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FORMULASI DAN UJI ANTIOKSIDAN SEDIAAN GEL EKSTRAK DAUN MARPUYAN (Rhodamnia Cinerea Jack) Musyirna Rahmah Nst; Deni Anggraini Anggraini; Armon Fernando; Anita Lukman; Rajeb Fadillah
JURNAL KATALISATOR Vol. 8 No. 2 (2023): Jurnal Katalisator Volume 8 No. 2, Oktober 2023
Publisher : LLDIKTI X Sumbar, Riau, Jambi, Kepri

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62769/katalisator.v8i2.2343

Abstract

Tumbuhan marpuyan merupakan jenis tumbuhan liar banyak tersebar di wilayah Indonesia. Secara empiris, marpuyan dimanfaatkan oleh masyarakat untuk berbagai pengobatan. Daun tumbuhan marpuyan berpotensi sebagai antioksidan. Hasil penelitian terdahulu melaporkan ekstrak etanol daun marpuyan mempunyai aktivitas tabir surya yang kuat. Formulasi sediaan topikal dalam bentuk gel lebih baik  karena memberikan efek nyaman dikulit. Tujuan penelitian ini adalah memformula ekstrak etanol daun marpuyan dalam bentuk sediaan gel dan menentukan aktivitas antioksidan. Formulasi gel ekstrak etanol daun marpuyan 3 variasi konsentrasi yaitu 0,5% (FI), 1% (FII) dan 2% (FIII). Pengujian aktivitas antioksidan dilakukan dengan menggunakan metode DPPH. Evaluasi gel meliputi pengamatan organoleptis, pH, homogenitas, uji stabilitas freeze and thaw, uji daya sebar, uji daya lekat dan uji iritasi. Hasil penelitian menunjukkan gel ekstrak etanol daun marpuyan memiliki aktivitas antioksidan yang sangat kuat pada FII (1%) dan FIII (2%). Hasil uji stabilitas menunjukkan gel gel ekstrak etanol daun marpuyan tidak stabil setelah disimpan 8 minggu dan tidak memenuhi persyaratan uji daya sebar.
UJI VALIDASI METODE DAN PENETAPAN KADAR RANITIDIN DALAM SEDIAAN TABLET SECARA SPEKTROFOTOMETRI UV: METHOD VALIDATION TEST AND DETERMINATION OF RANITIDINE CONTENT IN TABLET PREPARATIONS BY UV SPECTROPHOTOMETRY Dona, Rahma; Ningrum, Tilar Eka Widia; Nasution, Musyirna Rahmah; Fernando, Armon; Syahbandi, Ilham; Milianty, Jesy
JFL : Jurnal Farmasi Lampung Vol. 13 No. 2 (2024): JFL : Jurnal Farmasi Lampung
Publisher : Program Studi Farmasi-Fakultas Matematika dan Ilmu Pengetahuan Alam-Universitas Tulang Bawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37090/jfl.v13i2.1805

Abstract

This study aims to determine the levels of ranitidine in generic and trade name tablet preparations by UV spectrophotometry. Based on the results obtained linearity value of r = 0.9999 with limit of detection (LOD) 0.1667 ppm and limit of quantitation (LOQ) 0.5558 ppm. Precision obtained RSD results of 0.641% and in accuracy obtained % recovery at 3 concentrations of 9, 12 and 15 ppm respectively 101.05; 100.63; and 100.33%. The results of the determination of levels in ranitidine tablet preparations with five generic tablets and five trade name tablets have met the requirements for levels in medicinal preparations for ranitidine tablet preparations according to the Indonesian Pharmacopoeia VI Edition, which contains ranitidine not less than 90.0% and not more than 110.0%. It can be concluded that the UV spectrophotometric method used in the study has met the parameters set in the validation test so that this method can be applied to the analysis of determining ranitidine levels in a laboratory. Keywords:  Ranitidine, UV Spectrophotometry, Method validation
ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER DARI EKSTRAK METANOL DAUN MARPUYAN (Rhodamnia cinerea Jack.) Musyirna Rahmah Nst; Dwi Andreyas; Rahma Dona; Emrizal; Emma Susanti; Ihsan Ikhtiarudin; Rahayu Utami
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.671

Abstract

A study on isolation and antibacterial activity of secondary metabolites from the methanol extract of Marpuyan (Rhodamnia cinerea Jack.) Leaves on Escherichia coli has been carried out. Isolation was carried out by column chromatography methods. Whereas the antibacterial activity test was carried out using agar diffusion method. The results of the isolation produced 17.9 mg of RC-F13 isolate compound in the form of light yellow crystals, with a melting point of 170-172oC and soluble in methanol. The results of identification of RC- F13 isolate compounds through testing with AlCl3 reagents, positive including the flavonoid group, were strengthened by the results of the UV spectrum and FT-IR spectrum. Based on the results of the UV spectrum, it was seen that the RC- F13 isolate compound showed λ max 353.60, 257.00 and 209.20 nm. The FT-IR spectrum shows the presence of several functional groups such as OH, C aliphatic C-H, C = O carbonyl, C = C aromatic and C-O. testing the antibacterial activity of methanol extract with a concentration of 20%; 10%; 1%; 0.1% and 0.01%, fraction 13 at 1% concentration; 0.1% and 0.01% and RC- F13 isolate compound concentration of 0.1%, against Escherichia coli bacteria did not show any antibacterial activity which was marked by the absence of clear areas around the disc.
ISOLASI DAN UJI AKTIVITAS ANTIBAKTERI SENYAWA METABOLIT SEKUNDER DARI EKSTRAK METANOL DAUN MARPUYAN (Rhodamnia cinerea Jack.) Musyirna Rahmah Nst; Dwi Andreyas; Rahma Dona; Emrizal; Emma Susanti; Ihsan Ikhtiarudin; Rahayu Utami
Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan Vol. 9 No. 2 (2023): Jurnal Ilmiah Manuntung: Sains Farmasi Dan Kesehatan
Publisher : Sekolah Tinggi Ilmu Kesehatan Samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v9i2.671

Abstract

A study on isolation and antibacterial activity of secondary metabolites from the methanol extract of Marpuyan (Rhodamnia cinerea Jack.) Leaves on Escherichia coli has been carried out. Isolation was carried out by column chromatography methods. Whereas the antibacterial activity test was carried out using agar diffusion method. The results of the isolation produced 17.9 mg of RC-F13 isolate compound in the form of light yellow crystals, with a melting point of 170-172oC and soluble in methanol. The results of identification of RC- F13 isolate compounds through testing with AlCl3 reagents, positive including the flavonoid group, were strengthened by the results of the UV spectrum and FT-IR spectrum. Based on the results of the UV spectrum, it was seen that the RC- F13 isolate compound showed λ max 353.60, 257.00 and 209.20 nm. The FT-IR spectrum shows the presence of several functional groups such as OH, C aliphatic C-H, C = O carbonyl, C = C aromatic and C-O. testing the antibacterial activity of methanol extract with a concentration of 20%; 10%; 1%; 0.1% and 0.01%, fraction 13 at 1% concentration; 0.1% and 0.01% and RC- F13 isolate compound concentration of 0.1%, against Escherichia coli bacteria did not show any antibacterial activity which was marked by the absence of clear areas around the disc.
Edukasi Bahaya Konsumsi Minuman Kemasan yang Berlebihan bagi Kesehatan Ginjal Susanti, Emma; Febriana, Mira; Ulfa, Rodia; Utami, Rahayu; Tambunan, Beatrix Evalin; Hanifa, Dhea; Fahri, Elifia Cahyani; Safli, Fazza Aulia; A’dilah, Nur; Afandi, Rifath; Silalahi, Rizka Fitri; Andriani, Sindy; Nurhaliza, Siti; Novianti, Yetri
Jurnal Bakti Nusantara Vol. 2 No. 2 (2024): Jurnal Bakti Nusantara
Publisher : Pustaka Media Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63763/jbn.v2i2.76

Abstract

Gagal ginjal dilaporkan menjadi salah satu penyakit tidak menular yang mematikan. Salah satu faktor penyebab terjadinya gagal ginjal kronis adalah karena mengkonsumsi minuman ringan yang kemasan. Tujuan pengabdian ini adalah mengedukasi masyarakat di Stadion Utama Riau tentang bahaya minuman kemasan yang berlebihan bagi kesehatan ginjal. Metode yang digunakan dalam kegiatan ini adalah ceramah dan diskusi serta pembagian leaflet kepada masyarakat. Pengukuran efektivitas kegiatan sosialisasi ini dilakukan dengan memberikan tes berbentuk kuisoner yang diberikan sebelum kegiatan sosialisasi sebagai tes awal (pretest) dan tes akhir setelah sosialisasi (post-test). Hasil yang diperoleh dari kegiatan ini adalah telah terjadi peningkatan pemahaman peserta tentang bahaya konsumsi minuman kemasan yang berlebihan bagi kesehatan ginjal setelah kegiatan dilaksanakan. Pengetahun yang baik akan bahaya konsumsi minuman kemasan yang berlebihan bagi kesehatan ginjal akan dapat meningkatkan kualitas kesehatan masyarakat.
PENAPISAN DAN KARAKTERISASI BAKTERI SELULOLITIK TERMOFILIK Lilik Septiana; Emma Susanti; Yuli Haryani; Zulmai Rani; Robiatun Rambe
FORTE JOURNAL Vol 4 No 2 (2024): Edisi Juli 2024
Publisher : Universitas Haji Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51771/fj.v4i2.974

Abstract

Bakteri selulolitik adalah bakteri yang mampu menghidrolisis kompleks selulosa menjadi oligosakarida yang lebih kecil dan akhirnya menjadi glukosaPenelitian penapisan dan karakterisasi bakteri selulolitik termofilik dari sumber air panas ini dilakukan untuk mendapatkan bakteri termofilik yang berpotensi sebagai penghasil selulase termostabil dan karakteristik bakteri tersebut. Penelitian ini menggunakan sampel dari sumber air panas Desa Sungai Pinang, Kabupaten Kuantan Singingi, dengan 4 titik pengambilan yang berbeda. Sebanyak 24 bakteri selulolitik diisolasi menggunakan medium spesifik yang mengandung carboxy methyl cellulose (CMC). Aktivitas selulolitik dari isolat yang diperoleh kemudian ditentukan berdasarkan kemampuan bakteri dalam menghidrolisis substrat CMC dengan mengukur zona bening yang terbentuk di sekitar koloni pada medium CMC-congo red. Hasil penelitian menunjukkan bahwa 15 dari 24 isolat (62,5%) mampu mendegradasi selulosa dengan indeks selulolitik (IS) yang beragam. Isolat SPT (III)7 memiliki aktivitas selulolitik tertinggi dengan nilai indeks selulolitik sebesar 4,80. Hasil karakterisasi morfologi dan fisiologi dari semua isolat yang diidentifikasi memperlihatkan bahwa isolat tersebut berupa bakteri Bacillus sp1 dan Bacillus sp2.
Pengaruh penambahan sari buah naga merah pada yoghurt susu kedelai serta uji aktivitas antibakteri Melzi Octaviani; Felycia Wardi; Emma Susanti

Publisher : Program Studi Ilmu dan Teknologi Pangan, Universitas Yudharta, Pasuruan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35891/tp.v15i1.4349

Abstract

Food is one of the most important needs for humans because it relates to daily nutritional needs. The solution to this problem is to consume food with good nutritional content supported by appropriate food processing innovations. Milk can be drunk directly or processed into various forms of food and drinks with milk-based ingredients, such as yogurt. This study aims to make yogurt products from soy milk using red dragon fruit juice as a substitute for sugar and to test their antibacterial activity in inhibiting Salmonella typhi and Shigella dysenteriae bacteria. This study used a completely randomized design (CRD) with 3 treatments, namely the addition of red dragon fruit juice with concentrations of 5%, 10%, and 15%, 3 replications, and the diffusion method for testing antibacterial activity. The results showed that the best yoghurt formula was obtained from F3 (yoghurt with the addition of 15% concentration of red dragon fruit juice). The panelist hedonic test gives values ranging from slightly like to like for color, aroma, taste, and texture; for organoleptic F3, these are: color (dark pink), taste (sour), texture (liquid-thick), and aroma (typical); pH 3.49; TAT 1.39%; Lactic Acid Bacteria (LAB) 2.09 x 1010 CFU/mL; and also had an average diameter of inhibition of 18.96 mm against Salmonella thypi (P<0.05) and 20.10 mm against Shigella dysenteriae (p<0.05). Soy milk yogurt with the addition of varying concentrations of red dragon fruit juice has antibacterial activity.
Shrimp Cracker Making Business in Indragiri Hilir Bathara, Lamun; Nugroho, Firman; Nasution, Tio Afandi; Simanjuntak, Asnika Putri; Nasution, Musyirna Rahmah
Jurnal Perikanan dan Kelautan Vol. 30 No. 2 (2025): June
Publisher : Fakultas Perikanan dan Kelautan Universitas Riau

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31258/jpk.30.2.252-256

Abstract

Indragiri Hilir is one of the districts with extensive waters and abundant fishery production. The potential for capture fisheries in Indragiri Hilir Regency is very large. In 2021, the potential for capture fisheries was 53,057.13 tons. Shrimp is a fishery commodity with high economic value and a favorite of Indonesian exports in the fisheries sector. Shrimp crackers are a series of food processing processes that combine tapioca flour with fresh shrimp to produce crispy snacks with a distinctive flavor. This process involves several critical stages that must be carried out carefully to produce high-quality products. Shrimp crackers are one of Indonesia's traditional snacks that have a distinctive taste and are in demand by various groups. Based on this, this study aims to determine how the shrimp cracker-making business process in Indragiri Hilir will be carried out in 2024. The research results obtained from this study are the shrimp cracker-making business in Indragiri Hilir, precisely in Tanah Merah Village, starting from the preparation, processing, and packaging stages. Shrimp crackers have been marketed to regions including Irian Jaya, Batam, Pekanbaru, Palembang, and Java. The development of the shrimp cracker processing business not only increases the livelihood of local people but also contributes to reducing unemployment in the area.
The Isolatıon, Characterızatıon, and Antıfungal Assay of Lactıc Acıd Bacterıa Isolated from Green Glutınous Rıce Tape Agaınst Aspergillus flavus Nasution, Musyirna Rahmah; Aulya, Nurliza; Dona, Rahma; Ningsih, Yozi Fiedya
Medical Laboratory Technology Journal Vol. 11 No. 1 (2025): June
Publisher : Poltekkes Kemenkes Banjarmasin Jurusan Analis Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31964/mltj.v11i1.645

Abstract

Green glutinous rice tape is a fermented food made from glutinous rice, katuk leaves (Sauropus androgynus), and yeast, originating from Tembilahan, Riau Province. This product can serve as a source of lactic acid bacteria (LAB) capable of producing antimicrobial compounds to inhibit pathogenic microorganisms, including Aspergillus flavus, a well-known spoilage fungus in food products. However, to date, no reports have explored the ability of LAB from green glutinous rice tape to inhibit the growth of Aspergillus flavus. This study aimed to isolate LAB from green glutinous rice tape, conduct macroscopic, microscopic, and biochemical characterizations, and evaluate the antifungal activity of the LAB isolates against Aspergillus flavus using the good diffusion method. The isolation process yielded four LAB isolates from Tembilahan green tape (TKHT-2, TKHT-3, TKHT-5, and TKHT-7), which were identified as members of the genus Lactobacillus sp., with antifungal activities of 25.50 ± 5.78 mm, 24.33 ± 0.62 mm, 22.16 ± 6.56 mm, and 18.66 ± 4.28 mm, respectively. The corresponding cell-free supernatants (CFS) from these isolates (TKHT-S2, TKHT-S3, TKHT-S5, and TKHT-S7) also demonstrated antifungal activity with inhibition zones of 19.83 ± 3.47 mm, 19.83 ± 4.24 mm, and 14.50 ± 3.26 mm, respectively. LAB cells and their cell-free supernatants partially inhibited Aspergillus flavus, indicating a fungistatic effect. These findings suggest the potential application of LAB from green glutinous rice tape as a natural preservative or antifungal agent in food products.
MEMANFAATAN INFUSED WATER UNTUK MENCEGAH DEHIDRASI DAN DETOKSIFIKASI TUBUH Dewi, Ratna Sari; Nasution, Musyirna Rahmah; Agustini, Tiara Tri; Arundita, Silvy; Anggraini, Annisa Fitri; Febrian, Dyan; Manik, Dhea Putri Bertuah Br; Ramadhani, Elsha Fadhika Dwi; Hanifa, Elvi; Afnita, Fakhiratunnisa; Diwa, Resi Oktamara; Nabilla, Vivi Gita; Amnan, Wekis Raya; Azhari, Weriska Restu
BESIRU : Jurnal Pengabdian Masyarakat Vol. 2 No. 5 (2025): BESIRU : Jurnal Pengabdian Masyarakat, Mei 2025
Publisher : Lembaga Pendidikan dan Penelitian Manggala Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62335/besiru.v2i5.1263

Abstract

Infused water merupakan salah satu cara untuk menjaga kesehatan dengan mudah. Memperbanyak meminum air dan mengonsumsi buah-buahan merupakan salah satu cara menjaga kesehatan. Tujuan kegiatan ini adalah memberikan pemahaman kepada masyarakat tentang manfaat infused water serta mengedukasi masyarakat bagaimana cara pembuatan infused water yang benar sehingga diharapkan program pengabdian masyarakat ini dapat meningkatkan derajat kesehatan masyarakat. Kegiatan pengabdian ini dilaksanakan pada haru minggu, 13 oktober 2024 di Car Free Day, Jalan Sudirman Pekanbaru, dengan tema “Pemanfaatan Infused Water Untuk Mencegah Dehidrasi Dan Detoksifikasi Tubuh” dengan pembagian leaflet, edukasi secara lisan terkait judul diangkat dan diakhiri dengan pembagian infused water. Hasil dari pemberian edukasi yang signifikan mengenai Infused Water kepada Masyarakat. Berdasarkan hasil pre-test dan post-test yang melibatkan 55 responden. Dari hasil uji statistic Wilcoxon juga menunjukan perbedaan yang signifikan antara tingkat pengetahuan sebelum dan sesudah edukasi (p-value < 0,05). Secara tidak langsung penyuluhan ini memberikan dampak yang baik untuk Masyarakat agar dapat selalu menerapkan mengkonsumsi infused water setiap hari.
Co-Authors -, Hasmalina ., Nofriyanti Abdi Wira Septama Abdifi, Reza Abrar Hafudz Qalbi Adinda Rusyamsi Afandi, Rifath Afnita, Fakhiratunnisa Afrida Yeti Agfa Febriyananda agistia, nesa Agistia, Nesa Agustini, Tiara Tri Akmal Djamaan Al Fadhilah, Shafira Alfian ) Alfitra Raisya alfitrah ramadhan Alimia Woelandri Amanda Putri Pratiwi Amnan, Wekis Raya Andarini Diharmi Andriani, Sindy Anggraini, Annisa Fitri Anita Lukman Anita Lukman Annisa Annisa Annisa Riski Permata Sari Antasya, Vaylia Aqilla, Alya Arfan Zasliadi Armon Fernando Arundita, Silvy Aulya, Nurliza Ayuni, Putri Azhari, Weriska Restu Azkia Wanudya Rahmadhani A’dilah, Nur Bella Ardhiyati Benni Iskandar Cahyani, Ardhia Regita Cindy Ayu Lestari Cindy Novia R Dasni Syafril Dasni Syafril Della Vasmawati Delvian Fikrani Deni Anggraini Denisya amanda Denisya Anggraini Depa Gloria Kristin Pardede Dessy Novita Sari Desvica Fitriyani Putri Dheanita Liana Dita Bina Julianti Habeahan Diwa, Resi Oktamara Dwi Andreyas Dwi Winarsih Elsa Etavianti Elsa Safitri Elvi Nurjannah Emrizal Enda Mora Enda Mora Etavianti, Elsa Fadiyah Yueflen Fahri, Elifia Cahyani Fahriza, Mela Febrian, Dyan Felycia Wardi Ferdy Firmansyah Fharisti Kirana Fina Aryani, Fina Firman Nugroho Fitri, Ramadini Fitri, Valentina Furi, Mustika Ginta Rio Maranti Gressy Novita Gustina &#039; Hafizah, Afrah Haiyul Fadhli Hanifa, Dhea Hanifa, Elvi Hasmalina - Hasmalina Nasution Hexsha Rizki Amelia Husnawati Ihksani, Nurul Ihsan Ikhtiaruddin Ihsan Ikhtiarudin Intan Putri Utami Jannah, Ninuk Rodhiatul Kamalrullah ) Kiranti Azlin Kolista Sisilawati Kolista Sisilawati Ladiona, Maria Yella Lamun Bathara Larasati Arsad Lilik Septiana Manik, Dhea Putri Bertuah Br Maria Yella Ladiona Marli, Nofrita Martina Br Manullang Masnun, Lidiatil Mayrade, Salma Yudhistira Mega Fatimah Rosana Meiriza Djohari, Meiriza Melati, Putri Melzi Octaviani Mery Sukmiwati Milianty, Jesy Mira Febriana Musyirna Rahma Nst musyirna Rahmah Muthmainnah, Nurillah Nabilah, Clara Nabilla, Vivi Gita Nanang Nasution, Tio Afandi Neni Frimayanti Ningrum, Tilar Eka Widia Ningsih, Yozi Fiedya Nofriyanti - Novianti, Yetri Nur Rahmadani Fitri Nuraina, Nuraina Nurhapipah, Nurhapipah Octavia, Richa Pardede, Depa Gloria Kristin Peng-Wei, Ching Pratiwi, Erniza Putri Binti Jakfar Putri Lestari, Putri Putri Putri, Putri R. Rizatita Fitriani Rabiatul Adawiyah Rahayu Utami Rahayu Utami Rahayu Utami Rahayu Utami Utami Rahma Dona Rahman, Sumiati Raja Adli Husein Raja adli husin Rajeb Fadillah ramadhan, alfitrah Ramadhani, Ayu Indah Ramadhani, Elsha Fadhika Dwi Ramanda safitri Ratna Sari Dewi Reza Abdifi Rizda Fitriani Robiatun Rambe Roli Oktaviana Ronapadua Sahara Ruska, Shinta Liana S.Farm., M.Farm., Apt, Sondang Khairani Safitri, Ramanda Safli, Fazza Aulia Sahara, Ronapadua Sakinah, Norma Salsabila alhamdania Balqis Salsabila Zahirah Ananda Saryono Saryono Selvi Aulia Wibowo Septi Muharni Serlin Partika Sari Silalahi, Rizka Fitri Silvera Devi Silvy Arundita Simanjuntak, Asnika Putri Siti Nurhaliza Sri Hardianti Sudarsi, Yulisma Suhelmi - Suhelmi - Sumiati Rahman Susi lestari - Syahbandi, Ilham Syamira Syaputri, Rezy Tambunan, Beatrix Evalin Titania T Nugroho Tri Budhi Murdiati Tri Budhi Murdiati Tria Halianti Triani, Leni Ulfa, Rodia Vaylia Antasya Wardi, Felycia Wei-Ching Peng Winda Sri Wahyuni Wira Noviana, Wira Noviana Wulan Desmar Utari Wulan, Nimas Yuharmen - Yuli Haryani Yulisma Sudarsi Yunelva, Rinda Zulmai Rani