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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Jurnal Ilmiah Farmasi Statistika Jurnal Kedokteran Brawijaya Jurnal Teknosains Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Pharmaceutical Science and Technology STOMATOGNATIC- Jurnal Kedokteran Gigi Indonesian Journal of Biotechnology Journal of Agromedicine and Medical Sciences Pharmacon Majalah Obat Tradisional Journal of Tropical Biodiversity and Biotechnology INDONESIAN JOURNAL OF PHARMACY JURNAL BIOLOGI INDONESIA Dental Journal (Majalah Kedokteran Gigi) The Indonesian Biomedical Journal Padjadjaran Journal of Dentistry Jurnal Kimia Terapan Indonesia JFIOnline YARSI Medical Journal Majalah Kesehatan Pharmamedika Pharmaceutical Sciences and Research (PSR)
Edy Meiyanto
Faculty Of Pharmacy, Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mathematics Mechanical Engineering Medicine & Pharmacology Public Health

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Chemopreventive Properties Curcuma heyneana Rhizome Ethanolic Extract on Hepatocellular Carcinoma Cells, JHH-4 Santoso, Christopher Filando; Rahmawati, Desty Restia; Nugraheni, Nadzifa; Adisusilo, Midori Rahmadhany Putri; Maharani, Dini; Hermawan, Adam; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 15, No 1 (2024)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev15iss1pp40-49

Abstract

Hepatocellular carcinoma is the most common type of liver cancer. Curcuminoids are natural polyphenol compounds abundant in Curcuma heyneana ethanolic extract (CHE) and are known to inhibit breast and cervical cancer cell proliferation. Based on previous research, curcuminoid compounds have been studied to inhibit the growth of the liver cancer cell model, HepG2. This study aims to examine the potential of CHE as a chemopreventive agent in liver cancer using JHH-4 cell as a model. CHE was obtained by maceration method using ethanol which was then identified for its phytochemical profile using thin layer chromatography (TLC). Then TLC results were quantified to calculate the levels of compounds present in the CHE based on spot intensity with ImageJ software. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) antioxidant assay was conducted to determine the radical scavenging activity of CHE. Cytotoxic activity of CHE on JHH-4 liver cancer cells was tested by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Extraction produces a yield of 10.2 %w/w. CHE contains 4.52 %w/w curcuminoid compound consisting of 0.49 %w/w curcumin, 3.21 %w/w demethoxycurcumin, and 0.82% w/w bisdemethoxycurcumin. CHE exhibited antioxidant activity with an IC50 value of 378.96 μg/mL, meanwhile ascorbic acid as a positive control has an IC50 value of 8.49 μg/mL. Cytotoxic activity of CHE on JHH-4 cells is characterized by an IC50 value of 16.62 μg/mL which is classified as having strong cytotoxic activity. This study concluded that CHE has the potential to be developed as a chemopreventive agent in liver cancer.Keywords: liver cancer, hepatocelullar carcinoma, Chemopreventive, antioxidant,Curcuma heyneana.
Pentagamaboronon-0-Sorbitol Induces Apoptosis through Elevation of Reactive Oxygen Species in Triple Negative Breast Cancer Cells Ramadani, Ratna Dwi; Utomo, Rohmad Yudi; Hermawan, Adam; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 12, No 1 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss1pp46-56

Abstract

Breast cancer is the most common type of cancer causing mortality for women due to metastasis. More than 50% of breast cancer patients are suffered lung metastases. One strategy to target the cancerous cell is Boron Neutron Captured Therapy (BNCT) which showed high affinity toward cancer cells and reported to have anti-proliferative as well as anti-metastatic activities. Pentagamaboronon-0 (PGB-0) is a curcumin analogue substance which had reported to exert anticancer activities against Her-2 expressing as well as triple negative breast cancer cells. Despite its great potency as BNCT agent candidate, this compound also exerted several anticancer properties. Complex formation of this substance with sorbitol was achieved to improve the solubility and maximize compound’s delivery to the target cells. This study aimed to investigate the ability of Pentagamaboronon-0-Sorbitol (PGB-0-So) to modulate cell cycle and induce apoptosis especially through the mechanisms of reactive oxygen species (ROS) modulation. The 3-(4,5-dimethylthiazzol-2yl)-2,5-diphenyltetrazolium (MTT) cytotoxicity assay of PGB-0-So against 4T1 breast cancer cell line were found to exert potential effect in dose-dependent manner with lethal concentration (IC50) values of 39 μM. The cytotoxicity of PGB-0-So complex was found to be increased considerably compared with that of PGB-0. Cell cycle modulation identified using propidium iodide (PI) staining showed cell accumulation in S phase following treatment with PGB-0-So. Apoptosis induction assay analyzed using flowcytometer with Annexin V and PI staining on its IC50 dose was found to induce programmed cell death (apoptosis). The sub-IC50 treatment of this compound was also improved the cellular ROS level which also took role in apoptosis induction. These findings suggest that PGB-0-So is potential as an anticancer agent.Keywords: Curcumin analogue, PGB-0-So, Anticancer, 4T1 cell line, ROS modulation.
Solanum nigrum Ethanolic Extract (SNE) Increases Cytotoxic Activity of Doxorubicin on MCF-7 Cell Putri, Dyaningtyas Dewi Pamungkas; Rivanti, Erlina; Istiaji, Raditya Prima; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 12, No 2 (2021)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev12iss2pp67-73

Abstract

Leunca (Solanum nigrum L.) is a potential source of natural anticancer agents. Solanum nigrum L. ethanolic extract (SNE) has cytotoxic activity in several cancer cell lines. We aimed to evaluate the ability of SNE to increase MCF-7 cell sensitivity to doxorubicin as a chemotherapeutic agent for breast cancer. Cell viability of SNE and its combination treatment with doxorubicin were conducted by 3-(4,5-dimethylthiazol-2-yl)-2.5-diphenyltetrazolium bromide (MTT) assay, and apoptosis assay was analyzed by Ethidium bromide-acridine orange method. The SNE showed a cytotoxic effect in the MCF-7 cell line with IC50 50 μg/mL. Combination treated DOX-SNE resulted in a combination index (CI) value of 0.21, indicating strong synergism SNE and doxorubicin. The SNE 25 μg/mL combined with doxorubicin 100 nM optimally induced apoptosis of MCF-7 cells. We concluded that SNE is the potential to be developed as a co-chemotherapeutic agent through apoptosis induction though the molecular mechanism need to explore.Keywords: Solanum nigrum L. herb ethanolic extract, doxorubicin, MCF-7, apoptosis.
Cytotoxic Activity and Senescence Modulatory Effect of Hesperetin on Triple-Negative Breast Cancer Cells and Kidney Cells Co-Treatment with Cisplatin Artanti, Anif Nur; Jenie, Riris Istighfari; Rumiyati, Rumiyati; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 14, No 3 (2023)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev14iss3pp181-188

Abstract

Cisplatin (Cisp) is a non-specific chemotherapeutic agent for breast cancer. Hesperetin (HST), a flavanone found in various citrus fruits, exhibits bioactive properties, functioning as an antioxidant, anti-inflammatory, and anticancer agent. The objective of this research was to investigate the potential of HST as a co-chemotherapeutic agent in conjunction with Cisp, specifically focusing on its cytotoxic effects against 4T1 triple-negative breast cancer cells and senescence modulatory effect on Vero normal kidney cells. The cytotoxic effect and viability cell of HST were evaluated through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium (MTT) assay. In addition, the effect of cellular senescence inhibition on the Vero cell line was measured using senescence-associated β-galactosidase (SA-β-gal) staining. In the MTT assay, both HST and cisplatin demonstrated a reduction in the viability of 4T1 cells in a dose-dependent manner, yielding IC50 values of 498 μM and 2 μM, respectively. The co-treatment of HST and cisplatin showed an increase in sensitivity of the 4T1 cells with a combination index of <1. HST showed low cytotoxic activity against Vero cells, with IC50 values of over 500 μM. HST decreased cellular senescence induced by cisplatin exposure on Vero cells. These results indicated that HST in co-treatment with cisplatin decreased 4T1 cell viability synergistically. HST independently reduces the cellular senescence of normal cells. Consequently, HST holds promise for potential development as a co-treatment agent in combination with cisplatin for breast cancer cells, and it may also serve as an alternative for counteracting senescence in healthy tissues.Keywords: cytotoxic, senescence, hesperetin, cisplatin, breast cancer.
Analog Curcumin, Pentagamavunon-0 (PGV-0), Induces Senescence and Increases Cytotoxic Effect of Doxorubicin on HCC 1954 Cells Angraini, Sonia Meta; Nugraheni, Nadzifa; Meiyanto, Edy; Hermawan, Adam
Indonesian Journal of Cancer Chemoprevention Vol 10, No 3 (2019)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev10iss3pp114-121

Abstract

Senescence defined as an irreversible cell cycle arrest. Senescence can inhibit cancer growth and suppress the progression of cancer. Some anticancer compounds are known to have the potential to induce senescence. Senescence defence against tumor development by preventing proliferation of cells with DNA damage. The study aimed to determine the cytotoxic effects and senescence induction of Pentagamavunon-0 (PGV-0) on Human Epidermal Growth Factor Receptor 2-positive (HER2-positive) breast cancer cells, HCC 1954. Cytotoxic tests carried out with 3- (4.5-dimethylthiazzol-2yl) -2.5-tidiphenyltetrazolium (MTT) assay showed that PGV-0 exhibited a strong cytotoxic effect with a the half maximal inhibitory concentration (IC50) value of 39 μM. Treatment with IC50 in sub-doses combined with doxorubicin showed cytotoxic enhancement effects. The senescence assay using SA-β-Galactosidase showed that the PGV-0 in a single treatment was able to induce senescence with a percentage of cell senescent of 15%. The combination treatment of PGV-0 at the half dose of IC50 with doxorubicin 100 nM was able to induce senescence with the percentage of senescent cells of 25%. Moreover, PGV-0 also increased intracellular reactive oxygen species (ROS). The results of this study indicate that PGV-0 exhibits cytotoxic effect, increases cytotoxic effect of doxorubicin and induces senescence that may correlate to the increasing of intracellular ROS in 1954 HCC cells.Keywords: Pentagamavunon (PGV-0), HCC 1954, Cytotoxic, Senescence
Co-Authors . Anindyajati . Larasati . Sugiyanto Adam Hermawan Adam Hermawan Adisusilo, Midori Rahmadhany Putri Aditya Fitriasari Aditya Fitriasari Agung Endro Nugroho Agusta Fauzi, Ilham Agustina Setiawati Ainun Wulandari Alexxander, . Alexxander, . Ameilinda Monikawati Ameilinda Monikawati Andita Pra Darma Andita Pra Darma Andriyani, Rina Angelina, Marissa Angraini, Sonia Meta Anif Nur Artanti, Anif Nur Ardriyanto, Maria Indra Arief Nurrochmad Arief Rahman Hakim Asih Triastuti Astrid Ayu Maruti Aulia Katarina Aulia Rahman, Faaza Ayu Maruti, Astrid B. Sudarto Banun Kusumawardani Chio Oka, Chio D., Andita Pra D., Andita Pra Da'i, Muhammad Da’i, Muhammad Dewi Arum Sekti, Dewi Arum Dewi Pamungkas Putri, Dyaningtyas Dewi Pratiwi Dini Maharani Djaswadi Dasuki Dwi Ana Nawangsari Dwi Ana Nawangsari, Dwi Ana Dwi Merry Christmarini Robin Dwi Nurahmanto Dyaningtyas D. P. Putri Dyaningtyas Dewi Putri Pamungkas Effendi, Fatiha Citra Endah Puji Septisetyani, Endah Puji Endah Puspitasari Endang Lukitaningsih Endang Purwaningsih Erlina Rivanti Erna Prawita Setyowati Esti, Yuni Fajar Fany Mutia Cahyani Farmasyanti, Cendrawasih Andusyana Feby Handoko, Fransiscus Fikri Amalia Fina Aryani Goenadi Fina Aryani Goenadi, Fina Aryani Fitria Rahmi Fiveri, Anis Fiveri, Anis Fortunella Tjondro Handayani, Sri Handayani, Sri Hanifa, Mila Hapsari, Novia Permata Hargiani, Fransisca Xaveria Harsan, Hayfa Salsabila Hastuti, Hanaan Emilia Adi Hendra Kurniawan Maury Hendri Wasito Heni Susilowati Herwandhani Putri Herwandhani Putri Ibrahim Arifin Ida Ayu Putu Sri Widnyani Ika Nurzijah Ika Rahmawati Sutejo Ikawati, Muthi' Ilham Agusta Fauzi Ilham Agusta Fauzi Imono Argo Donatus, Imono Argo Indrasetiawan, Puguh Indri Kusharyanti Inna Armandani, Inna Inna Armandari Iwan Sahrial Hamid JAKA WIDADA Jauhari, Fahmi Ihsanuddin Jenie, Riris Istighfari Jenie, Riris Istighfari Juni Ekowati Kadarsih Soejono, Sri Kadarsih Soejono, Sri Kartika Dyah Palupi Kartika Dyah Palupi Kato, Jun-Ya Kawai, Taro Kholid Alfan Nur Kholid Alfan Nur Komang Alit Paramitasari Kuijpers-Jagtman, Anne Marie Kumara, Dennaya Laras Widawaty Putri Lestari, Dinda Luthfia Indriyani M, Kawaichi M, Kawaichi Mae Sri Hartati Wahyuningsih Maran, Gergorius Gena Marcellino Rudyanto Maria Dwi Supriyati Maria Dwi Supriyati, Maria Dwi Masashi Kawaichi Masashi Kawaichi, Masashi Muflikhasari, Haruma Anggraini Muhammad Da&#039;i Muhammad Fithrul Mubarok, Muhammad Fithrul Muthi Ikawati N., Perdana Adhi N., Perdana Adhi Nabila, Klarissa Nanda Resa Pratama Niken Nur W, Niken Novi Hastuti, Novi Novianti, Metta Novitasari, Dhania Nugraheni, Nadzifa Nunuk Aries Nurulita Nunuk Purwanti Nurma Sabila Nurrachma, Marsya Yonna P.K.W., Diah Ayu P.K.W., Diah Ayu Perdana Adhi Nugroho Perdana Adhi Nugroho Prasetyaningrum, Pekik Wiji Pudjono Pudjono Putri, Amaliya Permata Putri, Herwandhani Putri, Nindya Budiana R A Susidarti Raditya Prima Istiaji Rahmah, Inggita Hasi Rahman, Faaza Aulia Rahmawati, Desty Restia Rahmi Khamsita Ramadani, Ratna Dwi Ratih Hardika Pratama Ratna Asmah Susidarti Ratna Asmah Susidarti Retno Ardhani Retno Murwanti Rifai, Fauziah Novita Putri Riris I Jenie Riris I Jenie, Riris I Riris Istighfari Jenie Riris Istighfari Jenie Riris Istighfari Jenie Risdian, Chandra Rita Riata Rohmad Yudi Utomo Rohmad Yudi Utomo Rosa Adelina Rosana Anna Ashari Rosana Anna Ashari, Rosana Anna Rosye H.R. Tanjung Rul Afiyah Syarif Rumiyati, Rumiyati Salsabila, Irfani Aura Santoso, Christopher Filando Sari Haryanti Sari Haryanti Sarmoko Sarmoko Sendy Junedi Sendy Junedy, Sendy Shigeru Sasaki Sismindari . Sitarina Widyarini Sofa Farida Sri . Handayani Sri Handayani Sri Kadarsih Soejono Sri Kasianningsih Sri Susilowati Sri Tasminatun Sugeng Riyanto Sugiyanto . Sugiyanto . Sukardiman Supardjan A. M. Supardjan A.M., Supardjan Supardjan AM Supardjan AM, Supardjan Susi Ari Kristina Tutuk Budiati Udin, Zalinar Umar A. Jenie Umar Anggara Jenie Umar Anggara Jenie Umar Anggara Jenie Widayanti, Wasita Rachma Yundari, Yundari Yurista Gilang Yurista Gilang Ikhtiarsyah Yuyun Farida Yuyun Farida, Yuyun Zufairo, Shofa Khamdanatuz Zulfin, Ummi Maryam