect of Wharton's Jelly (MSC-WJ) mesenchymal stem cells on the activity of the catalase enzyme in hyperglycemic Wistar rats. Methods: This study used 21 male Wistar rats aged 2-3 months with a body weight of 200-300 grams according to the inclusion and exclusion criteria. Mice were divided into 3 groups: negative control (K-), positive control (K+), and treatment (P). Group K- was only given food and drink without being given treatment. The K+ group was injected intraperitoneally with alloxan at a dose of 100 mg/kg BW so that the rats became hyperglycemic. Group P was given an alloxan injection and left for a week, then given MSC-WJ 3x106 cells through the tail vein and left for four weeks. After four weeks, all groups had their blood taken to examine the catalase enzyme. Result: Mean of catalase activity enzyme in the K-, K+, and P groups were 4.22 ± 0.27 units/mg, 2.39 ± 0.19 units/mg, and 3.93 ± 0.45 units /mg, respectively. Conclusion: This shows that the administration of mesenchymal stem cells Wharton's Jelly (MSC-WJ) has an effect on increasing the serum catalase enzyme activity of Wistar rats with hyperglycemia models.
Gambaran Kematian di RSUP Dr M Djamil Padang Rahmadiyani, Rahmadiyani; Susanti, Rika; Putri, Biomechy Oktomalio; Manela, Citra; Lestari, Tuti; Rustini, Rini
MAHESA : Malahayati Health Student Journal Vol 4, No 9 (2024): Volume 4 Nomor 9 (2024)
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/mahesa.v4i9.14854

Abstract

ABSTRACT The definition of death is stated in the Law of the Republic of Indonesia, this law explains the diagnostic criteria for clinical death and brain stem death. In forensic medicine, we study death, changes after death, and what is behind these changes. Forensic and Medicolegal Department of RSUP Dr. M. Djamil has a body register book which contains data on the deaths of incoming bodies containing name, gender, age, registration number, diagnosis, actions taken and so on. However, there has been no research regarding the alleged cause and manner of death at Dr. M. Djamil Padang. The aim of this study was to determine the description of deaths at RSUP Dr. M. Djamil Padang in 2018-2022. This research is a descriptive study which takes data from the body register book which is entered into the Forensic and Medicolegal Department of RSUP Dr. M. Djamil Padang 2018-2022. The number of bodies entered into the Forensic and Medicolegal Department of RSUP Dr. M. Djamil Padang from 2018 to 2022 is 16,765 bodies. Every year more than 50% of deaths occur in men with the largest age group being the late elderly at 24.2%-25.6% per year and 46.1%-53.1% per year of deaths from West Sumatra outside Padang. The largest group of causes of death based on ICD-10 is the group of symptoms, signs and other disorders at 33%-45% per year with the most frequent diagnoses being septic shock and MODS. Deaths occurring outside hospitals are less than 2% per year. The percentage of unnatural deaths is below 7% per year, of which as many as 40.5%-78.1% per year are not examined because of refusal from the family. Description of death at RSUP Dr. M. Djamil Padang is relatively same every year. Keywords: Forensics, Cause of Death, Description of Death  ABSTRAK Definisi kematian tercantum dalam Undang-Undang Republik Indonesia, yang menjelaskan tentang kriteria diagnosis mati klinis dan mati batang otak. Dalam kedokteran forensik dipelajari tentang kematian, perubahan setelah kematian, dan apa yang melatarbelakangi perubahan tersebut. Departemen Forensik dan Medikolegal RSUP Dr. M. Djamil memiliki buku register jenazah yang berisi data kematian jenazah yang masuk berisi nama, jenis kelamin, usia, nomor registrasi, diagnosis, tindakan yang dilakukan dan sebagainya. Namun, belum ada penelitian terkait dugaan sebab dan cara kematian di RSUP Dr. M. Djamil Padang. Tujuan penelitian ini adalah untuk mengetahui gambaran kematian di RSUP Dr. M. Djamil Padang pada tahun 2018-2022. Penelitian ini adalah penelitian deskriptif dimana mengambil data dari buku register jenazah yang masuk ke Departemen Forensik dan Medikolegal RSUP Dr. M. Djamil Padang tahun 2018-2022. Jumlah jenazah yang masuk ke Departemen Forensik dan Medikolegal RSUP Dr. M. Djamil Padang tahun 2018 hingga 2022 adalah 16.765 jenazah. Setiap tahunnya lebih dari 50% kematian pada laki-laki dengan kelompok usia terbanyak masa lansia akhir sebesar 24,2%-25,6% pertahun dan 46,1%-53,1% pertahun jenazah dari Sumatera Barat diluar Padang. Kelompok penyebab kematian berdasarkan ICD-10 yang terbanyak adalah kelompok gejala, tanda, dan kelainan lainnya sebesar 33%-45% pertahun dengan diagnosis terbanyak syok sepsis dan MODS. Kematian yang terjadi diluar rumah sakit kurang dari 2% pertahun. Persentase mati tidak wajar berada dibawah 7% pertahun, dimana sebanyak 40,5%-78,1% pertahun tidak dilakukan pemeriksaan karena penolakan dari pihak keluarga. Gambaran kematian di RSUP Dr. M. Djamil Padang relatif sama setiap tahunnya. Kata Kunci: Forensik, Penyebab Kematian, Gambaran Kematian
GAMBARAN FUNGSI PARU PADA MAHASISWA DAN RELAWAN LABORATORIUM DENGAN DAN TANPA RIWAYAT COVID-19 DI FAKULTAS KEDOKTERAN UNIVERSITAS ANDALAS TAHUN 2021 Dhiaulhaq, Zalva Indira; Afriwardi, Afriwardi; Ermayanti, Sabrina; Irawati, Lili; Russilawati, Russilawati; Putri, Biomechy Oktomalio
SINERGI : Jurnal Riset Ilmiah Vol. 2 No. 5 (2025): SINERGI : Jurnal Riset Ilmiah, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/sinergi.v2i5.1232

Abstract

Over the past two years, the COVID-19 pandemic has infected many individuals worldwide. Indonesia is one of the countries affected. This virus primarily infects the respiratory system. Some survivors have reported experiencing persistent symptoms after recovering from COVID-19, with some experiencing such symptoms for months. These persistent symptoms can also be referred to as long COVID-19. The purpose of this study is to determine the pulmonary function profile in medical students and laboratory volunteers with and without a history of COVID- 19 at the Faculty of Medicine, Andalas University. This is an observational study with a cross-sectional approach using a total sampling technique. The sample size is 43 COVID-19 survivors and 53 without history of COVID-19 from medical students and laboratory volunteers at the Faculty of Medicine, Andalas University. It is concluded and recommended that the respondents in this study have an average pulmonary function (FEV1, FVC, and FEV1/FVC ratio) in the normal category, with males being the majority among COVID-19 survivors and females among non-COVID-19 survivors.
Characteristics of Type 2 Diabetes Mellitus Patients With Diabetic Ketoacidosis: A Study in A National Referral Hospital in Indonesia Fuada, Afifah Annis; Aprilia, Dinda; Putri, Biomechy Oktomalio
Frontiers on Healthcare Research Vol. 1 No. 2 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n2.p17-23.2024

Abstract

Background: Diabetic ketoacidosis (DKA) is one of the acute complication of diabetes mellitus (DM) with high mortality and morbidity rates. Research data regarding the characteristics of patients with type 2 diabetes mellitus (T2DM) with and without DKA are not yet widely available. Therefore, further research is needed to minimize the annual morbidity and mortality rate and prevent complications at the earliest possible moment. This study was carried out to determine the differences in the characteristics of T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang period 1st January 2018 to 31stDecember 2020. Methods: This study used a comparative analytic study with a cross-sectional approach using the medical records of T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang period 1st January to 31st December 2020 with total sampling. Data analysis calculated by chi-square test, unpaired T-test, and Mann-Whitney test. Results: Most of T2DM patients with DKA were aged ≥ 40 years (62.1%), female (65.5%), secondary level of education (72.4%), DM diagnosis duration was ≤ 5 years (75.9%), had infection precipitating factors (65.5%), on insulin (58.6%), Body Mass Index (BMI) in overweight-obese criteria (55%), fasting blood glucose (FBG) < 250 mg/dl (62.1%), and post-prandial glucose (PPG) 250-600 mg/dl (51.7%). This study found that the association of age, DM diagnosis duration, precipitating factors, medication use, and PPG with DKA in T2DM patients (p<0.05). Conclusion: This study confirmed significant differences in age, DM diagnosis duration, precipitation factors, type of antidiabetic therapy, and PPG between T2DM patients with and without DKA in Dr. M. Djamil Central General Hospital Padang.
Community Empowerment in Rural Areas Through the Cultivation and Production of Traditional Medicines Based on Medicinal Plants in Batu Tanjung Village, Talawi, Sawahlunto City Dillasamola, Dwisari; Putri, Biomechy Oktomalio; Noverial; Fadil, Muhammad Syukri; Marwan; Hasibuan, Ahmad Daniel; Pratiwi, Eghinna Elsa; Hafsah, Nur; Oktafani, Reni; Fadhilla, Naylatul; Oktaviani, Dilla; Hendriansah; Putri, Popy Dwi; Amanda, Amelia; Muhadzid, Fayyadh Atsil; Dewi, Lativa Andam; Thoriq, Muhammad; Andrisyah, Fauzi; Azizi, Adni Salsabil; Yazid, Muhammad; Amalina, Azka; Naufal, Muhammad; Hanisa, Najma Syakina; Ramadhani, Nasywa Anjani; Mufadhdhal, Muhammad Asad
Warta Pengabdian Andalas Vol 32 No 4 (2025)
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat (LPPM) Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jwa.32.04.446-454.2025

Abstract

The utilization of Family Medicinal Plants (TOGA) is a strategic effort to enhance community health self-reliance, reduce dependence on synthetic drugs, and preserve local biodiversity. In Nagari Batu Tanjung, Talawi District, Sawahlunto City, the potential for TOGA is high due to favorable geography and extensive backyard land. However, its use remains limited because of low herbal literacy, minimal organic cultivation skills, and the absence of a properly managed communal garden. This community service program aimed to empower residents through education, direct practice, and guidance in cultivating and processing medicinal plants. Activities included awareness sessions on TOGA’s benefits, land preparation, planting of herbal seeds (ginger, turmeric, cardamom, sungkai, Java turmeric, aloe vera), and the establishment of a model TOGA garden. Based on pre- and post-test results from 40 participants, knowledge and cultivation skills improved significantly—from 40% to 95% of participants understanding proper TOGA cultivation. Active collaboration among residents, village officials, and students ensured the program’s success. Through Q&A sessions and hands-on practice, the community gained practical skills suited to local conditions. The established TOGA garden now serves as a learning medium, a health-supporting initiative, and a foundation for developing herbal products that promote sustainable economic empowerment.
Factors Associated with the Incidence of Hand Dermatitis Among Car and Motorcycle Wash Workers in East Padang District Shafiqah Zawira; Gardenia Akhyar; Selfi Renita Rusjdi; Ennesta Asri; Biomechy Oktomalio Putri; Yustini Alioes
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.997

Abstract

Introduction: Hand dermatitis is a common occupational skin disorder caused by repeated exposure to irritants or allergens. Workers in car and motorcycle wash services are particularly vulnerable due to their frequent contact with detergents and cleaning agents, as well as prolonged exposure to wet work. This study aimed to identify factors associated with hand dermatitis among workers in East Padang District. Methods: A quantitative analytical observational study with a cross-sectional design was conducted among 32 workers selected through simple random sampling. Data were collected through direct interviews using a validated questionnaire. Univariate and bivariate analyses were performed, with chi-square tests used to evaluate associations between hand dermatitis and variables including working period, duration of contact, age, atopic history, personal hygiene, and use of personal protective equipment (PPE). Results: Hand dermatitis was identified in 65.6% of respondents. Bivariate analysis revealed significant associations between duration of contact (p = 0.020), personal hygiene (p = 0.027), and PPE use (p < 0.000) and the incidence of hand dermatitis. No significant associations were found for working period (p = 0.798), age (p = 0.211), or atopic history (p = 0.637). Discussion: Prolonged exposure to irritants, inadequate hygiene practices, and non-use of PPE likely heighten skin barrier disruption, predisposing workers to dermatitis. Conversely, factors such as age and atopic predisposition may play a minor role in this occupational group. Conclusion: Duration of contact, personal hygiene, and the use of PPE are significantly associated with hand dermatitis among car and motorcycle wash workers. In contrast, working period, age, and atopic history show no meaningful relationship. Strengthening preventive practices, remarkably consistent PPE use, is essential.
The Relationship Between Knowledge Level and Social Media Use with Participation in the COVID-19 Vaccination Program in Pangkalan Kerinci Urban Village Fitri Salwa Huriani; Lili Irawati; Hardisman; Rosfita Rasyid; Biomechy Oktomalio Putri
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 12 No 2 (2025): JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol. 12.2 (2025)
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53366/jimki.v12i2.1001

Abstract

Introduction: COVID-19 vaccination represents a crucial public health strategy for controlling viral transmission by inducing protective immunity and reducing the severity of symptoms. Knowledge levels and social media exposure are among the factors that may influence individuals’ willingness to participate in vaccination programs. This study aimed to analyze the relationships between knowledge level, social media use, and community participation in the COVID-19 vaccination program in Pangkalan Kerinci Kota Urban Village. Methods: An analytic, cross-sectional design was employed involving 106 residents aged 17–65 years selected through proportionate stratified random sampling and consecutive recruitment. Data were analyzed using the Chi-square test. Results:Most respondents demonstrated good knowledge regarding COVID-19 vaccination and reported frequent use of social media platforms. Statistical analysis revealed no significant relationship between knowledge level and participation in the vaccination program (p = 0.610) or between social media use and vaccination participation (p = 0.302). Discussion:The absence of significant associations suggests that vaccination uptake in this population may be influenced more strongly by structural or contextual factors, such as access to health services, trust in local authorities, and availability of vaccination sites, rather than by cognitive understanding or social media exposure alone. High knowledge levels and active social media use do not necessarily translate into health-seeking behavior, indicating a possible gap between awareness and action. Future studies should explore additional determinants, including perception of risk, cultural influences, and policy-driven motivators. Conclusion: Knowledge level and social media use were not significantly associated with participation in the COVID-19 vaccination program in Pangkalan Kerinci Kota Urban Village.
Co-Authors Afriwardi Afriwardi Almahdy A Almahdy A Amalina, Azka Amanda, Amelia Andrisyah, Fauzi Antonius, Puja Agung Aprilia, Dinda Ari Yanto Wijaya Asterina, Asterina Azizi, Adni Salsabil Cesar, Afifah Raudhati Citra Manela Daan Khambri Desnita Dewi, Lativa Andam Dhiaulhaq, Zalva Indira Dia Rofinda, Zelly Dia Dian Pertiwi Dina Arfiani Dina Arfiani Rusjdi Dwi Sari Dillasamola Dwisari Dillasamola Elfira Yusri Elizabeth Bahar Endrinaldi Ennesta Asri Ermayanti, Sabrina Eryati Darwin Eryati Darwin Eryati Darwin Eva Decroli Fadhilla, Naylatul Fadil, Muhammad Syukri Fathiyyatul Khaira, Fathiyyatul Fathur Rahman Firdawati Firdawati Fitri Salwa Huriani Fortuna, Fory Fuada, Afifah Annis Gardenia Akhyar Hafsah, Nur Hanisa, Najma Syakina Hanum, Fathiya Juwita Hardisman Hasibuan, Ahmad Daniel Hendra, Gabriel Septian Hendriansah Hirowati Ali, Hirowati Husnil Kadri Isna Annisatuzzakiyah Lestari, Tuti Lili Irawati Mahata, Liganda Endo Malinda Meinapuri Marwan Mazara, Fitria Miftah Irramah Mohamad Reza Mufadhdhal, Muhammad Asad Muhadzid, Fayyadh Atsil Muhammad Naufal, Muhammad Muhammad Yazid Netti Suharti, Netti Nita Afriani Nita Afriani Noverial Noverial Noverial Noverial, Noverial Novita Ariani Novita Ariani Novita Purnama Sari Oktafani, Reni Oktaviani, Dilla Pratiwi, Eghinna Elsa Pritasa Muthia Ulfa Putri, Popy Dwi Rahmadiyani, Rahmadiyani Rahmat Syaifullah Rahmatini . Ramadhani, Dhea Amaliya Ramadhani, Nasywa Anjani Rauza Sukma Rita Rika Susanti Rini Rustini Rosfita Rasyid Roza Silvia Russilawati, Russilawati Salsabila Dhiyaa Syifa Sari, Novita Purnama Selfi Renita Rusjdi Shafiqah Zawira Sheila Diana Skunda Diliarosta SM Rezvi Syandana, Firjatul Tafdil, Zhafirah Khairunnisa Tegar Abdillah Thoriq, Muhammad Tofrizal Tuti Handayani Wirsma Arif Harahap YN Zuhal Chaisart Chaniago Yulia Kurniawati Yulistini, Yulistini Yusticia Katar Yustini Alioes Yustini Alioes Zawata Afnan Zehan Afifa Yusran