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Journal : Biota

Karakteristik Sel Punca Mesenkim yang Berasal dari Tali Pusat (Umbilical Cord Derived Mesenchymal Stem Cell/UCMSC) dari Macaca fascicularis dan Sekretomnya dalam Kondisi Hipoksia Dumingan, Alvian; Malik, Amarila; Rinendyaputri, Ratih; Utama, Hieronimus Adiyoga Nareswara; Sunarno, Sunarno; Purwaningtyas, Yoggi Ramadhani; Idrus, Hasta Handayani; Noverina, Rachmawati; Huda, Fathul; Faried, Ahmad
Biota Vol 17 No 1 (2024)
Publisher : Universitas Islam Negeri Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20414/jb.v17i1.492

Abstract

Mesenchymal Stem Cell (MSC) secretome has potential as a neuroprotective and neuroregenerative agent. It can have effects due to its paracrine factors, such as Brain Derived Neurotrophic Factor (BDNF) and Stromal-Cell Derived Factor-1 (SDF-1) which can be induced with hypoxia preconditioning. This compound may play a role in the treatment of neurological diseases. Stroke has become a neurological disease that contributes to high rates of mortality and morbidity worldwide. There have been several pre-clinical trials on animal stroke models using MSC secretomes from rats and humans, but no studies have been conducted on Non-Human Primate, such as Macaca fascicularis. This species has been widely used in biomedical research and part of it can be utilized for such studies which will reduce the cost of using human MSC. The results of this study, Umbilical Cord (UC)-MSCs of Macaca fascicularis have been successfully cultured and characterized in terms of phenotypic and differentiation. Hypoxia precondition was able to induce BDNF secretion up to 264 pg/mL and SDF-1 up to 666 pg/mL in the UCMSC secretome. Hypoxic preconditioning with 3% oxygen can induce the most optimal BDNF and SDF-1 secretion, compared to 1% and 5% hypoxia.
Co-Authors . SETIAWAN Achadiyani Achmad Adam Adriani Lawrencia Novalia Afiat Berbudi Agung B Sutiono Agung Budi Sutiono Agung Budi Sutiono Agung Budi Sutiono Agus Dwi Sastrawan Ajeng Diantini Ali Budi Harsono Alya Mardhotillah Azizah Amarila Malik Amelia Ganefianty Amira Puti Karima ANDI WIJAYA Andi Wijaya Angliana Chouw Angliana Chouw, Angliana Arwinder Singh Gill Astrid Tamara Maajid Budiman Azis, Rizal Ban Bolly, Hendrikus Masang Bayu W. Putera Benny Atmadja Wirjomartani Benny Isakh Beny Atmadja Wirjomartani Bethy Surjawathy Hernowo Billy Parulian Lubis Billy Yosua Costantin Pongajow Bilzardy Ferry Cynthia R. Sartika Cynthia Retna Sartika Cynthia Retna Sartika, Cynthia Retna Daniel Happy Putra Danny Halim Dedy Kurniawan Derrett, Sarah Dhuha, Alief Dian Ratih Laksmitawati Diana Krisanti Jasaputra Didik Priyandoko Dimas Erlangga Luftimas Dimyati Achmad Dumingan, Alvian Dwi A. P. Dewi Dwi Davidson Rihibiha Endang Sjamsudin Endang Sjamsudin Ermi Girsang Ervi Afifah Fahmi, Ismail Farid Yudoyono Farilaila Rayhani Firman Fuad Wirakusumah Firman Fuad Wirakusumah Firman Priguna Tjahjono Ganefianty, Amelia Gill, Arwinder Singh Ginting, Chrismis Novalinda Haifa, Rima Hanna Gunawan Hanna Sari W Kusuma Hanna Sari Widya Kusuma Hapsari, Putie Harry Murti Harry Murti Hasrayanti Agustina Heda Melinda Nataprawira Hendrikus Bolly Hendrikus Masang Ban Bolly Hendrikus Masang Ban Bolly Hermin Aminah Usman Hiroshi Koyama Huda, Fathul I M Kariasa I Made Kariasa I Nyoman Ehrich Lister Ida Parwati Indah, Astrina Rosaria Indra Bachtiar Ismail Fahmi Jeffrey ., Jeffrey Jefri Henky Julia Riswandani Julius July Kahdar Wiriadisastra Kalih Sarjono Keri Lestari Kharisma, Surti Wulan Leri Septiani Maman Abdurrahman Maryani, Euis McAllister, Susan MEILINAH HIDAYAT Melia, Regina Melisa Intan Barliana, Melisa Intan Mirna Sobana Mochammad Aris Widodo MUCHTAN SUJATNO Muhammad Agus Muljanto Muhammad Firdaus Muhammad Firdaus Muhammad Kusdiansah Muhammad Z. Arifin Muhammad Zafrullah Arifin Muhammad Zafrullah Arifin Mutakin Mutakin Nabilla Farah Naura Nainggolan, Ita Margaretha Nida Suryana Nina Puspitaningrum Noverina, Rachmawati NUGRAHA SUTADIPURA Oskar Ady Widarta Prayoga SURYADARMA Priandana Adya Eka Saputra Priandana Adya Eka Saputra Purwaningtyas, Yoggi Ramadhani Qlintang, Sandy Rachmawati Noverina Rachmawati Noverina Rachmawati Noverina Raden Roro Ratuningrum Anggorodiputro Raden Yohana, Raden RAHMAT, DENI Ratih Rinendyaputri Ratih Rinendyaputri Rayhani, Farilaila Renaldi Prasetia Reni Ghrahani Rilianawati Rilianawati Rima Haifa Rini Andriani Rizal Rizal Rizal Rizal Rizki, Kiki Ahmad Rizkiditia Nugraha Hadian Rizky Abdulah Robert Sinurat Rully Hanafi Dahlan Sarah Derrett Sarah Sumayyah Sarjono, Kalih Seila Arumwardana Sevline Esthetia Ompusunggu Singh, Arwinder Sobana, Mirna Soeprajogo, Adolf Setiabudi Solly Aryza Sri Suryanti Subangkit, Mawar Sugiarto, Yosafat Kurniawan Sunarno Sunarno Susan McAllister Sutiman Bambang Sumitro Sutiono, Agung B Syahril Samad, Syahril Syamsiar, Syamsiar Takayuki Ohira Takeshi Kawase Teguh Marfen Djajakusumah, Teguh Marfen Teresa Liliana Wargasetia The Fransiska Eltania Tinambunan, Nicholas Christian Tono Djuwantono Tono Djuwantono Tono Djuwantono Trajanus Laurens Yembise Tri Hanggono Achmad Triharsiwi, Dwi Nur Tuti Wahmurty Sapi'i Utama, Hieronimus Adiyoga Nareswara Vinna Kurniawati Sugiaman, Vinna Kurniawati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wahyu Widowati Widarta, Oskar Ady Wireni Ayuningtyas Wireni Ayuningtyas Yarman, Indra Prasetya Yosafat Kurniawan Sugiarto Yudi Mulyana Hidayat Yulius Hermanto Yuni Elsa Hadisaputri Yusuf Hariady Hariady Yusuf Sulaeman Effendi